Abstract：
:Mechanotransduction is crucial for touch sensation, hearing, proprioception, and pain sensing. In C. elegans, male ray neurons have been implicated to be involved in the mechanosensation required for mating behavior. However, whether ray neurons directly sense mechanical stimulation is not yet known, and the underlying molecular mechanisms have not been identified. Using in vivo calcium imaging, we recorded the touch-induced calcium responses in male ray neurons. Our data demonstrated that ray neurons are sensitive to mechanical stimulation in a neurotransmitter-independent manner. PKD-2, a putative sensor component for both mechanosensation and chemosensation in male-specific neurons, was not required for the touch-induced calcium responses in RnB neurons, whereas the TRPV channel OSM-9 shaped the kinetics of the responses. We further showed that RnB-neuron mechanosensation is likely mediated by an amiloride-sensitive DEG/ENaC channel. These observations lay a foundation for better understanding the molecular mechanisms of mechanosensation.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Zhang H,Yue X,Cheng H,Zhang X,Cai Y,Zou W,Huang G,Cheng L,Ye F,Kang Ldoi
10.1038/s41598-018-25542-1subject
Has Abstractpub_date
2018-05-08 00:00:00pages
7192issue
1issn
2045-2322pii
10.1038/s41598-018-25542-1journal_volume
8pub_type
杂志文章abstract：:In honeybees fast and efficient exploitation of nectar and pollen sources is achieved by persistent endothermy throughout the foraging cycle, which means extremely high energy costs. The need for food promotes maximisation of the intake rate, and the high costs call for energetic optimisation. Experiments on how honey...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28339
更新日期：2016-06-20 00:00:00
abstract：:Low-dimensional behavior of large systems of globally coupled oscillators has been intensively investigated since the introduction of the Ott-Antonsen ansatz. In this report, we generalize the Ott-Antonsen ansatz to second-order Kuramoto models in complex networks. With an additional inertia term, we find a low-dimens...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04783
更新日期：2014-05-02 00:00:00
abstract：:With Motor imagery (MI), movements are mentally rehearsed without overt actions; this procedure has been adopted in motor rehabilitation, primarily in brain-damaged patients. Here we rather tested the clinical potentials of MI in purely orthopaedic patients who, by definition, should maximally benefit of mental exerci...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65820-5
更新日期：2020-06-02 00:00:00
abstract：:Huntington's disease (HD) is a genetically-determined neurodegenerative disease. Characterising neuropathology in mouse models of HD is commonly restricted to cross-sectional ex vivo analyses, beset by tissue fixation issues. In vivo longitudinal magnetic resonance imaging (MRI) allows for disease progression to be pr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32423
更新日期：2016-09-01 00:00:00
abstract：:We report evidence of the transition from n- to p-type conduction of InN with increasing Mg dopant concentration by using photoconductivity (PC) measurement at room temperature. This transition is depicted as a conversion from negative to positive PC under above-bandgap optical excitation. The n- to p-type transition ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04371
更新日期：2014-03-13 00:00:00
abstract：:The sex-determining gene SRY induces SOX9 expression in the testes of eutherian mammals via two pathways. SRY binds to testis-specific enhancer of Sox9 (TESCO) with SF1 to activate SOX9 transcription. SRY also up-regulates ER71 expression, and ER71 activates Sox9 transcription. After the initiation of testis different...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32874
更新日期：2016-09-09 00:00:00
abstract：:TP53 mutation (i.e., loss of normal-p53) may evoke epithelial-mesenchymal transition (EMT), which was previously attributed to loss of certain miRNAs. However, not all epithelial cells undergo EMT upon TP53 mutation, and the p53-miRNA axis may not fully explain p53 function in epithelial integrity. We here show two mo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20043-7
更新日期：2018-01-25 00:00:00
abstract：:There is a huge request for the development of low dielectric constant polymeric materials for microelectronic applications. In thisstudy, polymer blends based on PVA:POZ with low dielectric constant has been fabricated. The results of XRD indicate that crystalline domain is enhanced at higher POZ concentration. Brill...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49715-8
更新日期：2019-09-11 00:00:00
abstract：:Synthetic fungicides are pesticides widely used in agriculture to control phytopathogenic fungi. The systemicity, persistency and intense application of some of these fungicides, such as boscalid, leads to long periods of exposure for honeybees via contaminated water, pollen and nectar. We exposed adult honeybees in t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-24746-9
更新日期：2018-05-08 00:00:00
abstract：:Low hydrophilicity of graphene is one of the major obstacles for biomaterials application. To create some hydrophilic groups on graphene is addressed this issue. Herein, COOH+ ion implantation modified graphene (COOH+/graphene) and COOH functionalized graphene were designed by physical ion implantation and chemical me...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37112
更新日期：2016-11-15 00:00:00
abstract：:A method for defect characterization is presented that allows to measure the activation energy, capture cross-section, and defect density in dielectric materials. This is exemplarily performed on aluminum oxide thin films deposited on hydrogen-terminated diamond. During the measurement, samples were illuminated using ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69240-3
更新日期：2020-07-27 00:00:00
abstract：:Spin switching of organometallic complexes by ferromagnetic surfaces is an important topic in the area of molecular nanospintronics. Moreover, graphene has been shown as a 2D surface for physisorption of molecular magnets and strain engineering on graphene can tune the spin state of an iron porphyrin (FeP) molecule fr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03405
更新日期：2013-12-03 00:00:00
abstract：:The extended Hückel (eH) tight-binding method has historically been prized for its computational ease and intuitive chemical clarity. However, its lack of quantitative predictiveness has prevented the eH method from being used as a tool for rapidly screening materials for desired electronic properties. In this work, w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28864-2
