Thymus algeriensis and Thymus fontanesii exert neuroprotective effect against chronic constriction injury-induced neuropathic pain in rats.

Abstract:

:We have previously demonstrated that the Thymus algeriensis and Thymus fontanesii extracts have powerful anti-inflammatory, antipyretic, and analgesic effects against acute pain models. We profiled their chemical composition and found many phenolic acids, flavonoids, and phenolic diterpenes. In this work, we investigated their antioxidant properties on HaCaT cells exposed to UVA-induced oxidative stress and examined their effects against chronic neuropathic pain and the underlying mechanisms. Through a rat chronic constriction injury (CCI) model, we induced chronic neuropathic pain by placing 4 loose ligatures around the right sciatic nerve for 14 days. Thermal and mechanical hyperalgesia in addition to cold and dynamic allodynia were tested on the day before surgery and on the 7th and 14th post-surgery days. Key markers of the nitrosative and oxidative stresses, in addition to markers of inflammation, were measured at day 14 post surgery. Histopathological examination and immunostaining of both synaptophysin and caspase-3 of sciatic nerve and brain stem were also performed. Results of this study showed that T. algeriensis extract suppresses UVA oxidative stress in HaCaT cells via activation of the Nrf-2 pathway. Both extracts attenuated hyperalgesia and allodynia at 7- and 14-days post-surgery with more prominent effects at day 14 of surgery. Their protective effects against neuropathic pain were mediated by inhibiting NOX-1, iNOS, by increasing the enzyme activity of catalase, and inhibition of inflammatory mediators, NF-κB, TNF-α, lipoxygenase, COX-2 enzymes, and PGE2. Furthermore, they improved deleterious structural changes of the brainstem and sciatic nerve. They also attenuated the increased caspase-3 and synaptophysin. The data indicate that both extracts have neuroprotective effects against chronic constriction injury-induced neuropathic pain. The observed protective effects are partially mediated through attenuation of oxidative and nitrosative stress and suppression of both neuroinflammation and neuronal apoptosis, suggesting substantial activities of both extracts in amelioration of painful peripheral neuropathy.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Rezq S,Alsemeh AE,D'Elia L,El-Shazly AM,Monti DM,Sobeh M,Mahmoud MF

doi

10.1038/s41598-020-77424-0

subject

Has Abstract

pub_date

2020-11-25 00:00:00

pages

20559

issue

1

issn

2045-2322

pii

10.1038/s41598-020-77424-0

journal_volume

10

pub_type

杂志文章
  • Non-commutativity and local indistinguishability of quantum states.

    abstract::We study the local indistinguishability problem of quantum states. By introducing an easily calculated quantity, non-commutativity, we present an criterion which is both necessary and sufficient for the local indistinguishability of a complete set of pure orthogonal product states. A constructive distinguishing proced...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep06336

    authors: Ma T,Zhao MJ,Wang YK,Fei SM

    更新日期:2014-09-11 00:00:00

  • S-Glutathionylated Serine Proteinase Inhibitors as Biomarkers for Radiation Exposure in Prostate Cancer Patients.

    abstract::In biological tissues, radiation causes the formation of reactive oxygen species (ROS), some of which lead to sequential oxidation of certain protein cysteine residues. Resultant cysteinyl radicals are subject to post-translational modification through S-glutathionylation. The present clinical trial was designed to de...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-50288-9

    authors: Zhang L,Zhang J,Ye Z,Manevich Y,Townsend DM,Marshall DT,Tew KD

    更新日期:2019-09-24 00:00:00

  • Magnetic thin-film insulator with ultra-low spin wave damping for coherent nanomagnonics.

    abstract::Wave control in the solid state has opened new avenues in modern information technology. Surface-acoustic-wave-based devices are found as mass market products in 100 millions of cellular phones. Spin waves (magnons) would offer a boost in today's data handling and security implementations, i.e., image processing and s...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep06848

    authors: Yu H,Kelly Od,Cros V,Bernard R,Bortolotti P,Anane A,Brandl F,Huber R,Stasinopoulos I,Grundler D

