Abstract：
:Experimental evidence supports that signaling pathways can induce different dynamics of transcription factor (TF) activation, but how an input signal is encoded by such a dynamic, noisy TF and further decoded by downstream genes remains largely unclear. Here, using a system of stochastic transcription with signal regulation, we show that (1) keeping the intensity of the signal noise invariant but prolonging the signal duration can both enhance the mutual information (MI) and reduce the energetic cost (EC); (2) if the signal duration is fixed, the larger MI needs the larger EC, but if the signal period is fixed, there is an optimal time that the signal spends at one lower branch, such that MI reaches the maximum; (3) if both the period and the duration are simultaneously fixed, increasing the input noise can always enhance MI in the case of transcription regulation rather than in the case of degradation regulation. In addition, we find that the input noise can induce stochastic focusing in a regulation-dependent manner. These results reveal not only the dynamic mechanism of noisy signal decoding in gene regulation but also the essential role of external noise in controlling gene expression levels.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Liu P,Wang H,Huang L,Zhou Tdoi
10.1038/srep42128subject
Has Abstractpub_date
2017-02-08 00:00:00pages
42128issn
2045-2322pii
srep42128journal_volume
7pub_type
杂志文章abstract：:SOX7 as a tumor suppressor belongs to the SOX F gene subfamily and is associated with a variety of human cancers, including breast cancer, but the mechanisms involved are largely unclear. In the current study, we investigated the interactions between SOX7 and AXIN2 in their co-regulation on the Wnt/β-catenin signal pa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26136
更新日期：2016-05-18 00:00:00
abstract：:Land use, habitat, and forage quality have emerged as critical factors influencing the health, productivity, and survival of honey bee colonies. However, characterization of the mechanistic relationship between differential land-use conditions and ultimate outcomes for honey bee colonies has been elusive. We assessed ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52485-y
更新日期：2019-11-07 00:00:00
abstract：:Site variation in fixation, staining, and scanning can confound automated tissue based image classifiers for disease characterization. In this study we incorporated stability into four feature selection methods for identifying the most robust and discriminating features for two prostate histopathology classification t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33026-5
更新日期：2018-10-08 00:00:00
abstract：:A composite of manganese monoxide loaded onto carbon nanotubes (CNTs@MnO) has been synthesized by a facile approach, in which the CNTs form a continuous conductive network connecting the electrocatalyst MnO nanoparticles together to facilitate good electrochemical performance. The electrocatalyst MnO shows favourable ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08012
更新日期：2015-01-30 00:00:00
abstract：:The atomic-scale response of dielectrics/ferroelectrics to electric fields is central to their functionality. Here we introduce an in situ characterization method that reveals changes in the local atomic structure in polycrystalline materials under fields. The method employs atomic pair distribution functions (PDFs), ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14678
更新日期：2015-10-01 00:00:00
abstract：:α-synuclein plays a key role in the pathogenesis of Parkinson's disease (PD); its deposits are found as amyloid fibrils in Lewy bodies and Lewy neurites, the histopathological hallmarks of PD. Amyloid fibrillation is a progressive polymerization path starting from peptide/protein misfolding and proceeding through the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26645-5
更新日期：2018-05-29 00:00:00
abstract：:Head and neck squamous cell carcinoma (HNSCC) development is a multistage process includes the normal, dysplasia and squamous cell carcinoma (SCC) stages. Recently, increasing evidence has suggested that the tumor microenvironment (TME) is an integral part of malignant transformation. Exploring certain key node genes ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20208
更新日期：2016-02-01 00:00:00
abstract：:Complex regulatory networks control epithelial-to-mesenchymal transition (EMT) but the underlying epigenetic control is poorly understood. Lysine-specific demethylase 1 (LSD1) is a key histone demethylase that alters the epigenetic landscape. Here we explored the role of LSD1 in global epigenetic regulation of EMT, ca...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17913-x
更新日期：2018-01-08 00:00:00
abstract：:The prominent comprehensive properties of solid-solution- and intermetallic-based Ti alloys are derived from their diverse microstructures induced by multi-component alloying, which results in a chemical composition complexity. A cluster-plus-glue-atom model, characterizing the chemical short-range orders, was introdu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40302-5
更新日期：2019-03-04 00:00:00
abstract：:At the basis of a trophic web, coprophagous animals like dung beetles (Scarabaeoidea) utilize resources that may have advantages (easy gain and handling) as well as drawbacks (formerly processed food). Several studies have characterized the nutrients, e.g. C/N ratios and organic matter content, for specific types of d...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12265-y
更新日期：2017-09-22 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-019-46785-6
更新日期：2019-07-17 00:00:00
abstract：:The recently evolved field of synthetic biology has revolutionized the way we think of biology as an "engineerable" discipline. The newly sprouted branch is constantly in need of simple, cost-effective and automatable DNA-assembly methods. We have developed a reliable DNA-assembly system, ZeBRα (Zero-Background Redα),...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39768-0
更新日期：2019-02-27 00:00:00
abstract：:Computational predictions of double gene knockout effects by flux balance analysis (FBA) have been used to characterized genome-wide patterns of epistasis in microorganisms. However, it is unclear how in silico predictions are related to in vivo epistasis, as FBA predicted only a minority of experimentally observed ge...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47935-6
更新日期：2019-08-14 00:00:00
abstract：:One of the factors that has increased the incidence and worse prognosis of breast cancer is obesity. In this condition, high amounts of leptin are secreted, which have proliferative, mitogenic, antiapoptotic, and proinflammatory activity that may be antagonistic to treatment with tamoxifen, considered the first choice...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55674-x
