Intratumor heterogeneity inferred from targeted deep sequencing as a prognostic indicator.

abstract：:Here we developed an orange light-absorbing chromoprotein named ShadowR as a novel acceptor for performing fluorescence lifetime imaging microscopy-based Förster resonance energy transfer (FLIM-FRET) measurement in living cells. ShadowR was generated by replacing hydrophobic amino acids located at the surface of the c...

journal_title：Scientific reports

authors： Murakoshi H,Horiuchi H,Kosugi T,Onda M,Sato A,Koga N,Nabekura J

更新日期：2019-08-19 00:00:00

abstract：:A single bout of electroacupuncture results in muscle contractions and increased whole body glucose uptake in women with polycystic ovary syndrome (PCOS). Women with PCOS have transcriptional and epigenetic alterations in the adipose tissue and we hypothesized that electroacupuncture induces epigenetic and transcripti...

journal_title：Scientific reports

authors： Kokosar M,Benrick A,Perfilyev A,Nilsson E,Källman T,Ohlsson C,Ling C,Stener-Victorin E

更新日期：2018-01-30 00:00:00

abstract：:Successful tick feeding is facilitated by an assortment of pharmacologically-active factors in tick saliva that create an immunologically privileged micro-environment in the host's skin. Through a process known as saliva-assisted transmission, bioactive tick salivary factors modulate the host environment, promoting tr...

journal_title：Scientific reports

authors： Hermance ME,Widen SG,Wood TG,Thangamani S

更新日期：2019-09-11 00:00:00

abstract：:A record 500,000 hectares burned in Portugal during the extreme wildfire season of 2017, with more than 120 human lives lost. Here we analyse the climatic factors responsible for the burned area (BA) from June to October series in Portugal for the period 1980-2017. Superposed onto a substantially stationary trend on B...

journal_title：Scientific reports

authors： Turco M,Jerez S,Augusto S,Tarín-Carrasco P,Ratola N,Jiménez-Guerrero P,Trigo RM

更新日期：2019-10-10 00:00:00

abstract：:Multiple predatory insect lineages have developed a raptorial lifestyle by which they strike and hold prey using modified forelegs armed with spine-like structures and other integumentary specialisations. However, how structures enabling the raptorial function evolved in insects remains largely hypothetical or inferre...

journal_title：Scientific reports

authors： Pérez-de la Fuente R,Peñalver E

更新日期：2019-09-13 00:00:00

abstract：:Chemotherapy often induces oral ulcerative mucositis (OUM) in patients with cancer, characterized by severe painful inflammation. Mouth-washing with the Japanese herbal medicine hangeshashinto (HST) ameliorates chemotherapy-induced OUM in patients with colorectal cancer. Previously, we demonstrated that HST decreased ...

journal_title：Scientific reports

authors： Miyano K,Eto M,Hitomi S,Matsumoto T,Hasegawa S,Hirano A,Nagabuchi K,Asai N,Uzu M,Nonaka M,Omiya Y,Kaneko A,Ono K,Fujii H,Higami Y,Kono T,Uezono Y

更新日期：2020-01-17 00:00:00

abstract：:Labeling nuclear proteins with electron dense probes in living cells has been a major challenge due to their inability to penetrate into nuclei. We developed a lipid-based approach for delivering antibodies coupled to 0.8 nm ultrasmall gold particles into the nucleus to label RNA polymerase II. Focussed Ion Beam slici...

journal_title：Scientific reports

authors： Orlov I,Schertel A,Zuber G,Klaholz B,Drillien R,Weiss E,Schultz P,Spehner D

更新日期：2015-02-09 00:00:00

abstract：:Neoadjuvant systemic treatment is increasingly being integrated in the standard treatment of pancreatic ductal adenocarcinoma (PDAC) patients to improve oncological outcomes. Current available imaging techniques remain unreliable in assessing response to therapies, as they cannot distinguish between (vital) tumor tiss...

journal_title：Scientific reports

authors： Vuijk FA,de Muynck LDAN,Franken LC,Busch OR,Wilmink JW,Besselink MG,Bonsing BA,Bhairosingh SS,Kuppen PJK,Mieog JSD,Sier CFM,Vahrmeijer AL,Verheij J,Fariňa-Sarasqueta A,Swijnenburg RJ

更新日期：2020-10-01 00:00:00

abstract：:A new kind of magnetically-doped antiferromagnetic (AFM) topological insulators (TIs) with stoichiometry Bi1.09Gd0.06Sb0.85Te3 has been studied by angle-resolved photoemission spectroscopy (ARPES), superconducting magnetometry (SQUID) and X-ray magnetic circular dichroism (XMCD) with analysis of its electronic structu...

journal_title：Scientific reports

authors： Shikin AM,Estyunin DA,Surnin YI,Koroleva AV,Shevchenko EV,Kokh KA,Tereshchenko OE,Kumar S,Schwier EF,Shimada K,Yoshikawa T,Saitoh Y,Takeda Y,Kimura A

