Abstract:
:Enterovirus 71 (EV71) is the predominant causative pathogen of hand-foot-and-mouth disease (HFMD). Contrary to other HFMD-causing enterovirus, EV71 can lead to severe neurological complications, even death. MicroRNAs (miRNAs) are small non-coding RNAs that constitute the largest family of gene regulators participating in numerous biological or pathological processes. We previously reported that miR-16-5p increases with severity of HFMD by investigating the expression patterns of host miRNAs in patients with HFMD. However, the mechanisms by which EV71 induces miR-16-5p expression are not clear, and the interaction between EV71 and miR-16-5p is not yet fully understood. Here, we confirmed EV71-induced expression of miR-16-5p both in vitro and in vivo and show that upregulation of miR-16-5p by EV71 infection may occur at the posttranscriptional level. Moreover, EV71-induced caspase activation facilitates the processing of pri-miR-16-1. We also revealed that miR-16-5p can promote EV71-induced nerve cells apoptosis through activating caspase-3. In addition, we found that miR-16-5p can inhibit EV71 replication. CCNE1 and CCND1, two important cell cycle regulators, play an important role in the suppression of EV71 replication by miR-16-5p. Therefore, miR-16-5p is a positive feedback regulator in EV71-induced apoptosis and a suppressor of virus replication. These results help in understanding the interaction network between miRNA and EV71 infection and provide a potential target for the development of antiviral therapy.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Zheng C,Zheng Z,Sun J,Zhang Y,Wei C,Ke X,Liu Y,Deng L,Wang Hdoi
10.1038/s41598-017-16616-7subject
Has Abstractpub_date
2017-11-27 00:00:00pages
16422issue
1issn
2045-2322pii
10.1038/s41598-017-16616-7journal_volume
7pub_type
杂志文章abstract::The 170 National Forests and Grasslands (NFs) in the conterminous United States are public lands that provide important ecosystem services such as clean water and timber supply to the American people. This study investigates the potential impacts of climate change on two key ecosystem functions (i.e., water yield and ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24441
更新日期:2016-04-21 00:00:00
abstract::Nonalcoholic fatty liver disease (NAFLD) is an important risk factor for the development of type 2 diabetes mellitus. Interferon gamma-induced protein 10 (IP-10), a proinflammatory chemokine, plays a crucial role in inflammatory diseases. This cross-sectional pilot study investigated whether circulating IP-10 is assoc...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1038/srep10096
更新日期:2015-05-11 00:00:00
abstract::We present an automated droplet microfluidic system (DMF) to generate monitored nanoliter aqueous droplets in oil and their deposition on a commercial stainless steel plate for MALDI-TOF analysis of peptides or protein digests. We demonstrate that DMF-MALDI combination focuses the analyte on the MALDI plate, increasin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-06660-8
更新日期:2017-07-28 00:00:00
abstract::Diabetic Retinopathy, the main cause of visual loss and blindness among working population, is a complication of Diabetes mellitus (DM), which has been described as a major public health challenge, so it is important to identify biomarkers to predict and to stratify patient´s possibility for developing DR. MicroRNAs (...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56172-w
更新日期:2019-12-23 00:00:00
abstract::Mitochondrial genomes exhibit diverse features among eukaryotes in the aspect of gene content, genome structure, and the mobile genetic elements such as introns and plasmids. Although the number of published mitochondrial genomes is increasing at tremendous speed, those of several lineages remain unexplored. Here, we ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41238-6
更新日期:2019-03-19 00:00:00
abstract::Ants are a dominant insect group in terrestrial ecosystems and many myrmecophilous species evolve to associate with ants to gain benefits. One iconic example is myrmecophilous butterflies that often produce ant-mimicking vibrational calls to modulate ant behaviors. Despite its popularity, empirical exploration of how ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54966-6
更新日期:2019-12-06 00:00:00
abstract::Daily life stress is an omnipresent phenomenon in modern society. Research has linked prolonged activation of the hypothalamic-pituitary-adrenal axis to psychiatric and somatic diseases. Everyday stressors substantially contribute to these health risks. Despite the notion that the physiological stress response is high...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33708-0
更新日期:2018-10-18 00:00:00