更新日期：2019-12-16 00:00:00
abstract：:To date, only two pigments have been identified in avian eggshells: rusty-brown protoporphyrin IX and blue-green biliverdin IXα. Most avian eggshell colours can be produced by a mixture of these two tetrapyrrolic pigments. However, tinamou (Tinamidae) eggshells display colours not easily rationalised by combination of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68070-7
更新日期：2020-07-09 00:00:00
abstract：:Hormones and placental factors are thought to underlie the maternal immunological changes during pregnancy. However, as several intestinal microbiota are linked to immune modulations, we hypothesized that the intestinal microbiota are altered during pregnancy in favor of species associated with pregnancy associated im...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28292-2
更新日期：2018-07-03 00:00:00
abstract：:The aim of this study was to investigate the characteristics of insulin producing cells (IPCs) differentiated from adipose-tissue derived stem cells (ADSCs) isolated from human subcutaneous and visceral adipose tissues and identify ADSCs suitable for differentiation into efficient and functional IPCs. Subcutaneous and...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49701-0
更新日期：2019-09-13 00:00:00
abstract：:Non-destructive measurements of deformations are a quite common application of holography but due to the intrinsic limits in the interferometric technique, those are generally confined only to small targets and in controlled environment. Here we present an advanced technique, based on Mid Infrared Digital Holography (...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23688
更新日期：2016-04-01 00:00:00
abstract：:Misfolding of translated proteins occurs in all domains of life. In most cells, misfolded proteins coalesce in discrete aggregates at distinct cellular locations. In many bacteria, including mycobacteria, protein aggregates are located at the cellular pole. Yet the mechanism by which aggregates are sorted to the mycob...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51132-w
更新日期：2019-10-10 00:00:00
abstract：:To better understand the recognition mechanism of RISC and the repertoire of guide-target interactions we introduced G:U wobbles and mismatches at various positions of the microRNA (miRNA) 'seed' region and performed all-atom molecular dynamics simulations of the resulting Ago-miRNA:mRNA ternary complexes. Our simulat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00569
更新日期：2012-01-01 00:00:00
abstract：:The same copper phosphate catalysts were synthesized by obtaining the methods involving solid state as well as liquid state reactions in this work. And then the optimised p-n hybrid junction photocatalysts have been synthesized following the same solid/liquid reaction pathways. The synthesized copper phosphate photoca...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21239-7
更新日期：2018-02-13 00:00:00
abstract：:Music and language are complex hierarchical systems in which individual elements are systematically combined to form larger, syntactic structures. Suggestions that music and language share syntactic processing resources have relied on evidence that syntactic violations in music interfere with syntactic processing in l...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36076-x
更新日期：2018-12-17 00:00:00
abstract：:Remodeling of the collagen architecture in the extracellular matrix (ECM) has been implicated in ovarian cancer. To quantify these alterations we implemented a form of 3D texture analysis to delineate the fibrillar morphology observed in 3D Second Harmonic Generation (SHG) microscopy image data of normal (1) and high ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35734
更新日期：2016-10-21 00:00:00
abstract：:Invariant Natural killer T (iNKT) cells rapidly produce copious amounts of multiple cytokines after in vivo activation, allowing for the direct detection of a number of cytokines directly ex vivo. However, for some cytokines this approach is suboptimal. Here, we report technical variations that allow the improved dete...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16832-1
更新日期：2017-11-30 00:00:00
abstract：:Metformin is an antidiabetic drug which possesses antiproliferative activity in cancer cells when administered at high doses, due to its unfavorable pharmacokinetics. The aim of this work was to develop a pharmacological tool for the release of metformin in proximity of the tumor, allowing high local concentrations, a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22054-w
更新日期：2018-03-02 00:00:00
abstract：:Hungarians who live in Central Europe today are one of the westernmost Uralic speakers. Despite of the proposed Volga-Ural/West Siberian roots of the Hungarian language, the present-day Hungarian gene pool is highly similar to that of the surrounding Indo-European speaking populations. However, a limited portion of sp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44272-6
更新日期：2019-05-24 00:00:00
abstract：:The proteins AtSEOR1 and AtSEOR2 occur as conjugates in the form of filaments in sieve elements of Arabidopsis thaliana. A reduced phytoplasma titre found in infected defective-mutant Atseor1ko plants in previous work raised the speculation that non-conjugated SEOR2 is involved in the phytohormone-mediated suppression...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71660-0
更新日期：2020-09-08 00:00:00
abstract：:Human papillomaviruses enter host cells via a clathrin-independent endocytic pathway involving tetraspanin proteins. However, post-endocytic trafficking required for virus capsid disassembly remains unclear. Here we demonstrate that the early trafficking pathway of internalised HPV particles involves tetraspanin CD63,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32337
更新日期：2016-08-31 00:00:00
abstract：:Deforestation associated with the initial settlement of New Zealand is a dramatic example of how humans can alter landscapes through fire. However, evidence linking early human presence and land-cover change is inferential in most continental sites. We employed a multi-proxy approach to reconstruct anthropogenic land ...
journal_title：Scientific reports
pub_type： 历史文章,杂志文章
doi：10.1038/s41598-018-30606-3
更新日期：2018-08-14 00:00:00
abstract：:Traumatic brain injury (TBI) is a leading cause of injury-related death worldwide, yet there are no approved neuroprotective therapies that improve neurological outcome post-injury. Transient opening of the blood-brain barrier following injury provides an opportunity for passive accumulation of intravenously administe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52622-7
更新日期：2019-11-06 00:00:00
