DMF-MALDI: droplet based microfluidic combined to MALDI-TOF for focused peptide detection.

abstract：:Numerous neurological dysfunctions are characterized by undesirable nerve activity. By providing reversible nerve blockage, electric stimulation with an implanted electrode holds promise in the treatment of these conditions. However, there are several limitations to its application, including poor bio-compatibility an...

journal_title：Scientific reports

authors： Skach J,Conway C,Barrett L,Ye H

更新日期：2020-10-22 00:00:00

abstract：:Previous experimental studies discovered universal growth of chains and nanowires of various chemical elements on a corrugated molecular network of Cu3N on the Cu(110). Herein, performing combined ab initio and quantum Hamiltonian studies we demonstrate that such chains can be used for a fast spin switching and entang...

journal_title：Scientific reports

authors： Sivkov IN,Bazhanov DI,Stepanyuk VS

更新日期：2017-06-05 00:00:00

abstract：:The semantic variant of primary progressive aphasia (svPPA) is a clinical syndrome characterized by neurodegeneration and progressive loss of semantic knowledge. Unlike many other forms of frontotemporal lobar degeneration (FTLD), svPPA has a highly consistent underlying pathology composed of TDP-43 (a regulator of RN...

journal_title：Scientific reports

authors： Bonham LW,Steele NZR,Karch CM,Broce I,Geier EG,Wen NL,Momeni P,Hardy J,Miller ZA,Gorno-Tempini ML,Hess CP,Lewis P,Miller BL,Seeley WW,Manzoni C,Desikan RS,Baranzini SE,Ferrari R,Yokoyama JS,International FTD-Genomic

更新日期：2019-07-26 00:00:00

abstract：:17α-ethynilestradiol (EE2) and tamoxifen (Tmx) are pollutants world-wide distributed in aquatic environments. Gilthead seabream, Sparus aurata L., is highlighted as a species model of intensively culture in anthropogenic disturbed environments. The effects of these pollutants on gilthead seabream reproduction and some...

journal_title：Scientific reports

authors： Valero Y,López-Cánovas AE,Rodenas MC,Cabas I,García-Hernández P,Arizcun M,García-Ayala A,Chaves-Pozo E

更新日期：2020-05-14 00:00:00

abstract：:Coral reefs around the world are undergoing severe decline in the past few decades. Mass coral mortalities have predominantly been reported to be caused by coral bleaching or disease outbreaks. Temporary hypoxic conditions caused by algal blooms can trigger mass coral mortalities though are reported rarely. In this st...

journal_title：Scientific reports

authors： Raj KD,Mathews G,Obura DO,Laju RL,Bharath MS,Kumar PD,Arasamuthu A,Kumar TKA,Edward JKP

更新日期：2020-12-17 00:00:00

abstract：:This prospective, single-blind, randomized study was designed to evaluate the effect of genotype-based warfarin dosing compared with standard warfarin dosing in Korean patients with mechanical cardiac valves. Patients were assigned to either the genotype-based dosing group or the standard dosing group using stratified...

journal_title：Scientific reports

authors： Lee KE,Yee J,Lee GY,Chung JE,Seong JM,Chang BC,Gwak HS

更新日期：2020-04-24 00:00:00

abstract：:Spin thermoelectrics represents a new paradigm of thermoelectricity that has a potential to overcome the fundamental limitation posed by the Wiedmann-Franz law on the efficiency of conventional thermoelectric devices. A typical spin thermoelectric device consists of a bilayer of a magnetic insulator and a high spin-or...

journal_title：Scientific reports

authors： Tian K,Tiwari A

更新日期：2019-02-28 00:00:00

abstract：:Vegetation buffers local diurnal land surface temperatures, however, this effect has found limited applications for remote vegetation characterization. In this work, we parameterize diurnal temperature variations as the thermal decay rate derived by using satellite daytime and nighttime land surface temperatures and m...

journal_title：Scientific reports

authors： Kumar SS,Prihodko L,Lind BM,Anchang J,Ji W,Ross CW,Kahiu MN,Velpuri NM,Hanan NP

更新日期：2020-06-17 00:00:00

abstract：:Drug metabolites usually have structures of split-ring resonators (SRRs), which might lead to negative permittivity and permeability in electromagnetic field. As a result, in the UV-vis region, the latent fingermarks images of drug addicts and non drug users are inverse. The optical properties of latent fingermarks ar...

journal_title：Scientific reports

authors： Shen Y,Ai Q

更新日期：2016-02-03 00:00:00

abstract：:The characterization of fully-defined in vitro hepatic culture systems requires testing of functional and morphological variables to obtain the optimal trophic support, particularly for cell therapeutics including bioartificial liver systems (BALs). Using serum-free fully-defined culture medium formulations, we measur...

journal_title：Scientific reports

authors： Nelson LJ,Treskes P,Howie AF,Walker SW,Hayes PC,Plevris JN

更新日期：2013-01-01 00:00:00

abstract：:The striatum plays important motor, associative and cognitive roles in brain functions. However, the rodent dorsolateral (the primate putamen) and dorsomedial (the primate caudate nucleus) striatum are not anatomically separated, making it difficult to distinguish their functions. By contrast, anatomical separation ex...

