Abstract：
:The ability of deep learning architectures to identify glaucomatous optic neuropathy (GON) in fundus photographs was evaluated. A large database of fundus photographs (n = 14,822) from a racially and ethnically diverse group of individuals (over 33% of African descent) was evaluated by expert reviewers and classified as GON or healthy. Several deep learning architectures and the impact of transfer learning were evaluated. The best performing model achieved an overall area under receiver operating characteristic (AUC) of 0.91 in distinguishing GON eyes from healthy eyes. It also achieved an AUC of 0.97 for identifying GON eyes with moderate-to-severe functional loss and 0.89 for GON eyes with mild functional loss. A sensitivity of 88% at a set 95% specificity was achieved in detecting moderate-to-severe GON. In all cases, transfer improved performance and reduced training time. Model visualizations indicate that these deep learning models relied on, in part, anatomical features in the inferior and superior regions of the optic disc, areas commonly used by clinicians to diagnose GON. The results suggest that deep learning-based assessment of fundus images could be useful in clinical decision support systems and in the automation of large-scale glaucoma detection and screening programs.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Christopher M,Belghith A,Bowd C,Proudfoot JA,Goldbaum MH,Weinreb RN,Girkin CA,Liebmann JM,Zangwill LMdoi
10.1038/s41598-018-35044-9subject
Has Abstractpub_date
2018-11-12 00:00:00pages
16685issue
1issn
2045-2322pii
10.1038/s41598-018-35044-9journal_volume
8pub_type
杂志文章abstract：:Interferon (IFN)-γ release assays (IGRAs) are used to diagnose latent tuberculosis (TB) infection (LTBI). To improve the accuracy of these tests, different approaches, such as alternative cytokine detection and using different antigens, are considered. Following this purpose, this study aims to evaluate the addition o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70204-w
更新日期：2020-08-06 00:00:00
abstract：:The fungal microbiota is an important component of the human gut microbiome and may be linked to gastrointestinal disease. In this study, the fungal microbiota of biopsy samples from adenomas and adjacent tissues was characterized by deep sequencing. Ascomycota, Glomeromycota and Basidiomycota were identified as the d...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/srep07980
更新日期：2015-01-23 00:00:00
abstract：:We consider the finite-temperature properties of the extended Bose-Hubbard model realized recently in an ETH experiment [Nature 532, 476 (2016)]. Competing short- and global-range interactions accommodate fascinating collective phenomena. We formulate a self-consistent mean-field theory to describe the behaviors of th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66054-1
更新日期：2020-06-03 00:00:00
abstract：:The intricate molecular processes underlying photosynthesis have long been studied using various analytic approaches. However, the three-dimensional (3D) dynamics of such photosynthetic processes remain unexplored due to technological limitations related to investigating intraorganellar mechanisms in vivo. By developi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29940
更新日期：2016-07-15 00:00:00
abstract：:Previously we reported that LIM1863 colorectal cancer (CRC) cells secrete three distinct extracellular vesicle subtypes - two subpopulations of exosomes (apical EpCAM-Exos and basolateral A33-Exos) and shed microvesicles (sMVs) - with distinct protein and miRNA signatures. Here, we extend our omics approach to underst...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38397
更新日期：2016-12-05 00:00:00
abstract：:The frequency noise of an optical frequency comb is routinely measured through the hetherodyne beat of one comb tooth against a stable continuous-wave laser. After frequency-to-voltage conversion, the beatnote is sent to a spectrum analyzer to retrive the power spectral density of the frequency noise. Because narrow-l...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16338
更新日期：2015-11-09 00:00:00
abstract：:Zebrafish embryos are translucent and develop rapidly in individual eggs ex utero; they are widely used as models for embryogenesis and organ development for human diseases and drug discovery. Lysine crotonylation (Kcr) is a type of histone post-translational modifications discovered in 2011. Kcr dynamics are involved...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22069-3
更新日期：2018-02-26 00:00:00
