Abstract:
:Hypoxia-inducible transcription factors (HIF) form heterodimeric complexes that mediate cell responses to hypoxia. The oxygen-dependent stability and activity of the HIF-α subunits is traditionally associated to post-translational modifications such as hydroxylation, acetylation, ubiquitination, and phosphorylation. Here we report novel evidence showing that unsaturated fatty acids are naturally occurring, non-covalent structural ligands of HIF-3α, thus providing the initial framework for exploring its exceptional role as a lipid sensor under hypoxia.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Fala AM,Oliveira JF,Adamoski D,Aricetti JA,Dias MM,Dias MVB,Sforça ML,Lopes-de-Oliveira PS,Rocco SA,Caldana C,Dias SMG,Ambrosio ALBdoi
10.1038/srep12698subject
Has Abstractpub_date
2015-08-03 00:00:00pages
12698issn
2045-2322pii
srep12698journal_volume
5pub_type
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