Abstract：
:There are few studies examining the association between homocysteine (Hcy) level and the risk of hypertension with consideration for folate and vitamin B12 as related to Hcy level. We simultaneously examined the associations of plasma levels of Hcy, folate, and vitamin B12, and dietary folate intake with the prevalence of hypertension. Participants included 1046 men and 1033 women (mean age ± standard deviation: 56.0 ± 8.9 years) in the Japan Multi-Institutional Collaborative Cohort Study. Dietary folate intake was estimated using a validated food frequency questionnaire. Hypertension was defined based on measured blood pressure and use of antihypertensive medication. A total of 734 participants (35.3%) had hypertension. Multivariate-adjusted odds ratios of hypertension for the highest quartile group of Hcy were 2.36 (95% CI 1.41-3.96) in men and 1.86 (95% CI 1.11-3.11) in women, as compared with the lowest group (P for trend = 0.014 and 0.005, respectively). Dietary folate intake was not correlated with hypertension in both men and women (P for trend = 0.099 and 0.703, respectively). Plasma vitamin B12 was positively associated with hypertension only in women (P for trend = 0.027). Plasma Hcy level was positively linked with hypertension after controlling for covariates, including folate and vitamin B12.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Tamura T,Kuriyama N,Koyama T,Ozaki E,Matsui D,Kadomatsu Y,Tsukamoto M,Kubo Y,Okada R,Hishida A,Sasakabe T,Kawai S,Naito M,Takashima N,Kadota A,Tanaka K,Hara M,Suzuki S,Nakagawa-Senda H,Takezaki T,Shimoshikiryo I,doi
10.1038/s41598-020-75267-3subject
Has Abstractpub_date
2020-10-28 00:00:00pages
18499issue
1issn
2045-2322pii
10.1038/s41598-020-75267-3journal_volume
10pub_type
杂志文章abstract：:The need for sensitive, robust, portable, and inexpensive biosensing platforms is of significant interest in clinical applications for disease diagnosis and treatment monitoring at the point-of-care (POC) settings. Rapid, accurate POC diagnostic assays play a crucial role in developing countries, where there are limit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08719
更新日期：2015-03-06 00:00:00
abstract：:We determined the nearly complete mitochondrial genomes of the Arctic Calanus glacialis and its North Atlantic sibling Calanus finmarchicus, which are key zooplankton components in marine ecosystems. The sequenced part of C. glacialis mitogenome is 27,342 bp long and consists of two contigs, while for C. finmarchicus ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13807-0
更新日期：2017-10-20 00:00:00
abstract：:Self-cleaving ribozymes fold into intricate structures, which orient active site groups into catalytically competent conformations. Most ribozyme families have distinct catalytic cores stabilized by tertiary interactions between domains peripheral to those cores. We show that large hepatitis delta virus (HDV)-like rib...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28179
更新日期：2016-06-15 00:00:00
abstract：:It is common to find in the literature different values for the working voltage window (WVW) range for aqueous-based supercapacitors. In many cases, even with the best intentions of the widening the operating voltage window, the measured current using the cyclic voltammetry (CV) technique includes a significant contri...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75851-7
更新日期：2020-11-05 00:00:00
abstract：:The formation and motion features of self interstitial atom (SIA) clusters in tungsten are studied by molecular dynamics (MD) simulations. The static calculations show that the SIA clusters are stable with binding energy over 2 eV. The SIA clusters exhibit a fast one dimensional (1D) motion along 〈111〉. Through analys...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05096
更新日期：2014-05-28 00:00:00
abstract：:Many studies speak in favor of a rhythmic mode of listening, by which the encoding of acoustic information is structured by rhythmic neural processes at the time scale of about 1 to 4 Hz. Indeed, psychophysical data suggest that humans sample acoustic information in extended soundscapes not uniformly, but weigh the ev...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-82008-7
更新日期：2021-01-27 00:00:00
abstract：:We introduce a concept that enables parallelized three-dimensional imaging throughout large volumes with isotropic 300-350 nm resolution. By staggering high aspect ratio illumination beams laterally and axially within the depth of focus of a digitally scanned light-sheet fluorescence microscope (LSFM), multiple image ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08113-8
更新日期：2017-08-24 00:00:00
