Profiling the impact of medium formulation on morphology and functionality of primary hepatocytes in vitro.

abstract：:A fast Endospore Germinability Assay (EGA) was validated with traditional plate counts to enumerate single endospore germination events for monitoring surface sterilization. The assay is based on a time-gated luminescence microscopy technique enabling visualization and enumeration of individual germinating endospores....

journal_title：Scientific reports

authors： Yung PT,Lester E,Ponce A

更新日期：2020-01-16 00:00:00

abstract：:Phylogenetic clustering approaches can elucidate HIV transmission dynamics. Comparisons across countries are essential for evaluating public health policies. Here, we used a standardised approach to compare the UK HIV Drug Resistance Database and the Swiss HIV Cohort Study while maintaining data-protection requirement...

journal_title：Scientific reports

authors： Ragonnet-Cronin ML,Shilaih M,Günthard HF,Hodcroft EB,Böni J,Fearnhill E,Dunn D,Yerly S,Klimkait T,Aubert V,Yang WL,Brown AE,Lycett SJ,Kouyos R,Brown AJ

更新日期：2016-09-19 00:00:00

abstract：:Heparan sulfate (HS) is a polysaccharide known to modulate many important biological processes, including Wnt signaling. However, the biochemical interaction between HS and Wnt molecules is not well characterized largely due to the lack of suitable methods. To determine the Wnt binding domain in HS, we used a Wnt sign...

journal_title：Scientific reports

authors： Gao W,Xu Y,Liu J,Ho M

更新日期：2016-05-17 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Zheng CM,Wang JY,Chen TT,Wu YC,Wu YL,Lin HT,Chiu SP,Chang TJ,Zheng JQ,Chu NF,Lin YM,Su SL,Lu KC,Chen JS,Sung FC,Lee CT,Yang Y,Hwang SJ,Wang MC,Hsu YH,Chiou HY,Kao S,Wu MY,Lin YF

更新日期：2020-04-15 00:00:00

abstract：:Barley (Hordeum vulgare L.) produces five leucine-derived hydroxynitrile glucosides, potentially involved in alleviating pathogen and environmental stresses. These compounds include the cyanogenic glucoside epiheterodendrin. The biosynthetic genes are clustered. Total hydroxynitrile glucoside contents were previously ...

journal_title：Scientific reports

authors： Ehlert M,Jagd LM,Braumann I,Dockter C,Crocoll C,Motawia MS,Møller BL,Lyngkjær MF

更新日期：2019-04-05 00:00:00

abstract：:Telomere DNA ends with a single-stranded 3' overhang. Long 3' overhangs may cause aberrant DNA damage responses and accelerate telomere attrition, which is associated with cancer and aging, respectively. Genetic studies have indicated several important players in preventing 5' end hyper-resection, yet detailed knowled...

journal_title：Scientific reports

authors： Runnberg R,Narayanan S,Cohn M

更新日期：2017-08-18 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Culbert NJ,Balestrino F,Dor A,Herranz GS,Yamada H,Wallner T,Bouyer J

更新日期：2019-06-05 00:00:00

abstract：:Exploiting pattern formation - such as that observed in nature - in the context of micro/nanotechnology could have great benefits if coupled with the traditional top-down lithographic approach. Here, we demonstrate an original and simple method to produce unique, localized and controllable self-organised patterns on e...

journal_title：Scientific reports

authors： Seghir R,Arscott S

更新日期：2015-10-06 00:00:00

abstract：:Immersive virtual reality has become increasingly popular to improve the assessment and treatment of health problems. This rising popularity is likely to be facilitated by the availability of affordable headsets that deliver high quality immersive experiences. As many health problems are more prevalent in older adults...

journal_title：Scientific reports

authors： Huygelier H,Schraepen B,van Ee R,Vanden Abeele V,Gillebert CR

更新日期：2019-03-14 00:00:00

abstract：:Among vector-borne diseases malaria is the leading cause of morbidity in the world, with more than 200 million cases per year and a large number of deaths. The techniques traditionally used for the detection of Plasmodium in humans and Anopheles mosquitoes include microscopy, IRMA, ELISA, antibody or molecular assays,...

journal_title：Scientific reports

authors： Murillo E,Muskus C,Agudelo LA,Vélez ID,Ruiz-Lopez F

更新日期：2019-02-08 00:00:00

abstract：:Implantable cardioverter-defibrillators (ICD) are meant to fight life-threatening ventricular arrhythmias and reduce overall mortality. Ironically, life-saving shocks themselves have been shown to be independently associated with an increased mortality. We sought to identify myocardial changes at the protein level imm...