    更新日期:2014-10-30 00:00:00

  • SgRNA Expression of CRIPSR-Cas9 System Based on MiRNA Polycistrons as a Versatile Tool to Manipulate Multiple and Tissue-Specific Genome Editing.

    abstract::CRISPR/Cas9-mediated genome editing is a next-generation strategy for genetic modifications. Typically, sgRNA is constitutively expressed relying on RNA polymerase III promoters. Polymerase II promoters initiate transcription in a flexible manner, but sgRNAs generated by RNA polymerase II promoter lost their nuclease ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-06216-w

    authors: Xie C,Chen YL,Wang DF,Wang YL,Zhang TP,Li H,Liang F,Zhao Y,Zhang GY

    更新日期:2017-07-19 00:00:00

  • Enhancing the methanol tolerance of platinum nanoparticles for the cathode reaction of direct methanol fuel cells through a geometric design.

    abstract::Mastery over the structure of nanoparticles might be an effective way to enhance their performance for a given application. Herein we demonstrate the design of cage-bell nanostructures to enhance the methanol tolerance of platinum (Pt) nanoparticles while remaining their catalytic activity for oxygen reduction reactio...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep16219

    authors: Feng Y,Ye F,Liu H,Yang J

    更新日期:2015-11-18 00:00:00

  • Magnetite-Gold nanohybrids as ideal all-in-one platforms for theranostics.

    abstract::High-quality, 25 nm octahedral-shaped Fe3O4 magnetite nanocrystals are epitaxially grown on 9 nm Au seed nanoparticles using a modified wet-chemical synthesis. These Fe3O4-Au Janus nanoparticles exhibit bulk-like magnetic properties. Due to their high magnetization and octahedral shape, the hybrids show superior in vi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-29618-w

    authors: Efremova MV,Naumenko VA,Spasova M,Garanina AS,Abakumov MA,Blokhina AD,Melnikov PA,Prelovskaya AO,Heidelmann M,Li ZA,Ma Z,Shchetinin IV,Golovin YI,Kireev II,Savchenko AG,Chekhonin VP,Klyachko NL,Farle M,Majouga AG,Wi

    更新日期:2018-07-26 00:00:00

  • Revealing nutritional requirements of MICP-relevant Sporosarcina pasteurii DSM33 for growth improvement in chemically defined and complex media.

    abstract::Microbial induced calcite precipitation (MICP) based on ureolysis has a high potential for many applications, e.g. restoration of construction materials. The gram-positive bacterium Sporosarcina pasteurii is the most commonly used microorganism for MICP due to its high ureolytic activity. However, Sporosarcina pasteur...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-79904-9

    authors: Lapierre FM,Schmid J,Ederer B,Ihling N,Büchs J,Huber R

    更新日期:2020-12-31 00:00:00

  • Resonance phenomena controlled by external feedback signals and additive noise in neural systems.

    abstract::Chaotic resonance is a phenomenon that can replace the fluctuation source in stochastic resonance from additive noise to chaos. We previously developed a method to control the chaotic state for suitably generating chaotic resonance by external feedback even when the external adjustment of chaos is difficult, establish...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-48950-3

    authors: Nobukawa S,Shibata N,Nishimura H,Doho H,Wagatsuma N,Yamanishi T

    更新日期:2019-09-02 00:00:00

  • Long-term in vivo imaging reveals tumor-specific dissemination and captures host tumor interaction in zebrafish xenografts.

    abstract::Understanding mechanisms mediating tumor metastasis is crucial for diagnostic and therapeutic targeting. Here, we take advantage of a transparent embryonic zebrafish xenograft model (eZXM) to visualize and track metastatic cells in real time using selective plane illumination microscopy (SPIM) for up to 30 h. Injected...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-69956-2

    authors: Asokan N,Daetwyler S,Bernas SN,Schmied C,Vogler S,Lambert K,Wobus M,Wermke M,Kempermann G,Huisken J,Brand M,Bornhäuser M

    更新日期:2020-08-06 00:00:00

  • Form and function of the human and chimpanzee forefoot: implications for early hominin bipedalism.