abstract：:Tissue microarray (TMA) core images are a treasure trove for artificial intelligence applications. However, a common problem of TMAs is multiple sectioning, which can change the content of the intended tissue core and requires re-labelling. Here, we investigate different ensemble methods for colorectal tissue classifi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81352-y
更新日期：2021-01-27 00:00:00
abstract：:MicroRNAs (miRNAs) are small, non-coding RNAs that regulate a variety of biological processes. Recently, human liver-specific miRNA miR-122 has been reported to facilitate hepatitis C virus (HCV) replication in liver cells. HCV is one of the leading causes of liver diseases worldwide. In Pakistan, the estimated preval...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21510
更新日期：2016-02-22 00:00:00
abstract：:Single molecule microarrays have been used in quantitative proteomics, in particular, single cell analysis requiring high sensitivity and ultra-low limits of detection. In this paper, several image analysis methods are evaluated for their ability to accurately enumerate single molecules bound to a microarray spot. Cru...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18303-z
更新日期：2017-12-20 00:00:00
abstract：:Trimethylamine-N-Oxide (TMAO) is a microbiome-related metabolite that is cleared by the kidney and linked to renal function. We explored the relationship between TMAO and all-cause mortality, and determined whether this association was modified by renal function. A prospective study was performed among PREVEND partici...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13739-9
更新日期：2017-10-23 00:00:00
abstract：:Ultrafine-grained die-upset Nd-Fe-B magnets are of importance because they provide a wide researching space to redesign the textured structures. Here is presented a route to obtain a new die-upset magnet with substantially improved magnetic properties. After experiencing the optimized heat treatment, both the coercivi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38335
更新日期：2016-12-06 00:00:00
abstract：:Compact and power-efficient plastic electronic synapses are of fundamental importance to overcoming the bottlenecks of developing a neuromorphic chip. Memristor is a strong contender among the various electronic synapses in existence today. However, the speeds of synaptic events are relatively slow in most attempts at...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01619
更新日期：2013-01-01 00:00:00
abstract：:The present study aimed to evaluate the efficiency, effectiveness, and biocompatibility of two agents used for the chemomechanical removal of carious dentin. Sixty extracted carious human teeth were treated with a conventional bur (CBG) or chemomechanical agents - Papacarie Duo (PG) and Brix 3000 (BG). Treatment effic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65159-x
更新日期：2020-05-15 00:00:00
abstract：:Synapses are an early pathological target in many neurodegenerative diseases ranging from well-known adult onset conditions such as Alzheimer and Parkinson disease to neurodegenerative conditions of childhood such as spinal muscular atrophy (SMA) and neuronal ceroid lipofuscinosis (NCLs). However, the reasons why syna...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12603-0
更新日期：2017-09-29 00:00:00
abstract：:Climate-driven environmental change and land-use change often interact in their impact on biodiversity, but these interactions have received little scientific attention. Here we study the effects of climate-driven environmental variation (i.e. vegetation greenness) and land-use (protected versus unprotected areas) on ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31344-2
更新日期：2018-08-29 00:00:00
abstract：:Soil degradation due to erosion is a significant worldwide problem at different spatial (from pedon to watershed) and temporal scales. All stages and factors in the erosion process must be detected and evaluated to reduce this environmental issue and protect existing fertile soils and natural ecosystems. Laboratory st...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76926-1
更新日期：2020-11-19 00:00:00
abstract：:Psoriatic skin differs distinctly from normal skin by its thickened epidermis. Most gene expression comparisons utilize full-thickness biopsies, with substantial amount of dermis. We assayed the transcriptomes of normal, lesional, and non-lesional psoriatic epidermis, sampled as split-thickness skin grafts, with 5'-en...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22745
更新日期：2016-03-15 00:00:00
abstract：:Liraglutide, a glucagon-like peptide-1 receptor (GLP-1R) agonist, is widely used to treat diabetes. However, its effect on pulmonary arterial hypertension (PAH) is unknown. In this study, we investigated its effects on rats with monocrotaline (MCT)-induced PAH and mechanisms on rat pulmonary artery smooth muscle cells...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31788
