Abstract：
:We aimed to establish the collective influence of four lifestyle practices (physical activity, diet, smoking and alcohol consumption) on the prevalence and incidence of AMD. At baseline, 2428 participants aged 49+ with complete lifestyle and AMD data were examined, and of these, 1903 participants were re-examined 15 years later. AMD was assessed from retinal photographs. A health behaviour score was calculated, allocating 1 point for each poor behaviour: current smoking; fruits and vegetables consumed <4 serves daily; <3 episodes of physical activity per week; and >2 alcoholic drinks per day. Cross-sectional analysis showed that participants who engaged in all 4 poor health behaviours (n = 29) versus those who did not engage in unhealthy behaviours (reference group; n = 677) had greater odds of any and late AMD: multivariable-adjusted OR, 5.14 (95% CI, 1.04-25.45) and OR 29.53 (95% CI 2.72-321.16), respectively. A marginally non-significant association was observed between increasing number of poor health behaviours and 15-year incidence of early AMD (multivariable-adjusted P-trend = 0.08). Our data suggests that motivating patients with AMD to eat better, exercise more, limit alcohol intake and avoid smoking seems advisable to decelerate the development or worsening of existing AMD.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Gopinath B,Liew G,Flood VM,Joachim N,Burlutsky G,Mitchell Pdoi
10.1038/s41598-017-04697-3subject
Has Abstractpub_date
2017-06-28 00:00:00pages
4359issue
1issn
2045-2322pii
10.1038/s41598-017-04697-3journal_volume
7pub_type
杂志文章abstract：:Robust biomarker quantification is essential for the accurate diagnosis of diseases and is of great value in cancer management. In this paper, an innovative diagnostic platform is presented which provides automated molecularly imprinted solid-phase extraction (MISPE) followed by liquid chromatography-mass spectrometry...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44298
更新日期：2017-03-17 00:00:00
abstract：:Long non-coding RNAs (lncRNAs) have been found to play important roles in various biological processes; however, many of their functions remain unclear. In this study, we present a novel approach to identify the lncRNA-associated protein-protein interaction (PPI) modules and ascertain their functions in human lung squ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35939
更新日期：2016-10-27 00:00:00
abstract：:Few neuroimaigng studies on reading comprehension have been conducted under natural reading settings. In this study, we showed texts presented in a natural way during functional MRI (fMRI) measurements to reveal brain areas sensitive to reading comprehension. Specifically, this paradigm independently manipulated two h...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49632-w
更新日期：2019-09-13 00:00:00
abstract：:As fine particle (FP) pollution is harmful to humans, previous studies have focused on the mechanisms of FP removal by forests. The current study aims to compare the FP removal capacities of urban forests and wetlands on the leaf, canopy, and landscape scales. Water washing and scanning electron microscopy are used to...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep46214
更新日期：2017-04-10 00:00:00
abstract：:All-trans-retinoic acid (atRA), the active metabolite of vitamin A, is a critical signaling molecule during embryonic and fetal development and is necessary for maternal health. Fetal exposure to endogenous atRA is tightly regulated during gestation in a tissue specific manner and maternal exposure to exogenous retino...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40995-8
更新日期：2019-03-15 00:00:00
abstract：:Relative sea level rise at tide gauge Galveston Pier 21, Texas, is the combination of absolute sea level rise and land subsidence. We estimate subsidence rates of 3.53 mm/a during 1909-1937, 6.08 mm/a during 1937-1983, and 3.51 mm/a since 1983. Subsidence attributed to aquifer-system compaction accompanying groundwate...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74696-4
更新日期：2020-10-21 00:00:00
abstract：:Archaea are unique microorganisms that are present in ecological niches of high temperature, pH and salinity. A total of 157 archaea were obtained from thirteen sediment, water and rhizospheric soil samples collected from Rann of Kutch, Gujarat, India. With an aim to screen phosphate solubilizing archaea, a new medium...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12293
更新日期：2015-07-28 00:00:00
abstract：:Hesperiidae is one of the largest families of butterflies. Our knowledge of the higher systematics on hesperiids from China is still very limited. We infer the phylogenetic relationships of the subfamilies of Chinese skippers based on three mitochondrial genes (cytochrome b (Cytb), the NADH dehydrogenase subunit 1 (ND...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11140
更新日期：2015-06-10 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-60629-8
更新日期：2020-02-25 00:00:00
abstract：:The studies on the increasing incidence of thyroid abnormalities are scarce. The aim of this current study was to ascertain the effects of geographical region on thyroid abnormalities under the context of universal salt iodization (USI). We randomly selected 1255 participants residing in inland and 1248 in coast, with...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80248-7
更新日期：2021-01-13 00:00:00
abstract：:The 2011 Tohoku earthquake drastically changed human activities in some regions of Fukushima Prefecture, Japan. The subsequent tsunami damage and radioactive pollution from the Fukushima Daiichi nuclear power plant resulted in the evacuation of humans, and abandonment of agricultural lands, allowing population expansi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47982-z
更新日期：2019-08-08 00:00:00
abstract：:Mammalian cytokinetic abscission is mediated by the ESCRT membrane fission machinery. While much has been clarified on the topology and kinetics of abscission through high-resolution microscopy, key questions regarding the mechanism of abscission remain open. Here we apply cryogenic soft-X-ray tomography to elucidate ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27629
更新日期：2016-06-10 00:00:00
abstract：:Cytosine methylation at CpG dinucleotides is an epigenetic mechanism that affects the gene expression profiles responsible for the functional differences in various cells and tissues. Although gene expression patterns are dynamically altered in response to various stimuli, the intraindividual dynamics of DNA methylati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26424
更新日期：2016-05-19 00:00:00
abstract：:Splenic immune function was enhanced in diet-induced-obese (DIO) mice caused by Escherichia coli. The changes in spleen function on apoptosis were still unknown. Two hundred mice in groups Lean-E. coli and DIO-E. coli were intranasal instillation of E. coli. And another two hundred mice in groups Lean-PBS and DIO-PBS ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62044-5
