Abstract:
:Autism spectrum disorder involves persistent difficulties in social communication. Although these difficulties affect both verbal and nonverbal communication, there are no quantitative behavioral studies to date investigating the cross-modal coordination of verbal and nonverbal communication in autism. The objective of the present study was to characterize the dynamic relation between speech production and facial expression in children with autism and to establish how face-directed gaze modulates this cross-modal coordination. In a dynamic mimicry task, experiment participants watched and repeated neutral and emotional spoken sentences with accompanying facial expressions. Analysis of audio and motion capture data quantified cross-modal coordination between simultaneous speech production and facial expression. Whereas neurotypical children produced emotional sentences with strong cross-modal coordination and produced neutral sentences with weak cross-modal coordination, autistic children produced similar levels of cross-modal coordination for both neutral and emotional sentences. An eyetracking analysis revealed that cross-modal coordination of speech production and facial expression was greater when the neurotypical child spent more time looking at the face, but weaker when the autistic child spent more time looking at the face. In sum, social communication difficulties in autism spectrum disorder may involve deficits in cross-modal coordination. This finding may inform how autistic individuals are perceived in their daily conversations.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Sorensen T,Zane E,Feng T,Narayanan S,Grossman Rdoi
10.1038/s41598-019-54587-zsubject
Has Abstractpub_date
2019-12-04 00:00:00pages
18301issue
1issn
2045-2322pii
10.1038/s41598-019-54587-zjournal_volume
9pub_type
杂志文章abstract::Meaningful, reliable and valid mRNA expression analyses by real-time quantitative PCR (RT-qPCR) can only be achieved, if suitable reference genes are chosen for normalization and if appropriate RT-qPCR quality standards are met. Human periodontal ligament (hPDL) fibroblasts play a major mediating role in orthodontic t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15281-0
更新日期:2017-11-07 00:00:00
abstract::Regret results from comparing non-optimal outcomes containing both gain and loss parts to better alternatives during decision-making. The present fMRI study aimed to explore whether levels of regret could change when gain or loss part of a non-optimal outcome was focused during a sequential risk taking task, i.e. the ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41374
更新日期:2017-02-01 00:00:00
abstract::This study investigates the association between an index of mesozooplankton biomass, derived from the Continuous Plankton Recorder survey and satellite-derived productivity fronts in the North Atlantic. While chlorophyll-a content (CHL) is commonly described as a proxy for phytoplankton biomass, the size of productivi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41212-2
更新日期:2019-03-18 00:00:00
abstract::The aim of this study was to assess the liver stiffness values in children with obesity versus healthy children on 2D-SWE and TE taking into account different laboratory parameters. We performed a case-control study on 287 children aged between 3 to 18 years, admitted in a Romanian Pediatric Tertiary Hospital, which w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56358-2
更新日期:2019-12-24 00:00:00
abstract::In situ HfB2-SiC-VSi2 composite was fabricated by reactive pressureless sintering at the temperature of 2150 °C for 4 h under a vacuum atmosphere. In situ SiC and VSi2 reinforcements were formed using VC and Si powders as starting materials according to the following reaction: VC + 3Si = SiC + VSi2. Microstructural st...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73295-7
更新日期:2020-10-06 00:00:00
abstract::New techniques for the field detection of inorganic improvised explosive devices (IEDs) are urgently developed. Although ion mobility spectrometry (IMS) has been proved to be the most effective method for screening organic explosives, it still faces a major challenge to detect inorganic explosives owing to their low v...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06631
更新日期:2014-10-16 00:00:00
abstract::Individuals in the state of psychological suboptimal health keep increasing, only scales and questionnaires were used to diagnose in clinic under current conditions, and symptoms of high reliability and accuracy are destitute. Therefore, the noninvasive and precise laboratory diagnostic methods are needed. This study ...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/srep33820
更新日期:2016-09-21 00:00:00
abstract::Floral transition is influenced by environmental factors such as light and temperature. Plants are capable of integrating photoperiod and ambient temperature signaling into their developmental program. Despite extensive investigations on individual genetic pathways, little is known about the molecular components that ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12071
更新日期:2015-07-10 00:00:00
abstract::Tom40 is an integral protein of the mitochondrial outer membrane, which as the central component of the Translocase of the Outer Membrane (TOM) complex forms a channel for protein import. We characterize the diffusion properties of individual Tom40 molecules fused to the photoconvertable fluorescent protein Dendra2 wi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00195
更新日期:2011-01-01 00:00:00
abstract::Protein glycosylation has been described as the most abundant and complex post-translational modification occurring in nature. Recent studies have enhanced our view of how this modification occurs in bacteria highlighting the role of protein glycosylation in various processes such as biofilm formation, virulence and h...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23170-3
更新日期:2018-03-16 00:00:00
abstract::Cell fate decisions are controlled by the interplay of transcription factors and epigenetic modifiers, which together determine cellular identity. Here we elaborate on the role of miR302 in the regulation of cell plasticity. Overexpression of miR302 effected silencing of the TGFβ type II receptor and facilitated plast...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42407
更新日期:2017-02-14 00:00:00
abstract::Non-fibrillar protein aggregates that appear in the earlier stages of amyloid fibril formation are sometimes considered to play a key role in amyloid nucleation; however, the structural features of these aggregates currently remain unclear. We herein identified a characteristic pathway of fibril formation by human ins...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18390-y
更新日期:2018-01-08 00:00:00
abstract::The paper presents the procedure for planning an experiment to create standard sets of reagents for a technetium-99m generator based on glucose derivatives. All stages are presented from researching the required quantities of a substance, a reducing agent, a stabilizer and auxiliary components to developing lyophilize...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61707-7