更新日期：2019-03-18 00:00:00

abstract：:Quartz is a common phase in high-silica igneous rocks and is resistant to post-eruptive alteration, thus offering a reliable record of magmatic processes in silicic magma systems. Here we employ the 75 ka Toba super-eruption as a case study to show that quartz can resolve late-stage temporal changes in magmatic δ18O v...

journal_title：Scientific reports

authors： Budd DA,Troll VR,Deegan FM,Jolis EM,Smith VC,Whitehouse MJ,Harris C,Freda C,Hilton DR,Halldórsson SA,Bindeman IN

更新日期：2017-01-25 00:00:00

abstract：:We report the observation of replica symmetry breaking (RSB) in a weakly scattering optofluidic random laser (ORL). Coherent random lasing is indicated by the presence of narrow peaks rising out of the spectral background. This coherence helps to identify a random laser threshold, which is expected to be gradual with ...

journal_title：Scientific reports

authors： Sarkar A,Bhaktha BNS,Andreasen J

更新日期：2020-02-14 00:00:00

abstract：:This work demonstrates an anisotropic increase in resistivity with decreasing width in single crystal tungsten (W) nanowires having a height of 21 nm. Nanowire-widths were in the range of 15-451 nm, with the anisotropy observed for widths below 50 nm. The longitudinal directions of the nanowires coincided with the <10...

journal_title：Scientific reports

authors： Choi D,Moneck M,Liu X,Oh SJ,Kagan CR,Coffey KR,Barmak K

更新日期：2013-01-01 00:00:00

abstract：:The ultrathin SmCo5 nanoflakes with average thickness smaller than 50 nm are prepared by a novel method of solid particle (NaCl) and surfactant co-assisted ball milling. The as-prepared nanoflakes exhibit a narrower thickness distribution of 10-50 nm and high coercivity of 23 kOe. The possible formation mechanism of n...

journal_title：Scientific reports

authors： Zuo WL,Zhao X,Zhao TY,Hu FX,Sun JR,Shen BG

更新日期：2016-05-13 00:00:00

abstract：:Temporomandibular disorders (TMD), when progress to a chronic state, might contribute to psychosocial or psychological distress. This study aimed to evaluate the effect of stabilization splint (SS) therapy on pain, pain-related disability and psychological traits of chronic TMD patients, as well as to assess selected ...

journal_title：Scientific reports

authors： Alajbeg IZ,Vrbanović E,Lapić I,Alajbeg I,Vuletić L

更新日期：2020-07-03 00:00:00

abstract：:We study propagation in a cyclic symmetric multicore fiber where the core radii randomly fluctuate along the propagation direction. We propose a hybrid analytic-numerical method to optimize the amplitude and frequency of the fluctuations that suppress power transfer between outer and inner cores. This framework allows...

journal_title：Scientific reports

authors： Jaramillo Ávila B,Torres JM,León-Montiel RJ,Rodríguez-Lara BM

更新日期：2019-10-31 00:00:00

abstract：:In this study, we made a comparative efficacy and safety assessment of two different fixed combinations of drugs, viz., tafluprost/timolol (TAF/TIM) and latanoprost/carteolol (LAT/CAR), by determining their effects on intraocular pressure (IOP) in ocular normotensive monkeys and examining their toxic effects on ocular...

journal_title：Scientific reports

authors： Fuwa M,Shimazaki A,Mieda M,Yamashita N,Akaishi T,Taniguchi T,Kato M

更新日期：2019-05-16 00:00:00

abstract：:Cuprizone-induced demyelination in mice is a frequently used model in preclinical multiple sclerosis research. A recent quantitative clinically-targeted MRI method, fast macromolecular proton fraction (MPF) mapping demonstrated a promise as a myelin biomarker in human and animal studies with a particular advantage of ...

journal_title：Scientific reports

authors： Khodanovich MY,Sorokina IV,Glazacheva VY,Akulov AE,Nemirovich-Danchenko NM,Romashchenko AV,Tolstikova TG,Mustafina LR,Yarnykh VL

更新日期：2017-04-24 00:00:00

abstract：:An efficient [4 + 1] annulation between α-bromooximes and sulfur ylides via in situ generation of nitrosoalkenes under mild basic reaction conditions has been developed, providing an expeditious and scalable approach to synthesize biologically interesting isoxazoline derivatives with good to excellent yields. ...

journal_title：Scientific reports

authors： Hua TB,Liu CX,Hu WM,Wang L,Yang QQ

更新日期：2021-01-22 00:00:00

abstract：:Novel mesoporous silicas rolled with silica sheets with 2D regular spacing were prepared using a self-assembled graphene oxide (GO) template formed by mixing GO with Pluronic123 (P123). Self-assembled GO templated mesoporous silicas (SGT-PMS) showed well-developed X-ray diffraction peaks with d-spacings of 9.8-10.8 nm...

journal_title：Scientific reports

authors： Park KW,Kwon OY

更新日期：2020-04-10 00:00:00

abstract：:Biomass burning aerosols mainly consist of black carbon (BC) and organic aerosols (OAs), and some of OAs are brown carbon (BrC). This study simulates the colors of BrC, BC and their mixture with scattering OAs in the ambient atmosphere by using a combination of light scattering simulations, a two-stream radiative tran...