journal_title：Scientific reports

authors： Takaji M,Takemoto A,Yokoyama C,Watakabe A,Mizukami H,Ozawa K,Onoe H,Nakamura K,Yamamori T

更新日期：2016-11-02 00:00:00

abstract：:Increased p66Shc expression has been associated with diabetic nephropathy (DN). However, whether p66Shc can serve as a potential biomarker for tubular oxidative injury in DN is unknown. We measured the expression of p66Shc in peripheral blood monocytes (PBMs) and renal biopsy tissues from DN patients and then analysed...

journal_title：Scientific reports

authors： Xu X,Zhu X,Ma M,Han Y,Hu C,Yuan S,Yang Y,Xiao L,Liu F,Kanwar YS,Sun L

更新日期：2016-07-05 00:00:00

abstract：:Pyoverdine (PVDI) has been reported to act both as a siderophore for scavenging iron (a key nutrient) and a signaling molecule for the expression of virulence factors. This compound is itself part of a core set of virulence factors produced by Pseudomonas aeruginosa during infections. Once secreted into the bacterial ...

journal_title：Scientific reports

authors： Bonneau A,Roche B,Schalk IJ

更新日期：2020-01-10 00:00:00

abstract：:We combine matter-wave interferometry and cavity optomechanics to propose a coherent matter-light interface based on mechanical motion at the quantum level. We demonstrate a mechanism that is able to transfer non-classical features imprinted on the state of a matter-wave system to an optomechanical device, transducing...

journal_title：Scientific reports

authors： Xuereb A,Ulbricht H,Paternostro M

更新日期：2013-11-29 00:00:00

abstract：:Spinal Muscular Atrophy (SMA) is a monogenic neurodegenerative disorder and the leading genetic cause of infantile mortality. While several functions have been ascribed to the SMN (survival motor neuron) protein, their specific contribution to the disease has yet to be fully elucidated. We hypothesized that some, but ...

journal_title：Scientific reports

authors： Osman EY,Bolding MR,Villalón E,Kaifer KA,Lorson ZC,Tisdale S,Hao Y,Conant GC,Pires JC,Pellizzoni L,Lorson CL

更新日期：2019-07-01 00:00:00

abstract：:The prognostic value of current multigene assays for breast cancer is limited to hormone receptor-positive, human epidermal growth factor receptor 2-negative early breast cancer. Despite the prognostic significance of immune response-related genes in breast cancer, immune gene signatures have not been incorporated int...

journal_title：Scientific reports

authors： Lee H,Kwon MJ,Koo BM,Park HG,Han J,Shin YK

更新日期：2021-01-08 00:00:00

abstract：:Marigold (Tagetes erecta L.) is an important ornamental plant with a wide variety of flower colors. Despite its economic value, few biochemical and molecular studies have explored the generation of flower color in this species. To study the mechanism underlying marigold petal color, we performed a metabolite analysis ...

journal_title：Scientific reports

authors： Zhang H,Zhang S,Zhang H,Chen X,Liang F,Qin H,Zhang Y,Cong R,Xin H,Zhang Z

更新日期：2020-10-08 00:00:00

abstract：:Some styrene/maleic acid (SMA) copolymers solubilise membrane lipids and proteins to form polymer-bounded nanodiscs termed SMA/lipid particles (SMALPs). Although SMALPs preserve a lipid-bilayer core, they appear to be more dynamic than other membrane mimics. We used time-resolved Förster resonance energy transfer and ...

journal_title：Scientific reports

authors： Cuevas Arenas R,Danielczak B,Martel A,Porcar L,Breyton C,Ebel C,Keller S

更新日期：2017-04-05 00:00:00

abstract：:Spontaneous or treatment induced seroconversion in chronic HBV infection is rare and generation of anti-HBs antibodies is the current goal of HBV therapeutics. Here we investigated B and follicular T helper (Tfh) cell defects that persist in HBV infection despite long-term nucleos(t)ide analog (NUC) treatment and poss...

journal_title：Scientific reports

authors： Poonia B,Ayithan N,Nandi M,Masur H,Kottilil S

更新日期：2018-10-17 00:00:00

abstract：:Metal-organic frameworks (MOFs) are intriguing host materials in composite electrolytes due to their ability for tailoring host-guest interactions by chemical tuning of the MOF backbone. Here, we introduce particularly high sodium ion conductivity into the zeolitic imidazolate framework ZIF-8 by impregnation with the ...

journal_title：Scientific reports

authors： Nozari V,Calahoo C,Tuffnell JM,Adelhelm P,Wondraczek K,Dutton SE,Bennett TD,Wondraczek L

更新日期：2020-02-26 00:00:00

abstract：:This work explores simulations of polarized discussions from a general and theoretical premise. Specifically the question of whether a plausible avenue exists for a subgroup in an online social network to find a disagreement beneficial and what that benefit could be. A methodological framework is proposed which repres...

