Abstract:
:Trypanosoma cruzi is the etiological agent of Chagas disease, a neglected and emerging tropical disease, endemic to South America and present in non-endemic regions due to human migration. The MASP multigene family is specific to T. cruzi, accounting for 6% of the parasite's genome and plays a key role in immune evasion. A common feature of MASPs is the presence of two conserved regions: an N-terminal region codifying for signal peptide and a C-terminal (C-term) region, which potentially acts as GPI-addition signal peptide. Our aim was the analysis of the presence of an immune response against the MASP C-term region. We found that this region is highly conserved, released via exovesicles (EVs) and has an associated immune response as revealed by epitope affinity mapping, IFA and inhibition of the complement lysis assays. We also demonstrate the presence of a fast IgM response in Balb/c mice infected with T. cruzi. Our results reveal the presence of non-canonical secreted peptides in EVs, which can subsequently be exposed to the immune system with a potential role in evading immune system targets in the parasite.
journal_name
Sci Repjournal_title
Scientific reportsauthors
De Pablos LM,Díaz Lozano IM,Jercic MI,Quinzada M,Giménez MJ,Calabuig E,Espino AM,Schijman AG,Zulantay I,Apt W,Osuna Adoi
10.1038/srep27293subject
Has Abstractpub_date
2016-06-08 00:00:00pages
27293issn
2045-2322pii
srep27293journal_volume
6pub_type
杂志文章abstract::Quantum information science addresses how the processing and transmission of information are affected by uniquely quantum mechanical phenomena. Combination of two-qubit gates has been used to realize quantum circuits, however, scalability is becoming a critical problem. The use of three-qubit gates may simplify the st...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45353
更新日期:2017-03-31 00:00:00
abstract::Nerve fibers are known to reside within malignant tumors and the greater the neuronal density the worse prognosis for the patient. Recent discoveries using tumor bearing animal models have eluded to the autonomic nervous system having a direct effect on tumor growth and metastasis. We report the first direct and chron...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71670-y
更新日期:2020-09-09 00:00:00
abstract::Coronary plaque distribution, frequency and cut-off value of percent stenosis for developing vasospasm are uncertain in patients with vasospastic angina (VA). We enrolled 2960 patients who received coronary angiography (CAG) and ergonovine provocation test prospectively in 11 university hospitals in Korea. A total of ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62670-z
更新日期:2020-03-31 00:00:00
abstract::Tuberculosis is the leading cause of death among people living with HIV (PLH). Preventive tuberculosis therapy reduces mortality in PLH, especially in those with a positive tuberculin skin test (TST). New, more specific technologies for detecting latent tuberculosis infection (LTBI) are now commercially available. We ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-78737-w
更新日期:2020-12-11 00:00:00
abstract::Recent emergence of metasurfaces has enabled the development of ultra-thin flat optical components through different wavefront shaping techniques at various wavelengths. However, due to the non-adaptive nature of conventional metasurfaces, the focal point of the resulting optics needs to be fixed at the design stage, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39266-3
更新日期:2019-02-27 00:00:00
abstract::The aim of the present study was to compare the clinical, radiological and histomorphometrical outcome of simultaneous implant placement following augmentation of atrophic maxillary sinuses using allograft (block or particles). Consecutive patients with maxillary residual alveolar ridge height ≤3 mm, scheduled for sin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65874-5
更新日期:2020-06-03 00:00:00
abstract::The interplay between spin states and metallization in compressed CoCl2 is investigated by combining diffraction, resistivity and spectroscopy techniques under high-pressure conditions and ab-initio calculations. A pressure-induced metallization along with a Co2+ high-spin (S = 3/2) to low-spin (S = 1/2) crossover tra...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41337-4
更新日期:2019-04-01 00:00:00
abstract::Honeybee pupae morphology can be affected by a number of stressor, but in vivo investigation is difficult. A computed tomography (CT) technique was applied to visualize a comb's inner structure without damaging the brood. The CT scan was performed on a brood comb containing pupae developed from eggs laid by the queen ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46474-4
更新日期:2019-07-23 00:00:00
abstract::Interleukin-8 (IL-8) as an important cytokine involving in inflammatory and immune response, has been studied as effective adjuvants for vaccines in mammals. However, there are fewer reports about the characterization and adjuvant effects of IL-8 in fish. In this study, cloning and sequence analysis of IL-8 coding reg...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29310
更新日期:2016-07-04 00:00:00
abstract::The protein interface is key to understand protein function, providing a vital insight on how proteins interact with each other and with other molecules. Over the years, many computational methods to compare protein structures were developed, yet evaluating interface similarity remains a very difficult task. Here, we ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26497-z
更新日期:2018-05-29 00:00:00
abstract::Since its first implementation in otolaryngological surgery nearly a century ago, the surgical microscope has improved the accuracy and the safety of microsurgeries. However, the microscope shows only a magnified surface view of the surgical region. To overcome this limitation, either optical coherence tomography (OCT...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35176
更新日期:2016-10-12 00:00:00
abstract::We demonstrate the optical orbital angular momentum conservation during the transfer process from subwavelength plasmonic vortex lens (PVLs) to light and the generating process of surface plasmon polaritons (SPPs). Illuminating plasmonic vortex lenses with beams carrying optical orbital angular momentum, the SP vortic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03191
更新日期:2013-11-12 00:00:00
abstract::The study explored differences in the steroidogenic pathway between obese and nonobese women with polycystic ovary syndrome (PCOS) using liquid chromatography-tandem mass spectrometry (LC-MS/MS). 1044 women with PCOS (including 350 lean, 312 overweight and 382 obese) and 366 control women without PCOS (including 203 l...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14534-2
更新日期:2017-10-26 00:00:00
