Abstract：
:Injured adult tendons do not exhibit optimal healing through a regenerative process, whereas fetal tendons can heal in a regenerative fashion without scar formation. Hence, we compared FFs (mouse fetal fibroblasts) and AFs (mouse adult fibroblasts) as seed cells for the fabrication of scaffold-free engineered tendons. Our results demonstrated that FFs had more potential for tendon tissue engineering, as shown by higher levels of tendon-related gene expression. In the in situ AT injury model, the FFs group also demonstrated much better structural and functional properties after healing, with higher levels of collagen deposition and better microstructure repair. Moreover, fetal fibroblasts could increase the recruitment of fibroblast-like cells and reduce the infiltration of inflammatory cells to the injury site during the regeneration process. Our results suggest that the underlying mechanisms of better regeneration with FFs should be elucidated and be used to enhance adult tendon healing. This may assist in the development of future strategies to treat tendon injuries.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Tang QM,Chen JL,Shen WL,Yin Z,Liu HH,Fang Z,Heng BC,Ouyang HW,Chen Xdoi
10.1038/srep05515subject
Has Abstractpub_date
2014-07-03 00:00:00pages
5515issn
2045-2322pii
srep05515journal_volume
4pub_type
杂志文章abstract：:Heterocyclic amines (HCAs) are formed by cooking protein-rich foods, for instance, meat and fish, and are listed as possible human carcinogens. In the present study, the presence of five potential HCAs (IQ, MeIQ, MeIQx, 4,8-DiMeIQx, and PhIP) in cooked camel meat burgers was analyzed for the first time. The analysis w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01968-x
更新日期：2017-05-10 00:00:00
abstract：:Pellagra is a photosensitivity syndrome characterized by three "D's": diarrhea, dermatitis, and dementia as a result of niacin deficiency. However, the molecular mechanisms of photosensitivity dermatitis, the hallmark abnormality of this syndrome, remain unclear. We prepared niacin deficient mice in order to develop a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02973
更新日期：2013-10-17 00:00:00
abstract：:Polarization sensitive and insensitive color filters have important applications in the area of nano-spectroscopy and CCD imaging applications. Metallic nanostructures provide an efficient way to design and engineer ultrathin color filters. These nanostructures have capability to split the white light into fundamental...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07986-z
更新日期：2017-08-14 00:00:00
abstract：:Attosecond (asec) X-ray free-electron laser (XFEL) has attracted considerable interest over the past years. Nowadays typical XFEL application experiments demand 1010-1011 photons per pulse, which corresponds to a peak power of terawatts (TW) in case of asec hard X-ray pulse. To the realization of such TW asec-XFEL pul...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-57905-y
更新日期：2020-01-28 00:00:00
abstract：:In this article a new spent catalyst sample preparation method was implemented for the purpose of molybdenum leaching in a single step. Further molybdenum and vanadium in the leach liquor were separated and their concentrations were enriched using the solvent extraction and stripping techniques. The impervious sulfur ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58972-x
更新日期：2020-02-06 00:00:00
abstract：:Clostridioides difficile is the leading cause of nosocomial infections and a worldwide urgent public health threat. Without doubt, there is an urgent need for new effective anticlostridial agents due to the increasing incidence and severity of C. difficile infection (CDI). The aim of the present study is to investigat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64882-9
更新日期：2020-05-07 00:00:00
abstract：:Prostate cancer is the most commonly diagnosed cancer in men with African American men disproportionally suffering from the burden of this disease. Biomarkers that could discriminate indolent from aggressive and drug resistance disease are lacking. MicroRNAs are small non-coding RNAs that affect numerous physiological...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46170-3
更新日期：2019-07-05 00:00:00
abstract：:Previous analyses of the Atlantic cod genome showed unique combinations of lacking and expanded number of genes for the immune system. The present study examined lysozyme activity, lysozyme gene distribution and expression in cod. Enzymatic assays employing specific bacterial lysozyme inhibitors provided evidence for ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28318
更新日期：2016-06-21 00:00:00
abstract：:Among the III-nitride semiconductors, InxGa1-xN is a key material for visible optical devices such as light-emitting diodes (LEDs), laser diodes, and solar cells. Light emission is achieved via electron-hole recombination within the InxGa1-xN layer. When InxGa1-xN-based blue LEDs were first commercialized, the high pr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39086-5
更新日期：2019-03-06 00:00:00
abstract：:The key to arthritis management is early diagnosis and treatment to prevent further joint destruction and maximize functional ability. Osteoarthritis (OA) and rheumatoid arthritis (RA) are two common types of arthritis that the primary care provider must differentiate, in terms of diagnosis and treatment. Effective an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35473-6
更新日期：2018-11-20 00:00:00
abstract：:In recent years, texture analysis of medical images has become increasingly popular in studies investigating diagnosis, classification and treatment response assessment of cancerous disease. Despite numerous applications in oncology and medical imaging in general, there is no consensus regarding texture analysis workf...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04151-4
更新日期：2017-06-22 00:00:00
abstract：:Optical feedback mechanisms are often obtained from well-defined resonator structures fabricated by top-down processes. Here, we demonstrate that two-dimensional networks of metallic nanowires dispersed on the semiconductor slab can provide strong in-plane optical feedback and, thus, form randomly-distributed Fabry-Pé...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24898
更新日期：2016-04-22 00:00:00
abstract：:Complex systems displaying recurrent spike patterns are ubiquitous in nature. Understanding the organization of these patterns is a challenging task. Here we study experimentally the spiking output of a semiconductor laser with feedback. By using symbolic analysis we unveil a nontrivial organization of patterns, revea...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04696
更新日期：2014-04-15 00:00:00
