Toll-like receptor 7 deficiency protects apolipoprotein E-deficient mice from diet-induced atherosclerosis.

abstract：:Recently, CuZr-based bulk metallic glass (BMG) composites reinforced by the TRIP (transformation-induced plasticity) effect have been explored in attempt to accomplish an optimal of trade-off between strength and ductility. However, the design of such BMG composites with advanced mechanical properties still remains a ...

journal_title：Scientific reports

authors： Qin YS,Han XL,Song KK,Tian YH,Peng CX,Wang L,Sun BA,Wang G,Kaban I,Eckert J

更新日期：2017-02-13 00:00:00

abstract：:CRISPR-Cas9/gRNA exhibits therapeutic efficacy against latent human immunodeficiency virus (HIV) genome but the delivery of this therapeutic cargo to the brain remains as a challenge. In this research, for the first time, we demonstrated magnetically guided non-invasive delivery of a nano-formulation (NF), composed of...

journal_title：Scientific reports

authors： Kaushik A,Yndart A,Atluri V,Tiwari S,Tomitaka A,Gupta P,Jayant RD,Alvarez-Carbonell D,Khalili K,Nair M

更新日期：2019-03-08 00:00:00

abstract：:Link prediction in complex networks aims at predicting the missing links from available datasets which are always incomplete and subject to interfering noises. To obtain high prediction accuracy one should try to complete the missing information and at the same time eliminate the interfering noise from the datasets. G...

journal_title：Scientific reports

authors： Xu X,Liu B,Wu J,Jiao L

更新日期：2017-11-07 00:00:00

abstract：:Neurokinin B (NKB) is a hypothalamic neuropeptide binding preferentially to the neurokinin 3 receptor. Expression of the gene encoding NKB is elevated in postmenopausal women. Furthermore, rodent studies suggest that NKB signalling may mediate menopausal hot flushes. However, the effects of NKB administration on hot f...

journal_title：Scientific reports

authors： Jayasena CN,Comninos AN,Stefanopoulou E,Buckley A,Narayanaswamy S,Izzi-Engbeaya C,Abbara A,Ratnasabapathy R,Mogford J,Ng N,Sarang Z,Ghatei MA,Bloom SR,Hunter MS,Dhillo WS

更新日期：2015-02-16 00:00:00

abstract：:Genes with similar roles in the cell cluster on chromosomes, thus benefiting from coordinated regulation. This allows gene function to be inferred by transferring annotations from genomic neighbors, following the guilt-by-association principle. We performed a systematic search for co-occurrence of >1000 gene functions...

journal_title：Scientific reports

authors： Mihelčić M,Šmuc T,Supek F

更新日期：2019-12-20 00:00:00

abstract：:Membrane protein oligomerization mediates a wide range of biological events including signal transduction, viral infection and membrane curvature induction. However, the relative contributions of protein-protein and protein-membrane interactions to protein oligomerization remain poorly understood. Here, we used the Ca...

journal_title：Scientific reports

authors： Tao M,Isas JM,Langen R

更新日期：2020-03-24 00:00:00

abstract：:We established in vivo and in vitro models to investigate the role of αB-Crystallin (CryAB) and assess the ability of aspirin (ASA) to protect the myocardium during prolonged heat stress. Thirty-day-old chickens were divided into three groups (n = 90): heat stress (HS, 40±1 °C); ASA(-)HS(+), 1 mg/kg ASA orally 2 h bef...

journal_title：Scientific reports

authors： Tang S,Yin B,Song E,Chen H,Cheng Y,Zhang X,Bao E,Hartung J

更新日期：2016-11-18 00:00:00

abstract：:Eph receptors have emerged as targets for therapy in both neoplastic and non-neoplastic disease, however, particularly in non-neoplastic diseases, redundancy of function limits the effectiveness of targeting individual Eph proteins. We have shown previously that a soluble fusion protein, where the EphA4 ectodomain was...

journal_title：Scientific reports

authors： Pegg CL,Cooper LT,Zhao J,Gerometta M,Smith FM,Yeh M,Bartlett PF,Gorman JJ,Boyd AW

更新日期：2017-07-26 00:00:00

abstract：:The regular rise and fall of the sun resulted in the development of 24-h rhythms in virtually all organisms. In an evolutionary heartbeat, humans have taken control of their light environment with electric light. Humans are highly sensitive to light, yet most people now use light until bedtime. We evaluated the impact...

journal_title：Scientific reports

authors： Cain SW,McGlashan EM,Vidafar P,Mustafovska J,Curran SPN,Wang X,Mohamed A,Kalavally V,Phillips AJK

