Abstract：
:Hydroxyapatite (HA) is the principal inorganic component of bones and teeth and has been widely used as a bone repair material because of its good biocompatibility and bioactivity. Understanding the interactions between proteins and HA is crucial for designing biomaterials for bone regeneration. In this study, we evaluated the effects of atomic-level nano-structured HA (110) surfaces on the adsorption of bone morphogenetic protein-7 (BMP-7) and its derived peptide (KQLNALSVLYFDD) using molecular dynamics and density functional theory methods. The results indicated that the atomic-level morphology of HA significantly affected the interaction strength between proteins and HA substrates. The interactions of BMP-7 and its derived peptide with nano-concave and nano-pillar HA surfaces were stronger than those with flat or nano-groove HA surfaces. The results also revealed that if the groove size of nano-structured HA surfaces matched that of residues in the protein or peptide, these residues were likely to spread into the grooves of the nano-groove, nano-concave, and nano-pillar HA, further strengthening the interactions. These results are helpful in better understanding the adsorption behaviors of proteins onto nano-structured HA surfaces, and provide theoretical guidance for designing novel bioceramic materials for bone regeneration and tissue engineering.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Wang Q,Wang M,Lu X,Wang K,Fang L,Ren F,Lu Gdoi
10.1038/s41598-017-15219-6subject
Has Abstractpub_date
2017-11-09 00:00:00pages
15152issue
1issn
2045-2322pii
10.1038/s41598-017-15219-6journal_volume
7pub_type
杂志文章abstract：:Multicolor microscopy tools necessary to localize and visualize the complexity of subcellular systems are limited by current fluorophore technology. While commercial fluorophores cover spectral space from the ultraviolet to the near infrared region and are optimized for conventional bandpass based fluorescence microsc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22892-8
更新日期：2018-03-15 00:00:00
abstract：:This retrospective study was undertaken to identify predictors for the development of hypocalcaemia even with prophylactic administration of calcium and vitamin D, and to help guide future strategies to improve the safety, efficacy, and QOL of patients receiving denosumab. Between January 2016 and February 2020, a tot...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80243-y
更新日期：2021-01-13 00:00:00
abstract：:The regeneration capacity of knee cartilage can be enhanced by applying periosteal grafts, but this effect varies depending on the different sources of the periosteal grafts applied for cartilage formation. Tibia periosteum can be used to enhance cartilage repair. However, long-term analysis has not been conducted. Th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65448-5
更新日期：2020-05-20 00:00:00
abstract：:Maternal obesity and overnutrition during pregnancy and lactation can program an increased risk of obesity in offspring. In this context, improving maternal metabolism may help reduce the intergenerational transmission of obesity. Here we show that, in Sprague-Dawley rats, selectively altering obese maternal gut micro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20683
更新日期：2016-02-12 00:00:00
abstract：:Polygenic risk scores (PRS) from genome-wide association studies (GWAS) are increasingly used to predict disease risks. However some included variants could be false positives and the raw estimates of effect sizes from them may be subject to selection bias. In addition, the standard PRS approach requires testing over ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41262
更新日期：2017-02-01 00:00:00
abstract：:To describe the rationale and surgical technique and compare the clinical effect of posterior percutaneous endoscopic cervical discectomy (PPECD) using the Delta system versus that of conventional PPECD (key-hole) surgery for the treatment of symptomatic cervical spondylotic radiculopathy (CSR). A retrospective analys...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67381-z
更新日期：2020-06-24 00:00:00
abstract：:The correlation between hepatitis B virus (HBV) infection and metabolic syndrome (MetS) remains to be clarified. In this study, we explored this association in a large population in Southwest China. This was a cross-sectional study, with pooled adult health data. Multivariate logistic regression analysis, controlling ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62609-4
更新日期：2020-04-21 00:00:00