abstract：:To assess differences between secondary high myopia (SHM) due to congenital glaucoma and primary high myopia (PHM) and non-highly myopic eyes (NHM) in the relationships between axial length and Bruch's membrane (BM) thickness and retinal pigment epithelium (RPE) density. The histomorphometric study included human glob...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62096-7
更新日期：2020-03-20 00:00:00
abstract：:Delivery and expression of recombinant genes, a key methodology for many applications in biological research, remains a challenge especially for mature neurons. Here, we report easy, highly efficient and well tolerated transduction of adult peripheral and central neuronal populations of diverse species in culture usin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38928
更新日期：2016-12-13 00:00:00
abstract：:Nanomaterials are extensively studied in electrochemical energy storage and conversion systems because of their structural advantages. However, their volumetric energy density still needs improvement due to the high surface area, especially the carbon based nanocomposites. Constructing hierarchical micro-scaled materi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33682
更新日期：2016-09-21 00:00:00
abstract：:This study investigated a rabbit model of autologous simple oral mucosal epithelium transplantation (SOMET) for limbal stem cell deficiency (LSCD). LSCD was created in the SOMET group and the Control group. In the SOMET group, oral mucosa harvested from the buccal region was treated with dispase, cut into small pieces...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54571-7
更新日期：2019-12-02 00:00:00
abstract：:Bile acid (BA) signatures are altered in many disease states. BA metabolism is an important microbial function to assist gut colonization and persistence, as well as microbial survival during gastro intestinal (GI) transit and it is an important criteria for potential probiotic bacteria. Microbes that express bile sal...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58069-5
更新日期：2020-01-24 00:00:00
abstract：:Increasing levels of human activity threaten wildlife populations through direct mortality, habitat degradation, and habitat fragmentation. Area closures can improve habitat quality for wildlife, but may be difficult to achieve where tourism or other economic drivers are a priority. Temporal closures that limit human ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40581-y
更新日期：2019-03-07 00:00:00
abstract：:We generated self-induced retinal ganglion cells (RGCs) with functional axons from human induced pluripotent stem cells. After development of the optic vesicle from the induced stem cell embryoid body in three-dimensional culture, conversion to two-dimensional culture, achieved by supplementation with BDNF, resulted i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08344
更新日期：2015-02-10 00:00:00
abstract：:The anisotropic shape of DNA molecules allows them to form lyotropic liquid crystals (LCs) at high concentrations. This liquid crystalline arrangement is also found in vivo (e.g., in bacteriophage capsids, bacteria or human sperm nuclei). However, the role of DNA liquid crystalline organization in living organisms sti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22863-z
更新日期：2018-03-14 00:00:00
abstract：:Intermediate level radioactive waste (ILW) generally contains a heterogeneous range of organic and inorganic materials, of which some are encapsulated in cement. Of particular concern are cellulosic waste items, which will chemically degrade under the conditions predicted during waste disposal, forming significant qua...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26963-8
更新日期：2018-06-08 00:00:00
abstract：:Efficient isolation and genetic analysis of circulating tumor cells (CTCs) from cancer patients' blood is a critical step for clinical applications using CTCs. Here, we report a novel CTC-isolation method and subsequent genetic analysis. CTCs from the blood were complexed with magnetic beads coated with antibodies aga...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37392
更新日期：2016-11-28 00:00:00
abstract：:Despite efforts during the past decades, loop modeling remains a difficult part of protein structure modeling. Several approaches have been developed in the framework of crystal structures. However, for homology models, the modeling of loops is still far from being solved. We propose DaReUS-Loop, a data-based approach...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32079-w
更新日期：2018-09-12 00:00:00
abstract：:Previous studies have evaluated gene expression in Alzheimer's disease (AD) brains to identify mechanistic processes, but have been limited by the size of the datasets studied. Here we have implemented a novel meta-analysis approach to identify differentially expressed genes (DEGs) in published datasets comprising 450...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/srep12393
