Molecular dynamics simulations of Ago silencing complexes reveal a large repertoire of admissible 'seed-less' targets.

abstract：:At the post-synaptic density (PSD), large protein complexes dynamically form and dissociate in response to synaptic activity, comprising the biophysical basis for learning and memory. The use of detergents to isolate the PSD and release its membrane-associated proteins complicates studies of these activity-dependent p...

journal_title：Scientific reports

authors： Lautz JD,Gniffke EP,Brown EA,Immendorf KB,Mendel RD,Smith SEP

更新日期：2019-07-26 00:00:00

abstract：:Magnesium battery is potentially a safe, cost-effective, and high energy density technology for large scale energy storage. However, the development of magnesium battery has been hindered by the limited performance and the lack of fundamental understandings of electrolytes. Here, we present a study in understanding co...

journal_title：Scientific reports

authors： Shao Y,Liu T,Li G,Gu M,Nie Z,Engelhard M,Xiao J,Lv D,Wang C,Zhang JG,Liu J

更新日期：2013-11-04 00:00:00

abstract：:Nitrous oxide (N2O) is a potent greenhouse gas. In North China, vegetable fields are amended with high levels of N fertilizer and irrigation water, which causes massive N2O flux. The aim of this study was to determine the contribution of microbial processes to N2O production and characterize isotopic signature effects...

journal_title：Scientific reports

authors： Zhang W,Li Y,Xu C,Li Q,Lin W

更新日期：2016-07-08 00:00:00

abstract：:V-domain immunoglobulin (Ig) suppressor of T cell activation (VISTA) is an immune checkpoint that maintains peripheral T cell quiescence and inhibits anti-tumor immune responses. VISTA functions by dampening the interaction between myeloid cells and T cells, orthogonal to PD-1 and other checkpoints of the tumor-T cell...

journal_title：Scientific reports

authors： Mehta N,Maddineni S,Kelly RL,Lee RB,Hunter SA,Silberstein JL,Parra Sperberg RA,Miller CL,Rabe A,Labanieh L,Cochran JR

更新日期：2020-09-16 00:00:00

abstract：:Solar thermoelectric generators (STEGs), which are used for various applications, (particularly small size electronic devices), have optical concentration systems for high energy conversion efficiency. In this study, a refraction-assisted STEG (R-STEG) is designed based on phase-change materials. As the phase-change m...

journal_title：Scientific reports

authors： Kim MS,Kim MK,Jo SE,Joo C,Kim YJ

更新日期：2016-06-10 00:00:00

abstract：:This study aimed to define the width and length of the dental arch in 12-year-old Vietnamese children, and to elucidate differences between genders and among ethnic groups. A cross-sectional study was conducted in 4565 12 years-old children from the 4 major ethnic groups in Vietnam (Kinh, Muong, Thai, and Tay), with a...

journal_title：Scientific reports

authors： Dung TM,Ngoc VTN,Hiep NH,Khoi TD,Xiem VV,Chu-Dinh T,Cieslar-Pobuda A,Stoufi E,Show PL,Tao Y,Bac ND,Van Ba N,Le QA,Pham VH,Chu DT

更新日期：2019-02-28 00:00:00

abstract：:Gestational diabetes mellitus (GDM) is conventionally confirmed with oral glucose tolerance test (OGTT) in 24 to 28 weeks of gestation, but it is still uncertain whether it can be predicted with secondary use of electronic health records (EHRs) in early pregnancy. To this purpose, the cost-sensitive hybrid model (CSHM...

journal_title：Scientific reports

authors： Qiu H,Yu HY,Wang LY,Yao Q,Wu SN,Yin C,Fu B,Zhu XJ,Zhang YL,Xing Y,Deng J,Yang H,Lei SD

更新日期：2017-11-27 00:00:00

abstract：:Beside its unique nutritional content breast milk also contains live cells from the mother. Fate of these cells in the offspring has not been adequately described. In this study, we aimed to detect and identify maternal cells in the suckling's blood and the brain. Green fluorescent protein expressing transgenic female...

journal_title：Scientific reports

authors： Aydın MŞ,Yiğit EN,Vatandaşlar E,Erdoğan E,Öztürk G

更新日期：2018-09-24 00:00:00

abstract：:We report an experimental demonstration of positive-negative sub-wavelength interference without correlation. Typically, people can achieve sub-wavelength effects with correlation measurement no matter by using bi-photon or thermal light sources. In this paper, we adopt a thermal light source, and we count the realiza...

journal_title：Scientific reports

authors： Dou LY,Cao DZ,Xu DQ,Zhang AN,Song XB

更新日期：2021-01-28 00:00:00

abstract：:Effective quality assurance is essential in any screening programme. This article provides a unique insight into key quality indicators of five rounds of the first population-based colorectal cancer screening programme implemented in Spain (2000-2012), providing the results according to the type of screening (prevalen...