更新日期：2016-09-01 00:00:00
abstract：:Phagocytosis is a process in which target cells or particles are engulfed and taken up by other cells, typically professional phagocytes; this process is crucial in many physiological processes and disease states. The detection of targets for phagocytosis is directed by a complex repertoire of cell surface receptors. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-38127-9
更新日期：2019-02-13 00:00:00
abstract：:17α-ethynilestradiol (EE2) and tamoxifen (Tmx) are pollutants world-wide distributed in aquatic environments. Gilthead seabream, Sparus aurata L., is highlighted as a species model of intensively culture in anthropogenic disturbed environments. The effects of these pollutants on gilthead seabream reproduction and some...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64522-2
更新日期：2020-05-14 00:00:00
abstract：:Despite our increasing understanding of zebrafish heart development and regeneration, there is limited information about the distribution of endothelial cells (ECs) in the adult zebrafish heart. Here, we investigate and compare the distribution of cardiac ECs (cECs) in adult mouse and zebrafish ventricles. Surprisingl...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02461-1
更新日期：2017-06-02 00:00:00
abstract：:Intuitively, deriving meaning from an abstract image is a uniquely human, idiosyncratic experience. Here we show that, despite having no universally recognised lexical association, abstract images spontaneously elicit specific concepts conveyed by words, with a consistency akin to that of concrete images. We presented...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25441-5
更新日期：2018-05-08 00:00:00
abstract：:E. coli is the main causative agent of mastitis in dairy cows, but the mechanism of molecular regulation underlying the occurrence and development of mastitis has not yet been fully elucidated. In this study, an E. coli-induced mastitis model was created and RNASeq technology was used to measure the miRNA expression p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30518-2
更新日期：2018-08-23 00:00:00
abstract：:Microbial survival in dynamic environments requires the ability to successfully respond to abrupt changes in osmolarity. The mechanosensitive channel of large conductance (MscL) is a ubiquitous channel that facilitates the survival of bacteria and archaea under severe osmotic downshock conditions by relieving excess t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32536-6
更新日期：2018-10-01 00:00:00
abstract：:Inorganic elements are important components of medicinal herbs, and provide valuable experimental evidence for the quality evaluation and control of traditional Chinese medicine (TCM). In this study, to investigate the relationship between the inorganic elemental fingerprint and geographical origin identification of c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12933-z
更新日期：2017-10-03 00:00:00
abstract：:This retrospective cohort study investigated the association between in-hospital survival and two-dimensional (2D) echocardiography within 24 hours after the return of spontaneous circulation (ROSC) in patients who underwent in-hospital cardiopulmonary resuscitation (ICPR) after in-hospital cardiopulmonary arrest (IHC...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56153-z
更新日期：2020-01-08 00:00:00
abstract：:Progression of age can influence gait characteristics. Previous research has investigated lower extremity joint mechanics between young and elderly people in locomotion, however little is known about whether differences exist between young and middle age people. Ten young healthy subjects (22.8 ± 5.3 years) and ten mi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41750-9
更新日期：2019-04-03 00:00:00
abstract：:Solar thermal energy conversion has attracted substantial renewed interest due to its applications in industrial heating, air conditioning, and electricity generation. Achieving stagnation temperatures exceeding 200 °C, pertinent to these technologies, with unconcentrated sunlight requires spectrally selective absorbe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05235-x
更新日期：2017-07-13 00:00:00
abstract：:Acoustic manipulation by an ultrasonic phased array provides an entirely new approach to processes such as coalescence, mixing, separation, and evaporation occurring in the generation of new materials, physical property measurement, the biomedical industry, etc. However, to date, ultrasonic phased arrays have not been...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28451-5
更新日期：2018-07-05 00:00:00