journal_title：Scientific reports

authors： Bodin A,Labas V,Bisson A,Teixeira-Gomes AP,Blasco H,Tomas D,Combes-Soia L,Marcelo P,Miquelestorena-Standley E,Baron C,Angoulvant D,Babuty D,Clementy N

更新日期：2020-11-20 00:00:00

abstract：:Salts containing radical cations of 1,2,4,5-tetrakis(isopropylthio)benzene (TPB) and 1,2,4,5-tetrakis(ethylthio) benzene (TEB) have been successfully synthesized with . These newly synthesized salts have been characterized by UV-Vis absorption, EPR spectroscopy, conductivity measurement, single crystal X-ray diffracti...

journal_title：Scientific reports

authors： Chen X,Gao F,Yang W

更新日期：2016-07-11 00:00:00

abstract：:The large and complex genome of Pseudomonas aeruginosa, which consists of significant portions (up to 20%) of transferable genetic elements contributes to the rapid development of antibiotic resistance. The whole genome sequences of 22 strains isolated from eye and cystic fibrosis patients in Australia and India betwe...

journal_title：Scientific reports

authors： Subedi D,Vijay AK,Kohli GS,Rice SA,Willcox M

更新日期：2018-10-23 00:00:00

abstract：:The aberrant expression of human sodium iodide symporter (NIS) in breast cancer (BC) has raised the possibility of using targeted radioiodide therapy. Here we investigate modulation of endogenous, functional NIS expression by histone deacetylase inhibitors (HDACi) in vitro and in vivo. Luciferase reporter based initia...

journal_title：Scientific reports

authors： Kelkar MG,Senthilkumar K,Jadhav S,Gupta S,Ahn BC,De A

更新日期：2016-01-18 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Gibson KM,Jair K,Castel AD,Bendall ML,Wilbourn B,Jordan JA,Crandall KA,Pérez-Losada M,DC Cohort Executive Committee.

更新日期：2020-04-22 00:00:00

abstract：:This study analyzed hourly mass concentration observations of PM2.5 (particulate matters with diameter less than 2.5 μm) at 512 stations in China from December 2013 to May 2015. We found that the mean concentrations of PM2.5 during the winter and spring of 2015 Dec. 2014 to Feb. 2015 and Mar. 2015 to May 2015) decreas...

journal_title：Scientific reports

authors： Wang X,Wang K,Su L

更新日期：2016-11-02 00:00:00

abstract：:Fatty acid oxidation and subsequent ketogenesis is one of the major mechanisms to maintain hepatic lipid homeostasis under fasting conditions. Fasting hormone glucagon has been shown to stimulate ketone body production through activation of PPARα; however, the signal pathway linking glucagon to PPARα is largely undisc...

journal_title：Scientific reports

authors： Zhang ZN,Gong L,Lv S,Li J,Tai X,Cao W,Peng B,Qu S,Li W,Zhang C,Luan B

更新日期：2016-03-17 00:00:00

abstract：:Rheumatoid arthritis (RA) patients have been observed to be at a lower risk of developing Alzheimer's Disease (AD). Clinical trials have showed no relationship between nonsteroidal anti-inflammatory drug (NSAID) use and AD. The aim of this study was to establish if there is a causal link between RA and AD. A systemati...

journal_title：Scientific reports

authors： Policicchio S,Ahmad AN,Powell JF,Proitsi P

更新日期：2017-10-09 00:00:00

abstract：:Our understanding of the structure and regulation of Plasmodium vivax genes is limited by our inability to grow the parasites in long-term in vitro cultures. Most P. vivax studies must therefore rely on patient samples, which typically display a low proportion of parasites and asynchronous parasites. Here, we present ...

journal_title：Scientific reports

authors： Kim A,Popovici J,Vantaux A,Samreth R,Bin S,Kim S,Roesch C,Liang L,Davies H,Felgner P,Herrera S,Arévalo-Herrera M,Ménard D,Serre D

更新日期：2017-08-10 00:00:00

abstract：:Cystic fibrosis (CF) patients experience heightened levels of anxiety and depression. Stress from dealing with chronic disease and rigorous treatment regimens certainly are primary contributors to these outcomes. We previously have demonstrated that microtubule alterations in CF are linked to a number of CF phenotypes...

journal_title：Scientific reports

authors： Corey DA,Rymut SM,Kelley TJ

更新日期：2020-10-01 00:00:00

abstract：:LiYF4:Eu nanophosphors with a single tetragonal phase are synthesized, and various strategies to enhance the Eu(3+) emission from the nanophosphors are investigated. The optimized Eu(3+) concentration is 35 mol%, and the red emission peaks due to the (5)D0 →(7)FJ (J = 1 and 2) transitions of Eu(3+) ions are further en...

