Laparoscopic Resection of Residual Retroperitoneal Tumor Mass in Advanced Nonseminomatous Testicular Germ Cell Tumors; a Feasible and Safe Oncological Procedure.

Abstract:

:Ten-year oncological experience of the University Medical Center Groningen with conventional laparotomy (C-RRRTM) and laparoscopy (L-RRRTM) is described concerning resection of residual retroperitoneal tumor masses (RRTM) in a large series of patients with advanced nonseminomatous testicular germ cell tumors (NSTGCT). 150 consecutive patients with disseminated NSTGCT required adjunctive surgery after combination chemotherapy. L-RRRTM was scheduled in 89 and C-RRRTM in 61 patients. Median residual tumor diameter was 20 mm in the L-RRRTM versus 42 mm in the C-RRRTM group (p < 0.001). Conversion rate was 15% in the L-RRRTM group. Perioperative complications occurred in 5 patients (6%) in the L-RRRTM and 7 (12%, NS) in the C-RRRTM group. Median duration of L-RRRTM was 156 minutes vs. 221 minutes for C-RRRTM (p < 0.001). 17/89 patients in the L-RRRTM group had postoperative complications versus 18/61 patients in the C-RRRTM group (NS). Median postoperative stay in the L-RRRTM group was 2 vs. 6 days in the C-RRRTM group (p < 0.001). During a median follow-up of 79 months, 27 patients had recurrences: 8 (9%) in the L-RRRTM group and 19 (31%) in the C-RRRTM group (p < 0.001). Laparoscopic resection of RRTM for advanced NSTGCT is feasible and an oncologically safe option in appropriately selected patients.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Öztürk Ç,Been LB,van Ginkel RJ,Gietema JA,Hoekstra HJ

doi

10.1038/s41598-019-52109-5

subject

Has Abstract

pub_date

2019-11-01 00:00:00

pages

15837

issue

1

issn

2045-2322

pii

10.1038/s41598-019-52109-5

journal_volume

9

pub_type

杂志文章
  • Effect of in situ VSi2 and SiC phases on the sintering behavior and the mechanical properties of HfB2-based composites.

    abstract::In situ HfB2-SiC-VSi2 composite was fabricated by reactive pressureless sintering at the temperature of 2150 °C for 4 h under a vacuum atmosphere. In situ SiC and VSi2 reinforcements were formed using VC and Si powders as starting materials according to the following reaction: VC + 3Si = SiC + VSi2. Microstructural st...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-73295-7

    authors: Ghadami S,Taheri-Nassaj E,Baharvandi HR,Ghadami F

    更新日期:2020-10-06 00:00:00

  • Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptide.

    abstract::Characterisation of G protein-coupled receptors (GPCR) relies on the availability of a toolbox of ligands that selectively modulate different functional states of the receptors. To uncover such molecules, we explored a unique strategy for ligand discovery that takes advantage of the evolutionary conservation of the 60...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep41002

    authors: Di Giglio MG,Muttenthaler M,Harpsøe K,Liutkeviciute Z,Keov P,Eder T,Rattei T,Arrowsmith S,Wray S,Marek A,Elbert T,Alewood PF,Gloriam DE,Gruber CW

    更新日期:2017-02-01 00:00:00

  • HBcAb seropositivity is correlated with poor HIV viremia control in an Italian cohort of HIV/HBV-coinfected patients on first-line therapy.

    abstract::The morbidity and mortality rates of human immunodeficiency virus (HIV)-hepatitis B virus (HBV) coinfection are higher than that of either infection alone. Outcomes and the virological response to antiretrovirals (combination antiretroviral therapy, cART) were explored in HIV/HBV subjects in a cohort of Italian patien...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-46976-1

    authors: Malagnino V,Cerva C,Maffongelli G,Teti E,Foroghi Biland L,Cesta N,De Masi M,Stingone C,Armenia D,Svicher V,Salpini R,Andreoni M,Sarmati L

