Abstract:
:Identification of novel brominated contaminants in the environment, especially the derivatives and byproducts of brominated flame retardants (BFRs), has become a wide concern because of their adverse effects on human health. Herein, we qualitatively and quantitatively identified three byproducts of tetrabromobisphenol-S bis(2,3-dibromopropyl ether) (TBBPS-BDBPE), including TBBPS mono(allyl ether) (TBBPS-MAE), TBBPS mono(2-bromoallyl ether) (TBBPS-MBAE) and TBBPS mono(2,3-dibromopropyl ether) (TBBPS-MDBPE) as novel brominated contaminants. Meanwhile, the mass spectra and analytical method for determination of TBBPS-BDBPE byproducts were presented for the first time. The detectable concentrations (dry weight) of TBBPS-MAE, TBBPS-MBAE and TBBPS-MDBPE were in the ranges 28-394 μg/g in technical TBBPS-BDBPE and 0.1-4.1 ng/g in mollusks collected from the Chinese Bohai Sea. The detection frequencies in mollusk samples were 5%, 39%, 95% for TBBPS-MAE, TBBPS-MBAE and TBBPS-MDBPE, respectively, indicating their prevailing in the environment. The results showed that they could be co-produced and leaked into the environment with production process, and might be more bioaccumulative and toxic than TBBPS-BDBPE. Therefore, the production and use of TBBPS derivatives lead to unexpected contamination to the surrounding environment. This study also provided an effective approach for identification of novel contaminants in the environment with synthesized standards and Orbitrap high resolution mass spectrometry.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Liu AF,Tian Y,Yin NY,Yu M,Qu GB,Shi JB,Du YG,Jiang GBdoi
10.1038/srep11741subject
Has Abstractpub_date
2015-07-01 00:00:00pages
11741issn
2045-2322pii
srep11741journal_volume
5pub_type
杂志文章abstract::Tumor genetic heterogeneity may underlie poor clinical outcomes because diverse subclones could be comprised of metastatic and drug resistant cells. Targeted deep sequencing has been used widely as a diagnostic tool to identify actionable mutations in cancer patients. In this study, we evaluated the clinical utility o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41098-0
更新日期:2019-03-14 00:00:00
abstract::Primary biliary cholangitis (PBC) is an autoimmune liver disease characterized by the destruction of interlobular biliary ductules, which progressively leads to cholestasis, hepatic fibrosis, cirrhosis, and eventually liver failure. Several mouse models have been used to clarify the pathogenesis of PBC and are general...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15661-6
更新日期:2017-11-10 00:00:00
abstract::Honeybees (Apis mellifera L.), which unquestionably play an economically important role in pollination and agricultural production, are at risk of decline. To study changes in gene expression in insects upon exposure to pesticides or other external stimuli, appropriate reference genes are required for data normalizati...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73125-w
更新日期:2020-09-30 00:00:00
abstract::p97 is a highly abundant, homohexameric AAA+ ATPase that performs a variety of essential cellular functions. Characterized as a ubiquitin-selective chaperone, p97 recognizes proteins conjugated to K48-linked polyubiquitin chains and promotes their removal from chromatin and other molecular complexes. Changes in p97 ex...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46949-4
更新日期:2019-07-17 00:00:00
abstract::Methylacetoin (3-hydroxy-3-methylbutan-2-one) and 2-methyl-2,3-butanediol are currently obtained exclusively via chemical synthesis. Here, we report, to the best of our knowledge, the first alternative route, using engineered Escherichia coli. The biological synthesis of methylacetoin was first accomplished by reversi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02445
更新日期:2013-01-01 00:00:00
abstract::Among the bacterial symbionts harbored by the model organism Paramecium, many still lack a recent investigation that includes a molecular characterization. The genus Lyticum consists of two species of large-sized bacteria displaying numerous flagella, despite their inability to move inside their hosts' cytoplasm. We p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03305
更新日期:2013-11-22 00:00:00
abstract::Irreversible electroporation (IRE) is an emerging, minimally invasive technique for solid tumors ablation, under clinical investigation for cancer therapy. IRE affects only the cell membrane, killing cells while preserving the extracellular matrix structure. Current reports indicate tumors recurrence rate after IRE av...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08485