journal_title：Scientific reports

authors： Kim SY,Won YH,Jang HS

更新日期：2015-01-19 00:00:00

abstract：:The effect of AM fungi spatial distribution on individual plant development may determine the dynamics of the whole plant community. We investigated whether clonal plants display, like for other resources, a foraging or a specialization response, to adapt to the distribution of AM fungi. Two separate experiments were ...

journal_title：Scientific reports

authors： Vannier N,Bittebiere AK,Vandenkoornhuyse P,Mony C

更新日期：2016-11-25 00:00:00

abstract：:In social interactions, including cooperation and conflict, individuals can adjust their behaviour over the shorter term through learning within a generation, and natural selection can change behaviour over the longer term of many generations. Here we investigate the evolution of cognitive bias by individuals investin...

journal_title：Scientific reports

authors： Leimar O,McNamara JM

更新日期：2019-11-08 00:00:00

abstract：:Abscisic acid (ABA) is an ancient stress hormone and is detectable in a wide variety of organisms where it regulates innate immunity and inflammation. Previously, we showed that oral supplementation with ABA decreased parasitemia in a mouse model of malaria, decreased liver and spleen pathology and reduced parasite tr...

journal_title：Scientific reports

authors： Glennon EKK,Megawati D,Torrevillas BK,Ssewanyana I,Huang L,Aweeka F,Greenhouse B,Adams LG,Luckhart S

更新日期：2018-06-11 00:00:00

abstract：:Current reports on the changes in peripheral blood regulatory T cell (Tregs) to CD4+ T cell ratio in systemic sclerosis (SSc) patients are varied in their conclusions. We therefore performed a meta-analysis to identify the actual change in the proportion of peripheral Tregs in SSc. Three databases, namely EMBASE, ISI ...

journal_title：Scientific reports

authors： Deng C,Li W,Chen S,Li Y

更新日期：2017-03-02 00:00:00

abstract：:Members of the Eph family of receptor tyrosine kinases have been implicated in a wide array of human cancers. The EphB4 receptor is ubiquitously expressed in head and neck squamous cell carcinoma (HNSCC) and has been shown to impart tumorigenic and invasive characteristics to these cancers. In this study, we investiga...

journal_title：Scientific reports

authors： Bhatia S,Hirsch K,Sharma J,Oweida A,Griego A,Keysar S,Jimeno A,Raben D,Krasnoperov V,Gill PS,Pasquale EB,Wang XJ,Karam SD

更新日期：2016-12-12 00:00:00

abstract：:Inconsistent findings have reported on the inflammatory potential of diet and cardiovascular disease (CVD) and mortality risk. The aim of this meta-analysis was to investigate the association between the inflammatory potential of diet as estimated by the dietary inflammatory index (DII) score and CVD or mortality risk...

journal_title：Scientific reports

authors： Zhong X,Guo L,Zhang L,Li Y,He R,Cheng G

更新日期：2017-07-25 00:00:00

abstract：:In comparison to genome-wide association studies (GWAS), there has been poor replication of gene expression studies in chronic obstructive pulmonary disease (COPD). We performed microarray gene expression profiling on a large sample of resected lung tissues from subjects with severe COPD. Comparing 111 COPD cases and ...

journal_title：Scientific reports

authors： Morrow JD,Zhou X,Lao T,Jiang Z,DeMeo DL,Cho MH,Qiu W,Cloonan S,Pinto-Plata V,Celli B,Marchetti N,Criner GJ,Bueno R,Washko GR,Glass K,Quackenbush J,Choi AM,Silverman EK,Hersh CP

更新日期：2017-03-13 00:00:00

abstract：:Ancestor microbes started colonizing inland habitats approximately 2.7 to 3.5 billion years ago. With some exceptions, the key physiological adaptations of microbiomes associated with marine-to-land transitions have remained elusive. This is essentially caused by the lack of suitable systems that depict changes in mic...

journal_title：Scientific reports

authors： Dini-Andreote F,van Elsas JD,Olff H,Salles JF

更新日期：2018-06-21 00:00:00

abstract：:Tumor progression, limited efficacy of current standard treatments, and the rise in patient mortality are associated with gene expression caused by the synergistic action of intratumoral hypoxia and HIF-1α activation. For this reason, recent investigations have focused on HIF-targeting therapeutic agents, with encoura...

journal_title：Scientific reports

authors： Mangraviti A,Raghavan T,Volpin F,Skuli N,Gullotti D,Zhou J,Asnaghi L,Sankey E,Liu A,Wang Y,Lee DH,Gorelick N,Serra R,Peters M,Schriefer D,Delaspre F,Rodriguez FJ,Eberhart CG,Brem H,Olivi A,Tyler B

更新日期：2017-11-02 00:00:00