Abstract:
:We have previously demonstrated that the Thymus algeriensis and Thymus fontanesii extracts have powerful anti-inflammatory, antipyretic, and analgesic effects against acute pain models. We profiled their chemical composition and found many phenolic acids, flavonoids, and phenolic diterpenes. In this work, we investigated their antioxidant properties on HaCaT cells exposed to UVA-induced oxidative stress and examined their effects against chronic neuropathic pain and the underlying mechanisms. Through a rat chronic constriction injury (CCI) model, we induced chronic neuropathic pain by placing 4 loose ligatures around the right sciatic nerve for 14 days. Thermal and mechanical hyperalgesia in addition to cold and dynamic allodynia were tested on the day before surgery and on the 7th and 14th post-surgery days. Key markers of the nitrosative and oxidative stresses, in addition to markers of inflammation, were measured at day 14 post surgery. Histopathological examination and immunostaining of both synaptophysin and caspase-3 of sciatic nerve and brain stem were also performed. Results of this study showed that T. algeriensis extract suppresses UVA oxidative stress in HaCaT cells via activation of the Nrf-2 pathway. Both extracts attenuated hyperalgesia and allodynia at 7- and 14-days post-surgery with more prominent effects at day 14 of surgery. Their protective effects against neuropathic pain were mediated by inhibiting NOX-1, iNOS, by increasing the enzyme activity of catalase, and inhibition of inflammatory mediators, NF-κB, TNF-α, lipoxygenase, COX-2 enzymes, and PGE2. Furthermore, they improved deleterious structural changes of the brainstem and sciatic nerve. They also attenuated the increased caspase-3 and synaptophysin. The data indicate that both extracts have neuroprotective effects against chronic constriction injury-induced neuropathic pain. The observed protective effects are partially mediated through attenuation of oxidative and nitrosative stress and suppression of both neuroinflammation and neuronal apoptosis, suggesting substantial activities of both extracts in amelioration of painful peripheral neuropathy.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Rezq S,Alsemeh AE,D'Elia L,El-Shazly AM,Monti DM,Sobeh M,Mahmoud MFdoi
10.1038/s41598-020-77424-0subject
Has Abstractpub_date
2020-11-25 00:00:00pages
20559issue
1issn
2045-2322pii
10.1038/s41598-020-77424-0journal_volume
10pub_type
杂志文章abstract::We study the local indistinguishability problem of quantum states. By introducing an easily calculated quantity, non-commutativity, we present an criterion which is both necessary and sufficient for the local indistinguishability of a complete set of pure orthogonal product states. A constructive distinguishing proced...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06336
更新日期:2014-09-11 00:00:00
abstract::In biological tissues, radiation causes the formation of reactive oxygen species (ROS), some of which lead to sequential oxidation of certain protein cysteine residues. Resultant cysteinyl radicals are subject to post-translational modification through S-glutathionylation. The present clinical trial was designed to de...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50288-9
更新日期:2019-09-24 00:00:00
abstract::Wave control in the solid state has opened new avenues in modern information technology. Surface-acoustic-wave-based devices are found as mass market products in 100 millions of cellular phones. Spin waves (magnons) would offer a boost in today's data handling and security implementations, i.e., image processing and s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06848
更新日期:2014-10-30 00:00:00
abstract::CRISPR/Cas9-mediated genome editing is a next-generation strategy for genetic modifications. Typically, sgRNA is constitutively expressed relying on RNA polymerase III promoters. Polymerase II promoters initiate transcription in a flexible manner, but sgRNAs generated by RNA polymerase II promoter lost their nuclease ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-06216-w
更新日期:2017-07-19 00:00:00
abstract::Mastery over the structure of nanoparticles might be an effective way to enhance their performance for a given application. Herein we demonstrate the design of cage-bell nanostructures to enhance the methanol tolerance of platinum (Pt) nanoparticles while remaining their catalytic activity for oxygen reduction reactio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16219
更新日期:2015-11-18 00:00:00
abstract::High-quality, 25 nm octahedral-shaped Fe3O4 magnetite nanocrystals are epitaxially grown on 9 nm Au seed nanoparticles using a modified wet-chemical synthesis. These Fe3O4-Au Janus nanoparticles exhibit bulk-like magnetic properties. Due to their high magnetization and octahedral shape, the hybrids show superior in vi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29618-w
更新日期:2018-07-26 00:00:00
