A novel HDAC inhibitor, CG200745, inhibits pancreatic cancer cell growth and overcomes gemcitabine resistance.

abstract：:Several carbon dots doping with diferent elements (Ca, Ag, Au) were fabricated and their catalytic properties had been investigated in this paper. It was found that the Ag-doped carbon dots (CDAg) had played a role of mimic enzyme on the reaction of HAuCl4-H2O2 and generated nanogold particles with surface enhanced Ra...

journal_title：Scientific reports

authors： Wang H,Huang X,Wen G,Jiang Z

更新日期：2019-07-10 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Zhang Y,Launay H,Schramm A,Lebrun R,Gontero B

更新日期：2018-08-29 00:00:00

abstract：:A difficult problem in quantum network communications is how to efficiently transmit quantum information over large-scale networks with common channels. We propose a solution by developing a quantum encoding approach. Different quantum states are encoded into a coherent superposition state using quantum linear optics....

journal_title：Scientific reports

authors： Luo MX,Xu G,Chen XB,Yang YX,Wang X

更新日期：2014-04-02 00:00:00

abstract：:This paper has been retracted at the request of the authors. ...

journal_title：Scientific reports

authors： Lei X,Liang Y,Chen J,Xiao S,Lei J,Li J,Duanmu J,Jiang Q,Liu D,Tang C,Li T

更新日期：2018-08-02 00:00:00

abstract：:Hibernation in mammals is a remarkable state of heterothermy wherein metabolic rates are reduced, core body temperatures reach ambient levels, and key physiological functions are suspended. Typically, hibernation is observed in cold-adapted mammals, though it has also been documented in tropical species and even prima...

journal_title：Scientific reports

authors： Blanco MB,Dausmann KH,Ranaivoarisoa JF,Yoder AD

更新日期：2013-01-01 00:00:00

abstract：:Coordination polymerization leads to various metal-organic frameworks (MOFs) with unique physical properties and chemical functionalities. One of the challenges towards their applications as porous materials is to make MOFs optimally conductive to be used as electronic components. Here, it is demonstrated that Co-MOF-...

journal_title：Scientific reports

authors： Shiozawa H,Bayer BC,Peterlik H,Meyer JC,Lang W,Pichler T

更新日期：2017-05-26 00:00:00

abstract：:Brønsted-Lewis acidic ionic liquids (ILs) were applied to catalyze cellobiose to prepare levulinic acid (LA) in one pot under hydrothermal conditions. Under the optimum conditions, the highest LA yield of 67.51% was obtained when low [HO3S-(CH2)3-mim]Cl-FeCl3 (molar fraction of FeCl3 x = 0.60) was used. This indicated...

journal_title：Scientific reports

authors： Liu S,Wang K,Yu H,Li B,Yu S

更新日期：2019-02-12 00:00:00

abstract：:Laser-Stimulated Fluorescence (LSF) is used to identify fully fledged feathering in the hatchling enantiornithine bird specimen MPCM-LH-26189, supporting precocial nesting behavior in this extinct group. The LSF results include the detection of a long pennaceous wing feather as well as cover feathers around the body. ...

journal_title：Scientific reports

authors： Kaye TG,Pittman M,Marugán-Lobón J,Martín-Abad H,Sanz JL,Buscalioni AD

更新日期：2019-03-21 00:00:00

abstract：:Inflammatory reactions activated by pattern recognition receptors (PRRs) on the membrane of innate immune cells play an important role in atherosclerosis. Whether the PRRs of the C-type lectin receptor (CLR) family including Dectin-2 may be involved in the pathogenesis of atherosclerosis remains largely unknown. Recen...

journal_title：Scientific reports

authors： Thiem K,Hoeke G,van den Berg S,Hijmans A,Jacobs CWM,Zhou E,Mol IM,Mouktaroudi M,Bussink J,Kanneganti TD,Lutgens E,Stienstra R,Tack CJ,Netea MG,Rensen PCN,Berbée JFP,van Diepen JA

更新日期：2019-03-13 00:00:00

abstract：:The transglutaminase (TG) family comprises eight isozymes that form the isopeptide bonds between glutamine and lysine residues and contribute to the fibrotic diseases via crosslinking-mediated stabilization of ECM and the activation of TGF-β in several tissues. However, despite a growing body of evidence implicating T...

journal_title：Scientific reports

authors： Tatsukawa H,Tani Y,Otsu R,Nakagawa H,Hitomi K

更新日期：2017-03-22 00:00:00

abstract：:To compare the efficacy and safety of triple therapy combining intravitreal injection of anti-vascular endothelial growth factor, trabeculectomy, and pan-retinal photocoagulation via binocular indirect ophthalmoscopy, with that of transscleral cyclophotocoagulation (TCP) to treat neovascular glaucoma in the angle-clos...

