Unsaturated fatty acids as high-affinity ligands of the C-terminal Per-ARNT-Sim domain from the Hypoxia-inducible factor 3α.

Abstract:

:Hypoxia-inducible transcription factors (HIF) form heterodimeric complexes that mediate cell responses to hypoxia. The oxygen-dependent stability and activity of the HIF-α subunits is traditionally associated to post-translational modifications such as hydroxylation, acetylation, ubiquitination, and phosphorylation. Here we report novel evidence showing that unsaturated fatty acids are naturally occurring, non-covalent structural ligands of HIF-3α, thus providing the initial framework for exploring its exceptional role as a lipid sensor under hypoxia.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Fala AM,Oliveira JF,Adamoski D,Aricetti JA,Dias MM,Dias MVB,Sforça ML,Lopes-de-Oliveira PS,Rocco SA,Caldana C,Dias SMG,Ambrosio ALB

doi

10.1038/srep12698

subject

Has Abstract

pub_date

2015-08-03 00:00:00

pages

12698

issn

2045-2322

pii

srep12698

journal_volume

5

pub_type

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