Nedd4-2 haploinsufficiency causes hyperactivity and increased sensitivity to inflammatory stimuli.

abstract：:The analysis of the choroid in the eye is crucial for our understanding of a range of ocular diseases and physiological processes. Optical coherence tomography (OCT) imaging provides the ability to capture highly detailed cross-sectional images of the choroid yet only a very limited number of commercial OCT instrument...

journal_title：Scientific reports

authors： Kugelman J,Alonso-Caneiro D,Read SA,Hamwood J,Vincent SJ,Chen FK,Collins MJ

更新日期：2019-09-16 00:00:00

abstract：:GABAergic and glutamatergic dysfunction in the dorsolateral prefrontal cortex (DLPFC) are thought to be the core pathophysiological mechanisms of schizophrenia. Recently, we have established a method to index these functions from the DLPFC using the paired transcranial magnetic stimulation (TMS) paradigms of short int...

journal_title：Scientific reports

authors： Noda Y,Barr MS,Zomorrodi R,Cash RFH,Farzan F,Rajji TK,Chen R,Daskalakis ZJ,Blumberger DM

更新日期：2017-12-06 00:00:00

abstract：:Mixed strain infections of Mycobacterium tuberculosis make diagnosis, treatment, and control of tuberculosis (TB) more difficult. This study was aimed to evaluate the relationship between mixed infections, antibiotic resistance patterns and treatment of TB patients. In this study, among 2850 suspected TB clinical samp...

journal_title：Scientific reports

authors： Kargarpour Kamakoli M,Sadegh HR,Farmanfarmaei G,Masoumi M,Fateh A,Javadi G,Rahimi Jamnani F,Vaziri F,Siadat SD

更新日期：2017-01-25 00:00:00

abstract：:Vitiligo is an acquired depigmentation disorder largely caused by defective melanocyte- or autoimmunity-induced melanocyte destruction. The aryl hydrocarbon receptor (AHR) is essential for melanocyte homeostasis and immune process, and abnormal AHR was observed in vitiligo. We previously identified the T allele of AHR...

journal_title：Scientific reports

authors： Wang X,Li K,Liu L,Shi Q,Song P,Jian Z,Guo S,Wang G,Li C,Gao T

更新日期：2015-09-15 00:00:00

abstract：:Clinical success of effective gene therapy is mainly hampered by the insufficiency of safe and efficient internalization of a transgene to the targeted cellular site. Therefore, the development of a safe and efficient nanocarrier system is one of the fundamental challenges to transfer the therapeutic genes to the dise...

journal_title：Scientific reports

authors： Tariq I,Ali MY,Sohail MF,Amin MU,Ali S,Bukhari NI,Raza A,Pinnapireddy SR,Schäfer J,Bakowsky U

更新日期：2020-12-08 00:00:00

abstract：:The present study reports the use of one-dimensional carbon wrapped VO2(M) nanofiber (VO2(M)/C) as a cost-effective counter electrode for dye-sensitized solar cells (DSSCs); where M denotes monoclinic crystal system. Uniform short length nanofiber was synthesised by a sol-gel based simple and versatile electrospinning...

journal_title：Scientific reports

authors： Gnanasekar S,Kollu P,Jeong SK,Grace AN

更新日期：2019-03-26 00:00:00

abstract：:Here we investigated whether endothelial colony forming cells (ECFC) and mesenchymal progenitor cells (MPC) form vascular networks and restore blood flow in ischemic skeletal muscle, and whether host myeloid cells play a role. ECFC + MPC, ECFC alone, MPC alone, or vehicle alone were injected into the hind limb ischemi...

journal_title：Scientific reports

authors： Kang KT,Lin RZ,Kuppermann D,Melero-Martin JM,Bischoff J

更新日期：2017-04-10 00:00:00

abstract：:In order to understand the physical properties of materials it is necessary to determine the 3D positions of all atoms. There has been significant progress towards this goal using electron tomography. However, this method requires a relatively high electron dose and often extended acquisition times which precludes the...

journal_title：Scientific reports

authors： Chen LG,Warner J,Kirkland AI,Chen FR,Van Dyck D

更新日期：2017-09-07 00:00:00

abstract：:Pancreatic cancer (PC), as the leading cause of cancer death worldwide, is one of the deadliest tumors with a very low 5-year survival rate. Therefore, it is urgent to seek new biomarkers of PC for more accurate and reliable treatments. To identify the differentially expressed miRNAs (DEM) in PC tissues, we performed ...

journal_title：Scientific reports

authors： Wang HL,Zhou R,Liu J,Chang Y,Liu S,Wang XB,Huang MF,Zhao Q

更新日期：2017-09-13 00:00:00

abstract：:Glioblastoma multiforme (GBM) is a highly invasive and chemoradioresistant brain malignancy. Temozolomide (TMZ), a DNA-alkylating agent, is effective against GBM and has become the standard first-line drug. However, the mechanism by which TMZ regulates the progression of GBM remains elusive. Here, we demonstrate that ...