journal_title：Scientific reports

authors： Liu C,Chung CE,Zhang F,Yin Y

更新日期：2016-06-16 00:00:00

abstract：:A spontaneous exchange bias (SEB) discovered by Wang et al. [Phys. Rev. Lett. 106 (2011) 077203.] after zero-field cooling (ZFC) has attracted recent attention due to its interesting physics. In this letter, we report a giant SEB tuned by Sb-doping in Ni50Mn38Ga12-xSbx Heusler alloys. Such an SEB was switched on below...

journal_title：Scientific reports

authors： Tian F,Cao K,Zhang Y,Zeng Y,Zhang R,Chang T,Zhou C,Xu M,Song X,Yang S

更新日期：2016-08-01 00:00:00

abstract：:The exopeptidases of family S46 are exceptional, as the closest homologs of these enzymes are the endopeptidases of clan PA. The three-dimensional structure of S46 enzymes is unknown and only one of the catalytic residues, the serine, has been identified. The catalytic histidine and aspartate residues are not experime...

journal_title：Scientific reports

authors： Suzuki Y,Sakamoto Y,Tanaka N,Okada H,Morikawa Y,Ogasawara W

更新日期：2014-03-06 00:00:00

abstract：:sp-Hybridized carbon atomic wires are appealing systems with large property tunability. In particular, their electronic properties are intimately related to length, structure, and type of functional end-groups as well as to other effects such as the intermolecular charge transfer with metal nanoparticles. Here, by a c...

journal_title：Scientific reports

authors： Milani A,Barbieri V,Facibeni A,Russo V,Li Bassi A,Lucotti A,Tommasini M,Tzirakis MD,Diederich F,Casari CS

更新日期：2019-02-07 00:00:00

abstract：:Platelet-derived growth factor receptor beta (PDGFRβ) affects in numerous human cancers and has been recognized as a promising molecular target for cancer therapies. The overexpression of PDGFRβ could be a biomarker for cancer diagnosis. Radiolabeled ligands having high affinity for the molecular target could be usefu...

journal_title：Scientific reports

authors： Effendi N,Mishiro K,Takarada T,Makino A,Yamada D,Kitamura Y,Shiba K,Kiyono Y,Odani A,Ogawa K

更新日期：2018-07-10 00:00:00

abstract：:The interplay between the quasi 1-dimensional CuO-chains and the 2-dimensional CuO2 planes of YBa(2)Cu(3)O(6+x) (YBCO) has been in focus for a long time. Although the CuO-chains are known to be important as charge reservoirs that enable superconductivity for a range of oxygen doping levels in YBCO, the understanding o...

journal_title：Scientific reports

authors： Magnuson M,Schmitt T,Strocov VN,Schlappa J,Kalabukhov AS,Duda LC

更新日期：2014-11-12 00:00:00

abstract：:The host mechanisms involved in Escherichia coli O157 super-shedding in cattle is largely unknown. In this study, the comparison of transcriptomes of intestinal tissues between super-shedders (SS) and cattle negative for E. coli O157 (NS) was performed, aiming to identify genes that are potentially associated with sup...

journal_title：Scientific reports

authors： Wang O,McAllister TA,Plastow G,Stanford K,Selinger B,Guan LL

更新日期：2017-08-09 00:00:00

abstract：:Freezing colloidal suspensions widely exists in nature and industry. Interface instability has attracted much attention for the understandings of the pattern formation in freezing colloidal suspensions. However, the interface instability modes, the origin of the ice banding or ice lamellae, are still unclear. In-situ ...

journal_title：Scientific reports

authors： Wang L,You J,Wang Z,Wang J,Lin X

更新日期：2016-03-21 00:00:00

abstract：:Rheumatoid arthritis (RA) is an autoimmune disease characterized by progressive immune-mediated joint deterioration. Current treatments are not antigen specific and are associated with various adverse. We have previously demonstrated that tolerogenic dendritic cells (Tol-DC) are potent antigen-specific immune regulato...

journal_title：Scientific reports

authors： Li R,Zhang Y,Zheng X,Peng S,Yuan K,Zhang X,Min W

更新日期：2017-02-23 00:00:00

abstract：:Trichosporon asahii is a pathogenic fungus that causes deep mycosis in patients with neutropenia. Establishing an experimental animal model for quantitatively evaluating pathogenicity and developing a genetic recombination technology will help to elucidate the infection mechanism of T. asahii and promote the developme...

journal_title：Scientific reports

authors： Matsumoto Y,Yamazaki H,Yamasaki Y,Tateyama Y,Yamada T,Sugita T

更新日期：2020-07-03 00:00:00

abstract：:In the northeastern United States, chronic wasting disease has recently been detected in white-tailed deer (Odocoileus virginianus) populations, and understanding the relationship between landscape configuration and home range may improve disease surveillance and containment efforts. The objectives of our study were t...

journal_title：Scientific reports

authors： Walter WD,Evans TS,Stainbrook D,Wallingford BD,Rosenberry CS,Diefenbach DR

更新日期：2018-10-02 00:00:00