journal_title：Scientific reports

authors： Binefa G,Garcia M,Milà N,Fernández E,Rodríguez-Moranta F,Gonzalo N,Benito L,Clopés A,Guardiola J,Moreno V

更新日期：2016-01-20 00:00:00

abstract：:The natural ligand 17β-estradiol (E2) is so far believed to induce a unique agonist-bound active conformation in the ligand binding domain (LBD) of the estrogen receptors (ERs). Both subtypes, ERα and ERβ, are transcriptionally activated in the presence of E2 with ERβ being somewhat less active than ERα under similar ...

journal_title：Scientific reports

authors： Souza PCT,Textor LC,Melo DC,Nascimento AS,Skaf MS,Polikarpov I

更新日期：2017-06-14 00:00:00

abstract：:In this paper we report a low complexity compression method that is suitable for compact optical scanning holography (OSH) systems with different optical settings. Our proposed method can be divided into 2 major parts. First, an automatic decision maker is applied to select the rows of holographic pixels to be scanned...

journal_title：Scientific reports

authors： Tsang PW,Poon TC,Liu JP,Kim T,Kim YS

更新日期：2016-10-06 00:00:00

abstract：:The stethoscope is used as first line diagnostic tool in assessment of patients with pulmonary symptoms. However, there is much debate about the diagnostic accuracy of this instrument. This meta-analysis aims to evaluate the diagnostic accuracy of lung auscultation for the most common respiratory pathologies. Studies ...

journal_title：Scientific reports

authors： Arts L,Lim EHT,van de Ven PM,Heunks L,Tuinman PR

更新日期：2020-04-30 00:00:00

abstract：:The general model presented here for the formation of chromatin domains, LADs and TADs, is primarily based on the 3-D structures of the corresponding DNA sequences, the GC-poor and GC-rich isochores. Indeed, the low-heterogeneity GC-poor isochores locally are intrinsically stiff and curved because of the presence of i...

journal_title：Scientific reports

authors： Bernardi G

更新日期：2018-12-13 00:00:00

abstract：:Perivascular spaces (PVSs) in brain have a close relationship with typical neurological diseases. The quantitative studies of PVSs are meaningful but usually difficult, due to their thin and weak signals and also background noise in the 7 T brain magnetic resonance images (MRI). To clearly distinguish the PVSs in the ...

journal_title：Scientific reports

authors： Hou Y,Park SH,Wang Q,Zhang J,Zong X,Lin W,Shen D

更新日期：2017-08-17 00:00:00

abstract：:Tumor-associated immune response plays a critical role in cancer pathogenesis. This study evaluated clinical implications of T cell cytokines and regulatory T cells (Tregs) in HCC patients treated with TACE. Whole blood was obtained for analysis of T cell cytokines (IL-1β, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12p70...

journal_title：Scientific reports

authors： Lee HL,Jang JW,Lee SW,Yoo SH,Kwon JH,Nam SW,Bae SH,Choi JY,Han NI,Yoon SK

更新日期：2019-03-01 00:00:00

abstract：:Nature disasters and terrorist attacks have occurred globally in recent years. Posttraumatic stress disorder (PTSD) has gained increasing attention, but its incidence and comorbidities in the general population are different from those inside the disaster areas. The present study estimated incident PTSD and comorbid d...

journal_title：Scientific reports

authors： Chang JC,Yen AM,Chen HH,Chen SL,Chiu SY,Fann JC,Lee CS

更新日期：2017-01-27 00:00:00

abstract：:The design, fabrication, and characterization of ultra-high responsivity photodetectors based on mesoscopic multilayer MoS2 is presented, which is a less explored system compared to direct band gap monolayer MoS2 that has received increasing attention in recent years. The device architecture is comprised of a metal-se...

journal_title：Scientific reports

authors： Saenz GA,Karapetrov G,Curtis J,Kaul AB

更新日期：2018-01-19 00:00:00

abstract：:The newly designed fentanyl derivative [( ±)-N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenyl propionamide] (NFEPP) was recently shown to produce analgesia selectively via peripheral mu-opioid receptors (MOR) at acidic pH in rat inflamed tissues. Here, we examined the pH-dependency of NFEPP binding to brain MOR and it...

journal_title：Scientific reports

authors： Baamonde A,Menéndez L,González-Rodríguez S,Lastra A,Seitz V,Stein C,Machelska H

更新日期：2020-10-29 00:00:00

abstract：:In the three domains of life, vitamin B12 (cobalamin) is primarily used in methyltransferase and isomerase reactions. The methyltransferase complex MtrA-H of methanogenic archaea has a key function in energy conservation by catalysing the methyl transfer from methyl-tetrahydromethanopterin to coenzyme M and its coupli...

