Genome-wide landscape of DNA methylomes and their relationship with mRNA and miRNA transcriptomes in oxidative and glycolytic skeletal muscles.

abstract：:DNA methylation may be involved in development of type 1 diabetes (T1D), but previous epigenome-wide association studies were conducted among cases with clinically diagnosed diabetes. Using multiple pre-disease peripheral blood samples on the Illumina 450 K and EPIC platforms, we investigated longitudinal methylation ...

journal_title：Scientific reports

authors： Johnson RK,Vanderlinden LA,Dong F,Carry PM,Seifert J,Waugh K,Shorrosh H,Fingerlin T,Frohnert BI,Yang IV,Kechris K,Rewers M,Norris JM

更新日期：2020-02-28 00:00:00

abstract：:Coordination polymerization leads to various metal-organic frameworks (MOFs) with unique physical properties and chemical functionalities. One of the challenges towards their applications as porous materials is to make MOFs optimally conductive to be used as electronic components. Here, it is demonstrated that Co-MOF-...

journal_title：Scientific reports

authors： Shiozawa H,Bayer BC,Peterlik H,Meyer JC,Lang W,Pichler T

更新日期：2017-05-26 00:00:00

abstract：:In this paper, we present an evolutionary trust game, taking punishment and protection into consideration, to investigate the formation of trust in the so-called sharing economy from a population perspective. This sharing economy trust model comprises four types of players: a trustworthy provider, an untrustworthy pro...

journal_title：Scientific reports

authors： Chica M,Chiong R,Adam MTP,Teubner T

更新日期：2019-12-24 00:00:00

abstract：:Remote photoplethysmography (PPG) is an optical measurement technique with established applications in vital signs monitoring. Recently, the consensual understanding of blood volume variations (BVVs) as the origin of PPG signals was challenged, raising validity concerns about the remote SpO2 methodology. Recognizing t...

journal_title：Scientific reports

authors： Moço AV,Stuijk S,de Haan G

更新日期：2018-05-31 00:00:00

abstract：:S-resistin, a non-secretable resistin isoform, acts as an intracrine factor that regulates adipocyte maduration, inflammatory and insulin response in 3T3-L1 cells. However, its intracellular function in vivo is still unknown. In this study, we analyze the central role of s-resistin, decreasing its hypothalamic express...

journal_title：Scientific reports

authors： Rodríguez M,Pintado C,Moltó E,Gallardo N,Fernández-Martos CM,López V,Andrés A,Arribas C

更新日期：2018-03-02 00:00:00

abstract：:Lipidomic analyses address the problem of characterizing the lipid components of given cells, tissues and organisms by means of chromatographic separations coupled to high-resolution, tandem mass spectrometry analyses. A number of software tools have been developed to help in the daunting task of mass spectrometry sig...

journal_title：Scientific reports

authors： Manzini S,Busnelli M,Colombo A,Kiamehr M,Chiesa G

更新日期：2020-08-07 00:00:00

abstract：:Lytic bacteriophages are valuable therapeutic agents against bacterial infections. There is continual effort to obtain new phages to increase the effectivity of phage preparations against emerging phage-resistant strains. Here we described the genomic diversity of spontaneous host-range mutants of kayvirus 812. Five m...

journal_title：Scientific reports

authors： Botka T,Pantůček R,Mašlaňová I,Benešík M,Petráš P,Růžičková V,Havlíčková P,Varga M,Žemličková H,Koláčková I,Florianová M,Jakubů V,Karpíšková R,Doškař J

更新日期：2019-04-02 00:00:00

abstract：:Most pollination in large-scale agriculture is dependent on managed colonies of a single species, the honey bee Apis mellifera. More than 1 million hives are transported to California each year just to pollinate the almonds, and bees are trucked across the country for various cropping systems. Concerns have been raise...

journal_title：Scientific reports

authors： Simone-Finstrom M,Li-Byarlay H,Huang MH,Strand MK,Rueppell O,Tarpy DR

更新日期：2016-08-24 00:00:00

abstract：:Understanding the excited-state dynamics in perovskite photovoltaics is necessary for progress in these materials, but changes in dynamics depending on the fabrication processes used for perovskite photoactive layers remain poorly characterised. Here we report a comparative study on femtosecond transient absorption (T...

journal_title：Scientific reports

authors： Kim IS,Jo C,Kang R,Kim DY,Son SJ,Hwang IW,Ko DK

更新日期：2017-11-28 00:00:00

abstract：:Mitochondria act as a platform for antiviral innate immunity, and the immune system depends on activation of the retinoic acid-inducible gene I (RIG-I)-like receptors (RLR) signaling pathway via an adaptor molecule, mitochondrial antiviral signaling. We report that RLR-mediated antiviral innate immunity requires oxida...

journal_title：Scientific reports

authors： Yoshizumi T,Imamura H,Taku T,Kuroki T,Kawaguchi A,Ishikawa K,Nakada K,Koshiba T