journal_title：Scientific reports

authors： Hong Y,Hu Y,Dou H,Wang C,Zhang C,Ma Z

更新日期：2018-05-04 00:00:00

abstract：:Rust fungi are plant pathogens that secrete an arsenal of effector proteins interfering with plant functions and promoting parasitic infection. Effectors are often species-specific, evolve rapidly, and display low sequence similarities with known proteins. How rust fungal effectors function in host cells remains elusi...

journal_title：Scientific reports

authors： de Guillen K,Lorrain C,Tsan P,Barthe P,Petre B,Saveleva N,Rouhier N,Duplessis S,Padilla A,Hecker A

更新日期：2019-12-02 00:00:00

abstract：:Rice breeding has achieved great productivity improvements by semi-dwarf varieties and hybrid vigour. Due to poor understanding of genetic basis of elite backbone varieties, the continuous increasing in rice yield still faces great challenges. Here, 52 elite rice varieties from three historical representative pedigree...

journal_title：Scientific reports

authors： Zheng X,Li L,Liang F,Tan C,Tang S,Yu S,Diao Y,Li S,Hu Z

更新日期：2017-03-22 00:00:00

abstract：:The foregut endoderm gives rise to several organs including liver, pancreas, lung and thyroid with important roles in human physiology. Understanding which genes and signalling pathways regulate their development is crucial for understanding developmental disorders as well as diseases in adulthood. We exploited unique...

journal_title：Scientific reports

authors： Trubiroha A,Gillotay P,Giusti N,Gacquer D,Libert F,Lefort A,Haerlingen B,De Deken X,Opitz R,Costagliola S

更新日期：2018-04-04 00:00:00

abstract：:Eucalyptus globulus is an aromatic medicinal plant which known for its 1,8-cineole main pharmacological constituent exhibits as natural analgesic agent. Eucalyptus globulus-loaded micellar nanoparticle was developed via spontaneous emulsification technique and further evaluation for its analgesic efficacy study, in vi...

journal_title：Scientific reports

authors： Aziz ZAA,Nasir HM,Ahmad A,Setapar SHM,Ahmad H,Noor MHM,Rafatullah M,Khatoon A,Kausar MA,Ahmad I,Khan S,Al-Shaeri M,Ashraf GM

更新日期：2019-09-23 00:00:00

abstract：:The autoimmune disorder Aicardi-Goutières syndrome (AGS) is characterized by a constitutive type I interferon response. SAMHD1 possesses both dNTPase and RNase activities and mutations in SAMHD1 cause AGS; however, how SAMHD1-deficiency causes the type I interferon response in patients with AGS remains unknown. Here, ...

journal_title：Scientific reports

authors： Oh C,Ryoo J,Park K,Kim B,Daly MB,Cho D,Ahn K

更新日期：2018-01-08 00:00:00

abstract：:Quality assessment of protein models using no other information than the structure of the model itself has been shown to be useful for structure prediction. Here, we introduce two novel methods, ProQRosFA and ProQRosCen, inspired by the state-of-art method ProQ2, but using a completely different description of a prote...

journal_title：Scientific reports

authors： Uziela K,Shu N,Wallner B,Elofsson A

更新日期：2016-10-04 00:00:00

abstract：:Turner syndrome (TS) is associated with decreased bone mineral density and increased fracture rate. However, the developmental trajectory of bone density or body composition in patients with TS is still unclear. The present study tested the hypothesis that different karyotypes and/or age contributes to abnormal body c...

journal_title：Scientific reports

authors： Shi K,Liu L,He YJ,Li D,Yuan LX,Lash GE,Li L

更新日期：2016-11-30 00:00:00

abstract：:The ability to assemble nano- and micro- sized colloidal components into highly ordered configurations is often cited as the basis for developing advanced materials. However, the dynamics of stochastic grain boundary formation and motion have not been quantified, which limits the ability to control and anneal polycrys...

journal_title：Scientific reports

authors： Edwards TD,Yang Y,Beltran-Villegas DJ,Bevan MA

更新日期：2014-08-20 00:00:00

abstract：:Cellular clearance mechanisms including the autophagy-lysosome pathway are impaired in amyotrophic lateral sclerosis (ALS). One of the most important proteins involved in the regulation of autophagy is the lysosomal Ca2+ channel Mucolipin TRP channel 1 (TRPML1). Therefore, we investigated the role of TRPML1 in a neuro...

journal_title：Scientific reports

authors： Tedeschi V,Petrozziello T,Sisalli MJ,Boscia F,Canzoniero LMT,Secondo A

更新日期：2019-07-24 00:00:00

abstract：:Ricco's area (the largest area of visual space in which stimulus area and intensity are inversely proportional at threshold) has previously been hypothesised to be a result of centre/surround antagonism in retinal ganglion cell receptive fields, but recent evidence suggests a sizeable cortical contribution. Here, Ricc...