    更新日期:2019-08-16 00:00:00

  • Inhibition of HIV-1 reactivation by a telomerase-derived peptide in a HSP90-dependent manner.

    abstract::A peptide vaccine designed to induce T-cell immunity to telomerase, GV1001, has been shown to modulate cellular signaling pathways and confer a direct anti-cancer effect through the interaction with heat shock protein (HSP) 90 and 70. Here, we have found that GV1001 can modulate transactivation protein-mediated human ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep28896

    authors: Kim H,Choi MS,Inn KS,Kim BJ

    更新日期:2016-07-01 00:00:00

  • Increased aqueous autotaxin and lysophosphatidic acid levels are potential prognostic factors after trabeculectomy in different types of glaucoma.

    abstract::We explored the potential relevance of aqueous lysophosphatidic acid (LPA) and autotaxin (ATX) levels on postoperative outcomes of trabeculectomy, and the effects of ATX on fibrotic response in cultured human conjunctiva fibroblast (HCF) cells. We enrolled 70 glaucomatous eyes which underwent trabeculectomy, and quant...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-29649-3

    authors: Igarashi N,Honjo M,Kurano M,Yatomi Y,Igarashi K,Kano K,Aoki J,Aihara M

    更新日期:2018-07-27 00:00:00

  • Multi-locus DNA metabarcoding of zooplankton communities and scat reveal trophic interactions of a generalist predator.

    abstract::To understand the ecosystem dynamics that underpin the year-round presence of a large generalist consumer, the Bryde's whale (Balaenoptera edeni brydei), we use a DNA metabarcoding approach and systematic zooplankton surveys to investigate seasonal and regional changes in zooplankton communities and if whale diet refl...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-36478-x

    authors: Carroll EL,Gallego R,Sewell MA,Zeldis J,Ranjard L,Ross HA,Tooman LK,O'Rorke R,Newcomb RD,Constantine R

    更新日期:2019-01-22 00:00:00

  • Triple-doped KMnF3:Yb3+/Er3+/Tm3+ nanocubes: four-color upconversion emissions with strong red and near-infrared bands.

    abstract::Triple-doped (Yb(3+)/Er(3+)/Tm(3+)) KMnF3 nanocubes with uniform sizes of 250 nm were synthesized by a facile hydrothermal route using the oleic acid as the capping agent. It was found that these nanocubes can simultaneously exhibited four-color (blue, green, red and NIR) upconversion emissions under a single 980 nm n...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep17088

    authors: Wang H,Hong X,Han R,Shi J,Liu Z,Liu S,Wang Y,Gan Y

    更新日期:2015-11-26 00:00:00

  • Mesoporous Silica Supported Pd-MnOx Catalysts with Excellent Catalytic Activity in Room-Temperature Formic Acid Decomposition.

    abstract::For the application of formic acid as a liquid organic hydrogen carrier, development of efficient catalysts for dehydrogenation of formic acid is a challenging topic, and most studies have so far focused on the composition of metals and supports, the size effect of metal nanoparticles, and surface chemistry of support...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep33502

    authors: Jin MH,Oh D,Park JH,Lee CB,Lee SW,Park JS,Lee KY,Lee DW

    更新日期:2016-09-26 00:00:00

  • Effect of environmental history on the habitat-forming kelp Macrocystis pyrifera responses to ocean acidification and warming: a physiological and molecular approach.

    abstract::The capacity of marine organisms to adapt and/or acclimate to climate change might differ among distinct populations, depending on their local environmental history and phenotypic plasticity. Kelp forests create some of the most productive habitats in the world, but globally, many populations have been negatively impa...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-021-82094-7

    authors: Fernández PA,Navarro JM,Camus C,Torres R,Buschmann AH

    更新日期:2021-01-28 00:00:00

  • East Asian summer monsoon precipitation variability since the last deglaciation.

