Abstract:
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journal_name
Sci Repjournal_title
Scientific reportsauthors
Oviedo-Casado S,Urbina A,Prior Jdoi
10.1038/s41598-018-21980-zsubject
Has Abstractpub_date
2018-03-13 00:00:00pages
4676issue
1issn
2045-2322pii
10.1038/s41598-018-21980-zjournal_volume
8pub_type
已发布勘误abstract::Breast cancer is a serious problem causing the death of women across the world. At present, one of the major challenges is to design drugs to target breast cancer specific gene(s). RNA interference (RNAi) is an important technique for targeted gene silencing that may lead to promising novel therapeutic strategies for ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08948-1
更新日期:2017-08-18 00:00:00
abstract::P-type doping in high Al-content AlGaN alloys is a main challenge for realizing AlGaN-based deep ultraviolet optoelectronics devices. According to the first-principles calculations, Mg activation energy may be reduced so that a high hole concentration can be obtained by introducing nanoscale (AlN)5/(GaN)1 superlattice...
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pub_type: 杂志文章
doi:10.1038/srep44223
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abstract::Ca(x)Zn(1-x)O alloys are potential candidates to achieve wide band-gap, which might significantly promote the band gap engineering and heterojunction design. We performed a crystal structure search for CaO-ZnO system under pressure, using an ab initio evolutionary algorithm implemented in the USPEX code. Four stable o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11003
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abstract::Several reviews have analyzed the factors that affect the change in soil organic C (SOC) when forest is converted to agricultural land; however, the effects of forest type and cultivation stage on these changes have generally been overlooked. We collated observations from 453 paired or chronosequential sites where for...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04062
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abstract::The morbidity and mortality rates of human immunodeficiency virus (HIV)-hepatitis B virus (HBV) coinfection are higher than that of either infection alone. Outcomes and the virological response to antiretrovirals (combination antiretroviral therapy, cART) were explored in HIV/HBV subjects in a cohort of Italian patien...
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pub_type: 杂志文章
doi:10.1038/s41598-019-46976-1
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abstract::Relative sea level rise at tide gauge Galveston Pier 21, Texas, is the combination of absolute sea level rise and land subsidence. We estimate subsidence rates of 3.53 mm/a during 1909-1937, 6.08 mm/a during 1937-1983, and 3.51 mm/a since 1983. Subsidence attributed to aquifer-system compaction accompanying groundwate...
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pub_type: 杂志文章
doi:10.1038/s41598-020-74696-4
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abstract::Habitat fragmentation can reduce population viability, especially for area-sensitive species. The Minimum Area Requirements (MAR) of a population is the area required for the population's long-term persistence. In this study, the response of occupancy probability of giant pandas against habitat patch size was studied ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37715
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abstract::Sorption and desorption determine the amount of an herbicide in soil solution. Therefore, knowledge of the sorption and desorption coefficients in different soils is an essential factor to estimate the potential for environmental contamination by herbicides. We evaluated the feasibility of multivariate and linear disc...
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pub_type: 杂志文章
doi:10.1038/s41598-019-44405-x
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abstract::The κ opioid receptor (κOR) is a member of G-protein-coupled receptors, and is considered as a promising drug target for treating neurological diseases. κOR selective 6'-GNTI was proved to be a G-protein biased agonist, whereas 5'-GNTI acts as an antagonist. To investigate the molecular mechanism of how these two liga...
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pub_type: 杂志文章
doi:10.1038/srep18913
更新日期:2016-01-08 00:00:00
abstract::Sorting nexin 27 (SNX27) recycles PSD-95, Dlg1, ZO-1 (PDZ) domain-interacting membrane proteins and is essential to sustain adequate brain functions. Here we define a fundamental SNX27 function in T lymphocytes controlling antigen-induced transcriptional activation and metabolic reprogramming. SNX27 limits the activat...
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pub_type: 杂志文章
doi:10.1038/s41598-017-16370-w
更新日期:2017-11-27 00:00:00
abstract::The innate and adaptive immune systems fail to control HCV infection in the majority of infected individuals. HCV is an ssRNA virus, which suggests a role for Toll-like receptors (TLRs) 7 and 8 in initiating the anti-viral response. Here we demonstrate that HCV genomic RNA harbours specific sequences that initiate an ...
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pub_type: 杂志文章
doi:10.1038/srep29447
更新日期:2016-07-07 00:00:00
abstract::Reduced near-infrared reflectance observed in September 1973 in Skylab images of the western flank of Mt. Etna has been interpreted as an eruption precursor of the January 1974 eruption. Until now, it has been unclear when this signal started, whether it was sustained and which process(es) could have caused it. By ana...
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pub_type: 杂志文章
doi:10.1038/srep44019
更新日期:2017-03-07 00:00:00
abstract::Pearl millet hybrids biofortified with iron (Fe) and zinc (Zn) promise to be part of a long-term strategy to combat micronutrient malnutrition in the arid and semi-arid tropical (SAT) regions of the world. Biofortification through molecular breeding is the way forward to achieving a rapid trait-based breeding strategy...