更新日期:2015-02-16 00:00:00
abstract::Phytophthora root and stem rot of soybean [Glycine max (L.) Merr.] caused by Phytophthora sojae is a destructive disease worldwide. Phenylalanine ammonia-lyase (PAL) is one of the most extensively studied enzymes related to plant responses to biotic and abiotic stresses. However, the molecular mechanism of PAL in soyb...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07832-2
更新日期:2017-08-03 00:00:00
abstract::Colour polymorphism may be maintained within a population by disruptive-selection. One hypothesis proposes that different morphs are adapted to different ambient light conditions, with lighter morphs having a selective advantage in bright conditions and darker morphs having advantages in darker conditions. The mechani...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07829-x
更新日期:2017-08-22 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-62742-0
更新日期:2020-04-10 00:00:00
abstract::The protective effect of estrogens against chronic glomerular diseases is admitted but remains debated during acute kidney injury (AKI). Using a model of resuscitated hemorrhagic shock in C57/Bl6 female mice, this study evaluated at 1 and 21 days the renal effect of (1) endogenous estrogen, using ovariectomized mice w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73974-5
更新日期:2020-10-14 00:00:00
abstract::Stimulation with lipopolysaccharide (LPS; endotoxin) not only causes rapid production of proinflammatory cytokines, but also induces a state of LPS hypo-responsiveness to a second LPS stimulation (endotoxin tolerance (ET)). Murine bone marrow-derived MCs (BMMCs) and peritoneal MCs (PMCs) developed ET as shown by an ab...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04890-4
更新日期:2017-07-03 00:00:00
abstract::Time-series data from multicomponent systems capture the dynamics of the ongoing processes and reflect the interactions between the components. The progression of processes in such systems usually involves check-points and events at which the relationships between the components are altered in response to stimuli. Det...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08937
更新日期:2015-03-11 00:00:00
abstract::Switching magnetizations with femtosecond circularly polarized lasers may have revolutionary impacts on magnetic data storage and relevant applications. Achievements in ferrimagnetic and ferromagnetic materials of various structures strongly imply a general phenomenon of fundamental atom-laser interaction. Rotating an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41294
更新日期:2017-01-24 00:00:00
abstract::We propose a virtual sound barrier system that blocks sound transmission through openings without affecting access, light and air circulation. The proposed system applies active control technique to cancel sound transmission with a double layered loudspeaker array at the edge of the opening. Unlike traditional transpa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13546-2
更新日期:2017-10-17 00:00:00
abstract::Polycrystalline CeGe is investigated by means of DC and AC susceptibility, non-linear DC susceptibility, electrical transport and heat capacity measurements in the low temperature regime. This compound shows two peaks at low magnetic field around TI ~ 10.7 and TII ~ 7.3 K due to antiferromagnetic ordering and subseque...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41565-8
更新日期:2019-03-26 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-62436-7
更新日期:2020-04-16 00:00:00
abstract::Engineering of efflux pumps is a promising way to improve host's tolerance to biofuels such as medium-chain alcohols (CmOHs); however, this strategy is restricted by poor understanding of the efflux pumps engaged in extrusion of solvents. In this study, several Escherichia coli mutants of multidrug transporters were e...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16505
更新日期:2015-11-13 00:00:00
abstract::The effects of sea salt aerosols (SSA) on cloud microphysical processes, precipitation, and upper troposphere/lower stratosphere water vapour in tropical cyclones were studied with the Weather Research and Forecasting with Chemistry model. Two numerical experiments were conducted: a control experiment (CTL) and an exp...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51757-x
更新日期:2019-10-22 00:00:00
