Presence of heterocyclic amine carcinogens in home-cooked and fast-food camel meat burgers commonly consumed in Saudi Arabia.

Abstract:

:Heterocyclic amines (HCAs) are formed by cooking protein-rich foods, for instance, meat and fish, and are listed as possible human carcinogens. In the present study, the presence of five potential HCAs (IQ, MeIQ, MeIQx, 4,8-DiMeIQx, and PhIP) in cooked camel meat burgers was analyzed for the first time. The analysis was performed in home-cooked and fast-food burger samples containing food additives. The applied cooking technique for the home-cooked samples was pan frying for a controlled cooking time and temperature. In the control cooked meat samples (samples that contained no food additives), the concentrations of MeIQx, 4,8-DiMeIQx, and PhIP ranged from 2.47 ng/g to 4.89 ng/g, whereas IQ and MeIQ were found to be below the limit of quantification. The concentrations contents of MeIQx, 4,8-DiMeIQx, and PhIP in the home-cooked and fast-food samples ranged from 1.52 ng/g to 2.13 ng/g and 1.85 ng/g to 3.46 ng/g, respectively. IQ and MeIQ were not detected in either type of sample. In comparison to the control samples, the home-cooked and fast-food samples produced lower levels of HCAs. Such observations could result from the existence of antioxidants in incorporated food additives, which induce pro-oxidative effects with the successive formation and/or scavenging of free radicals.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Rizwan Khan M,Naushad M,Abdullah Alothman Z

doi

10.1038/s41598-017-01968-x

subject

Has Abstract

pub_date

2017-05-10 00:00:00

pages

1707

issue

1

issn

2045-2322

pii

10.1038/s41598-017-01968-x

journal_volume

7

pub_type

杂志文章
  • Biofilm formation in enterococci: genotype-phenotype correlations and inhibition by vancomycin.

    abstract::Enterococci are nosocomial pathogens that can form biofilms, which contribute to their virulence and antibiotic resistance. Although many genes involved in biofilm formation have been defined, their distribution among enterococci has not been comprehensively studied on a genome scale, and their diagnostic ability to p...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-05901-0

    authors: Hashem YA,Amin HM,Essam TM,Yassin AS,Aziz RK

    更新日期:2017-07-18 00:00:00

  • Tracking actomyosin at fluorescence check points.

    abstract::Emerging concepts for on-chip biotechnologies aim to replace microfluidic flow by active, molecular-motor driven transport of cytoskeletal filaments, including applications in bio-simulation, biocomputation, diagnostics, and drug screening. Many of these applications require reliable detection, with minimal data acqui...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep01092

    authors: Lard M,ten Siethoff L,Månsson A,Linke H

    更新日期:2013-01-01 00:00:00

  • SOX9 Regulates Cancer Stem-Like Properties and Metastatic Potential of Single-Walled Carbon Nanotube-Exposed Cells.

    abstract::Engineered nanomaterials hold great promise for the future development of innovative products but their adverse health effects are a major concern. Recent studies have indicated that certain nanomaterials, including carbon nanotubes (CNTs), may be carcinogenic. However, the underlying mechanisms behind their potential...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-12037-8

    authors: Voronkova MA,Luanpitpong S,Rojanasakul LW,Castranova V,Dinu CZ,Riedel H,Rojanasakul Y

    更新日期:2017-09-14 00:00:00

  • Comparative Systems Analyses Reveal Molecular Signatures of Clinically tested Vaccine Adjuvants.

    abstract::A better understanding of the mechanisms of action of human adjuvants could inform a rational development of next generation vaccines for human use. Here, we exploited a genome wide transcriptomics analysis combined with a systems biology approach to determine the molecular signatures induced by four clinically tested...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep39097

    authors: Olafsdottir TA,Lindqvist M,Nookaew I,Andersen P,Maertzdorf J,Persson J,Christensen D,Zhang Y,Anderson J,Khoomrung S,Sen P,Agger EM,Coler R,Carter D,Meinke A,Rappuoli R,Kaufmann SH,Reed SG,Harandi AM

    更新日期:2016-12-13 00:00:00

  • Influence of age and gender on sex steroid receptors in rat masticatory muscles.

    abstract::The temporomandibular muscle dysfunction is characterized by myofascial pain and is more prevalent in women of reproductive age. Sex steroid hormones are hypothetically involved in the dysfunction, but few are the studies of steroid receptors in masticatory and mastication-related muscles. Our aim was to determine est...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-54774-y

    authors: Galhardo APM,Mukai MK,Mori M,Carvalho KC,Baracat MCP,Simões MJ,Soares JM Jr,Baracat EC

    更新日期:2019-12-05 00:00:00

  • Joint genome-wide association and transcriptome sequencing reveals a complex polygenic network underlying hypocotyl elongation in rapeseed (Brassica napus L.).

