Abstract：
:Intrinsic disorder occurs when (part of) a protein remains unfolded during normal functioning. Intrinsically-disordered regions can contain segments that 'fold on binding' to another molecule. Here, we perform bioinformatical parsing of human 'folding-on-binding' (FB) proteins, into four subsets: Ordered regions, FB regions, Disordered regions that surround FB regions ('Disordered-around-FB'), and Other-Disordered regions. We examined the composition and evolutionary behaviour (across vertebrate orthologs) of these subsets. From a convergence of three separate analyses, we find that for hydrophobicity, Ordered regions segregate from the other subsets, but the Ordered and FB regions group together as highly conserved, and the Disordered-around-FB and Other-Disordered regions as less conserved (with a lesser significant difference between Ordered and FB regions). FB regions are highly-conserved with net positive charge, whereas Disordered-around-FB have net negative charge and are relatively less hydrophobic than FB regions. Indeed, these Disordered-around-FB regions are excessively hydrophilic compared to other disordered regions generally. We describe how our results point towards a possible compositionally-based steering mechanism of folding-on-binding.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Narasumani M,Harrison PMdoi
10.1038/srep18586subject
Has Abstractpub_date
2015-12-18 00:00:00pages
18586issn
2045-2322pii
srep18586journal_volume
5pub_type
杂志文章abstract：:Mayaro virus (MAYV) causes an acute febrile illness similar to that produced by chikungunya virus (CHIKV), an evolutionary relative in the Semliki Forest virus complex of alphaviruses. MAYV emergence is typically sporadic, but recent isolations and outbreaks indicate that the virus remains a public health concern. Giv...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56551-3
更新日期：2019-12-31 00:00:00
abstract：:Microscopic swimming devices hold promise for radically new applications in lab-on-a-chip and microfluidic technology, diagnostics and drug delivery etc. In this paper, we demonstrate the experimental verification of a new class of autonomous ferromagnetic swimming devices, actuated and controlled solely by an oscilla...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44142
更新日期：2017-03-09 00:00:00
abstract：:Plasmacytoid dendritic cells (pDCs) are specialized in the production of interferons (IFNs) in response to viral infections. The Flaviviridae family comprises enveloped RNA viruses such as Hepatitis C virus (HCV) and Dengue virus (DENV). Cell-free flaviviridae virions poorly stimulate pDCs to produce IFN. By contrast,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29235-7
更新日期：2018-07-18 00:00:00
abstract：:Platelet Derived Growth Factor Receptor (PDGFR) signaling is a central mitogenic pathway in development, as well as tissue repair and homeostasis. The rules governing the binding of PDGF ligand to the receptor to produce activation and downstream signaling have been well defined over the last several decades. In cultu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75774-3
更新日期：2020-11-09 00:00:00
abstract：:Using symbiotic farming methods [cover crops and chicken grazing (+ C)] in a winter fallow field, we found that the soil organic matter and total nitrogen of the + C treatment were 5.2% and 26.6% higher, respectively, than those of a treatment with cover crops and no chicken grazing (- C). The annual rice grain yield ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69407-y
更新日期：2020-07-28 00:00:00
abstract：:The purpose of this study was to analyze spatiotemporal parameters of gait in children using varyingly loaded Backpacks(BP). This cross-sectional study examined 231 schoolchildren (118 boys, 113 girls) aged six to 12 years, carrying a traditional BP to manipulate loading (Crossing Backpack Children Arpenaz 7 Litres, J...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48675-3
更新日期：2019-08-21 00:00:00
abstract：:The prefrontal cortex (PF) is involved in outcome-based flexible adaptation in a dynamically changing environment. The outcome signal dissipates gradually over time, but the temporal dynamics of this dissipation remains unknown. To examine this issue, we analyzed the outcome-related activity of PF neurons in 2 monkeys...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25622
更新日期：2016-05-10 00:00:00
abstract：:A detailed characterisation of the molecular determinants of membrane binding by α-synuclein (αS), a 140-residue protein whose aggregation is associated with Parkinson's disease, is of fundamental significance to clarify the manner in which the balance between functional and dysfunctional processes are regulated for t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27125
更新日期：2016-06-08 00:00:00
abstract：:Caterpillars have long been used as models for studying animal defence. Their impressive armour, including flamboyant warning colours, poisonous spines, irritating sprays, and mimicry of plant parts, snakes and bird droppings, has been extensively documented. But research has mainly focused on visual and chemical disp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31469
更新日期：2016-08-11 00:00:00
abstract：:Pulmonary Arterial Hypertension (PAH) is a rare and progressive disease with low incidence and prevalence, and elevated mortality. PAH is characterized by increased mean pulmonary artery pressure. The aim of this study was to analyse patients with combined mutations in BMPR2, ACVRL1, ENG and KCNA5 genes and to establi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33570
更新日期：2016-09-15 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-019-50846-1
更新日期：2019-10-18 00:00:00
abstract：:Animal coloration is a poorly-understood aspect of phenotypic variability. Here I expand initial studies of the colour gamut of birds by providing the first quantitative description of the colour variation of an entire avifauna: Australian landbirds (555 species). The colour of Australian birds occupies a small fracti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18514
更新日期：2015-12-18 00:00:00
abstract：:Coxsackievirus A24 variant (CVA24v) is a major causative agent of acute hemorrhagic conjunctivitis outbreaks worldwide, yet the evolutionary and transmission dynamics of the virus remain unclear. To address this, we analyzed and compared the 3C and partial VP1 gene regions of CVA24v isolates obtained from five outbrea...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70436-w
更新日期：2020-08-13 00:00:00