    abstract::During bipedal walking, modern humans dorsiflex their forefoot at the metatarsophalangeal joints (MTPJs) prior to push off, which tightens the plantar soft tissues to convert the foot into a stiff propulsive lever. Particular features of metatarsal head morphology such as "dorsal doming" are thought to facilitate this...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep30532

    authors: Fernández PJ,Holowka NB,Demes B,Jungers WL

    更新日期:2016-07-28 00:00:00

  • Ultra-purification of Lipopolysaccharides reveals species-specific signalling bias of TLR4: importance in macrophage function.

    abstract::TLR4 location, and bacterial species-derived lipopolysaccharides, play a significant role in the downstream activation of transcription factors, accessory molecules, and products. Here, this is demonstrated through the use of classically-activated and alternatively-activated macrophages. We show that, when polarized, ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-79145-w

    authors: Stephens M,Liao S,von der Weid PY

    更新日期:2021-01-14 00:00:00

  • Chromophore-Assisted Light Inactivation of Mitochondrial Electron Transport Chain Complex II in Caenorhabditis elegans.

    abstract::Mitochondria play critical roles in meeting cellular energy demand, in cell death, and in reactive oxygen species (ROS) and stress signaling. Most Caenorhabditis elegans loss-of-function (lf) mutants in nuclear-encoded components of the respiratory chain are non-viable, emphasizing the importance of respiratory functi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep29695

    authors: Wojtovich AP,Wei AY,Sherman TA,Foster TH,Nehrke K

    更新日期:2016-07-21 00:00:00

  • High Sensitivity and Selectivity of AsP Sensor in Detecting SF6 Decomposition Gases.

    abstract::The sensing properties of monolayer arsenic phosphorus (AsP) for the adsorption of SF6, H2O, O2, and SF6 decomposition gases (SO2 and H2S) are theoretically investigated by the first-principle calculations. We calculate the adsorption energy, equilibrium distance, Mulliken charge transfer, and electron localization fu...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-30643-y

    authors: Jin W,Guofeng Y,Junjun X,Jianming L,Qing C,Dunjun C,Hai L,Rong Z,Youdou Z

    更新日期:2018-08-13 00:00:00

  • Genetic variants in the transcription regulatory region of MEGF10 are associated with autism in Chinese Han population.

    abstract::Multiple epidermal growth factor-like-domains 10 (MEGF10), a critical member of the apoptotic engulfment pathway, mediates axon pruning and synapse elimination during brain development. Previous studies indicated that synaptic pruning deficit was associated with autism-related phenotypes. However, the relationship bet...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-02348-1

    authors: Wu Z,Qin J,You Y,Ma Y,Jia M,Wang L,Lu T,Yue W,Ruan Y,Zhang D,Li J,Wang L

    更新日期:2017-05-23 00:00:00

  • Ex vivo evaluation of an atherosclerotic human coronary artery via histology and high-resolution hard X-ray tomography.

    abstract::Atherosclerotic arteries exhibit characteristic constrictions and substantial deviations from cylindrical shape. Therefore, determining the artery's cross-section along the centerline is challenging, although high-resolution isotropic three-dimensional data are available. Herein, we apply high-resolution computed tomo...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-50711-1

    authors: Buscema M,Hieber SE,Schulz G,Deyhle H,Hipp A,Beckmann F,Lobrinus JA,Saxer T,Müller B

    更新日期:2019-10-04 00:00:00

  • Structural and mechanistic divergence of the small (p)ppGpp synthetases RelP and RelQ.

    abstract::The nutritional alarmones ppGpp and pppGpp (collectively: (p)ppGpp) are nucleotide-based second messengers enabling bacteria to respond to environmental and stress conditions. Several bacterial species contain two highly homologous (p)ppGpp synthetases named RelP (SAS2, YwaC) and RelQ (SAS1, YjbM). It is established t...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-20634-4

    authors: Steinchen W,Vogt MS,Altegoer F,Giammarinaro PI,Horvatek P,Wolz C,Bange G

    更新日期:2018-02-01 00:00:00

  • Active and passive sexual roles that arise in Drosophila male-male courtship are modulated by dopamine levels in PPL2ab neurons.