abstract::Microbial induced calcite precipitation (MICP) based on ureolysis has a high potential for many applications, e.g. restoration of construction materials. The gram-positive bacterium Sporosarcina pasteurii is the most commonly used microorganism for MICP due to its high ureolytic activity. However, Sporosarcina pasteur...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79904-9
更新日期:2020-12-31 00:00:00
abstract::Chaotic resonance is a phenomenon that can replace the fluctuation source in stochastic resonance from additive noise to chaos. We previously developed a method to control the chaotic state for suitably generating chaotic resonance by external feedback even when the external adjustment of chaos is difficult, establish...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48950-3
更新日期:2019-09-02 00:00:00
abstract::Understanding mechanisms mediating tumor metastasis is crucial for diagnostic and therapeutic targeting. Here, we take advantage of a transparent embryonic zebrafish xenograft model (eZXM) to visualize and track metastatic cells in real time using selective plane illumination microscopy (SPIM) for up to 30 h. Injected...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69956-2
更新日期:2020-08-06 00:00:00
abstract::During bipedal walking, modern humans dorsiflex their forefoot at the metatarsophalangeal joints (MTPJs) prior to push off, which tightens the plantar soft tissues to convert the foot into a stiff propulsive lever. Particular features of metatarsal head morphology such as "dorsal doming" are thought to facilitate this...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30532
更新日期:2016-07-28 00:00:00
abstract::TLR4 location, and bacterial species-derived lipopolysaccharides, play a significant role in the downstream activation of transcription factors, accessory molecules, and products. Here, this is demonstrated through the use of classically-activated and alternatively-activated macrophages. We show that, when polarized, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79145-w
更新日期:2021-01-14 00:00:00
abstract::Mitochondria play critical roles in meeting cellular energy demand, in cell death, and in reactive oxygen species (ROS) and stress signaling. Most Caenorhabditis elegans loss-of-function (lf) mutants in nuclear-encoded components of the respiratory chain are non-viable, emphasizing the importance of respiratory functi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29695
更新日期:2016-07-21 00:00:00
abstract::The sensing properties of monolayer arsenic phosphorus (AsP) for the adsorption of SF6, H2O, O2, and SF6 decomposition gases (SO2 and H2S) are theoretically investigated by the first-principle calculations. We calculate the adsorption energy, equilibrium distance, Mulliken charge transfer, and electron localization fu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30643-y
更新日期:2018-08-13 00:00:00
abstract::Multiple epidermal growth factor-like-domains 10 (MEGF10), a critical member of the apoptotic engulfment pathway, mediates axon pruning and synapse elimination during brain development. Previous studies indicated that synaptic pruning deficit was associated with autism-related phenotypes. However, the relationship bet...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02348-1
更新日期:2017-05-23 00:00:00
abstract::Atherosclerotic arteries exhibit characteristic constrictions and substantial deviations from cylindrical shape. Therefore, determining the artery's cross-section along the centerline is challenging, although high-resolution isotropic three-dimensional data are available. Herein, we apply high-resolution computed tomo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50711-1
更新日期:2019-10-04 00:00:00
abstract::The nutritional alarmones ppGpp and pppGpp (collectively: (p)ppGpp) are nucleotide-based second messengers enabling bacteria to respond to environmental and stress conditions. Several bacterial species contain two highly homologous (p)ppGpp synthetases named RelP (SAS2, YwaC) and RelQ (SAS1, YjbM). It is established t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20634-4
更新日期:2018-02-01 00:00:00
abstract::The neurology of male sexuality has been poorly studied owing to difficulties in studying brain circuitry in humans. Dopamine (DA) is essential for both physiological and behavioural responses, including the regulation of sexuality. Previous studies have revealed that alterations in DA synthesis in dopaminergic neuron...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep44595
更新日期:2017-03-15 00:00:00
abstract::Gelatin-coupled cellulose (GCC) microgel with whisker-like structure is prepared and used to incorporate into casein (CA) matrix to construct reinforced CA-based composite films by solution casting. The GCC microgel has excellent dispersibility and stability in water, which contributes to the hydrophobicity and signif...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37848-1
更新日期:2019-02-04 00:00:00