    abstract::Hypocotyl elongation is considered an important typical seedling trait contributing directly to an increase in and stabilization of the yield in Brassica napus, but its molecular genetic mechanism is poorly understood. In the present study, hypocotyl lengths of 210 lines were measured in an illuminated culture room. A...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep41561

    authors: Luo X,Xue Z,Ma C,Hu K,Zeng Z,Dou S,Tu J,Shen J,Yi B,Fu T

    更新日期:2017-01-31 00:00:00

  • Dilute-As AlNAs Alloy for Deep-Ultraviolet Emitter.

    abstract::The band structures of dilute-As AlNAs alloys with As composition ranging from 0% up to 12.5% are studied by using First-Principle Density Functional Theory (DFT) calculation. The energy band gap shows remarkable reduction from 6.19 eV to 3.87 eV with small amount of As content in the AlNAs alloy, which covers the dee...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep22215

    authors: Tan CK,Borovac D,Sun W,Tansu N

    更新日期:2016-02-24 00:00:00

  • Automated Retinal Layer Segmentation Using Graph-based Algorithm Incorporating Deep-learning-derived Information.

    abstract::Regular drusen, an accumulation of material below the retinal pigment epithelium (RPE), have long been established as a hallmark early feature of nonneovascular age-related macular degeneration (AMD). Advances in imaging have expanded the phenotype of AMD to include another extracellular deposit, reticular pseudodruse...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-66355-5

    authors: Mishra Z,Ganegoda A,Selicha J,Wang Z,Sadda SR,Hu Z

    更新日期:2020-06-12 00:00:00

  • Strong coupling of diffraction coupled plasmons and optical waveguide modes in gold stripe-dielectric nanostructures at telecom wavelengths.

    abstract::We propose a hybrid plasmonic device consisting of a planar dielectric waveguide covering a gold nanostripe array fabricated on a gold film and investigate its guiding properties at telecom wavelengths. The fundamental modes of a hybrid device and their dependence on the key geometric parameters are studied. A communi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep45196

    authors: Thomas PA,Auton GH,Kundys D,Grigorenko AN,Kravets VG

    更新日期:2017-03-24 00:00:00

  • GENetic characteristics and REsponse to lipid-lowering therapy in familial hypercholesterolemia: GENRE-FH study.

    abstract::Among the 146 patients enrolled in the Korean FH registry, 83 patients who had undergone appropriate LLT escalation and were followed-up for ≥ 6 months were analyzed for pathogenic variants (PVs). The achieved percentage of expected low-density lipoprotein-cholesterol (LDL-C) reduction (primary variable) and achieveme...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-75901-0

    authors: Kim H,Lee CJ,Pak H,Kim DI,Rhee MY,Lee BK,Ahn Y,Cho BR,Woo JT,Hur SH,Jeong JO,Lee JH,Lee SH

    更新日期:2020-11-09 00:00:00

  • VEGF/Flk1 Mechanism is Involved in Roxarsone Promotion of Rat Endothelial Cell Growth and B16F10 Xenograft Tumor Angiogenesis.

    abstract::The potential angiogenic effect of roxarsone, a feed additive widely used to promote animal growth worldwide, was demonstrated recently. We explored the mechanism of vascular endothelial growth factor (VEGF) and its receptor (VEGFR) in roxarsone promotion of rat vascular endothelial cells (ECs) and B16F10 mouse xenogr...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-53870-3

    authors: Chen S,Xu J,Wei Q,Zhao Z,Chen X,Cui H,Zhang Y

    更新日期:2019-11-22 00:00:00

  • MoS2 Heterojunctions by Thickness Modulation.

    abstract::In this work, we report lateral heterojunction formation in as-exfoliated MoS2 flakes by thickness modulation. Kelvin probe force microscopy is used to map the surface potential at the monolayer-multilayer heterojunction, and consequently the conduction band offset is extracted. Scanning photocurrent microscopy is per...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep10990

    authors: Tosun M,Fu D,Desai SB,Ko C,Kang JS,Lien DH,Najmzadeh M,Tongay S,Wu J,Javey A

    更新日期:2015-06-30 00:00:00

  • Comparative study between deep learning and QSAR classifications for TNBC inhibitors and novel GPCR agonist discovery.

    abstract::Machine learning is a well-known approach for virtual screening. Recently, deep learning, a machine learning algorithm in artificial neural networks, has been applied to the advancement of precision medicine and drug discovery. In this study, we performed comparative studies between deep neural networks (DNN) and othe...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-73681-1

    authors: Tsou LK,Yeh SH,Ueng SH,Chang CP,Song JS,Wu MH,Chang HF,Chen SR,Shih C,Chen CT,Ke YY

    更新日期:2020-10-08 00:00:00

  • A rationale for surgical debulking to improve anti-PD1 therapy outcome in non small cell lung cancer.