更新日期：2020-11-05 00:00:00

abstract：:WRINKLED1 (WRI1), an APETALA2 (AP2)-type transcription factor, has been shown to be required for the regulation of carbon partitioning into fatty acid (FA) synthesis in plant seeds. To our knowledge, the regulatory network of WRI1 remains unknown in Prunus sibirica kernel (PSK), a novel woody biodiesel feedstock in Ch...

journal_title：Scientific reports

authors： Deng S,Mai Y,Shui L,Niu J

更新日期：2019-02-25 00:00:00

abstract：:Ca2+ release-activated Ca2+ (CRAC) channels elevate cytoplasmic Ca2+ concentration, which is essential for T cell activation, differentiation and effector functions. T cell receptor stimulation induces depletion of the endoplasmic reticulum (ER) Ca2+ stores, which is sensed by stromal interaction molecule 1 (STIM1). S...

journal_title：Scientific reports

authors： Woo JS,Sun Z,Srikanth S,Gwack Y

更新日期：2020-09-02 00:00:00

abstract：:Poor oral health is not only associated with diabetes and cardiovascular disease but adverse pregnancy outcomes. However the influence of dental caries on pregnancy is unknown. The aim of this study was to evaluate the association between dental caries and adverse pregnancy outcomes and the effect of treatment for den...

journal_title：Scientific reports

authors： Cho GJ,Kim SY,Lee HC,Kim HY,Lee KM,Han SW,Oh MJ

更新日期：2020-03-24 00:00:00

abstract：:The villous cytotrophoblastic cells have the ability to fuse and differentiate, forming the syncytiotrophoblast (STB). The syncytialisation process is essential for placentation. Nevertheless, the mechanisms involved in cell fusion and differentiation are yet to be fully elucidated. It has been suggested that cell sur...

journal_title：Scientific reports

authors： Bastida-Ruiz D,Wuillemin C,Pederencino A,Yaron M,Martinez de Tejada B,Pizzo SV,Cohen M

更新日期：2020-06-15 00:00:00

abstract：:Soils are an important source of nitrogen in many of the world's cropping systems. Especially in low-input production systems, nitrogen release from soil organic matter turn-over is the major part of the crop's nitrogen supply and research suggests that this process is significantly affected by changes in climate. The...

journal_title：Scientific reports

authors： Nendel C,Melzer D,Thorburn PJ

更新日期：2019-04-10 00:00:00

abstract：:Emerging evidence indicates the existence of a new class of cancer genes that act as "signal linkers" coordinating oncogenic signals between mutated and differentially expressed genes. While frequently mutated oncogenes and differentially expressed genes, which we term Class I cancer genes, are readily detected by mos...

journal_title：Scientific reports

authors： Ghanat Bari M,Ung CY,Zhang C,Zhu S,Li H

更新日期：2017-08-01 00:00:00

abstract：:One century of oceanographic measurements has evidenced gradual increases in temperature and salinity of western Mediterranean water masses, even though the vertical stratification has basically remained unchanged. Starting in 2005, the basic structure of the intermediate and deep layers abruptly changed. We report he...

journal_title：Scientific reports

authors： Schroeder K,Chiggiato J,Bryden HL,Borghini M,Ben Ismail S

更新日期：2016-03-11 00:00:00

abstract：:An accurate knowledge of tissue optical properties (absorption coefficients, μa, and reduced scattering coefficients, μs') is critical for precise modeling of light propagation in biological tissue, essential for developing diagnostic and therapeutic optical techniques that utilize diffusive photons. A great number of...

journal_title：Scientific reports

authors： Hoshi Y,Tanikawa Y,Okada E,Kawaguchi H,Nemoto M,Shimizu K,Kodama T,Watanabe M

更新日期：2019-06-24 00:00:00

abstract：:This work presents the measurement of the permittivities of water and methanol in the D-band. Water is a reference medium for dielectric measurement. The dielectric permittivity of water in the millimeter wave range is a fundamental parameter in many applications, and needs to be investigated systematically. The measu...

journal_title：Scientific reports

authors： Liu X,Yu J

更新日期：2019-12-06 00:00:00

abstract：:Stabilization exercise (SE) is evident for the management of chronic non-specific low back pain (LBP). The optimal dose-response-relationship for the utmost treatment success is, thus, still unknown. The purpose is to systematically review the dose-response-relationship of stabilisation exercises on pain and disabilit...

journal_title：Scientific reports

authors： Mueller J,Niederer D

更新日期：2020-10-09 00:00:00

abstract：:The microtubule cytoskeleton is composed of α-tubulin and β-tubulin heterodimers, and it serves to regulate the shape, motility, and division of a cell. Post-translational modifications including acetylation are closely associated with the functional aspects of the microtubule, involving in a number of pathological di...

