Abstract：
:The epithelial-mesenchymal plasticity, in tight association with stemness, contributes to the mammary gland homeostasis, evolution of early neoplastic lesions and cancer dissemination. Focused on cell surfaceome, we used mouse models of pre-neoplastic mammary epithelial and cancer stem cells to reveal the connection between cell surface markers and distinct cell phenotypes. We mechanistically dissected the TGF-β family-driven regulation of Sca-1, one of the most commonly used adult stem cell markers. We further provided evidence that TGF-β disrupts the lineage commitment and promotes the accumulation of tumor-initiating cells in pre-neoplastic cells.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Remšík J,Pícková M,Vacek O,Fedr R,Binó L,Hampl A,Souček Kdoi
10.1038/s41598-020-67827-4subject
Has Abstractpub_date
2020-07-09 00:00:00pages
11396issue
1issn
2045-2322pii
10.1038/s41598-020-67827-4journal_volume
10pub_type
杂志文章abstract：:Pearl millet hybrids biofortified with iron (Fe) and zinc (Zn) promise to be part of a long-term strategy to combat micronutrient malnutrition in the arid and semi-arid tropical (SAT) regions of the world. Biofortification through molecular breeding is the way forward to achieving a rapid trait-based breeding strategy...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76230-y
更新日期：2020-11-10 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-68522-0
更新日期：2020-07-10 00:00:00
abstract：:Invasive non-native species have pervasive impacts on native biodiversity, including population extirpations and species extinctions. Identifying reasons why a population of a native species is extirpated following an invasion often relies on literature-based results of anecdotal observations. The well-established sch...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78328-9
更新日期：2020-12-10 00:00:00
abstract：:Multidrug-resistant enterococcal pathogens, especially vancomycin-resistant enterococci (VRE), are among the pathogens that require new antibiotic innovation. The colonization of the gut represents a major pathway by which VRE can cause infection and spread to other patients. In the current study, auranofin (FDA-appro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26674-0
更新日期：2018-05-29 00:00:00
abstract：:In this report we have evaluated radiation effective dose received by patients during ECG-gated CCTA examinations based on gender, heart rate, tube voltage protocol and body mass index (BMI). A total of 1,824 patients were retrospectively recruited (1,139 men and 685 women) and they were divided into Group 1 (CCTA wit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40758-5
更新日期：2019-03-13 00:00:00
abstract：:The nuclear factor κB (NF-κB) pathway plays a key role in innate and adaptive immunity, cell proliferation and survival, inflammation and tumors development. MiR-146a is an immune system regulator that has anti-inflammatory function in multiple cell types and conditions. Here we demonstrate activation of canonical NF-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41530-5
更新日期：2019-03-26 00:00:00
abstract：:While most large river-deltas in the world are facing the risk of subsidence and erosion in the Anthropocene, it is suspected that the Changjiang submerged delta (CSD) could be subjected to the impacts of the world's largest dam, the Three Gorges Dam (TGD). Here we firstly indicate that the CSD went through high accum...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06600
更新日期：2014-10-16 00:00:00
abstract：:Canalization is a result of intrinsic developmental buffering that ensures phenotypic robustness under genetic variation and environmental perturbation. As a consequence, animal phenotypes are remarkably consistent within a species under a wide range of conditions, a property that seems contradictory to evolutionary c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16717
更新日期：2015-11-18 00:00:00
abstract：:The aim of this study was to determine the association of residual feed intake (RFI) with growth performance, blood metabolic parameters, and body composition factors in growing lambs. Individual body weight (BW) and dry matter intake (DMI) were determined in 137 male Hu lambs that were given a pellet feed four times ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13042-7
更新日期：2017-10-04 00:00:00
abstract：:Here we report a high efficiency photocatalyst, i.e., Mn(2+)-doped and N-decorated ZnO nanofibers (NFs) enriched with vacancy defects, fabricated via electrospinning and a subsequent controlled annealing process. This nanocatalyst exhibits excellent visible-light photocatalytic activity and an apparent quantum efficie...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32711
更新日期：2016-09-07 00:00:00
abstract：:New techniques for the field detection of inorganic improvised explosive devices (IEDs) are urgently developed. Although ion mobility spectrometry (IMS) has been proved to be the most effective method for screening organic explosives, it still faces a major challenge to detect inorganic explosives owing to their low v...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06631
更新日期：2014-10-16 00:00:00
abstract：:Olfactory receptors (ORs) mediate olfactory chemo-sensation in OR neurons. Herein, we have demonstrated that the OR chemo-sensing machinery functions in pancreatic β-cells and modulates insulin secretion. First, we found several OR isoforms, including OLFR15 and OLFR821, to be expressed in pancreatic islets and a β-ce...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19765-5
更新日期：2018-01-24 00:00:00
abstract：:Oxidative stress plays a role in the progression of chronic heart failure (CHF). We investigated whether systemic oxidative stress is linked to exercise intolerance and skeletal muscle abnormalities in patients with CHF. We recruited 30 males: 17 CHF patients, 13 healthy controls. All participants underwent blood test...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81736-0
更新日期：2021-01-26 00:00:00
abstract：:Small-molecule inhibitors of non-canonical IκB kinases TANK-binding kinase 1 (TBK1) and IκB kinase ε (IKKε) have shown to stimulate β-cell regeneration in multiple species. Here we demonstrate that TBK1 is predominantly expressed in β-cells in mammalian islets. Proteomic and transcriptome analyses revealed that geneti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76600-6