abstract::Signaling by members of the transforming growth factor-β (TGF-β) superfamily, such as TGF-β3 and BMP7, and oxygen tension play a pivotal role in chondrocyte biology. The objective of this research was to investigate the endogenous BMP7 expression in human osteoarthritis (OA) cartilage and the effect of oxygen tension ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27602-y
更新日期:2018-07-06 00:00:00
abstract::Tobacco hairy root (HR) cultures, which have been widely used for the heterologous production of target compounds, have an innate capacity to bioconvert exogenous t-resveratrol (t-R) into t-piceatannol (t-Pn) and t-pterostilbene (t-Pt). We established genetically engineered HR carrying the gene encoding stilbene synth...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18330-w
更新日期:2017-12-21 00:00:00
abstract::ABX464 is a first-in-class, clinical-stage, small molecule for oral administration that has shown strong anti-inflammatory effects in the DSS-model for inflammatory bowel disease (IBD) and also prevents replication of the HIV virus. ABX464 which binds to cap binding complex (CBC) has demonstrated safety and efficacy i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37813-y
更新日期:2019-01-28 00:00:00
abstract::The compound Sr0.5Ce0.5FBiS2 belongs to the intensively studied family of layered BiS2 superconductors. It attracts special attention because superconductivity at T sc = 2.8 K was found to coexist with local-moment ferromagnetic order with a Curie temperature T C = 7.5 K. Recently it was reported that upon replacing...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17637-y
更新日期:2017-12-12 00:00:00
abstract::Geochemical discrimination has recently been recognised as a potentially useful proxy for identifying tsunami deposits in addition to classical proxies such as sedimentological and micropalaeontological evidence. However, difficulties remain because it is unclear which elements best discriminate between tsunami and no...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07077
更新日期:2014-11-17 00:00:00
abstract::The intensity of a nonlinear terahertz (THz) source is primarily given by its spectral density. In this letter, we introduce triangular Selinium (Se) as a novel THz emitter and show numerically its superior properties to the currently used crystals for intense THz generation. The excellent phase matching enables the a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08059
更新日期:2015-01-27 00:00:00
abstract::Reversible polymeric networks can show self-healing properties due to their ability to reassemble after application of stress and fracture, but typically the relation between equilibrium molecular dynamics and self-healing kinetics has been difficult to disentangle. Here we present a well-characterized, self-assembled...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32356
更新日期:2016-09-01 00:00:00
abstract::Alveolar β2-receptor blockade worsens lung diffusion in heart failure (HF). This effect could be mitigated by stimulating alveolar β2-receptors. We investigated the safety and the effects of indacaterol on lung diffusion, lung mechanics, sleep respiratory behavior, cardiac rhythm, welfare, and exercise performance in ...
journal_title:Scientific reports
pub_type: 杂志文章,随机对照试验
doi:10.1038/s41598-020-62644-1
更新日期:2020-04-28 00:00:00
abstract::Atmospheric new particle formation (NPF) and growth significantly influences climate by supplying new seeds for cloud condensation and brightness. Currently, there is a lack of understanding of whether and how marine biota emissions affect aerosol-cloud-climate interactions in the Arctic. Here, the aerosol population ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03328-1
更新日期:2017-06-12 00:00:00
abstract::Diagnosability is central to taxonomy as are type specimens which define taxa. New advances in technologies and the discovery of new informative traits must be matched with previous taxonomic decisions based on name-bearing type specimens. Consequently, the challenge of sequencing highly degraded DNA from historical t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42310-x
更新日期:2019-04-09 00:00:00
abstract::Caspase-2 is known to be involved in oxidative-stress mediated neuronal cell death. In this study, we demonstrated that rotenone-induced neuronal cell death is mediated by caspase-2 activation via PIDDosome formation. Our newly designed TAT-fused peptides, which contains wild-type helix number3 (H3) from RAIDD and PID...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31198
更新日期:2016-08-09 00:00:00
abstract::Antibody phage display has been pivotal in the quest to generate human monoclonal antibodies for biomedical and research applications. Target antigen preparation is a main bottleneck associated with the panning process. This includes production complexity, downstream purification, quality and yield. In many instances,...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42628-6
更新日期:2019-04-15 00:00:00