abstract::The sweetpotato whitefly Bemisia tabaci (Gennadius) was challenged with different combinations of matrine (insecticide) and Lecanicillium muscarium (entomopathogenic fungus). Our results revealed a synergistic relationship between matrine and L. muscarium on mortality and enzyme activities of B. tabaci. To illustrate ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep46558
更新日期:2017-04-20 00:00:00
abstract::T2-weighted cardiovascular magnetic resonance (CMR) using a 3-slice approach has been shown to accurately quantify the edema-based area-at-risk (AAR) in ST-segment elevation myocardial infarction (STEMI). We aimed to compare the performance of a 3-slice approach to full left ventricular (LV) coverage for the AAR by T1...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05127-0
更新日期:2017-07-07 00:00:00
abstract::Bose Einstein condensates of spin-1 atoms are known to exist in two different phases, both having spontaneously broken spin-rotation symmetry, a ferromagnetic and a polar condensate. Here we show that in two spatial dimensions it is possible to achieve a quantum phase transition from a polar condensate into a singlet ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30876-x
更新日期:2018-08-20 00:00:00
abstract::Filth flies cause billions of dollars of losses annually to the animal production industry. Fluralaner is a relatively new pesticide currently sold for control of fleas, ticks, and mites on companion animals and poultry. We examined the efficacy of fluralaner against three species of filth flies. Insecticide-susceptib...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68121-z
更新日期:2020-07-07 00:00:00
abstract::Graphene thin films have great potential to function as transparent electrodes in organic electronic devices, due to their excellent conductivity and high transparency. Recently, organic light-emitting diodes (OLEDs)have been successfully demonstrated to possess high luminous efficiencies with p-doped graphene anodes....
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09693
更新日期:2015-04-20 00:00:00
abstract::Lung cancer (LC) is the leading cause of cancer-related deaths. Downregulation of CDK1, 4 and 6, key regulators of cell cycle progression, correlates with decreased LC cell proliferation. Enforced expression of miRNAs (miRs) is a promising approach to regulate genes. Here, we study the combinatorial treatment of miR-1...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28872-2
更新日期:2018-07-12 00:00:00
abstract::Although affective and semantic word properties are known to independently influence our sensorimotor system, less is known about their interaction. We investigated this issue applying a data-driven mixed-effects regression approach, evaluating the impact of lexical-semantic properties on electrophysiological paramete...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56382-2
更新日期:2019-12-27 00:00:00
abstract::Fc domain fusion can improve the therapeutic effects of relatively small biological molecules such as peptides, cytokines, and antibody fragments. Fc fusion proteins can also be used to enhance the cytotoxic effects of small bispecific antibodies (bsAbs). However, fragmentation of Fc fusion proteins, which mainly occu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35489-y
更新日期:2018-11-22 00:00:00
abstract::Fitting Ordinary Differential Equation (ODE) models of signal transduction networks (STNs) to experimental data is a challenging problem. Computational parameter fitting algorithms simulate a model many times with different sets of parameter values until the simulated STN behaviour match closely with experimental data...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30118-0
更新日期:2018-08-03 00:00:00
abstract::Temporal binding of urea to lysozyme was examined using X-ray diffraction of single crystals of urea/lysozyme complexes prepared by soaking native lysozyme crystals in solutions containing 9 M urea. Four different soak times of 2, 4, 7 and 10 hours were used. The five crystal structures (including the native lysozyme)...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32277
更新日期:2016-08-30 00:00:00
abstract::Ribonucleotide reductases (RNR) catalyze the last step of deoxyribonucleotide synthesis, and are therefore essential to DNA-based life. Three forms of RNR exist: classes I, II, and III. While eukaryotic cells use only class Ia RNR, bacteria can harbor any combination of classes, granting them adaptability. The opportu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17917-7
更新日期:2017-12-20 00:00:00