更新日期：2020-11-09 00:00:00
abstract：:To determine whether p16 INK4a deletion ameliorated renal tubulointerstitial injury by inhibiting a senescence-associated secretory phenotype (SASP) in Bmi-1-deficient (Bmi-1 -/-) mice, renal phenotypes were compared among 5-week-old Bmi-1 and p16 INK4a double-knockout, and Bmi-1 -/- and wild-type mice. Fifth-passage ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06868-8
更新日期：2017-08-08 00:00:00
abstract：:The Field Effect sensors are broadly used for detecting various target analytes in chemical and biological solutions. We report the conditions under which the pH sensitivity of an Ion Sensitive Field Effect transistor (ISFET) sensor can be significantly enhanced. Our theory and simulations show that by using pH buffer...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41305
更新日期：2017-02-02 00:00:00
abstract：:The consumption of bovine milk and meat is considered a risk factor for colon- and breast cancer formation, and milk consumption has also been implicated in an increased risk for developing Multiple Sclerosis (MS). A number of highly related virus-like DNAs have been recently isolated from bovine milk and sera and fro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21317-w
更新日期：2018-02-12 00:00:00
abstract：:Adult hippocampal neurogenesis is associated with learning and affective behavioural regulation. Its diverse functionality is segregated along the septotemporal axis from the dorsal to ventral hippocampus. However, features distinguishing immature neurons in these regions have yet to be characterized. Additionally, al...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30467
更新日期：2016-07-29 00:00:00
abstract：:The threshold size for enlarged abdominal lymph nodes (E-ALNs), a common pediatric disorder, has yet to be standardized. According to the maximum short-axis diameter, this study divided ALNs into Grade A (≥ 10 mm), Grade B (8-10 mm), Grade C (5-8 mm), and Grade D (< 5 mm, normal). To identify the threshold size for E-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81339-9
更新日期：2021-01-19 00:00:00
abstract：:This study presents atomic scale characterization of grain boundary defect structure in a functional oxide with implications for a wide range of electrochemical and electronic behavior. Indeed, grain boundary engineering can alter transport and kinetic properties by several orders of magnitude. Here we report experime...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02680
更新日期：2013-01-01 00:00:00
abstract：:Amplification of liver injury is mediated by macrophages but the signaling by which the macrophage inflammasome enhances liver injury is not completely understood. The CCAAT/Enhancer Binding Protein-β (C/EBPβ) is a critical signaling molecule for macrophages because expression of a dominant inhibitor of C/EBPβ DNA-bin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24268
更新日期：2016-04-12 00:00:00
abstract：:Tidal Disruption Events (TDEs) are processes where stars are torn apart by the strong gravitational force near to a massive or supermassive black hole. If a jet is launched in such a process, particle acceleration may take place in internal shocks. We demonstrate that jetted TDEs can simultaneously describe the observ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29022-4
更新日期：2018-07-17 00:00:00
abstract：:Other than hard bones and shells, it is rare for soft tissues to fossilize, but occasionally they are well-preserved in amber. Here, we focus on both modern and fossilized species of the land snail superfamily Cyclophoroidea. Phylogenetic relationships within the Cyclophoroidea were previously studied using extant spe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51840-3
更新日期：2019-11-04 00:00:00
abstract：:Marine Fungi are potent secondary metabolite producers. However, limited genetic information are available their biosynthetic gene clusters (BGCs) and their biotechnological applications. To overcome this lack of information, herein, we used next-generation sequencing methods for genome sequencing of two marine fungi,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28473-z
更新日期：2018-07-05 00:00:00
abstract：:This corrects the article DOI: 10.1038/srep25577. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/srep46944
更新日期：2018-02-16 00:00:00
abstract：:AgDNV is a powerful gene transduction tool and potential biological control agent for Anopheles mosquitoes. Using a GFP reporter virus system, we investigated AgDNV host range specificity in four arthropod cell lines (derived from An. gambiae, Aedes albopictus and Drosophila melanogaster) and six mosquito species from...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12701
更新日期：2015-07-29 00:00:00
abstract：:The histological spectrum of nonalcoholic fatty liver diseases (NAFLD) ranges from hepatic steatosis to steatohepatitis and fibrosis. Berberine (BBR) is known for its therapeutic effect on obesity, hyperglycaemia and dyslipidaemia; however, its effect on NAFLD has yet to be thoroughly explored. Db/db mice and methioni...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20848
更新日期：2016-02-09 00:00:00
abstract：:Recent studies of Asian glaciers have shown that glaciers in eastern Karakoram and West Kunlun have been slightly gaining mass while those in nearby Jammu Kashmir and Himalayas are losing mass, at rates of more than 0.5 m w.e.yr-1 and about 0.3 m w.e.yr-1, respectively. Two possible explanations have been proposed for...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14256-5
更新日期：2017-10-20 00:00:00
abstract：:The Serra Gaúcha region is the most important temperate fruit-producing area in southern Brazil. Despite mealybugs (Hemiptera: Pseudococcidae) infesting several host plants in the region, there is a lack of information about the composition of species damaging different crops. A survey of mealybug species associated w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15983-5
更新日期：2017-11-16 00:00:00
abstract：:Optical feedback mechanisms are often obtained from well-defined resonator structures fabricated by top-down processes. Here, we demonstrate that two-dimensional networks of metallic nanowires dispersed on the semiconductor slab can provide strong in-plane optical feedback and, thus, form randomly-distributed Fabry-Pé...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24898
更新日期：2016-04-22 00:00:00