更新日期：2017-07-14 00:00:00

abstract：:By eliminating the spherical aberrations of microsphere we derived a simple but useful formula on the focusing of dielectric microsphere. On basis of this formula, not only can researchers determine the parameters of an optical microsphere system with super-resolution, but they can also perform parameter transformatio...

journal_title：Scientific reports

authors： Xia T,Guo H,Hu J,Zhuang S

更新日期：2017-07-18 00:00:00

abstract：:A previous randomized, controlled trial had demonstrated that complete intraureteral stent placement (CIU-SP) was superior to conventional stent placement (C-SP) in terms of improvement of stent-related urinary symptoms. However, it is unclear as to which subdomain symptom and cohort could benefit the most from CIU-SP...

journal_title：Scientific reports

authors： Matsuzaki T,Yoshida T,Murota T,Nakao K,Taguchi M,Kinoshita H,Matsuda T

更新日期：2020-09-28 00:00:00

abstract：:Three-dimensional (3D) cell cultures produce more in vivo-like multicellular structures such as spheroids that cannot be obtained in two-dimensional (2D) cell cultures. Thus, they are increasingly employed as models for cancer and drug research, as well as tissue engineering. It has proven challenging to stabilize sph...

journal_title：Scientific reports

authors： Lou YR,Kanninen L,Kaehr B,Townson JL,Niklander J,Harjumäki R,Jeffrey Brinker C,Yliperttula M

更新日期：2015-09-01 00:00:00

abstract：:Cardiorenal syndrome is defined by primary heart failure conditions influencing or leading to renal injury or dysfunction. Dilated cardiomyopathy (DCM) is a major co-existing form of heart failure (HF) with renal diseases. Myocardin (MYOCD), a cardiac-specific co-activator of serum response factor (SRF), is increased ...

journal_title：Scientific reports

authors： Mittal A,Rana S,Sharma R,Kumar A,Prasad R,Raut SK,Sarkar S,Saikia UN,Bahl A,Dhandapany PS,Khullar M

更新日期：2019-04-10 00:00:00

abstract：:A cross-correlative precession electron diffraction - atom probe tomography investigation of Cr segregation in a Fe(Cr) nanocrystalline alloy was undertaken. Solute segregation was found to be dependent on grain boundary type. The results of which were compared to a hybrid Molecular Dynamics and Monte Carlo simulation...

journal_title：Scientific reports

authors： Zhou X,Yu XX,Kaub T,Martens RL,Thompson GB

更新日期：2016-10-06 00:00:00

abstract：:Bradysia odoriphaga and Bradysia difformis are devastating pests of vegetable, ornamental crops and edible mushrooms causing significant losses. Temperature may be an important factor restricting their population abundance in the summer. To determine the effects of short-term heat shock on adults, their survival, long...

journal_title：Scientific reports

authors： Zhu G,Xue M,Luo Y,Ji G,Liu F,Zhao H,Sun X

更新日期：2017-10-17 00:00:00

abstract：:Mucus is responsible for controlling transport and barrier function in biological systems, and its properties can be significantly affected by compositional and environmental changes. In this study, the impacts of pH and CaCl2 were examined on the solution-to-gel transition of mucin, the primary structural component o...

journal_title：Scientific reports

authors： Curnutt A,Smith K,Darrow E,Walters KB

更新日期：2020-05-29 00:00:00

abstract：:Ferroelectric-relaxor behavior of Ba(Zr0.3Ti0.7)O3 nanofibers (BZT NF) with a large aspect ratio were prepared via electrospinning and surface modified by PVP as dielectric fillers. The nanocomposite flexible films based on surface modified BZT NF and polyvinylidene fluoride (PVDF) were fabricated via a solution casti...

journal_title：Scientific reports

authors： Liu S,Xue S,Xiu S,Shen B,Zhai J

更新日期：2016-05-17 00:00:00

abstract：:Fc domain fusion can improve the therapeutic effects of relatively small biological molecules such as peptides, cytokines, and antibody fragments. Fc fusion proteins can also be used to enhance the cytotoxic effects of small bispecific antibodies (bsAbs). However, fragmentation of Fc fusion proteins, which mainly occu...

journal_title：Scientific reports

authors： Suzuki S,Annaka H,Konno S,Kumagai I,Asano R

更新日期：2018-11-22 00:00:00

abstract：:A series of novel dioxin-containing pyrazoline derivatives with thiourea skeleton have been designed, synthesized and evaluated for their EGFR/HER-2 inhibitory and anti-proliferation activities. A majority of them displayed selective HER-2 inhibitory activity against EGFR inhibitory activity. Compound C20 displayed th...

journal_title：Scientific reports

authors： Yang B,Yang YS,Yang N,Li G,Zhu HL

更新日期：2016-06-08 00:00:00

abstract：:Global biodiversity hotspots (GBHs) are increasingly vulnerable to human stressors such as anthropogenic climate change, which will alter the ecology of these habitats, even where protected. The longleaf pine (Pinus palustris) ecosystem (LPE) of the North American Coastal Plain is a GBH where disturbances are integral...