journal_title：Scientific reports

authors： Je S,Ennis FA,Woodhouse JM,Sengpiel F,Redmond T

更新日期：2018-03-01 00:00:00

abstract：:Based on density functional theory and non-equilibrium Green's function formalism, we explore the effect of Fe atom in Au-Fe@C20-Au monomer and dimer systems in comparison with the C20 fullerene molecular junctions. We calculate the spin-dependent transmission coefficient, spin polarization and also their spin thermoe...

journal_title：Scientific reports

authors： Khalatbari H,Vishkayi SI,Soleimani HR

更新日期：2020-12-03 00:00:00

abstract：:The general model presented here for the formation of chromatin domains, LADs and TADs, is primarily based on the 3-D structures of the corresponding DNA sequences, the GC-poor and GC-rich isochores. Indeed, the low-heterogeneity GC-poor isochores locally are intrinsically stiff and curved because of the presence of i...

journal_title：Scientific reports

authors： Bernardi G

更新日期：2018-12-13 00:00:00

abstract：:Fibroblast growth factor 21 (FGF21) is a metabolic hormone having anti-oxidative and anti-hypertrophic effects. However, the regulation of FGF21 expression during acute myocardial infarction (AMI) remains unclear. We tested blood samples from 50 patients with AMI and 43 patients with stable angina pectoris (sAP) for F...

journal_title：Scientific reports

authors： Sunaga H,Koitabashi N,Iso T,Matsui H,Obokata M,Kawakami R,Murakami M,Yokoyama T,Kurabayashi M

更新日期：2019-08-14 00:00:00

abstract：:Neurotransmitters and peptide hormones are secreted into outside the cell by a vesicle fusion process. Although non-coding RNA (ncRNA) that include microRNA (miRNA) regulates gene expression inside the cell where they are transcribed, extracellular miRNA has been recently discovered outside the cells, proposing that m...

journal_title：Scientific reports

authors： Gümürdü A,Yildiz R,Eren E,Karakülah G,Ünver T,Genç Ş,Park Y

更新日期：2017-03-30 00:00:00

abstract：:Dolphin morbillivirus (DMV) has been responsible for several outbreaks of systemic infection and has resulted in cetacean strandings in the Mediterranean. In August-October 2016, seven striped dolphins (Stenella coeruleoalba) stranded on the Sicilian coastline (Italy) tested positive for DMV. Tissue samples from brain...

journal_title：Scientific reports

authors： Mira F,Rubio-Guerri C,Purpari G,Puleio R,Caracappa G,Gucciardi F,Russotto L,Loria GR,Guercio A

更新日期：2019-07-05 00:00:00

abstract：:Recent studies suggest that spatial training can maintain associative memory capacity in Tg2576 mice, but it is not known whether the beneficial effects can be inherited from the trained fathers to their offspring. Here, we exposed male wild-type and male 3XTg Alzheimer disease (AD) mice (3-m old) respectively to spat...

journal_title：Scientific reports

authors： Zhang S,Li X,Wang Z,Liu Y,Gao Y,Tan L,Liu E,Zhou Q,Xu C,Wang X,Liu G,Chen H,Wang JZ

更新日期：2017-05-08 00:00:00

abstract：:Agrostemma githago L. (corn cockle) is an herbaceous plant mainly growing in Europe. The seeds of the corn cockle are toxic and poisonings were widespread in the past by consuming contaminated flour. The toxic principle of Agrostemma seeds was attributed to triterpenoid secondary metabolites. Indeed, this is in part t...

journal_title：Scientific reports

authors： Weise C,Schrot A,Wuerger LTD,Adolf J,Gilabert-Oriol R,Sama S,Melzig MF,Weng A

更新日期：2020-09-21 00:00:00

abstract：:A challenge in regenerating large bone defects under load is to create scaffolds with large and interconnected pores while providing a compressive strength comparable to cortical bone (100-150 MPa). Here we design a novel hexagonal architecture for a glass-ceramic scaffold to fabricate an anisotropic, highly porous th...

journal_title：Scientific reports

authors： Roohani-Esfahani SI,Newman P,Zreiqat H

更新日期：2016-01-19 00:00:00

abstract：:Pseudoxanthoma Elasticum (PXE) is a rare disorder characterized by fragmentation and progressive calcification of elastic fibres in connective tissues. Although arterial hypertension (AHT) has been reported in PXE patients, its impact on pathological manifestations has as yet been unexplored. We investigated the conse...

journal_title：Scientific reports

authors： Omarjee L,Roy C,Leboeuf C,Favre J,Henrion D,Mahe G,Leftheriotis G,Martin L,Janin A,Kauffenstein G

更新日期：2019-11-08 00:00:00