abstract：:Supercontinuum generation in Kerr media has become a staple of nonlinear optics. It has been celebrated for advancing the understanding of soliton propagation as well as its many applications in a broad range of fields. Coherent spectral broadening of laser light is now commonly performed in laboratories and used in c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34344-4
更新日期：2018-11-21 00:00:00
abstract：:α-glucosidase is an essential enzyme located at the brush border of intestines. It is an important therapeutic target for type II diabetes. Herein we have designed a library of novel α-arylketones as inhibitors of α-glucosidase (yeast origin) via scaffold hopping and bioisosteric modification of known inhibitors of α-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13798-y
更新日期：2017-10-16 00:00:00
abstract：:Therapeutic strategies based on the principles of tissue engineering by self-assembly put forward the notion that functional regeneration can be achieved by utilising the inherent capacity of cells to create highly sophisticated supramolecular assemblies. However, in dilute ex vivo microenvironments, prolonged culture...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08729
更新日期：2015-03-04 00:00:00
abstract：:Until now, the only kind of practical quantum private query (QPQ), quantum-key-distribution (QKD)-based QPQ, focuses on the retrieval of a single bit. In fact, meaningful message is generally composed of multiple adjacent bits (i.e., a multi-bit block). To obtain a message a1a2···al from database, the user Alice has t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07537
更新日期：2014-12-18 00:00:00
abstract：:The spatial distributions of diverse facilities are often understood in terms of the optimization of the commute distance or the economic profit. Incorporating more general objective functions into such optimization framework may be useful, helping the policy decisions to meet various social and economic demands. As a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65337-x
更新日期：2020-05-25 00:00:00
abstract：:The macrophage migration inhibitory factor (MIF) is a cytokine that plays an important role in inhibiting the growth of pathogenic Mycobacterium tuberculosis (M.tb) and regulates immune responses against M.tb pathogen. MIF -173 G > C gene polymorphism may affect immunity in an individual and leads to susceptibility to...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-017-17308-y
更新日期：2017-12-05 00:00:00
abstract：:Amphibian oocytes have been extensively used for heterologous expression of membrane proteins for studying their biochemical and biophysical properties. So far, Xenopus laevis is the main amphibian used as oocytes source to express aquaglyceroporins in order to assess water and solutes permeability. However, this well...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37069-6
更新日期：2019-01-10 00:00:00
abstract：:Studies of morphological integration and modularity, and of anatomical complexity in human evolution typically focus on skeletal tissues. Here we provide the first network analysis of the musculoskeletal anatomy of both the fore- and hindlimbs of the two species of chimpanzee and humans. Contra long-accepted ideas, ne...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25262-6
更新日期：2018-05-02 00:00:00
abstract：:Frataxin is a highly conserved protein encoded by the frataxin (FXN) gene. The full-length 210-amino acid form of protein frataxin (1-210; isoform A) expressed in the cytosol of cells rapidly translocates to the mitochondria, where it is converted to the mature form (81-210) by mitochondrial processing peptidase. Matu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35346-y
更新日期：2018-11-19 00:00:00
abstract：:Despite advances in diabetic wound care, the significant number of amputations that occur every year demands more effective therapeutics. Herein, we offer an aminated polyethersulfone nanofiber-expanded human umbilical cord blood-derived CD34+ cells (henceforth CD34+ cells) effective therapy, tested in cutaneous wound...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44932-7
更新日期：2019-06-10 00:00:00
abstract：:In this paper, we prepared a novel structure to enhance the electroluminescence intensity from Si quantum dots/SiO2multilayers. An amorphous Si/SiO2 multilayer film was fabricated by plasma-enhanced chemical vapor deposition on a Pt nanoparticle (NP)-coated Si nanopillar array substrate. By thermal annealing, an embed...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11881
更新日期：2015-07-03 00:00:00
abstract：:In long-lived species, the age-, stage- and/or sex-dependent patterns of survival and reproduction determine the evolution of life history strategies, the shape of the reproductive value, and ultimately population dynamics. We evaluate the combined effects of age and sex in recruitment, breeder survival and breeding s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40204