abstract：:The recent development of a CRISPR-Cas9-based homing system for the suppression of Anopheles gambiae is encouraging; however, with current designs, the slow emergence of homing-resistant alleles is expected to result in suppressed populations rapidly rebounding, as homing-resistant alleles have a significant fitness a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02744-7
更新日期：2017-06-19 00:00:00
abstract：:The lignite biodegradation procedure to produce water-soluble humic materials (WSHM) with a Penicillium stain was established by previous studies in our laboratory. This study researched the effects of WSHM on the growth of Bradyrhizobium liaoningense CCBAU05525 and its nodulation on soybean. Results showed that WSHM ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10836
更新日期：2015-06-08 00:00:00
abstract：:G-quadruplexes (G4s) are nucleic acids secondary structures, epigenetic regulators in cells and viruses. In herpes simplex virus 1 (HSV-1)-infected cells, G4s are massively present during viral replication. We here aimed at investigating the possibility to target the HSV-1 G4s by a core extended naphtalene diimide (c-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02667-3
更新日期：2017-05-24 00:00:00
abstract：:Mitofusins are large transmembrane GTPases of the dynamin-related protein family, and are required for the tethering and fusion of mitochondrial outer membranes. Their full-length structures remain unknown, which is a limiting factor in the study of outer membrane fusion. We investigated the structure and dynamics of ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10687-2
更新日期：2017-08-31 00:00:00
abstract：:There has been much interest in understanding collective dynamics in networks of brain regions due to their role in behavior and cognitive function. Here we show that a simple, homogeneous system of densely connected oscillators, representing the aggregate activity of local brain regions, can exhibit a rich variety of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22074
更新日期：2016-02-26 00:00:00
abstract：:Aerosol particles emitted from various human activities deteriorate air quality and are suggested to increase public health risk. Numerous studies have emphasized the relationship between the mass and/or number concentration of aerosols (or commonly known as particulate matter (PM)) in the atmosphere and the incidence...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27156-z
更新日期：2018-06-11 00:00:00
abstract：:We investigated how skeletal muscle mass (SMM) affects spinal sagittal balance (radiographic parameters) in symptomatic spinal patients. The first purpose of this study was to evaluate the body composition and the spinal sagittal alignment in symptomatic spinal patients. The second purpose of this study was to compare...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33867-0
更新日期：2018-10-19 00:00:00
abstract：:Structural isomers, molecules having the same chemical formula but with atoms bonded in different order, are hard to identify using conventional spectroscopy and mass spectrometry. They exhibit virtually indistinguishable mass spectra when ionized by electrons. Laser mass spectrometry based on photoionization of the i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22055-9
更新日期：2018-02-28 00:00:00
abstract：:Transgenic expression of I-E molecules prevents diabetes in NOD mice. So far, the precise role of these non-classical MHC II molecules remains elusive. Here, we showed that transgenic expression of I-E(k) alpha 16 molecule in NOD mice selectively reduced Th17 cells in the thymus and pancreatic draining lymph nodes. Th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12941
更新日期：2015-08-07 00:00:00
abstract：:Photodynamic therapy (PDT), wherein light sensitive non-toxic agents are locally and selectively activated using light, has emerged as an appealing alternative to traditional cancer chemotherapy. Yet to date, PDT efficacy has been mostly characterized using 2D cultures. Compared to 2D cultures, 3D sphere culture gener...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12175
更新日期：2015-07-08 00:00:00
abstract：:Bisoprolol (B) exerts potential cardioprotective effects against myocardial ischemia/reperfusion (I/R) injury. Unfolded protein response (UPR) attenuates I/R injury induced apoptosis by reducing oxidative damage and inflammation response. The current study investigated whether the protective effects of bisoprolol resu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12366-8
更新日期：2017-09-19 00:00:00
abstract：:Surface hydrophobicity of silicon with sound durability under mechanical abrasion is highly desirable for practical needs. However, the reported micro-pyramid/nanowires structures suffer from the saturation characteristics of contact angle at around 132 degree, which impede the promotions toward reaching the state of ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37853-4
更新日期：2019-02-07 00:00:00
abstract：:TRPA1 is a Ca2+-permeable ion channel involved in many sensory disorders such as pain, itch and neuropathy. Notably, the function of TRPA1 depends on Ca2+, with low Ca2+ potentiating and high Ca2+ inactivating TRPA1. However, it remains unknown how Ca2+ exerts such contrasting effects. Here, we show that Ca2+ regulate...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45098
更新日期：2017-03-23 00:00:00
abstract：:Recent data suggest that tumor laterality and mucinous histology may be clinically relevant. We investigated how both variables impact on the prognosis and the response to therapies in a large population-based cohort of cancer patients. Incidence data, clinical and pathological features, and outcome were systematicall...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40096-6
更新日期：2019-03-06 00:00:00
abstract：:The product of the meiosis-expressed gene 1 (MEIG1) is found in the cell bodies of spermatocytes and recruited to the manchette, a structure unique to elongating spermatids, by Parkin co-regulated gene (PACRG). This complex is essential for targeting cargo to the manchette during sperm flagellum assembly. Here we show...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18278
更新日期：2016-01-04 00:00:00
abstract：:The prevalence of consanguineous marriage and genetic disorders are high in Saudi Arabia. There were records on the practices of Saudis toward prenatal diagnosis (PND) and termination of pregnancy (TOP), however the sample sizes are small. This study has targeted the Saudi Arabian community and family history of genet...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53655-8
更新日期：2019-11-21 00:00:00
abstract：:Outdoor air pollution is a growing public health concern, particularly in urban settings. However, there are limited epidemiological data on outdoor air pollution in rural areas with substantial levels of air pollution attributed to solid fuel burning for household cooking and heating. Xuanwei and Fuyuan are rural cou...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68229-2
更新日期：2020-07-09 00:00:00