journal_title：Scientific reports

authors： Zampieri NE,Pau S,Okamoto DK

更新日期：2020-05-21 00:00:00

abstract：:Mammalian innate and acquired immune responses involve a coordinated, sequential, and self limiting sequence of events controlled by positive and negative regulatory mechanism. MicroRNAs have been implicated as a negative regulator for diverse biological events including immune responses. However, the involvement of m...

journal_title：Scientific reports

authors： Jun H,Ying H,Daiwen C,Bing Y,Xiangbing M,Ping Z,Jie Y,Zhiqing H,Junqiu L

更新日期：2015-07-31 00:00:00

abstract：:Single-nucleotide polymorphisms (SNPs) in cytokine genes can affect gene expression and thereby modulate inflammation and carcinogenesis. However, the data on the association between SNPs in the interleukin 1 beta gene (IL1B) and colorectal cancer (CRC) are conflicting. We found an association between a 4-SNP haplotyp...

journal_title：Scientific reports

authors： Sanabria-Salas MC,Hernández-Suárez G,Umaña-Pérez A,Rawlik K,Tenesa A,Serrano-López ML,Sánchez de Gómez M,Rojas MP,Bravo LE,Albis R,Plata JL,Green H,Borgovan T,Li L,Majumdar S,Garai J,Lee E,Ashktorab H,Brim H,Li L,

更新日期：2017-02-03 00:00:00

abstract：:Calcium regulation plays a central role in cardiac function. Several variants in the calcium channel Cav1.2 have been implicated in arrhythmic syndromes. We screened patients with Brugada syndrome, short QT syndrome, early repolarisation syndrome, and idiopathic ventricular fibrillation to determine the frequency and ...

journal_title：Scientific reports

authors： Blancard M,Debbiche A,Kato K,Cardin C,Sabrina G,Gandjbakhch E,Probst V,Haissaguerre M,Extramiana F,Hocini M,Olivier G,Leenhardt A,Guicheney P,Rougier JS

更新日期：2018-10-02 00:00:00

abstract：:There are few studies examining the association between homocysteine (Hcy) level and the risk of hypertension with consideration for folate and vitamin B12 as related to Hcy level. We simultaneously examined the associations of plasma levels of Hcy, folate, and vitamin B12, and dietary folate intake with the prevalenc...

journal_title：Scientific reports

authors： Tamura T,Kuriyama N,Koyama T,Ozaki E,Matsui D,Kadomatsu Y,Tsukamoto M,Kubo Y,Okada R,Hishida A,Sasakabe T,Kawai S,Naito M,Takashima N,Kadota A,Tanaka K,Hara M,Suzuki S,Nakagawa-Senda H,Takezaki T,Shimoshikiryo I,

更新日期：2020-10-28 00:00:00

abstract：:Meishan boars are known for their early sexual maturity. However, they exhibit a significantly smaller testicular size and a reduced proportion of Sertoli cells and daily sperm production compared with Duroc boars. The testes of Duroc and Meishan boars at 20, 75 and 270 days of age were used for histological and trans...

journal_title：Scientific reports

authors： Ding H,Luo Y,Liu M,Huang J,Xu D

更新日期：2016-02-11 00:00:00

abstract：:Decline in episodic memory performance usually causes the first clinical symptoms of Alzheimer's disease. At present, Alzheimer's disease can only be diagnosed at a very late stage when neurodegeneration and cognitive impairment is already irreversible. New early disease markers are needed for earlier and more efficie...

journal_title：Scientific reports

authors： Konki M,Lindgren N,Kyläniemi M,Venho R,Laajala E,Ghimire B,Lahesmaa R,Kaprio J,Rinne JO,Lund RJ

更新日期：2020-08-25 00:00:00

abstract：:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is thought to be a pure genetic form of subcortical vascular cognitive impairment (SVCI). The aim of this study was to compare white matter integrity and cortical thickness between typical CADASIL, a genetic form, and ...

journal_title：Scientific reports

authors： Kim KW,Kwon H,Kim YE,Yoon CW,Kim YJ,Kim YB,Lee JM,Yoon WT,Kim HJ,Lee JS,Jang YK,Kim Y,Jang H,Ki CS,Youn YC,Shin BS,Bang OY,Kim GM,Chung CS,Kim SJ,Na DL,Duering M,Cho H,Seo SW

更新日期：2019-01-28 00:00:00

abstract：:Emerging evidence indicates the existence of a new class of cancer genes that act as "signal linkers" coordinating oncogenic signals between mutated and differentially expressed genes. While frequently mutated oncogenes and differentially expressed genes, which we term Class I cancer genes, are readily detected by mos...

journal_title：Scientific reports

authors： Ghanat Bari M,Ung CY,Zhang C,Zhu S,Li H

更新日期：2017-08-01 00:00:00

abstract：:Adulterant herbal materials are a threat to consumer safety. In this study, we used DNA barcoding to investigate the proportions and varieties of adulterant species in traditional Chinese medicine (TCM) markets. We used a DNA barcode database of TCM (TCMD) that was established by our group to investigate 1436 samples ...

journal_title：Scientific reports

authors： Han J,Pang X,Liao B,Yao H,Song J,Chen S

更新日期：2016-01-07 00:00:00