    abstract::Anti-PD1 immunotherapy has emerged as a gold-standard treatment for first- or second-line treatment of stage IV NSCLC, with response rates ranging from 10 to 60%. Strategies to improve the disease control rate are needed. Several reports suggested that debulking surgery enhances anti-tumor immunity. We aimed at examin...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-52913-z

    authors: Guisier F,Cousse S,Jeanvoine M,Thiberville L,Salaun M

    更新日期:2019-11-15 00:00:00

  • Abseq: Ultrahigh-throughput single cell protein profiling with droplet microfluidic barcoding.

    abstract::Proteins are the primary effectors of cellular function, including cellular metabolism, structural dynamics, and information processing. However, quantitative characterization of proteins at the single-cell level is challenging due to the tiny amount of protein available. Here, we present Abseq, a method to detect and...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep44447

    authors: Shahi P,Kim SC,Haliburton JR,Gartner ZJ,Abate AR

    更新日期:2017-03-14 00:00:00

  • Validity assessment of the single-point insulin sensitivity estimator (spise) for diagnosis of cardiometabolic risk in post-pubertal hispanic adolescents.

    abstract::Insulin measurements are not advised for cardiometabolic risk screening in large groups. Here we assessed the accuracy of the single-point insulin sensitivity estimator (SPISE) to diagnose cardiometabolic risk in Chilean adolescents. In 678 post-pubertal adolescents (52% males, M(SD) age = 16.8 (0.2) years), height, w...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-71074-y

    authors: Correa-Burrows P,Blanco E,Gahagan S,Burrows R

    更新日期:2020-09-01 00:00:00

  • Volatile organic metabolites identify patients with breast cancer, cyclomastopathy, and mammary gland fibroma.

    abstract::The association between cancer and volatile organic metabolites in exhaled breaths has attracted increasing attention from researchers. The present study reports on a systematic study of gas profiles of metabolites in human exhaled breath by pattern recognition methods. Exhaled breath was collected from 85 patients wi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep05383

    authors: Wang C,Sun B,Guo L,Wang X,Ke C,Liu S,Zhao W,Luo S,Guo Z,Zhang Y,Xu G,Li E

    更新日期:2014-06-20 00:00:00

  • The functional role of time compression.

    abstract::Multisensory integration provides continuous and stable perception from separate sensory inputs. Here, we investigated the functional role of temporal binding between the visual and the tactile senses. To this end we used the paradigm of compression that induces shifts in time when probe stimuli are degraded, e.g., by...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep25843

    authors: Zimmermann E,Derichs C,Fink GR

    更新日期:2016-05-16 00:00:00

  • Src activation in the hypothalamic arcuate nucleus may play an important role in pain hypersensitivity.

    abstract::Src family of kinases (SFKs) has been found to play an important role in the regulation of nociception. However, how each member of this family acts in the central nervous system (CNS) structures involved in the relay and/or modulation of nociceptive signals, and thereby contributes to the formation and maintenance of...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-40572-z

    authors: Ma H,Yao C,Ma P,Zhou J,Gong S,Tao J,Yu XM,Jiang X

    更新日期:2019-03-07 00:00:00

  • Partially spatially coherent digital holographic microscopy and machine learning for quantitative analysis of human spermatozoa under oxidative stress condition.

    abstract::Semen quality assessed by sperm count and sperm cell characteristics such as morphology and motility, is considered to be the main determinant of men's reproductive health. Therefore, sperm cell selection is vital in assisted reproductive technology (ART) used for the treatment of infertility. Conventional bright fiel...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-39523-5

    authors: Dubey V,Popova D,Ahmad A,Acharya G,Basnet P,Mehta DS,Ahluwalia BS

    更新日期:2019-03-05 00:00:00

  • Author Correction: Infectious DNAs derived from insect-specific flavivirus genomes enable identification of pre- and post-entry host restrictions in vertebrate cells.

    abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-019-44657-7

    authors: Piyasena TBH,Setoh YX,Hobson-Peters J,Newton ND,Bielefeldt-Ohmann H,McLean BJ,Vet LJ,Khromykh AA,Hall RA

    更新日期:2019-06-05 00:00:00

  • Omega-3 fatty acids does not affect physical activity and body weight in primary school children - a double-blind randomized placebo-controlled trial.

    abstract::It was hypothesized that supplementation of omega-3 fatty acids could increase physical activity (PA) levels, where traditional interventions often fail. The aim of this double-blind, randomized, placebo-controlled trail was to evaluate the effects of 15-week administration of omega-3 fatty acids on objectively measur...

    journal_title:Scientific reports

    pub_type: 杂志文章,随机对照试验

    doi:10.1038/s41598-018-31229-4

    authors: Svensson V,Johansson E,Fischer M,Deng SL,Hagströmer M,Danielsson P

    更新日期:2018-08-24 00:00:00

  • Optical Twist Induced by Plasmonic Resonance.

