Abstract：
:In the central nervous system of vertebrates, cell bodies of neurons are often assembled as nuclei or cellular layers that play specific roles as functional units. The purpose of this work was to selectively highlight such cell assemblies by magnetic resonance imaging using signals from water protons that are associated with intracellular paramagnetic ions, while saturating lipid-associated water protons as well as extracellular free water protons. Given the significant correlation between image signal intensity and water proton density, the high signal intensities observed for such cell assemblies must be attributed to their abundant paramagnetic-ion-associated water protons. In the hippocampal formation, the technique visualized cell assemblies that were so far not depicted in human in vivo. In the brainstem, the technique delineated noradrenergic neuron groups such as the locus coeruleus in human and mice in vivo. Their reduced magnetization-transfer ratios together with their prolonged relaxation times compared to other gray matter indicate that the source of their high signal intensity is not the presence of T1-shortening molecules, e.g., neuromelanin, but their high water content. Given the general absence of neuromelanin in noradrenergic neurons of rodents, their high signal intensity in mice in vivo further supports this view.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Watanabe T,Wang X,Tan Z,Frahm Jdoi
10.1038/s41598-019-41587-2subject
Has Abstractpub_date
2019-03-25 00:00:00pages
5084issue
1issn
2045-2322pii
10.1038/s41598-019-41587-2journal_volume
9pub_type
杂志文章,评审abstract：:Recently, the use of a liquid biopsy has shown promise in monitoring tumor burden. While point mutations have been extensively studied, chromosomal rearrangements have demonstrated greater tumor specificity. Such rearrangements can be identified in the tumor and subsequently detected in the plasma of patients using qu...
journal_title：Scientific reports
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更新日期：2016-07-20 00:00:00
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pub_type： 杂志文章
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pub_type： 已发布勘误
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pub_type： 杂志文章
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更新日期：2016-11-23 00:00:00
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pub_type： 杂志文章
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更新日期：2017-01-30 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2019-03-12 00:00:00
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pub_type： 杂志文章
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更新日期：2018-02-14 00:00:00
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pub_type： 杂志文章
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更新日期：2020-06-04 00:00:00
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pub_type： 杂志文章
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更新日期：2014-08-15 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2018-01-11 00:00:00
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journal_title：Scientific reports
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更新日期：2014-07-03 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2019-11-26 00:00:00
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pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 临床试验,杂志文章,多中心研究
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更新日期：2015-05-11 00:00:00
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journal_title：Scientific reports
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更新日期：2016-04-14 00:00:00
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pub_type： 杂志文章
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更新日期：2018-08-21 00:00:00