abstract::There is a definite relationship between alcohol consumption and colorectal cancer (CRC) development. We investigated effect of alcohol consumption on CRC patients' progression and prognosis by utilizing epidemiological data and found patients with alcohol consumption increased risks of tumor-node-metastasis (TNM), or...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26856-w
更新日期:2018-06-05 00:00:00
abstract::Textile forms of solar cells possess special advantages over other types of solar cells, including their light weight, high flexibility, and mechanical robustness. Recent demand for wearable devices has promoted interest in the development of high-efficiency textile-based solar cells for energy suppliers. However, the...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05322
更新日期:2014-06-24 00:00:00
abstract::Visceral leishmaniasis (VL) is a fatal form of leishmaniasis which affects 70 countries, worldwide. Increasing drug resistance, HIV co-infection, and poor health system require operative vaccination strategy to control the VL transmission dynamics. Therefore, a holistic approach is needed to generate T and B memory ce...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08842-w
更新日期:2017-08-15 00:00:00
abstract::The familial forms of early onset pre-eclampsia and related syndromes (HELLP) present with hypertension and proteinuria in the mother and growth restriction of the fetus. Genetically, these clinically similar entities are caused by different founder-dependent, placentally-expressed paralogous genes. All susceptibility...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32129
更新日期:2016-08-24 00:00:00
abstract::The relative effects of internal fixation strategies for intertrochanteric fracture after operation remain uncertain. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to address this important issue. We searched PubMed, EMBASE and CENTRAL for RCTs that compared different intern...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析,评审
doi:10.1038/srep18195
更新日期:2015-12-11 00:00:00
abstract::Multiple Sclerosis (MS) require medications controlling severity of the pathology and depression, affecting more than half of the patients. In this study, the effect of antidepressant drug fluvoxamine, a selective serotonin reuptake inhibitor, was investigated in vitro and in vivo. Nanomolar concentrations of fluvoxam...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04968-z
更新日期:2017-07-07 00:00:00
abstract::During anaerobic digestion (AD) process, process parameters e.g., VFA, pH, COD removal … and kinetic parameters e.g., hydrolysis rate, lag phase and methane production potential… are the important indicator for illustrating AD process performance, however, the AD process performance based on these parameters remains p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09977-6
更新日期:2017-08-24 00:00:00
abstract:ABSTARCT:Shape memory alloys (SMAs) have the ability to show large recoverable shape changes upon temperature, stress or magnetic field cycling. Their shape memory, material and magnetic properties (e.g. transformation temperatures, strain, saturation magnetization and strength) determine their prospects for applicatio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13434-9
更新日期:2017-11-01 00:00:00
abstract::Crops expressing Bacillus thuringiensis (Bt)-derived insecticidal protein genes have been commercially available for over 15 years and are providing significant value to growers. However, there remains the need for alternative insecticidal actives due to emerging insect resistance to certain Bt proteins. A screen of b...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03544-9
更新日期:2017-06-08 00:00:00
abstract::Systemic Lupus Erythematosus (SLE) is the prototype of autoimmune diseases, characterized by extensive gene expression perturbations in peripheral blood immune cells. Circumstantial evidence suggests that these perturbations may be due to altered epigenetic profiles and chromatin accessibility but the relationship bet...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73654-4
更新日期:2020-10-06 00:00:00
abstract::Recently, a computer-generated moiré profilometry was proposed by our research group. It can effectively avoid the influence of the transient caused by moiré fringes' direct acquisition and generally owns a higher accuracy. But when the spatial spectrum of the captured deformed pattern is severely aliased caused by th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44186-3
更新日期:2019-05-24 00:00:00
abstract::The General Unified Threshold model for Survival (GUTS) integrates previously published toxicokinetic-toxicodynamic models and estimates survival with explicitly defined assumptions. Importantly, GUTS accounts for time-variable exposure to the stressor. We performed three studies to test the ability of GUTS to predict...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29178
更新日期:2016-07-06 00:00:00
abstract::Papillary thyroid carcinoma (PTC) displays strong but so far largely uncharacterized heritability. Here we studied genetic predisposition in a family with six affected individuals. We genotyped all available family members and conducted whole exome sequencing of blood DNA from two affected individuals. Haplotype analy...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10566
更新日期:2015-07-02 00:00:00
abstract::Hepcidin, a cysteine-rich peptide hormone, secreted mainly by the liver, plays a central role in iron metabolism regulation. Emerging evidence suggests that disordered iron metabolism is a risk factor for various types of diseases including cancers. However, it remains challenging to apply current mass spectrometry (M...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43756-9
更新日期:2019-05-13 00:00:00
abstract::It has been a key issue for photovoltaic (PV) cells to survive under mechanical impacts by tiny dust. In this paper, the performance degradation and the damage behavior of PV cells subjected to massive dust impact are investigated using laser-shock driven particle impact experiments and mechanical modeling. The result...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80879-w
更新日期:2021-01-12 00:00:00
abstract::Hypoxia inducible factor-1α (HIF-1α) pathway is associated with many vascular diseases, including atherosclerosis, arterial aneurysms, pulmonary hypertension and chronic venous diseases. Significant HIF-1α expression could be found at the rupture edge at human abdominal aortic aneurysm (AAA) tissues. While our initial...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28612
更新日期:2016-07-01 00:00:00
abstract::The white spot syndrome virus (WSSV) causes mass mortalities in the aquaculture of shrimps worldwide. The mud shrimp Austinogebia edulis (Ngoc-Ho & Chan, 1992) is an economically important sea food item occurring along the west coast of Taiwan. While the population of A. edulis began to decrease with some fluctuations...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54837-0
更新日期:2019-12-09 00:00:00