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Prostaglandin E₂ is critical for the development of niacin-deficiency-induced photosensitivity via ROS production.

Abstract：

:Pellagra is a photosensitivity syndrome characterized by three "D's": diarrhea, dermatitis, and dementia as a result of niacin deficiency. However, the molecular mechanisms of photosensitivity dermatitis, the hallmark abnormality of this syndrome, remain unclear. We prepared niacin deficient mice in order to develop a murine model of pellagra. Niacin deficiency induced photosensitivity and severe diarrhea with weight loss. In addition, niacin deficient mice exhibited elevated expressions of COX-2 and PGE syntheses (Ptges) mRNA. Consistently, photosensitivity was alleviated by a COX inhibitor, deficiency of Ptges, or blockade of EP4 receptor signaling. Moreover, enhanced PGE2 production in niacin deficiency was mediated via ROS production in keratinocytes. In line with the above murine findings, human skin lesions of pellagra patients confirmed the enhanced expression of Ptges. Niacin deficiency-induced photosensitivity was mediated through EP4 signaling in response to increased PGE2 production via induction of ROS formation.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Sugita K,Ikenouchi-Sugita A,Nakayama Y,Yoshioka H,Nomura T,Sakabe J,Nakahigashi K,Kuroda E,Uematsu S,Nakamura J,Akira S,Nakamura M,Narumiya S,Miyachi Y,Tokura Y,Kabashima K

doi

10.1038/srep02973

subject

Has Abstract

pub_date

2013-10-17 00:00:00

pages

2973

issn

2045-2322

pii

srep02973

journal_volume

3

pub_type

杂志文章

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