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pub_type: 杂志文章
doi:10.1038/s41598-020-76230-y
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abstract::The activity of the ubiquitin proteasome system (UPS) is downregulated in aggregation diseases such as Alzheimer's disease (AD). In this study, we investigated the therapeutic potential of the Agouti-related peptide (AgRP), which is secreted by human mesenchymal stem cells (MSCs), in terms of its effect on the regulat...
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pub_type: 杂志文章
doi:10.1038/srep39340
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abstract::Radiotherapy with protons and heavier ions landmarks a novel era in the field of high-precision cancer therapy. To identify patients most benefiting from this technologically demanding therapy, fast assessment of comparative treatment plans utilizing different ion species is urgently needed. Moreover, to overcome unce...
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pub_type: 杂志文章
doi:10.1038/s41598-018-33194-4
更新日期:2018-10-04 00:00:00
abstract::Autism is a common and often severe neurodevelopmental disorder for which diverse pathophysiological processes have been proposed. Recent gene expression data comparing autistic and control brains suggest that the normal differential gene expression between frontal and temporal cortex is attenuated in autistic brains....
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01831
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abstract::In everyday life, people must often determine how much time and effort to allocate to cooperative activities. In the current study, we tested the hypothesis that the perception of others' effort investment in a cooperative activity may elicit a sense of commitment, leading people to allocate more time and effort to th...
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doi:10.1038/s41598-018-34096-1
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abstract::A number of human and animal in vitro or in vivo studies have investigated the relationship between dietary choline and betaine and cancer risk, suggesting that choline and betaine consumption may be protective for cancer. There are also a few epidemiologic studies exploring this relationship, however, with inconsiste...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/srep35547
更新日期:2016-10-19 00:00:00
abstract::The mitogen-activated protein kinase (MAPK) cascades, which play crucial roles in plant development processes, are universal modules of signal transduction in eukaryotes and consist of a core module of three sequentially phosphorylated kinases: MAPK, MAPK kinase (MAPKK), and MAPKK kinase (MAPKKK). This is the first re...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17615-4
更新日期:2017-12-18 00:00:00
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journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16896
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abstract::Geometric mean concentrations of fecal indicator bacteria E. coli and enterococci are commonly used to evaluate the microbial quality of irrigation, recreation, and other types of waters, as well in watershed-scale microbial water quality modeling. It is not known how the uncertainty of those geometric mean concentrat...
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abstract::Light regulates cGMP concentration in the photoreceptor cytoplasm by activating phosphodiesterase (PDE) molecules through a G-protein signalling cascade. Spontaneous PDE activity is present in rod outer segments even in darkness. This basal PDE activity (βdark) has not been determined in wild type mammalian photorecep...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37661-w
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abstract::Abnormal dopaminergic transmission has been implicated as a risk determinant of HIV-1-associated neurocognitive disorders. HIV-1 Tat protein increases synaptic dopamine (DA) levels by directly inhibiting DA transporter (DAT) activity, ultimately leading to dopaminergic neuron damage. Through integrated computational m...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39048
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abstract::High salinity frequently causes inhibition and even failure in anaerobic digestion. To explore the impact of increasing NaCl concentrations on biogas production, and reveal the microbial community variations in response to high salinity stress, the Illumina high-throughput sequencing technology was employed. The resul...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-01298-y
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abstract::Primary Sjogren's syndrome (pSS) confers increased risk for non-Hodgkin lymphoma (NHL) development. Two common polymorphisms, the c. 677C > T and c. 1298A > C, of the methylene-tetrahydrofolate reductase (MTHFR) gene, an enzyme essential in DNA synthesis and methylation, have been associated with susceptibility to NHL...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07347-w
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abstract::Because of the pathogenicity and low incidence of avian influenza virus infections in humans, the immune correlates of protection for avian influenza vaccines cannot be determined from clinical studies. Here, we used the ferret model to address this for an avian influenza H5N1 vaccine. Using oil-in-water adjuvants, we...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep44727
更新日期:2017-03-17 00:00:00
abstract::Grazing and burrowing organisms usually homogenise microalgal mats that form on benthic sediments of many aquatic ecosystems. In the absence of this disruption, microalgal mats can accrete laminated deposits (stromatolites). Stromatolites are rare in modern coastal ecosystems, but persist at locations where metazoans ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42614
更新日期:2017-02-16 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) is caused by chronic inflammation. Many inflammatory mediators induce the low grade systemic inflammation of COPD. Haptoglobin (Hp) is synthesized in the liver and by lung epithelial and alveolar macrophage cells. However, associations of the serum concentration and phenoty...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37406-9
更新日期:2019-01-17 00:00:00
abstract::Skeletal muscle represents the largest pool of body zinc, however, little is known about muscle zinc homeostasis or muscle-specific zinc functions. Zip14 (Slc39a14) was the most highly expressed zinc transporter in skeletal muscle of mice in response to LPS-induced inflammation. We compared metabolic parameters of ske...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61059-2
更新日期:2020-03-04 00:00:00
abstract::Angiotensin-converting enzyme (ACE) is an evolutionarily conserved peptidyl dipeptidase. Mammalian ACE converts angiotensin I to the active vasoconstrictor angiotensin II, thus playing a critical role for homeostasis of the renin-angiotensin system. In Drosophila, the ACE homolog Ance is expressed in specific regions ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13487-w
更新日期:2017-10-13 00:00:00