abstract::Statistical learning is a key mechanism for detecting regularities from a variety of sensory inputs. Precocial newborn domestic chicks provide an excellent model for (1) exploring unsupervised forms of statistical learning in a comparative perspective, and (2) elucidating the ecological function of statistical learnin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72090-8
更新日期:2020-09-15 00:00:00
abstract::Green fluorescent protein (GFP) is one of the most used reporter genes. We have used next-generation sequencing (NGS) to analyse the genetic diversity of a recombinant influenza A virus that expresses GFP and found a remarkable coverage dip in the GFP coding sequence. This coverage dip was present when virus-derived R...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26314
更新日期:2016-05-19 00:00:00
abstract::A novel and simple method to fabricate microchannels is reported based on an inkjet printing of a volatile solid mold. A liquid ink -1,6 hexanediol- ejected from a piezoelectric nozzle is instantaneously frozen when touching a cooled substrate. The created mold is then poured with PDMS. Once the PDMS is crosslinked, t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53729-7
更新日期:2019-11-25 00:00:00
abstract::Being one of the most common trees in forests, Pinus sylvestris L. is a frequently used raw material for wood products. Its specific odour is, however, mostly unresolved to date. Accordingly, we investigated Scots pine wood samples grown in Germany for their main odorant composition. We employed dedicated odorant anal...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26626-8
更新日期:2018-05-29 00:00:00
abstract::Kabuki Syndrome (KS) is a rare disorder characterized by distinctive facial features, short stature, skeletal abnormalities, and neurodevelopmental deficits. Previously, we showed that loss of function of RAP1A, a RAF1 regulator, can activate the RAS/MAPK pathway and cause KS, an observation recapitulated in other gen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28709-y
更新日期:2018-07-17 00:00:00
abstract::Web search tools are widely used by the general public to obtain health-related information, and analysis of search data is often suggested for public health monitoring. We analyzed popularity of searches related to smell loss and taste loss, recently listed as symptoms of COVID-19. Searches on sight loss and hearing ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-77316-3
更新日期:2020-11-25 00:00:00
abstract::Joint deterioration and associated chronic pain are common among people with haemophilia (PWH), having an impact on quality-of-life. Though non-pharmacological strategies are recommended, psychological interventions to promote pain control and quality-of-life have scarcely been tested in haemophilia. This randomised c...
journal_title:Scientific reports
pub_type: 杂志文章,随机对照试验
doi:10.1038/s41598-019-49827-1
更新日期:2019-09-16 00:00:00
abstract::Excessive activation of inflammation and the accompanying lung vascular endothelial barrier disruption are primary pathogenic features of acute lung injury (ALI). Microtubule-associated protein 4 (MAP4), a tubulin assembly-promoting protein, is important for maintaining the microtubule (MT) cytoskeleton and cell-cell ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08895
更新日期:2015-03-09 00:00:00
abstract::The aim of this systematic review was taken to investigate the efficacy and safety of docetaxel plus thalidomide vs. docetaxel alone for treating androgen-independent prostate cancer (AIPC). Data were collected from different databases independently by three researchers according to the pre-defined inclusion and exclu...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析,评审
doi:10.1038/srep04818
更新日期:2014-04-28 00:00:00
abstract::The white spot syndrome virus (WSSV) causes mass mortalities in the aquaculture of shrimps worldwide. The mud shrimp Austinogebia edulis (Ngoc-Ho & Chan, 1992) is an economically important sea food item occurring along the west coast of Taiwan. While the population of A. edulis began to decrease with some fluctuations...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54837-0
更新日期:2019-12-09 00:00:00
abstract::Lower respiratory infections, such as community-acquired pneumonia (CAP), and chronic obstructive pulmonary disease (COPD) rank among the most frequent causes of death worldwide. Improved diagnostics and profound pathophysiological insights are urgent clinical needs. In our cohort, we analysed transcriptional networks...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-57108-0
更新日期:2020-01-14 00:00:00
abstract::Intestinal injury and immune dysfunction are commonly encountered after irradiation therapy. While the curative abilities of ginseng root have been reported in prior studies, there is little known regarding its role in immunoregulation of intestinal repairability in cancer patients treated with irradiation. Our curren...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32188-6