更新日期：2015-07-23 00:00:00
abstract：:New techniques for the field detection of inorganic improvised explosive devices (IEDs) are urgently developed. Although ion mobility spectrometry (IMS) has been proved to be the most effective method for screening organic explosives, it still faces a major challenge to detect inorganic explosives owing to their low v...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06631
更新日期：2014-10-16 00:00:00
abstract：:Geometric mean concentrations of fecal indicator bacteria E. coli and enterococci are commonly used to evaluate the microbial quality of irrigation, recreation, and other types of waters, as well in watershed-scale microbial water quality modeling. It is not known how the uncertainty of those geometric mean concentrat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58603-5
更新日期：2020-02-03 00:00:00
abstract：:We report localised-surface-plasmon (LSP) enhanced deep-ultraviolet light-emitting diodes (deep-UV LEDs) using Al nanoparticles for LSP coupling. Polygonal Al nanoparticles were fabricated on the top surfaces of the deep-UV LEDs using the oblique-angle deposition method. Both the top- and bottom-emission electrolumine...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04380
更新日期：2014-03-14 00:00:00
abstract：:The ongoing evolution of microbial pathogens represents a significant issue in diagnostic PCR/qPCR. Many assays are burdened with false negativity due to mispriming and/or probe-binding failures. Therefore, PCR/qPCR assays used in the laboratory should be periodically re-assessed in silico on public sequences to evalu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37869-w
更新日期：2019-02-07 00:00:00
abstract：:Epilepsy, that comprises a wide spectrum of neuronal disorders and accounts for about one percent of global disease burden affecting people of all age groups, is recognised as apasmara in the traditional medicinal system of Indian antiquity commonly known as Ayurveda. Towards exploring the molecular level complex regu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46715-6
更新日期：2019-07-22 00:00:00
abstract：:Multi-drug resistant efflux transporters found in Blood-Brain Barrier (BBB) acts as a functional barrier, by pumping out most of the drugs into the blood. Previous studies showed focused ultrasound (FUS) induced microbubble oscillation can disrupt the BBB by loosening the tight junctions in the brain endothelial cells...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31201
更新日期：2016-08-11 00:00:00
abstract：:Agricultural land is typically managed based on visible plant life at the expense of the belowground majority. However, microorganisms mediate processes sustaining plant life and the soil environment. To understand the role of microbes we first must understand what controls soil microbial community assembly. We assess...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45369
更新日期：2017-03-28 00:00:00
abstract：:Anaerobic ammonium oxidation (anammox) is known to autotrophically convert ammonium to dinitrogen gas with nitrite as the electron acceptor, but little is known about their released microbial products and how these are relative to heterotrophic growth in anammox system. In this work, we applied a mathematical model to...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27576
更新日期：2016-06-07 00:00:00
abstract：:The patterns of evolution and expression of tissue-specific genes are poorly understood beyond sex-specific genes. Accordingly, we identified 3,191 tissue-specific genes and 38,745 common genes using 22 RNA-seq datasets from cultivated peanut. The expression levels of tissue-specific genes were significantly lower tha...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09905-8
更新日期：2017-08-21 00:00:00
abstract：:We aimed to determine if prematurity and lower birth weight are associated with poorer lung function in a non-western developed setting with less marked confounding by socioeconomic position. Using multivariable linear regression in Hong Kong's "Children of 1997" birth cohort, adjusted associations of prematurity and ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56086-7
更新日期：2020-01-15 00:00:00
abstract：:The western North-Atlantic coast experienced major coastal floods in recent years. Coastal floods are primarily composed of tides and storm surges due to tropical (TCs) and extra-tropical cyclones (ETCs). We present a reanalysis from 1988 to 2015 of extreme sea levels that explicitly include TCs for the western North-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40157-w
更新日期：2019-03-04 00:00:00