    abstract::The lack of a precisely-dated, unequivocal climate proxy from northern China, where precipitation variability is traditionally considered as an East Asian summer monsoon (EASM) indicator, impedes our understanding of the behaviour and dynamics of the EASM. Here we present a well-dated, pollen-based, ~20-yr-resolution ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep11186

    authors: Chen F,Xu Q,Chen J,Birks HJ,Liu J,Zhang S,Jin L,An C,Telford RJ,Cao X,Wang Z,Zhang X,Selvaraj K,Lu H,Li Y,Zheng Z,Wang H,Zhou A,Dong G,Zhang J,Huang X,Bloemendal J,Rao Z

    更新日期:2015-06-18 00:00:00

  • Small-scale pig farmers' behavior, silent release of African swine fever virus and consequences for disease spread.

    abstract::The expanding distribution of African swine fever (ASF) is threatening the pig industry worldwide. Most outbreaks occur in backyard and small-scale herds, where poor farmers often attempt to limit the disease's economic consequences by the emergency sale of their pigs. The risk of African swine fever virus (ASFV) rele...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep17074

    authors: Costard S,Zagmutt FJ,Porphyre T,Pfeiffer DU

    更新日期:2015-11-27 00:00:00

  • Influence of tunnel ionization to third-harmonic generation of infrared femtosecond laser pulses in air.

    abstract::Here we present an experimental as well as theoretical study of third-harmonic generation in tightly focused femtosecond filaments in air at the wavelength of [Formula: see text]. At low intensities, longitudinal phase matching is dominating in the formation of 3rd harmonics, whereas at higher intensities locked X-wav...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-74263-x

    authors: Tamulienė V,Juškevičiūtė G,Buožius D,Vaičaitis V,Babushkin I,Morgner U

    更新日期:2020-10-15 00:00:00

  • Mediators of the association between low socioeconomic status and poor glycemic control among type 2 diabetics in Bangladesh.

    abstract::Although low socioeconomic status (SES) is related to poor glycemic control, the underlying mechanisms remain unclear. We examined potentially modifiable factors involved in the association between low SES and poor glycemic control using data from the baseline survey of a multicenter, prospective cohort study. Five hu...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-63253-8

    authors: Rahman M,Nakamura K,Hasan SMM,Seino K,Mostofa G

    更新日期:2020-04-21 00:00:00

  • Genome and secretome analysis of Pochonia chlamydosporia provide new insight into egg-parasitic mechanisms.

    abstract::Pochonia chlamydosporia infects eggs and females of economically important plant-parasitic nematodes. The fungal isolates parasitizing different nematodes are genetically distinct. To understand their intraspecific genetic differentiation, parasitic mechanisms, and adaptive evolution, we assembled seven putative chrom...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-19169-5

    authors: Lin R,Qin F,Shen B,Shi Q,Liu C,Zhang X,Jiao Y,Lu J,Gao Y,Suarez-Fernandez M,Lopez-Moya F,Lopez-Llorca LV,Wang G,Mao Z,Ling J,Yang Y,Cheng X,Xie B

    更新日期:2018-01-18 00:00:00

  • Solution structure of Gaussia Luciferase with five disulfide bonds and identification of a putative coelenterazine binding cavity by heteronuclear NMR.

    abstract::Gaussia luciferase (GLuc) is a small luciferase (18.2 kDa; 168 residues) and is thus attracting much attention as a reporter protein, but the lack of structural information is hampering further application. Here, we report the first solution structure of a fully active, recombinant GLuc determined by heteronuclear mul...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-76486-4

    authors: Wu N,Kobayashi N,Tsuda K,Unzai S,Saotome T,Kuroda Y,Yamazaki T

    更新日期:2020-11-18 00:00:00

  • Quantitative metabolic imaging using endogenous fluorescence to detect stem cell differentiation.

    abstract::The non-invasive high-resolution spatial mapping of cell metabolism within tissues could provide substantial advancements in assessing the efficacy of stem cell therapy and understanding tissue development. Here, using two-photon excited fluorescence microscopy, we elucidate the relationships among endogenous cell flu...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep03432

    authors: Quinn KP,Sridharan GV,Hayden RS,Kaplan DL,Lee K,Georgakoudi I

    更新日期:2013-12-05 00:00:00

  • Lipocalin 2 Does Not Play A Role in Celastrol-Mediated Reduction in Food Intake and Body Weight.