更新日期:2018-09-17 00:00:00
abstract::Alternative splicing of cancer-related genes is a common cellular mechanism accounting for cancer cell transcriptome complexity and affecting cell cycle control, proliferation, apoptosis, angiogenesis, invasion, and metastasis. In this study, we describe the discovery and molecular cloning of thirty novel transcripts ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16269-6
更新日期:2017-12-11 00:00:00
abstract::In this report we have evaluated radiation effective dose received by patients during ECG-gated CCTA examinations based on gender, heart rate, tube voltage protocol and body mass index (BMI). A total of 1,824 patients were retrospectively recruited (1,139 men and 685 women) and they were divided into Group 1 (CCTA wit...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40758-5
更新日期:2019-03-13 00:00:00
abstract::Caspase-2 is known to be involved in oxidative-stress mediated neuronal cell death. In this study, we demonstrated that rotenone-induced neuronal cell death is mediated by caspase-2 activation via PIDDosome formation. Our newly designed TAT-fused peptides, which contains wild-type helix number3 (H3) from RAIDD and PID...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31198
更新日期:2016-08-09 00:00:00
abstract::Four plant tumorigenic strains 932, 1019, 1078T and 1081 isolated from cane gall tumors on thornless blackberry (Rubus sp.) were characterized. They shared low sequence identity with related Rhizobium spp. based on comparisons of 16S rRNA gene (≤98%) and housekeeping genes atpD, recA and rpoB (<90%). Phylogenetic anal...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27485-z
更新日期:2018-06-13 00:00:00
abstract::Bee-pollinated plants face a dilemma in that bees both passively transport pollen grains among conspecific flowers and actively collect pollen to feed their larvae. Therefore, mechanisms that reduce pollen collection by bees have evolved in melittophilous plants. Malvaceae pollen is uncollectable for corbiculate bees ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41262-6
更新日期:2019-03-18 00:00:00
abstract::Pesticides, including neonicotinoids, typically target pest insects by being neurotoxic. Inadvertent exposure to foraging insect pollinators is usually sub-lethal, but may affect cognition. One cognitive trait, spatial working memory, may be important in avoiding previously-visited flowers and other spatial tasks such...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep38957
更新日期:2016-12-13 00:00:00
abstract::Cassava is one of the most important root crops as a reliable source of food and carbohydrates. Carbohydrate metabolism and starch accumulation in cassava storage root is a cascade process that includes large amounts of proteins and cofactors. Here, comparative proteomics were conducted in cassava root at nine develop...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19643
更新日期:2016-01-21 00:00:00
abstract::This work demonstrates the first application of direct broadband (1 GHz-30 GHz) quality (Q) factor measurements of the uniform precession mode in magnetised garnet spheres for the accurate determination of the room-temperature intrinsic ferromagnetic linewidth (ΔH). The spheres were enclosed in a subwavelength cavity,...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45699-7
更新日期:2019-07-01 00:00:00
abstract::The association between maternal cadmium (Cd) exposure during pregnancy and the increased risk of fetal growth restriction (FGR) remains controversial. The present study evaluated the association between maternal serum Cd level and risk of small for gestational age (SGA) infants in a Chinese population. The present st...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1038/srep22631
更新日期:2016-03-03 00:00:00
abstract::Toll-like receptor 7 (TLR7) mediates autoantigen and viral RNA-induced cytokine production. Increased TLR7 expression in human atherosclerotic lesions suggests its involvement in atherogenesis. Here we demonstrated TLR7 expression in macrophages, smooth muscle cells (SMCs), and endothelial cells from mouse atheroscler...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00977-0
更新日期:2017-04-12 00:00:00
abstract::We investigate theoretically the effect of periodic magnetic barriers on the transport for a Weyl semimetal. We find that there are momentum and spin filtering tunneling behaviors, which is controlled by the numbers of the magnetic barriers. For the tunneling through periodic square-shaped magnetic barriers, the trans...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-47334-x
更新日期:2019-07-29 00:00:00