Abstract：
:Genome-scale metabolic network models can be used for various analyses including the prediction of metabolic responses to changes in the environment. Legumes are well known for their rhizobial symbiosis that introduces nitrogen into the global nutrient cycle. Here, we describe a fully compartmentalised, mass and charge-balanced, genome-scale model of the clover Medicago truncatula, which has been adopted as a model organism for legumes. We employed flux balance analysis to demonstrate that the network is capable of producing biomass components in experimentally observed proportions, during day and night. By connecting the plant model to a model of its rhizobial symbiont, Sinorhizobium meliloti, we were able to investigate the effects of the symbiosis on metabolic fluxes and plant growth and could demonstrate how oxygen availability influences metabolic exchanges between plant and symbiont, thus elucidating potential benefits of inter organism amino acid cycling. We thus provide a modelling framework, in which the interlinked metabolism of plants and nodules can be studied from a theoretical perspective.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Pfau T,Christian N,Masakapalli SK,Sweetlove LJ,Poolman MG,Ebenhöh Odoi
10.1038/s41598-018-30884-xsubject
Has Abstractpub_date
2018-08-21 00:00:00pages
12504issue
1issn
2045-2322pii
10.1038/s41598-018-30884-xjournal_volume
8pub_type
杂志文章abstract：:The epithelial-mesenchymal plasticity, in tight association with stemness, contributes to the mammary gland homeostasis, evolution of early neoplastic lesions and cancer dissemination. Focused on cell surfaceome, we used mouse models of pre-neoplastic mammary epithelial and cancer stem cells to reveal the connection b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67827-4
更新日期：2020-07-09 00:00:00
abstract：:The bioactive lipid sphingosine 1-phosphate (S1P) is a degradation product of sphingolipids that are particularly abundant in neurons. We have shown previously that neuronal S1P accumulation is toxic leading to ER-stress and an increase in intracellular calcium. To clarify the neuronal function of S1P, we generated br...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37064
更新日期：2016-11-24 00:00:00
abstract：:Understanding how a pathogen can grow on different substrates and how this growth impacts its dispersal are critical to understanding the risks and control of emerging infectious diseases. Pseudogymnoascus destructans (Pd) causes white-nose syndrome (WNS) in many bat species and can persist in, and transmit from, the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80707-1
更新日期：2021-01-12 00:00:00
abstract：:Atherosclerosis arises from leukocyte infiltration and thickening of the artery walls and constitutes a major component of vascular disease pathology, but the molecular events underpinning this process are not fully understood. Proteins containing an Asn-Gly-Arg (NGR) motif readily undergo deamidation of asparagine to...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06202-2
更新日期：2017-07-18 00:00:00
abstract：:The aim of this study is to develop an internal-external correlation model for internal motion estimation for lung cancer radiotherapy. Deformation vector fields that characterize the internal-external motion are obtained by respectively registering the internal organ meshes and external surface meshes from the 4DCT i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22023-3
更新日期：2018-02-27 00:00:00
abstract：:The temperature dependence of the resistivity (ρ) of Ag-doped Bi2Se3 (AgxBi2-xSe3) shows insulating behavior above 35 K, but below 35 K, ρ suddenly decreases with decreasing temperature, in contrast to the metallic behavior for non-doped Bi2Se3 at 1.5-300 K. This significant change in transport properties from metalli...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41906-7
更新日期：2019-03-29 00:00:00
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journal_title：Scientific reports
pub_type： 临床试验,杂志文章
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更新日期：2019-10-02 00:00:00
abstract：:Recently, a computer-generated moiré profilometry was proposed by our research group. It can effectively avoid the influence of the transient caused by moiré fringes' direct acquisition and generally owns a higher accuracy. But when the spatial spectrum of the captured deformed pattern is severely aliased caused by th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44186-3
更新日期：2019-05-24 00:00:00
abstract：:Carcinoembryonic antigen (CEA) is the only blood based protein biomarker at present, used for preoperative screening of advanced colorectal cancer (CRC) patients to determine the appropriate curative treatments and post-surveillance screening for tumour recurrence. Current diagnostics for CRC detection have several li...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80354-6
更新日期：2021-01-12 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13143
更新日期：2015-08-13 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
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更新日期：2020-11-18 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02076
更新日期：2013-01-01 00:00:00
abstract：:Antimicrobial peptides (AMPs) exhibit broad-spectrum antimicrobial activity, and have promise as new therapeutic agents. While the adult North American bullfrog (Rana [Lithobates] catesbeiana) is a prolific source of high-potency AMPs, the aquatic tadpole represents a relatively untapped source for new AMP discovery. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-38442-1
更新日期：2019-02-06 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02251-9
更新日期：2017-05-17 00:00:00
abstract：:Animal morphology and behavior often appear to evolve cooperatively. However, it is difficult to assess how strictly these two traits depend on each other. The genitalia morphologies and courtship behaviors in insects, which vary widely, may be a good model for addressing this issue. In Diptera, phylogenetic analyses ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36301-7
更新日期：2019-01-18 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27602-y
更新日期：2018-07-06 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02744-7
更新日期：2017-06-19 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27038
更新日期：2016-06-01 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21395
更新日期：2016-02-26 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
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pub_type： 已发布勘误
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更新日期：2018-07-23 00:00:00
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pub_type： 杂志文章
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更新日期：2015-08-03 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2014-12-19 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2018-11-02 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52832-z
更新日期：2019-11-11 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30856
更新日期：2016-08-05 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17305-1
更新日期：2017-12-04 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71419-7
更新日期：2020-09-03 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55570-4
更新日期：2019-12-13 00:00:00
abstract：:Employing theranostic nanoparticles, which combine both therapeutic and diagnostic capabilities in one dose, has promise to propel the biomedical field toward personalized medicine. Here we investigate the theranostic properties of topological insulator bismuth selenide (Bi2Se3) in in vivo and in vitro system for the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01998
更新日期：2013-01-01 00:00:00