journal_title：Scientific reports

authors： Garibay I,Mantzaris AV,Rajabi A,Taylor CE

更新日期：2019-12-09 00:00:00

abstract：:The critical importance of human milk to infants and even human civilization has been well established. Yet our understanding of the milk microbiome has been limited to cataloguing OTUs and computation of community diversity. To the best of our knowledge, there has been no report on the bacterial interactions within t...

journal_title：Scientific reports

authors： Sam Ma Z,Guan Q,Ye C,Zhang C,Foster JA,Forney LJ

更新日期：2015-02-05 00:00:00

abstract：:Dendritic Cells (DCs) recognize infectious non-self molecules and engage the adaptive immune system thereby initiating long lasting, antigen-specific responses. As such, the ability to activate DCs is considered a key tool to enhance the efficacy and quality of vaccination. Here we report a novel immunomodulatory sulf...

journal_title：Scientific reports

authors： Manzo E,Cutignano A,Pagano D,Gallo C,Barra G,Nuzzo G,Sansone C,Ianora A,Urbanek K,Fenoglio D,Ferrera F,Bernardi C,Parodi A,Pasquale G,Leonardi A,Filaci G,De Palma R,Fontana A

更新日期：2017-07-24 00:00:00

abstract：:Information spreading in complex networks is often modeled as diffusing information with certain probability from nodes that possess it to their neighbors that do not. Information cascades are triggered when the activation of a set of initial nodes - seeds - results in diffusion to large number of nodes. Here, several...

journal_title：Scientific reports

authors： Jankowski J,Bródka P,Kazienko P,Szymanski BK,Michalski R,Kajdanowicz T

更新日期：2017-04-18 00:00:00

abstract：:Sensory development of the human brain begins prenatally, allowing cortical auditory responses to be recorded at an early age in preterm infants. Despite several studies focusing on the temporal characteristics of preterm infants' cortical responses, few have been conducted on frequency analysis of these responses. In...

journal_title：Scientific reports

authors： Daneshvarfard F,Abrishami Moghaddam H,Dehaene-Lambertz G,Kongolo G,Wallois F,Mahmoudzadeh M

更新日期：2019-07-23 00:00:00

abstract：:Uterus transplantation (UTx) is a potential option for women with uterine factor infertility to have a child. The clinical features indicating irreversible rejection of the uterus are unknown. In our experimental series of allogeneic UTx in cynomolgus macaques, six female macaques were retrospectively examined, which ...

journal_title：Scientific reports

authors： Kisu I,Emoto K,Masugi Y,Yamada Y,Matsubara K,Obara H,Matoba Y,Banno K,Kato Y,Saiki Y,Itagaki I,Kawamoto I,Iwatani C,Murase M,Nakagawa T,Tsuchiya H,Ishigaki H,Urano H,Ema M,Ogasawara K,Aoki D,Nakagawa K,Shiina

更新日期：2020-08-17 00:00:00

abstract：:The genetic sexing of animals having long gestation periods offers significant benefits in regard to breeding management among their populations living in captivity. In our study, a new increased-sensitivity PCR method for fetal sexing was developed and tested successfully on elephants, from only a small volume of mat...

journal_title：Scientific reports

authors： Vincze B,Gáspárdy A,Biácsi A,Papp EÁ,Garamvölgyi L,Sós E,Cseh S,Kovács G,Pádár Z,Zenke P

更新日期：2019-10-24 00:00:00

abstract：:Radiotherapy (RT) is one of the most frequently used methods for cancer treatment. Despite remarkable advancements in RT techniquesthe treatment of radioresistant tumours (i.e. high-grade gliomas) is not yet satisfactory. Finding novel approaches less damaging for normal tissues is of utmost importance. This would mak...

journal_title：Scientific reports

authors： Lamirault C,Doyère V,Juchaux M,Pouzoulet F,Labiod D,Dendale R,Patriarca A,Nauraye C,Le Dudal M,Jouvion G,Hardy D,Massioui NE,Prezado Y

更新日期：2020-08-11 00:00:00

abstract：:The rise of antibiotic resistance (AMR) is one of the most important public health threats worldwide.Today, increasing attention is being paid to multidrug resistant staphylococci isolated from healthcare and non-healthcare environments as the treatment of these bacteria has become increasingly difficult. In this stud...

journal_title：Scientific reports

authors： Cave R,Misra R,Chen J,Wang S,Mkrtchyan HV

更新日期：2019-08-01 00:00:00

abstract：:Mucositis is the limiting toxicity of radio(chemo)therapy of head and neck cancer. Diagnostics, prophylaxis and correction of this condition demand new accurate and objective approaches. Here we report on an in vivo longitudinal monitoring of the oral mucosa dynamics in 25 patients during the course of radiotherapy of...

journal_title：Scientific reports

authors： Maslennikova AV,Sirotkina MA,Moiseev AA,Finagina ES,Ksenofontov SY,Gelikonov GV,Matveev LA,Kiseleva EB,Zaitsev VY,Zagaynova EV,Feldchtein FI,Gladkova ND,Vitkin A

更新日期：2017-11-28 00:00:00