journal_title：Scientific reports

authors： Han SJ,Kim JH,Kim JI,Park KM

更新日期：2016-06-08 00:00:00

abstract：:Dopamine is an important neurotransmitter that plays a key role in a wide range of both locomotive and cognitive functions in humans. Disturbances on the dopaminergic system cause, among others, psychosis, Parkinson's disease and Huntington's disease. Antipsychotics are drugs that interact primarily with the dopamine ...

journal_title：Scientific reports

authors： Goode-Romero G,Winnberg U,Domínguez L,Ibarra IA,Vargas R,Winnberg E,Martínez A

更新日期：2020-12-09 00:00:00

abstract：:Electrochemical capacitors (EC) have received tremendous interest due to their high potential to satisfy the urgent demand in many advanced applications. The development of new electrode materials is considered to be the most promising approach to enhance the EC performance substantially. Herein, we present a high-cap...

journal_title：Scientific reports

authors： Zhou J,Li N,Gao F,Zhao Y,Hou L,Xu Z

更新日期：2014-08-15 00:00:00

abstract：:The ability to shape the index profile of optical fibers holds the key to fully flexible engineering of their optical properties and future applications. We present a new approach for the development of a graded index fused silica fiber based on core nanostructurization. A graded index core is obtained by means of dis...

journal_title：Scientific reports

authors： Anuszkiewicz A,Kasztelanic R,Filipkowski A,Stepniewski G,Stefaniuk T,Siwicki B,Pysz D,Klimczak M,Buczynski R

更新日期：2018-08-17 00:00:00

abstract：:Nitric oxide (NO) produced by endothelial cells in response to cytokines displays anti-inflammatory activity by preventing the adherence, migration and activation of neutrophils. The molecular mechanism by which NO operates at the blood-endothelium interface to exert anti-inflammatory properties is largely unknown. He...

journal_title：Scientific reports

authors： Lai TS,Lindberg RA,Zhou HL,Haroon ZA,Dewhirst MW,Hausladen A,Juang YL,Stamler JS,Greenberg CS

更新日期：2017-11-23 00:00:00

abstract：:Exposure to stress during early life affects subsequent behaviors and increases the vulnerability to adult pathologies, a phenomenon that has been well documented in humans and rodents. In this study, we introduce a chronic unpredictable stress protocol adapted to young zebrafish, which is an increasingly popular vert...

journal_title：Scientific reports

authors： Golla A,Østby H,Kermen F

更新日期：2020-06-25 00:00:00

abstract：:Oil repellent surface have lots of practical applications in many fields. Current oil repellent coating may suffer from limited liquid repellency to oils or environmental risks. In this work, we report an eco-friendly 'green' processes for preparing oil-repellent surface using a renewable and environmentally benign bi...

journal_title：Scientific reports

authors： Xu LP,Han D,Wu X,Zhang Q,Zhang X,Wang S

更新日期：2016-11-29 00:00:00

abstract：:Understanding magma fragmentation mechanisms in explosive eruptions is a key requirement for volcanic hazard assessment, eruption management and risk mitigation. This paper focuses on a type case small explosivity eruption (July-August 2015 eruption of Piton de la Fournaise). These eruptions, despite being often overl...

journal_title：Scientific reports

authors： Edwards MJ,Pioli L,Harris AJL,Gurioli L,Thivet S

更新日期：2020-08-18 00:00:00

abstract：:According to the Source Monitoring Framework, the origin of a memory is remembered through the retrieval of specific features (e.g. perceptive, sensitive, affective signals). In two source discrimination tasks, we studied the ability of cuttlefish to remember the modality in which an item had been presented several ho...

journal_title：Scientific reports

authors： Billard P,Clayton NS,Jozet-Alves C

更新日期：2020-03-25 00:00:00

abstract：:Amyloid-β (Aβ) deposition is known to starts decades before the onset of clinical symptoms of Alzheimer's disease (AD), however, the detailed pathophysiological processes underlying this preclinical period are not well understood. This study aimed to investigate functional network alterations in cognitively intact eld...

journal_title：Scientific reports

authors： Nakamura A,Cuesta P,Kato T,Arahata Y,Iwata K,Yamagishi M,Kuratsubo I,Kato K,Bundo M,Diers K,Fernández A,Maestú F,Ito K

更新日期：2017-07-26 00:00:00

abstract：:The mechanisms underlying bladder contractile disorders such as overactive bladder are not fully understood, and there is limited understanding of the receptor systems modulating spontaneous bladder contractions. We investigated the potential for histamine to have a role in mediating contractility of the urothelium wi...

journal_title：Scientific reports

authors： Stromberga Z,Chess-Williams R,Moro C

更新日期：2019-03-07 00:00:00