    abstract::The neurology of male sexuality has been poorly studied owing to difficulties in studying brain circuitry in humans. Dopamine (DA) is essential for both physiological and behavioural responses, including the regulation of sexuality. Previous studies have revealed that alterations in DA synthesis in dopaminergic neuron...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep44595

    authors: Chen SL,Chen YH,Wang CC,Yu YW,Tsai YC,Hsu HW,Wu CL,Wang PY,Chen LC,Lan TH,Fu TF

    更新日期:2017-03-15 00:00:00

  • Preparation and characterization of homogeneous and enhanced casein protein-based composite films via incorporating cellulose microgel.

    abstract::Gelatin-coupled cellulose (GCC) microgel with whisker-like structure is prepared and used to incorporate into casein (CA) matrix to construct reinforced CA-based composite films by solution casting. The GCC microgel has excellent dispersibility and stability in water, which contributes to the hydrophobicity and signif...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-37848-1

    authors: Yao Y,Wang H,Wang R,Chai Y

    更新日期:2019-02-04 00:00:00

  • Co-treatment of TGF-β3 and BMP7 is superior in stimulating chondrocyte redifferentiation in both hypoxia and normoxia compared to single treatments.

    abstract::Signaling by members of the transforming growth factor-β (TGF-β) superfamily, such as TGF-β3 and BMP7, and oxygen tension play a pivotal role in chondrocyte biology. The objective of this research was to investigate the endogenous BMP7 expression in human osteoarthritis (OA) cartilage and the effect of oxygen tension ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-27602-y

    authors: Huang X,Zhong L,Post JN,Karperien M

    更新日期:2018-07-06 00:00:00

  • Tailoring tobacco hairy root metabolism for the production of stilbenes.

    abstract::Tobacco hairy root (HR) cultures, which have been widely used for the heterologous production of target compounds, have an innate capacity to bioconvert exogenous t-resveratrol (t-R) into t-piceatannol (t-Pn) and t-pterostilbene (t-Pt). We established genetically engineered HR carrying the gene encoding stilbene synth...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-18330-w

    authors: Hidalgo D,Georgiev M,Marchev A,Bru-Martínez R,Cusido RM,Corchete P,Palazon J

    更新日期:2017-12-21 00:00:00

  • Both anti-inflammatory and antiviral properties of novel drug candidate ABX464 are mediated by modulation of RNA splicing.

    abstract::ABX464 is a first-in-class, clinical-stage, small molecule for oral administration that has shown strong anti-inflammatory effects in the DSS-model for inflammatory bowel disease (IBD) and also prevents replication of the HIV virus. ABX464 which binds to cap binding complex (CBC) has demonstrated safety and efficacy i...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-37813-y

    authors: Vautrin A,Manchon L,Garcel A,Campos N,Lapasset L,Laaref AM,Bruno R,Gislard M,Dubois E,Scherrer D,Ehrlich JH,Tazi J

    更新日期:2019-01-28 00:00:00

  • Macroscopic phase separation of superconductivity and ferromagnetism in Sr0.5Ce0.5FBiS2-x Se x revealed by μSR.

    abstract::The compound Sr0.5Ce0.5FBiS2 belongs to the intensively studied family of layered BiS2 superconductors. It attracts special attention because superconductivity at T sc  = 2.8 K was found to coexist with local-moment ferromagnetic order with a Curie temperature T C  = 7.5 K. Recently it was reported that upon replacing...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-17637-y

    authors: Nikitin AM,Grinenko V,Sarkar R,Orain JC,Salis MV,Henke J,Huang YK,Klauss HH,Amato A,Visser A

    更新日期:2017-12-12 00:00:00

  • Machine-learning techniques for geochemical discrimination of 2011 Tohoku tsunami deposits.

    abstract::Geochemical discrimination has recently been recognised as a potentially useful proxy for identifying tsunami deposits in addition to classical proxies such as sedimentological and micropalaeontological evidence. However, difficulties remain because it is unclear which elements best discriminate between tsunami and no...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep07077

    authors: Kuwatani T,Nagata K,Okada M,Watanabe T,Ogawa Y,Komai T,Tsuchiya N

    更新日期:2014-11-17 00:00:00

  • Spectrally intense terahertz source based on triangular Selenium.