journal_title：Scientific reports

authors： Wagner T,Ermler U,Shima S

更新日期：2016-06-21 00:00:00

abstract：:A tribochemistry-assisted method has been developed for nondestructive surface nanofabrication on GaAs. Without any applied electric field and post etching, hollow nanostructures can be directly fabricated on GaAs surfaces by sliding a SiO2 microsphere under an ultralow contact pressure in humid air. TEM observation o...

journal_title：Scientific reports

authors： Song C,Li X,Dong H,Yu B,Wang Z,Qian L

更新日期：2015-03-12 00:00:00

abstract：:It has been reported that in patients with operable stage I non-small cell lung cancer (NSCLC), overall survival (OS) is better in those who undergo hypofractionated stereotactic radiation therapy (HSRT) than in those who undergo surgery. However, the reason that HSRT has a better OS has not been fully explored. Here,...

journal_title：Scientific reports

authors： Zhang T,Yu H,Ni C,Zhang T,Liu L,Lv Q,Zhang Z,Wang Z,Wu D,Wu P,Chen G,Wang L,Wei Q,Huang J,Wang X

更新日期：2017-07-07 00:00:00

abstract：:In this study, we developed a novel poly (lactic-co-glycolic acid)-dextran (PLD)-based nanodelivery system to enhance the anticancer potential of cisplatin (CDDP) in osteosarcoma cells. A nanosized CDDP-loaded PLGA-DX nanoparticle (PLD/CDDP) controlled the release rate of CDDP up to 48 h. In vitro cytotoxicity assay s...

journal_title：Scientific reports

authors： Liu P,Sun L,Zhou DS,Zhang P,Wang YH,Li D,Li QH,Feng RJ

更新日期：2015-12-01 00:00:00

abstract：:When multiple information are spread on social networks, there may be Cooperation and Competition among these information. Based on a new spreading model of multiple information, we studied Cooperation and Competition in information spreading, and analyzed the influence of different factors on Cooperation and Competit...

journal_title：Scientific reports

authors： Zhu Z,Gao C,Zhang Y,Li H,Xu J,Zan Y,Li Z

更新日期：2020-07-22 00:00:00

abstract：:Magnetic carboxyl functional nanoporous polymer (MCFNP) was chemically fabricated by incorporation of magnetic Fe3O4 precursor into the carboxyl functional nanoporous polymer (CFNP). The as-synthesized MCFNP was characterized and used as an adsorbent for rapid adsorption removal of methylene blue (MB) from wastewater....

journal_title：Scientific reports

authors： Su H,Li W,Han Y,Liu N

更新日期：2018-04-25 00:00:00

abstract：:The cuticle of the beetle Chrysina chrysargyrea reflects left-handed polarized light in the broad spectral range from 340 to 1000 nm. Interference oscillations in the experimental Mueller-matrix spectroscopic ellipsometry data reveal that transparent materials comprise the cuticle. A spectral analysis of the interfere...

journal_title：Scientific reports

authors： Mendoza-Galván A,Del Río LF,Järrendahl K,Arwin H

更新日期：2018-04-24 00:00:00

abstract：:Human papillomavirus (HPV)-positive head and neck squamous cell carcinoma (HNSCC) is biologically distinct from HPV-negative HNSCC. Outside of HPV-status, few tumor-intrinsic variables have been identified that correlate to improved survival. As part of exploratory analysis into the trace elemental composition of orop...

journal_title：Scientific reports

authors： Poropatich K,Paunesku T,Zander A,Wray B,Schipma M,Dalal P,Agulnik M,Chen S,Lai B,Antipova O,Maxey E,Brown K,Wanzer MB,Gursel D,Fan H,Rademaker A,Woloschak GE,Mittal BB

更新日期：2019-11-18 00:00:00

abstract：:There is a growing appreciation for the diverse regulatory consequences of the family of proteins that bind to the secondary channel of E. coli RNA polymerase (RNAP), such as GreA, GreB or DksA. Similar binding sites could suggest a competition between them. GreA is characterised to rescue stalled RNAP complexes due t...

journal_title：Scientific reports

authors： Fernández-Coll L,Potrykus K,Cashel M,Balsalobre C

更新日期：2020-09-30 00:00:00

abstract：:Our motor system can generate representations which carry information about the goals of another agent's actions. However, it is not known whether motor representations play a deeper role in social understanding, and, in particular, whether they enable tracking others' beliefs. Here we show that, for adult observers, ...

journal_title：Scientific reports

authors： Low J,Edwards K,Butterfill SA

更新日期：2020-07-09 00:00:00

abstract：:We have previously demonstrated that the Thymus algeriensis and Thymus fontanesii extracts have powerful anti-inflammatory, antipyretic, and analgesic effects against acute pain models. We profiled their chemical composition and found many phenolic acids, flavonoids, and phenolic diterpenes. In this work, we investiga...

journal_title：Scientific reports

authors： Rezq S,Alsemeh AE,D'Elia L,El-Shazly AM,Monti DM,Sobeh M,Mahmoud MF

更新日期：2020-11-25 00:00:00