    abstract::Harvesting light for optical torque is of significant importance, owing to its ability to rotate nano- or micro-objects. Nevertheless, applying a strong optical torque remains a challenging task: angular momentum must conserve but light is limited. A simple argument shows the tendency for two objects with strong mutua...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep27927

    authors: Chen J,Wang N,Cui L,Li X,Lin Z,Ng J

    更新日期:2016-06-13 00:00:00

  • Multiple sclerosis drug FTY-720 toxicity is mediated by the heterotypic fusion of organelles in neuroendocrine cells.

    abstract::FTY-720 (Fingolimod) was one of the first compounds authorized for the treatment of multiple sclerosis. Among its other activities, this sphingosine analogue enhances exocytosis in neuroendocrine chromaffin cells, altering the quantal release of catecholamines. Surprisingly, the size of chromaffin granules is reduced ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-55106-w

    authors: Gimenez-Molina Y,García-Martínez V,Villanueva J,Davletov B,Gutiérrez LM

    更新日期:2019-12-05 00:00:00

  • Chronic hepatitis C liver microenvironment: role of the Th17/Treg interplay related to fibrogenesis.

    abstract::The role of the different lymphocyte populations in liver microenvironment of chronic hepatitis C (CHC) patients is still matter of debate. Since Th17 and Treg have opposite functions, their balance could affect disease progression. The aim was to explore liver microenvironment and its peripheral blood counterpart in ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-13777-3

    authors: Rios DA,Valva P,Casciato PC,Frias S,Soledad Caldirola M,Gaillard MI,Bezrodnik L,Bandi J,Galdame O,Ameigeiras B,Krasniansky D,Brodersen C,Mullen E,Matteo EN,Preciado MV

    更新日期:2017-10-16 00:00:00

  • Tuning the entanglement between orbital reconstruction and charge transfer at a film surface.

    abstract::The interplay between orbital, charge, spin, and lattice degrees of freedom is at the core of correlated oxides. This is extensively studied at the interface of heterostructures constituted of two-layer or multilayer oxide films. Here, we demonstrate the interactions between orbital reconstruction and charge transfer ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep04206

    authors: Cui B,Song C,Li F,Wang GY,Mao HJ,Peng JJ,Zeng F,Pan F

    更新日期:2014-02-26 00:00:00

  • CVD growth of large area smooth-edged graphene nanomesh by nanosphere lithography.

    abstract::Current etching routes to process large graphene sheets into nanoscale graphene so as to open up a bandgap tend to produce structures with rough and disordered edges. This leads to detrimental electron scattering and reduces carrier mobility. In this work, we present a novel yet simple direct-growth strategy to yield ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep01238

    authors: Wang M,Fu L,Gan L,Zhang C,Rümmeli M,Bachmatiuk A,Huang K,Fang Y,Liu Z

    更新日期:2013-01-01 00:00:00

  • Cysteine allows ovarian cancer cells to adapt to hypoxia and to escape from carboplatin cytotoxicity.

    abstract::Ovarian cancer is the second most common gynaecologic malignancy and the main cause of death from gynaecologic cancer, due to late diagnosis and chemoresistance. Studies have reported the role of cysteine in cancer, by contributing for hydrogen sulphide (H2S) generation and as a precursor of glutathione (GSH). However...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-27753-y

    authors: Nunes SC,Ramos C,Lopes-Coelho F,Sequeira CO,Silva F,Gouveia-Fernandes S,Rodrigues A,Guimarães A,Silveira M,Abreu S,Santo VE,Brito C,Félix A,Pereira SA,Serpa J

    更新日期:2018-06-22 00:00:00

  • Investigation of the Roles of Plasma Species Generated by Surface Dielectric Barrier Discharge.

    abstract::As an emerging sterilization technology, cold atmospheric plasma offers a dry, non-thermal, rapid process that is minimally damaging to a majority of substrates. However, the mechanisms by which plasma interacts with living cells are poorly understood and the plasma generation apparatuses are complex and resource-inte...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-35166-0

    authors: Pai K,Timmons C,Roehm KD,Ngo A,Narayanan SS,Ramachandran A,Jacob JD,Ma LM,Madihally SV

    更新日期:2018-11-12 00:00:00

  • Different response of the taxonomic, phylogenetic and functional diversity of birds to forest fragmentation.

    abstract::Habitat fragmentation is considered as major threat to biodiversity worldwide. Biodiversity can be described as taxonomic, functional and phylogenetic diversity. However, the effect of forest fragmentation on taxonomic, phylogenetic and functional diversity is barely understood. We compare the response of taxonomic (s...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-76917-2

    authors: Bełcik M,Lenda M,Amano T,Skórka P

    更新日期:2020-11-23 00:00:00