    abstract::The intensity of a nonlinear terahertz (THz) source is primarily given by its spectral density. In this letter, we introduce triangular Selinium (Se) as a novel THz emitter and show numerically its superior properties to the currently used crystals for intense THz generation. The excellent phase matching enables the a...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep08059

    authors: Shalaby M,Hauri CP

    更新日期:2015-01-27 00:00:00

  • Unveiling the molecular mechanism of self-healing in a telechelic, supramolecular polymer network.

    abstract::Reversible polymeric networks can show self-healing properties due to their ability to reassemble after application of stress and fracture, but typically the relation between equilibrium molecular dynamics and self-healing kinetics has been difficult to disentangle. Here we present a well-characterized, self-assembled...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep32356

    authors: Yan T,Schröter K,Herbst F,Binder WH,Thurn-Albrecht T

    更新日期:2016-09-01 00:00:00

  • Effects of β2-receptor stimulation by indacaterol in chronic heart failure treated with selective or non-selective β-blockers: a randomized trial.

    abstract::Alveolar β2-receptor blockade worsens lung diffusion in heart failure (HF). This effect could be mitigated by stimulating alveolar β2-receptors. We investigated the safety and the effects of indacaterol on lung diffusion, lung mechanics, sleep respiratory behavior, cardiac rhythm, welfare, and exercise performance in ...

    journal_title:Scientific reports

    pub_type: 杂志文章,随机对照试验

    doi:10.1038/s41598-020-62644-1

    authors: Contini M,Spadafora E,Barbieri S,Gugliandolo P,Salvioni E,Magini A,Apostolo A,Palermo P,Alimento M,Agostoni P

    更新日期:2020-04-28 00:00:00

  • Arctic sea ice melt leads to atmospheric new particle formation.

    abstract::Atmospheric new particle formation (NPF) and growth significantly influences climate by supplying new seeds for cloud condensation and brightness. Currently, there is a lack of understanding of whether and how marine biota emissions affect aerosol-cloud-climate interactions in the Arctic. Here, the aerosol population ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-03328-1

    authors: Dall Osto M,Beddows DCS,Tunved P,Krejci R,Ström J,Hansson HC,Yoon YJ,Park KT,Becagli S,Udisti R,Onasch T,O Dowd CD,Simó R,Harrison RM

    更新日期:2017-06-12 00:00:00

  • Mitogenomics of historical type specimens of Australasian turtles: clarification of taxonomic confusion and old mitochondrial introgression.

    abstract::Diagnosability is central to taxonomy as are type specimens which define taxa. New advances in technologies and the discovery of new informative traits must be matched with previous taxonomic decisions based on name-bearing type specimens. Consequently, the challenge of sequencing highly degraded DNA from historical t...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-42310-x

    authors: Kehlmaier C,Zhang X,Georges A,Campbell PD,Thomson S,Fritz U

    更新日期:2019-04-09 00:00:00

  • Rescuing neuronal cell death by RAIDD- and PIDD- derived peptides and its implications for therapeutic intervention in neurodegenerative diseases.

    abstract::Caspase-2 is known to be involved in oxidative-stress mediated neuronal cell death. In this study, we demonstrated that rotenone-induced neuronal cell death is mediated by caspase-2 activation via PIDDosome formation. Our newly designed TAT-fused peptides, which contains wild-type helix number3 (H3) from RAIDD and PID...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep31198

    authors: Jang TH,Lim IH,Kim CM,Choi JY,Kim EA,Lee TJ,Park HH

    更新日期:2016-08-09 00:00:00

  • Development of a Phage Display Panning Strategy Utilizing Crude Antigens: Isolation of MERS-CoV Nucleoprotein human antibodies.

    abstract::Antibody phage display has been pivotal in the quest to generate human monoclonal antibodies for biomedical and research applications. Target antigen preparation is a main bottleneck associated with the panning process. This includes production complexity, downstream purification, quality and yield. In many instances,...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-42628-6

    authors: Lim CC,Woo PCY,Lim TS

    更新日期:2019-04-15 00:00:00