Serum Vitamin D Level Does not Affect The Sensitivity of Parathyroid Adenoma Localization Tests.

Abstract:

:The aim of the present study was to evaluate the predictive value of 25-hydroxyvitamin D, calcium and parathormone level, co-existence of thyroid nodule, thyroidectomy history and adenoma volume on the success of neck ultrasound (US) and technetium-99m sestamibi (MIBI) scan in primary hyperparathyroidism (PHP) patients. This study included 256 patients with PHP who underwent parathyroidectomy. 169 (%66) patients had vitamin D deficiency and 56 (%22) of patients had insufficiency. The sensitivity of US and MIBI studies showed no difference between vitamin D deficiency, insufficiency and replete groups (%80.5, %82 and %71 (p > 0.05) and %81, %84 and %71 respectively (p > 0.05)). Vitamin D level was not found to be an independent predictor of localization on either US or MIBI scan after adjusting for different variables (p > 0.05). Calcium level was found to be an independent predictor for US sensitivity (r2:0,033, p:0,032) and parathormone level for MIBI sensitivity (r2:0,05, p:0,025). The co-existence of nodular thyroid disease and history of thyroidectomy significantly decreased the sensitivity of US (%76 and %43). MIBI sensitivity was not impaired by nodular disease but the history of thyroidectomy also impaired the sensitivity of MIBI (%43). As a result vitamin D level does not affect the sensitivity of preoperative localization tests.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Sencar ME,Sakiz D,Unsal IO,Hepsen S,Calapkulu M,Gumus P,Ucan B,Ozbek M,Cakal E

doi

10.1038/s41598-019-48536-z

subject

Has Abstract

pub_date

2019-08-19 00:00:00

pages

12035

issue

1

issn

2045-2322

pii

10.1038/s41598-019-48536-z

journal_volume

9

pub_type

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