journal_title：Scientific reports

authors： Yamaki T,Suenaga Y,Iuchi T,Alagu J,Takatori A,Itami M,Araki A,Ohira M,Inoue M,Kageyama H,Yokoi S,Saeki N,Nakagawara A

更新日期：2013-01-01 00:00:00

abstract：:The aim of this study is to determine the prevalence and incidence of ankylosing spondylitis (AS) in South Korea, 2010-2015. This study was conducted using the Health Insurance Review Agency (HIRA) database, which includes information on every patient diagnosed with AS. The incidence and prevalence of AS were evaluate...

journal_title：Scientific reports

authors： Park JS,Hong JY,Park YS,Han K,Suh SW

更新日期：2018-05-16 00:00:00

abstract：:Traffic-related air pollution is known to be associated with skin aging manifestations. We previously found that the use of fossil fuels was associated with skin aging, but no direct link between indoor air pollutants and skin aging manifestations has ever been shown. Here we directly measured the indoor PM2.5 exposur...

journal_title：Scientific reports

authors： Ding A,Yang Y,Zhao Z,Hüls A,Vierkötter A,Yuan Z,Cai J,Zhang J,Gao W,Li J,Zhang M,Matsui M,Krutmann J,Kan H,Schikowski T,Jin L,Wang S

更新日期：2017-11-10 00:00:00

abstract：:Interference of two combined white light beams produces Newton colors if one of the beams is retarded relative to the other by from 400 nm to 2000 nm. In this case the corresponding interfering spectral components are added as two scalars at the beam combination. If the retardance is below 400 nm the two-beam interfer...

journal_title：Scientific reports

authors： Shribak M

更新日期：2015-11-27 00:00:00

abstract：:The growing interest in engineered tumor models prompted us to devise a method for the non-invasive assessment of such models. Here, we report on bioluminescence imaging (BLI) for the assessment of engineered tumor models in the fertilized chicken egg, i.e, chick chorioallantoic membrane (CAM) assay. One prostate canc...

journal_title：Scientific reports

authors： Jefferies B,Lenze F,Sathe A,Truong N,Anton M,von Eisenhart-Rothe R,Nawroth R,Mayer-Kuckuk P

更新日期：2017-07-10 00:00:00

abstract：:We have recently reported that repeated systemic treatments of extract from Corydalis yanhusuo alleviate neuropathic pain and levo-tetrahydropalmatine (l-THP) is one of active components from Corydalis. We designed this study to investigate antinociceptive effect of l-THP in acute and chronic pain models and related m...

journal_title：Scientific reports

authors： Kang DW,Moon JY,Choi JG,Kang SY,Ryu Y,Park JB,Lee JH,Kim HW

更新日期：2016-12-02 00:00:00

abstract：:Advances in lab-on-a-chip (LOC) devices have led to significant improvements in the on-chip manipulation, separation, sorting, and isolation of particles and cells. Among various LOC-based approaches such as inertia-based methods, acoustophoresis, and magnetophoresis, the planar-slanted-electrode dielectrophoresis (DE...

journal_title：Scientific reports

authors： Dalili A,Taatizadeh E,Tahmooressi H,Tasnim N,Rellstab-Sánchez PI,Shaunessy M,Najjaran H,Hoorfar M

更新日期：2020-07-16 00:00:00

abstract：:Renal fibrosis is one of the important pathways involved in end-stage renal failure. Investigating the metabolic changes in the progression of disease may enhance the understanding of its pathogenesis and therapeutic information. In this study, (1)H-nuclear magnetic resonance (NMR)-based metabonomics was firstly used ...

journal_title：Scientific reports

authors： Zhao L,Dong M,Liao S,Du Y,Zhou Q,Zheng H,Chen M,Ji J,Gao H

更新日期：2016-06-03 00:00:00

abstract：:Accurate and detailed knowledge of California's groundwater is of paramount importance for statewide water resources planning and management, and to sustain a multi-billion-dollar agriculture industry during prolonged droughts. In this study, we use water supply and demand information from California's Department of W...

journal_title：Scientific reports

authors： Massoud EC,Purdy AJ,Miro ME,Famiglietti JS

更新日期：2018-08-27 00:00:00

abstract：:Behavioral alterations emerging after central or peripheral vision loss suggest that cerebral reorganization occurs for both the afferented and deafferented early visual cortex (EVC). We explored the functional reorganization of the central and peripheral EVC following visual field defects specifically affecting centr...

journal_title：Scientific reports

authors： Sabbah N,Sanda N,Authié CN,Mohand-Saïd S,Sahel JA,Habas C,Amedi A,Safran AB

更新日期：2017-02-24 00:00:00

abstract：:Crystalline atomic layers on solid surfaces are composed of a single building block, unit cell, that is copied and stacked together to form the entire two-dimensional crystal structure. However, it appears that this is not an unique possibility. We report here on synthesis and characterization of the one-atomic-layer-...