    abstract::Celastrol is a leptin-sensitizing agent with profound anti-obesity effects in diet-induced obese (DIO) mice. However, the genes and pathways that mediate celastrol-induced leptin sensitization have not been fully understood. By comparing the hypothalamic transcriptomes of celastrol and vehicle-treated DIO mice, we ide...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-49151-8

    authors: Feng X,Guan D,Auen T,Choi JW,Salazar-Hernandez MA,Faruk F,Copps KD,Ozcan U

    更新日期:2019-09-05 00:00:00

  • Effects of the technique and drill design used during the osteotomy on the thermal and histological stimulation.

    abstract::The objective of our in vivo study was to compare the effects of the osteotomy on the thermal alterations, the bone healing and count of polymorphonuclear cells, comparing the drill design (cylindrical or conical) using continuous or intermittent movement. Twelve rabbits were used, which were made four osteotomies (n ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-77762-z

    authors: Gehrke SA,Treichel TLE,Aramburú Júnior J,de Aza PN,Prados-Frutos JC

    更新日期:2020-11-26 00:00:00

  • A staged screening of registered drugs highlights remyelinating drug candidates for clinical trials.

    abstract::There is no treatment for the myelin loss in multiple sclerosis, ultimately resulting in the axonal degeneration that leads to the progressive phase of the disease. We established a multi-tiered platform for the sequential screening of drugs that could be repurposed as remyelinating agents. We screened a library of 2,...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep45780

    authors: Eleuteri C,Olla S,Veroni C,Umeton R,Mechelli R,Romano S,Buscarinu MC,Ferrari F,Calò G,Ristori G,Salvetti M,Agresti C

    更新日期:2017-04-07 00:00:00

  • Multi-beam two-photon polymerization for fast large area 3D periodic structure fabrication for bioapplications.

    abstract::Two-photon polymerization (TPP) is capable of fabricating 3D structures with dimensions from sub-µm to a few hundred µm. As a direct laser writing (DLW) process, fabrication time of 3D TPP structures scale with the third order, limiting its use in large volume fabrication. Here, we report on a scalable fabrication met...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-64955-9

    authors: Maibohm C,Silvestre OF,Borme J,Sinou M,Heggarty K,Nieder JB

    更新日期:2020-05-26 00:00:00

  • Allopurinol partially prevents disuse muscle atrophy in mice and humans.

    abstract::Disuse muscle wasting will likely affect everyone in his or her lifetime in response to pathologies such as joint immobilization, inactivity or bed rest. There are no good therapies to treat it. We previously found that allopurinol, a drug widely used to treat gout, protects muscle damage after exhaustive exercise and...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-21552-1

    authors: Ferrando B,Gomez-Cabrera MC,Salvador-Pascual A,Puchades C,Derbré F,Gratas-Delamarche A,Laparre L,Olaso-Gonzalez G,Cerda M,Viosca E,Alabajos A,Sebastiá V,Alberich-Bayarri A,García-Castro F,Viña J

    更新日期:2018-02-23 00:00:00

  • A Neural Network Approach to Identify the Peritumoral Invasive Areas in Glioblastoma Patients by Using MR Radiomics.

    abstract::The challenge in the treatment of glioblastoma is the failure to identify the cancer invasive area outside the contrast-enhancing tumour which leads to the high local progression rate. Our study aims to identify its progression from the preoperative MR radiomics. 57 newly diagnosed cerebral glioblastoma patients were ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-66691-6

    authors: Yan JL,Li C,van der Hoorn A,Boonzaier NR,Matys T,Price SJ

    更新日期:2020-06-16 00:00:00

  • US Power Production at Risk from Water Stress in a Changing Climate.