更新日期：2020-03-20 00:00:00
abstract：:The food supply is being increasingly challenged by climate change and water scarcity. However, incremental changes in traditional cropping systems have achieved only limited success in meeting these multiple challenges. In this study, we applied a systematic approach, using model simulation and data from two groups o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41587
更新日期：2017-02-03 00:00:00
abstract：:Ursolic acid (UA) has proved to have broad-spectrum anti-tumor effects, but its poor water solubility and incompetent targeting property largely limit its clinical application and efficiency. Here, we synthesized a nanoparticle-based drug carrier composed of chitosan, UA and folate (FA-CS-UA-NPs) and demonstrated that...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30782
更新日期：2016-07-29 00:00:00
abstract：:This study aimed to examine the effect of transcutaneous electrical nerve stimulation (TENS) on stair climbing capacity in individuals with pre-radiographic to mild knee osteoarthritis (OA). This is a secondary analysis of data from a single, participant-blinded, randomized controlled trial with a pre-post design. Par...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-020-64176-0
更新日期：2020-04-29 00:00:00
abstract：:We present theoretical results on the high-temperature phase stability and phonon spectra of paramagnetic bcc iron which explicitly take into account many-body effects. Several peculiarities, including a pronounced softening of the [110] transverse (T1) mode and a dynamical instability of the bcc lattice in harmonic a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05585
更新日期：2014-07-07 00:00:00
abstract：:Extracellular vesicles derived from mesenchymal stem cells (MSCs) represent a novel approach for regenerative and immunosuppressive therapy. Recently, cytochalasin B-induced microvesicles (CIMVs) were shown to be effective drug delivery mediators. However, little is known about their immunological properties. We propo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67563-9
更新日期：2020-07-01 00:00:00
abstract：:Genetic factors affect host susceptibility to pathogens. In this population-based case control study, we explored the genetic polymorphisms of IL-17, TLR4 and miR-146a in association with pulmonary tuberculosis in a Chinese Han population. We recruited 1601 pulmonary tuberculosis patients matched with 1526 healthy con...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28586
更新日期：2016-06-24 00:00:00
abstract：:Type 2 diabetes mellitus (T2DM) is a low-grade chronic inflammatory diseases, which have been implicated in the pathogenesis of cognitive decline. We aim to evaluate associations between inflammatory markers and the risk of mild cognitive impairment (MCI) in T2DM. This study of 140 diabetic patients involved 71 with M...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12515-z
更新日期：2017-09-26 00:00:00
abstract：:Self-organization and pattern formation in network-organized systems emerges from the collective activation and interaction of many interconnected units. A striking feature of these non-equilibrium structures is that they are often localized and robust: only a small subset of the nodes, or cell assembly, is activated....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21360
更新日期：2016-02-17 00:00:00
abstract：:The transfer entropy is a well-established measure of information flow, which quantifies directed influence between two stochastic time series and has been shown to be useful in a variety fields of science. Here we introduce the transfer entropy of the backward time series called the backward transfer entropy, and sho...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36831
更新日期：2016-11-11 00:00:00
abstract：:We study heat dissipation of a multi-wall carbon nanotube (MWCNT) device fabricated from two crossed nanotubes on a SiNx substrate under the influence of a constant (DC) electric bias. By monitoring the temperature of the substrate, we observe negligible Joule heating within the nanotube lattice itself and instead hea...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46944-9
更新日期：2019-07-25 00:00:00
abstract：:Competing time scales involved in rapid rising micro-droplets in comparison to substantially slower biodegradation processes at oil-water interfaces highlights a perplexing question: how do biotic processes occur and alter the fates of oil micro-droplets (<500 μm) in the 400 m thick Deepwater Horizon deep-sea plume? F...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61214-9
更新日期：2020-03-09 00:00:00
abstract：:Moderate alcohol consumption is generally associated with reduced risk of type 2 diabetes. However, this beneficial effects of alcohol intake remains controversial due to inconsistent results across studies. The analysis was performed using data from the Ansung-Ansan cohort study. We categorized the participants into ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07549-2
更新日期：2017-08-04 00:00:00
abstract：:Elevated ground-level ozone (O3), which is an important aspect of air quality related to public health, has been causing increasing concern. This study investigated the spatiotemporal distribution of ground-level O3 concentrations in China using a dataset from the Chinese national air quality monitoring network during...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03929-w
更新日期：2017-06-16 00:00:00
abstract：:Recent advances in the HMP (human microbiome project) research have revealed profound implications of the human microbiome to our health and diseases. We postulated that there should be distinctive features associated with healthy and/or diseased microbiome networks. Following Occam's razor principle, we further hypot...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12959-3
更新日期：2017-10-16 00:00:00
abstract：:Natal habitat preference induction (NHPI) occurs when characteristics of the natal habitat influence the future habitat selection of an animal. However, the influence of NHPI after the dispersal phase has received remarkably little attention. We tested whether exposure to humans in the natal habitat helps understand w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42835-1
更新日期：2019-04-25 00:00:00
abstract：:Ten-year oncological experience of the University Medical Center Groningen with conventional laparotomy (C-RRRTM) and laparoscopy (L-RRRTM) is described concerning resection of residual retroperitoneal tumor masses (RRTM) in a large series of patients with advanced nonseminomatous testicular germ cell tumors (NSTGCT)....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52109-5
更新日期：2019-11-01 00:00:00