更新日期：2017-01-11 00:00:00
abstract：:The interaction between the T cell antigen receptor (TCR) and antigenic peptide in complex with major histocompatibility complex (MHC) molecules is a crucial step in T cell activation. The relative contributions of TCR:peptide and TCR:MHC contacts to the overall binding energy remain unclear. This has important implic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35326
更新日期：2016-10-13 00:00:00
abstract：:Knowledge of the ecology of N2-fixing (diazotrophic) plankton is mainly limited to oligotrophic (sub)tropical oceans. However, diazotrophs are widely distributed and active throughout the global ocean. Likewise, relatively little is known about the temporal dynamics of diazotrophs in productive areas. Between February...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39586-4
更新日期：2019-03-06 00:00:00
abstract：:This study aimed to examine the effect of transcutaneous electrical nerve stimulation (TENS) on stair climbing capacity in individuals with pre-radiographic to mild knee osteoarthritis (OA). This is a secondary analysis of data from a single, participant-blinded, randomized controlled trial with a pre-post design. Par...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-020-64176-0
更新日期：2020-04-29 00:00:00
abstract：:Ferroelectric-relaxor behavior of Ba(Zr0.3Ti0.7)O3 nanofibers (BZT NF) with a large aspect ratio were prepared via electrospinning and surface modified by PVP as dielectric fillers. The nanocomposite flexible films based on surface modified BZT NF and polyvinylidene fluoride (PVDF) were fabricated via a solution casti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26198
更新日期：2016-05-17 00:00:00
abstract：:A tetrameric N-acetyl galactosaminyl (GalNAc) peptidomimetic was constructed by N-acetylation of repeating proline-based hydroxamic acid units, followed by a convergent 'click chemistry' coupling. This novel glycopeptidomimetic was determined to effectively antagonize the interaction between a transmembrane hepatic le...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05513
更新日期：2014-07-01 00:00:00
abstract：:We aimed to establish the collective influence of four lifestyle practices (physical activity, diet, smoking and alcohol consumption) on the prevalence and incidence of AMD. At baseline, 2428 participants aged 49+ with complete lifestyle and AMD data were examined, and of these, 1903 participants were re-examined 15 y...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04697-3
更新日期：2017-06-28 00:00:00
abstract：:PICK1 (protein interacting with C-kinase 1) is a peripheral membrane protein that interacts with diverse membrane proteins. PICK1 has been shown to regulate the clustering and membrane localization of synaptic receptors such as AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors, metabotropic glutama...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20924
更新日期：2016-02-12 00:00:00
abstract：:We study stochastic particle systems made up of heterogeneous units. We introduce a general framework suitable to analytically study this kind of systems and apply it to two particular models of interest in economy and epidemiology. We show that particle heterogeneity can enhance or decrease the size of the collective...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01189
更新日期：2013-01-01 00:00:00
abstract：:Advances in Big Data make it possible to make short-term forecasts for market trends from previously unexplored sources. Trading strategies were recently developed by exploiting a link between the online search activity of certain terms semantically related to finance and market movements. Here we build on these earli...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50131-1
更新日期：2019-09-18 00:00:00
abstract：:Beta amyloid peptides (Aβ) are known risk factors involved in cognitive impairment, neuroinflammatory and apoptotic processes in Alzheimer's disease (AD). Phosphodiesterase 2 (PDE2) inhibitors increase the intracellular cAMP and/or cGMP activities, which may ameliorate cognitive deficits associated with AD. However, i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08070-2
更新日期：2017-09-21 00:00:00
abstract：:Plant chloroplasts proliferate through binary fission, and the stromal-side molecules that are involved in chloroplast division are bacterial derivatives. As in bacteria, the prokaryotic tubulin homolog FtsZ assembles into a ring-like structure (Z ring) at mid-chloroplast, and this process is followed by constriction....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03698-6
更新日期：2017-06-14 00:00:00