journal_title：Scientific reports

authors： Gruznev DV,Bondarenko LV,Matetskiy AV,Mihalyuk AN,Tupchaya AY,Utas OA,Eremeev SV,Hsing CR,Chou JP,Wei CM,Zotov AV,Saranin AA

更新日期：2016-01-19 00:00:00

abstract：:The manifestation of cognitive and physical impairment in stroke patients before the acute event suggests accumulating subclinical vascular pathology in the brain. We investigated whether impairments in cognitive and physical functioning were associated with an increased stroke risk. Between 2002 and 2008, 8,519 strok...

journal_title：Scientific reports

authors： Heshmatollah A,Mutlu U,Koudstaal PJ,Ikram MA,Ikram MK

更新日期：2020-04-14 00:00:00

abstract：:Nano/microfibrous structure can induce high cellular activities because of the topological similarity of the extracellular matrix, and thus, are widely used in various tissue regenerative materials. However, the fabrication of a bioceramic (high weight percent)-based 3D microfibrous structure is extremely difficult be...

journal_title：Scientific reports

authors： Kim M,Yun HS,Kim GH

更新日期：2017-06-09 00:00:00

abstract：:ABX464 is a first-in-class, clinical-stage, small molecule for oral administration that has shown strong anti-inflammatory effects in the DSS-model for inflammatory bowel disease (IBD) and also prevents replication of the HIV virus. ABX464 which binds to cap binding complex (CBC) has demonstrated safety and efficacy i...

journal_title：Scientific reports

authors： Vautrin A,Manchon L,Garcel A,Campos N,Lapasset L,Laaref AM,Bruno R,Gislard M,Dubois E,Scherrer D,Ehrlich JH,Tazi J

更新日期：2019-01-28 00:00:00

abstract：:Pituitary adenylate cyclase activating polypeptide (PACAP) is a regulatory and cytoprotective neuropeptide, its deficiency implies accelerated aging in mice. It is present in the auditory system having antiapoptotic effects. Expression of Ca2+-binding proteins and its PAC1 receptor differs in the inner ear of PACAP-de...

journal_title：Scientific reports

authors： Fulop DB,Humli V,Szepesy J,Ott V,Reglodi D,Gaszner B,Nemeth A,Szirmai A,Tamas L,Hashimoto H,Zelles T,Tamas A

更新日期：2019-10-10 00:00:00

abstract：:Efficient presentation of alien antigens triggers activation of T lymphocytes and robust host defense against invading pathogens. This pathophysiological process relies on the expression of major histocompatibility complex (MHC) molecules in antigen presenting cells such as macrophages. Aberrant MHC II transactivation...

journal_title：Scientific reports

authors： Fan Z,Li J,Li P,Ye Q,Xu H,Wu X,Xu Y

更新日期：2017-01-17 00:00:00

abstract：:The subtle mechanisms by which protein-DNA interactions remain functional across a wide range of temperatures are largely unknown. In this work, we manually curated available information relating fully sequenced archaeal genomes with organism growth temperatures. We built a motif that represents the core promoter of e...

journal_title：Scientific reports

authors： Aptekmann AA,Nadra AD

更新日期：2018-01-22 00:00:00

abstract：:The analysis of cell type-specific activity patterns during behaviors is important for better understanding of how neural circuits generate cognition, but has not been well explored from in vivo neurophysiological datasets. Here, we describe a computational approach to uncover distinct cell subpopulations from in vivo...

journal_title：Scientific reports

authors： Li M,Zhao F,Lee J,Wang D,Kuang H,Tsien JZ

更新日期：2015-07-27 00:00:00

abstract：:Grapevine is an important and extensively grown fruit crop, which is severely hampered by drought worldwide. So, comprehending the impact of drought on grapevine genetic resources is necessary. In the present study, RNA-sequencing was executed using cDNA libraries constructed from both drought-stress and control plant...

journal_title：Scientific reports

authors： Haider MS,Zhang C,Kurjogi MM,Pervaiz T,Zheng T,Zhang C,Lide C,Shangguan L,Fang J

更新日期：2017-10-13 00:00:00

abstract：:Multi-wavelength lasers have widespread applications (e.g. fiber telecommunications, pump-probe measurements, terahertz generation). Here, we report a nanotube-mode-locked all-fiber ultrafast oscillator emitting three wavelengths at the central wavelengths of about 1540, 1550, and 1560 nm, which are tunable by stretch...

journal_title：Scientific reports

authors： Liu X,Han D,Sun Z,Zeng C,Lu H,Mao D,Cui Y,Wang F

更新日期：2013-01-01 00:00:00

abstract：:Small ruminants, including sheep and goats are natural hosts of scrapie, and the progression of scrapie pathogenesis is strongly influenced by polymorphisms in the prion protein gene (PRNP). Although Korean native goats have been consumed as meat and health food, the evaluation of the susceptibility to scrapie in thes...

journal_title：Scientific reports

authors： Kim SK,Kim YC,Won SY,Jeong BH

更新日期：2019-10-25 00:00:00