更新日期：2018-07-12 00:00:00
abstract：:Fungal laccases (EC 1.10.3.2) are multi-copper oxidases that oxidize a wide variety of substrates. Despite extensive studies, the molecular basis for their diverse activity is unclear. Notably, there is no current way to rationally predict the activity of a laccase toward a given substrate. Such knowledge would greatl...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35633-8
更新日期：2018-11-23 00:00:00
abstract：:The brain-derived neurotrophic factor (BDNF) protein is essential for neuronal development. Val66Met (rs6265) is a functional polymorphism at codon 66 of the BDNF gene that affects neuroplasticity and has been associated with cognition, brain structure and function. The aim of this study was to clarify the relationshi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74780-9
更新日期：2020-10-21 00:00:00
abstract：:Second-harmonic generation (SHG) is the most specific label-free indicator of collagen accumulation in widespread pathologies such as fibrosis, and SHG-based measurements hold important potential for biomedical analyses. However, efficient collagen SHG scoring in histological slides is hampered by the limited depth-of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29863
更新日期：2016-07-20 00:00:00
abstract：:The three-dimensional construction of arrays of functional molecules on an electrode surface, such as organic semiconductors and redox-active molecules, is a considerable challenge in the fabrication of sophisticated junctions for molecular devices. In particular, well-defined organic layers with precise molecular gra...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11122
更新日期：2015-06-09 00:00:00
abstract：:Cancer hallmarks are evolutionary traits required by a tumour to develop. While extensively characterised, the way these traits are achieved through the accumulation of somatic mutations in key biological pathways is not fully understood. To shed light on this subject, we characterised the landscape of pathway alterat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25076-6
更新日期：2018-04-30 00:00:00
abstract：:3,4-Methylenedioxymethamphetamine (MDMA), a common recreational drug, is known to cause serotonergic neurotoxicity in the brain. Dextromethorphan (DM) is a widely used antitussive reported to exert anti-inflammatory effect in vivo. In this study, we examined the long-term effect of MDMA on the primate serotonergic sys...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38695
更新日期：2016-12-12 00:00:00
abstract：:There have been no large nationwide birth cohort studies examining for the effects of maternal alcohol use during pregnancy on placental abnormality. This study searched for associations between alcohol consumption and the placental abnormalities of placenta previa, placental abruption, and placenta accreta using the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46760-1
更新日期：2019-07-16 00:00:00
abstract：:Emergence of polyphagous herbivorous insects entails significant adaptation to recognize, detoxify and digest a variety of host-plants. Despite of its biological and practical importance - since insects eat 20% of crops - no exhaustive analysis of gene repertoires required for adaptations in generalist insect herbivor...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10461-4
更新日期：2017-09-25 00:00:00
abstract：:In order to elucidate features of the denatured state ensembles that exist in equilibrium with the native state under physiological conditions, we performed 1.4-μs molecular dynamics (MD) simulations at 400 K and 450 K using the monomer subunits of three CutA1 mutants from Escherichia coli: an SH-free mutant (Ec0SH) w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25825-7
更新日期：2018-05-16 00:00:00
abstract：:To compare the soil water balance, yield and water use efficiency (WUE) of spring maize under different mulching types in the Loess Plateau, a 7-year field experiment was conducted in the Changwu region of the Loess Plateau. Three treatments were used in this experiment: straw mulch (SM), plastic film mulch (PM) and c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38995
更新日期：2016-12-15 00:00:00
abstract：:In this study, the effects of different feeding frequencies on the growth and the expression of genes in the GH/IGF axis were assessed in juvenile Chinese sturgeon. The newly hatched Chinese sturgeons were bred for 38 days at three different feeding frequencies groups (feeding frequency of two times a day, TWD; three ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74120-x
更新日期：2020-10-15 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-63873-0
更新日期：2020-04-17 00:00:00
abstract：:We tested the hypothesis that epigenetic mechanisms in the brain and the immune system are associated with chronic pain. Genome-wide DNA methylation assessed in 9 months post nerve-injury (SNI) and Sham rats, in the prefrontal cortex (PFC) as well as in T cells revealed a vast difference in the DNA methylation landsca...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19615
更新日期：2016-01-28 00:00:00
abstract：:Cold agglutinin disease (CAD) is a rare form of autoimmune haemolytic anaemia, and because of its rareness, there is no standard treatment for CAD patients. We retrospectively analysed the response to rituximab-containing therapy in CAD patients at our hospital. All patients received rituximab-containing therapy for a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69465-2
更新日期：2020-07-29 00:00:00
abstract：:Faces presented upside-down are harder to recognize than presented right-side up, an effect known as the face inversion effect. With inversion the perceptual processing of the spatial relationship among facial parts is disrupted. Previous literature indicates a face inversion effect in chimpanzees toward familiar and ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02504
更新日期：2013-01-01 00:00:00
abstract：:High-quality broadband ultrasound transducers yield superior imaging performance in biomedical ultrasonography. However, proper design to perfectly bridge the energy between the active piezoelectric material and the target medium over the operating spectrum is still lacking. Here, we demonstrate a new anisotropic cone...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42863
更新日期：2017-02-17 00:00:00
abstract：:The work describes the development of a flexible, hydrogel embedded pH-sensor that can be integrated in inexpensive wearable and non-invasive devices at epidermal level for electrochemical quantification of H+ ions in sweat. Such a device can be useful for swift, real time diagnosis and for monitoring specific conditi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45399-2
更新日期：2019-06-20 00:00:00