abstract：:Mechanotransduction is crucial for touch sensation, hearing, proprioception, and pain sensing. In C. elegans, male ray neurons have been implicated to be involved in the mechanosensation required for mating behavior. However, whether ray neurons directly sense mechanical stimulation is not yet known, and the underlyin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25542-1
更新日期：2018-05-08 00:00:00
abstract：:The aim of the present study was to evaluate the association between statin use and the risk of age-related macular degeneration (AMD). A systematic search of the PubMed, EMBASE and ISI web of science databases was used to identify eligible published literatures without language restrictions up to April 2015. Summary ...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/srep18280
更新日期：2015-12-14 00:00:00
abstract：:The ability to wirelessly power electrical devices is becoming of greater urgency as a component of energy conservation and sustainability efforts. Due to health and safety concerns, most wireless power transfer (WPT) schemes utilize very low frequency, quasi-static, magnetic fields; power transfer occurs via magneto-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03642
更新日期：2014-01-10 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-28343-8
更新日期：2018-07-03 00:00:00
abstract：:Terahertz (THz) technology has emerged recently as a potential novel imaging modality in biomedical fields, including ophthalmology. However, the ocular biological responses after THz electromagnetic exposure have not been investigated. We conducted a rabbit study to evaluate the safety profiles of THz scanning on eye...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-82103-9
更新日期：2021-01-28 00:00:00
abstract：:Cucumber is an agriculturally and economically important vegetable crop worldwide. Fruit flesh thickness is an important trait for cucumber and also a central determinant of yield, yet little is known about the underlying mechanism of this trait. In this study, bulked segregant analysis (BSA) combined with specific le...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15829
更新日期：2015-10-28 00:00:00
abstract：:The mechanism of droplet drying is a widely concerned fundamental issue since controlling the deposition morphology of droplet has significant influence on printing, biology pattern, self-assembling and other solution-based devices fabrication. Here we reveal a striking different kinetics-controlled deposition regime ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24628
更新日期：2016-04-19 00:00:00
abstract：:Nedd4-2 (NEDD4L in humans) is a ubiquitin protein ligase best known for its role in regulating ion channel internalization and turnover. Nedd4-2 deletion in mice causes perinatal lethality associated with increased epithelial sodium channel (ENaC) expression in lung and kidney. Abundant data suggest that Nedd4-2 plays...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32957
更新日期：2016-09-08 00:00:00
abstract：:A series of La1-xCexCoO3 perovskite nanoparticles with rhombohedral phases was synthesized via sol-gel chemical process. X-ray diffraction (XRD), Transmission Electron Microscopy (TEM), Electron Diffraction Spectroscopy (EDS), Thermogravimetric Analysis (TGA), UV-Vis spectroscopy, Fourier Transform Infrared spectra (F...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71869-z
更新日期：2020-09-14 00:00:00
abstract：:Perinatal depression involves interplay between individual chronic and acute disease burdens, biological and psychosocial environmental and behavioural factors. Here we explored the predictive potential of specific psycho-socio-demographic characteristics for antenatal and postpartum depression symptoms and contributi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30874-z
更新日期：2018-08-24 00:00:00
abstract：:In recent pioneer experiment, a strong spin-orbit coupling, with equal Rashba and Dresselhaus strengths, has been created in a trapped Bose-Einstein condensate. Moreover, many exotic superfluid phenomena induced by this strong spin-orbit coupling have been predicted. In this report, we show that this novel spin-orbit ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03166
更新日期：2013-11-07 00:00:00
abstract：:Altering mechanical compliance in load carriage structures has shown to reduce metabolic cost and accelerative forces of carrying weight. Currently, modifications to load carriage structures have been primarily targeted at vertical motion of the carried mass. No study to date has investigated altering load carriage co...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32175-x
更新日期：2018-09-13 00:00:00
abstract：:Enterovirus 71 (EV71) is the predominant causative pathogen of hand-foot-and-mouth disease (HFMD). Contrary to other HFMD-causing enterovirus, EV71 can lead to severe neurological complications, even death. MicroRNAs (miRNAs) are small non-coding RNAs that constitute the largest family of gene regulators participating...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16616-7
更新日期：2017-11-27 00:00:00
abstract：:Keratoconus (KC) is an ectatic corneal disease characterized by progressive thinning and irregular astigmatism, and a leading indication for corneal transplantation. KC-associated changes have been demonstrated for the entire cornea, but the pathological thinning and mechanical weakening is usually localized. We perfo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39182-6
更新日期：2019-02-27 00:00:00
abstract：:We characterised changes in reproductive hormones-LH, FSH, SHBG and AMH-by chronological age and time around the menopause (reproductive age) in mid-life women and explored their associations with lifestyle and reproductive factors. We used data from 1608 women from a UK cohort who had repeat hormone measures and expe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77871-9
更新日期：2020-12-04 00:00:00
abstract：:The renin-angiotensin system (RAS) plays a key role in the control of vasoconstriction as well as sodium and fluid retention mediated mainly by angiotensin (Ang) II acting at the AT1 receptor (AT1R). Ang-(1-7) is another RAS peptide, identified as the endogenous ligand of the Mas receptor and known to counterbalance m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12074-3
更新日期：2017-09-19 00:00:00
abstract：:The submarine volcano Axial Seamount has exhibited an inflation predictable eruption cycle, which allowed for the successful forecast of its 2015 eruption. However, the exact triggering mechanism of its eruptions remains ambiguous. The inflation predictable eruption pattern suggests a magma reservoir pressure threshol...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67043-0
更新日期：2020-06-23 00:00:00