更新日期:2020-03-20 00:00:00
abstract::Osteoporosis is associated with reduced density and quality of bone leading to weakened skeleton thereby increasing the risk of fractures responsible for increased morbidity and mortality. Due to preference for western food style the consumption of salt intake in our diets has increased many folds. High dietary salt i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20896-y
更新日期:2018-02-06 00:00:00
abstract::The considerable range of genetic variation in human populations may partly reflect distinctive processes of adaptation to variable environmental conditions. However, the adaptive genomic signatures remain to be completely elucidated. This research explores candidate loci under selection at the population level by cha...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22468
更新日期:2016-03-02 00:00:00
abstract::Chronic inflammation can be a major driver of the failure of a variety of organs, including chronic kidney disease (CKD). The NLR family pyrin domain-containing 3 (NLRP3) inflammasome has been shown to play a pivotal role in inflammation in a mouse kidney disease model. Nuclear factor erythroid 2-related factor 2 (Nrf...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08054-2
更新日期:2017-08-18 00:00:00
abstract::The capacity of marine organisms to adapt and/or acclimate to climate change might differ among distinct populations, depending on their local environmental history and phenotypic plasticity. Kelp forests create some of the most productive habitats in the world, but globally, many populations have been negatively impa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-82094-7
更新日期:2021-01-28 00:00:00
abstract::Membrane fouling, i.e. accumulation of unwanted material on the surface of the membrane is a significant problem in filtration processes since it commonly degrades membrane performance and increases operating costs. Therefore, the advantages of early stage monitoring and control of fouling are widely recognized. In th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29268-y
更新日期:2018-07-23 00:00:00
abstract::Soil microbial responses to fire are likely to change over the course of forest recovery. Investigations on long-term changes in bacterial dynamics following fire are rare. We characterized the soil bacterial communities across three different times post fire in a 2 to 152-year fire chronosequence by Illumina MiSeq se...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32411
更新日期:2016-08-30 00:00:00
abstract::Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide, ranging from steatosis to non-alcoholic steatohepatitis (NASH). Recently, cerium oxide nanoparticles (CeO2NPs) have emerged as a new antioxidant agent with hepatoprotective properties in experimental liver disease. T...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49262-2
更新日期:2019-09-06 00:00:00
abstract::Epithelial ovarian cancer is a leading cause of death in gynecological cancers. While several systematic studies have revealed the mutation landscape of serous epithelial ovarian cancer, other non-serous subtypes of the disease have not been explored as extensively. Here we conduct exome sequencing of nine non-serous ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10432-9
更新日期:2017-08-29 00:00:00
abstract::Antigen-presenting cells including dendritic cells (DCs) express mannan receptors (MR) on their surface, which can be exploited in cancer therapy by designing immune-stimulatory viruses coated with mannan-modified capsids that then bind to DCs and initiate a potent immune response. Although the combination of anti-ang...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11275
更新日期:2015-06-18 00:00:00
abstract::Light-sheet microscopy enables considerable speed and phototoxicity gains, while quantitative-phase imaging confers label-free recognition of cells and organelles, and quantifies their number-density that, thermodynamically, is more representative of metabolism than size. Here, we report the fusion of these two imagin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76730-x
更新日期:2020-11-19 00:00:00
abstract::A novel imaging-driven technique with an integrated fluorescence signature to enable automated enumeration of two species of cyanobacteria and an alga of somewhat similar morphology to one of the cyanobacteria is presented to demonstrate proof-of-concept that high accuracy, imaging-based, rapid water quality analysis ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27406-0
更新日期:2018-06-13 00:00:00
abstract::Compared with the commercially available single nucleotide polymorphism (SNP) chip based on the Bead Chip technology, the solution hybrid selection (SHS)-based target enrichment SNP chip is not only design-flexible, but also cost-effective for genotype sequencing. In this study, we propose to design an animal SNP chip...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09285-z
更新日期:2017-08-17 00:00:00
abstract::Many experiments on human cooperation have revealed that individuals differ systematically in their tendency to cooperate with others. It has also been shown that individuals condition their behaviour on the overall cooperation level of their peers. Yet, little is known about how individuals respond to heterogeneity i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16144
更新日期:2015-11-04 00:00:00
abstract::The Casimir force exerted on a gold dipolar nanoparticle by a finite-thickness slab of the natural hyperbolic material namely, the ortorhombic crystalline modification of boron nitride, is investigated. The main contribution to the force originates from the TM-polarized waves, for frequencies at which the parallel and...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73995-0
更新日期:2020-10-08 00:00:00
abstract::Electroporation (EP), the increase of cell membrane permeability due to the application of electric pulses, is a universal phenomenon with a broad range of applications. In medicine, some of the foremost EP-based tumor treatments are electrochemotherapy (ECT), irreversible electroporation, and gene electrotransfer (GE...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79858-y
更新日期:2021-01-14 00:00:00
abstract::The combination of navigation and robotics in spine surgery has the potential to accurately identify and maintain bone entry position and planned trajectory. The goal of this study was to examine the feasibility, accuracy and efficacy of a new robot-guided system for semi-automated, minimally invasive, pedicle screw p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64462-x
更新日期:2020-05-05 00:00:00
abstract::Fetal cardiomyocytes actively proliferate to form the primitive heart in utero in mammals, but they stop dividing shortly after birth. The identification of essential molecules maintaining this active cardiomyocyte proliferation is indispensable for potential adult heart regeneration. A recent study has shown that thi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04823-1
更新日期:2017-06-30 00:00:00