    abstract::Thermoelectric power production in the United States primarily relies on wet-cooled plants, which in turn require water below prescribed design temperatures, both for cooling and operational efficiency. Thus, power production in US remains particularly vulnerable to water scarcity and rising stream temperatures under ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-12133-9

    authors: Ganguli P,Kumar D,Ganguly AR

    更新日期:2017-09-20 00:00:00

  • Embryonic/fetal mortality and intrauterine growth restriction is not exclusive to the CBA/J sub-strain in the CBA × DBA model.

    abstract::Inbred strains of mice are powerful models for understanding human pregnancy complications. For example, the exclusive mating of CBA/J females to DBA/2J males increases fetal resorption to 20-35% with an associated decline in placentation and maintenance of maternal Th1 immunity. More recently other complications of p...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep35138

    authors: McKelvey KJ,Yenson VM,Ashton AW,Morris JM,McCracken SA

    更新日期:2016-10-21 00:00:00

  • Differential parameters between activity flare and acute infection in pediatric patients with systemic lupus erythematosus.

    abstract::Systemic lupus erythematosus (SLE) patients are vulnerable to infections. We aim to explore the approach to differentiate active infection from disease activity in pediatric SLE patients. Fifty pediatric SLE patients presenting with 185 clinical visits were collected. The associations between both clinical and laborat...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-76789-6

    authors: Luo KL,Yang YH,Lin YT,Hu YC,Yu HH,Wang LC,Chiang BL,Lee JH

    更新日期:2020-11-16 00:00:00

  • Magnetic properties of ball-milled SrFe12O19 particles consolidated by Spark-Plasma Sintering.

    abstract::The room-temperature magnetic properties of ball-milled strontium hexaferrite particles consolidated by spark-plasma sintering are strongly influenced by the milling time. Scanning electron microscopy revealed the ball-milled SrFe12O19 particles to have sizes varying over several hundred nanometers. X-Ray powder-diffr...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep14112

    authors: Stingaciu M,Topole M,McGuiness P,Christensen M

    更新日期:2015-09-15 00:00:00

  • Effect of selected biocides on microbiologically influenced corrosion caused by Desulfovibrio ferrophilus IS5.

    abstract::The marine bacterial strain Desulfovibrio ferrophilus IS5, known for its lithotrophic growth ability to use metallic iron as a sole electron donor and for causing corrosion of steel, was used in the current study. Four commonly used biocides in the oil and gas industry, namely tetrakis(hydroxymethyl) phosphonium sulfa...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-34789-7

    authors: Sharma M,Liu H,Chen S,Cheng F,Voordouw G,Gieg L

    更新日期:2018-11-09 00:00:00

  • Quasi-Static Pull-in: an Instability in Electrostatic Actuators.

    abstract::We identify a new instability in electrostatic actuators dubbed quasi-static pull-in. We report experimental evidence of the instability and study its characteristics in two types of micro actuators operating in ambient air. We found that the underlying mechanism is a fast-slow dynamic interaction between slowly-varyi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-61534-w

    authors: Al-Ghamdi MS,Khater ME,Abdel-Rahman EM,Nepomuceno EG

    更新日期:2020-03-19 00:00:00

  • Doping colloidal bcc crystals - interstitial solids and meta-stable clusters.

    abstract::The addition of a small amount of dopant impurities to crystals is a common method to tune the properties of materials. Usually the doping grade is restricted by the low solubility of the dopants; increasing the doping concentration beyond this solubility limit leads to supersaturated solutions in which dopant cluster...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-12730-8

    authors: Higler R,Sprakel J

    更新日期:2017-10-03 00:00:00

  • Natural Intermediate Band in I 2 -II-IV-VI4 Quaternary Chalcogenide Semiconductors.

    abstract::An intermediate band in the band gap of semiconductors is fundamental to the development of the intermediate band solar cells, but it is usually produced artificially, which imposes technical challenges on the experimental realization. Here we found that there are natural intermediate bands in the band gaps of the I2-...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-19935-5

    authors: Liu Q,Cai Z,Han D,Chen S

    更新日期:2018-01-25 00:00:00