Abstract：
:Previous studies have evaluated gene expression in Alzheimer's disease (AD) brains to identify mechanistic processes, but have been limited by the size of the datasets studied. Here we have implemented a novel meta-analysis approach to identify differentially expressed genes (DEGs) in published datasets comprising 450 late onset AD (LOAD) brains and 212 controls. We found 3124 DEGs, many of which were highly correlated with Braak stage and cerebral atrophy. Pathway Analysis revealed the most perturbed pathways to be (a) nitric oxide and reactive oxygen species in macrophages (NOROS), (b) NFkB and (c) mitochondrial dysfunction. NOROS was also up-regulated, and mitochondrial dysfunction down-regulated, in healthy ageing subjects. Upstream regulator analysis predicted the TLR4 ligands, STAT3 and NFKBIA, for activated pathways and RICTOR for mitochondrial genes. Protein-protein interaction network analysis emphasised the role of NFKB; identified a key interaction of CLU with complement; and linked TYROBP, TREM2 and DOK3 to modulation of LPS signalling through TLR4 and to phosphatidylinositol metabolism. We suggest that NEUROD6, ZCCHC17, PPEF1 and MANBAL are potentially implicated in LOAD, with predicted links to calcium signalling and protein mannosylation. Our study demonstrates a highly injurious combination of TLR4-mediated NFKB signalling, NOROS inflammatory pathway activation, and mitochondrial dysfunction in LOAD.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Li X,Long J,He T,Belshaw R,Scott Jdoi
10.1038/srep12393subject
Has Abstractpub_date
2015-07-23 00:00:00pages
12393issn
2045-2322pii
srep12393journal_volume
5pub_type
杂志文章,meta分析abstract：:Copper-based compounds are promising entities for target-specific next-generation anticancer and NSAIDS therapeutics. In lieu of this, benzimidazole scaffold plays an important role, because of their wide variety of potential functionalizations and coordination modes. Herein, we report three copper complexes 1-3 with ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41063-x
更新日期：2019-03-27 00:00:00
abstract：:We present a mechanically active cell culture substrate that produces complex strain patterns and generates extremely high strain rates. The transparent miniaturized cell stretcher is compatible with live cell microscopy and provides a very compact and portable alternative to other systems. A cell monolayer is culture...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27915-y
更新日期：2018-07-02 00:00:00
abstract：:The aim of the present study was to evaluate the healthy lifestyle behaviors in hypertensive patients (aware, n = 1364 and not aware, n = 1213) based on 2011 national survey of risk factors of non-communicable disease (SuRFNCD) of Iran. Lifestyle score was calculated based on lifestyle behaviors, including smoking sta...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26823-5
更新日期：2018-05-31 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-57959-y
更新日期：2020-02-05 00:00:00
abstract：:Muscle wasting and atrophy are regulated by multiple molecular processes, including mRNA processing. Reduced levels of the polyadenylation binding protein nucleus 1 (PABPN1), a multifactorial regulator of mRNA processing, cause muscle atrophy. A proteomic study in muscles with reduced PABPN1 levels suggested dysregula...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74676-8
更新日期：2020-10-19 00:00:00
abstract：:Stability and integration are the goals for developing photonic devices. Spirooxazines have the property of photoinduced merocyanine-aggregation in polymer matrix, which can be applied to fluorescence emission and stable information storage. Although visible light coherent radiation with UV-assist has been used to ach...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22202-2
更新日期：2018-02-28 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00699-3
更新日期：2017-04-04 00:00:00
abstract：:Phase modulators are one of the key components of many applications in electromagnetic and opto-electric wave propagations. Phase-shifters play an integral role in communications, imaging and in coherent material excitations. In order to realize the terahertz (THz) electromagnetic spectrum as a fully-functional bandwi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38041
更新日期：2016-11-30 00:00:00
abstract：:Two of the most common nonhuman animals that interact with humans are domestic dogs (Canis familiaris) and cats (Felis catus). In contrast to dogs, the ability of domestic cats to communicate with humans has not been explored thoroughly. We used a habituation-dishabituation method to investigate whether domestic cats ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40616-4
更新日期：2019-04-04 00:00:00
abstract：:A two-dimensional electron gas (2DEG) with equal-strength Rashba and Dresselhaus spin-orbit coupling sustains persistent helical spin-wave states, which have remarkably long lifetimes. In the presence of an in-plane magnetic field, there exist single-particle excitations that have the character of propagating helical ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21818-8
更新日期：2018-02-22 00:00:00
abstract：:A new ether-based electrolyte to match lithium metal electrode is prepared by introducing 1, 4-dioxane as co-solvent into lithium bis(fluorosulfonyl)imide/1,2-dimethoxyethane solution. Under the synergetic effect of solvents and salt, this simple liquid electrolyte presents stable Li cycling with dendrite-free Li depo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21771
更新日期：2016-02-16 00:00:00
abstract：:In surface science and model catalysis, cerium oxide (ceria) is mostly grown as an ultra-thin film on a metal substrate in the ultra-high vacuum to understand fundamental mechanisms involved in diverse surface chemistry processes. However, such ultra-thin films do not have the contribution of a bulk ceria underneath, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21165
更新日期：2016-02-16 00:00:00
abstract：:Polymerized ionic liquids (polyILs) combine the unique properties of ionic liquids (ILs) with macromolecular polymers. But anion diffusivities in polyILs can be three orders of magnitude lower than that in ILs. Endeavors to improve ion transport in polyILs urgently need in-depth insights of ion transport in polyILs. A...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64689-8
更新日期：2020-05-08 00:00:00
abstract：:Oil palm (Elaeis guinensis Jacquin) is the most important source of vegetable oil and fat. Several linkage maps had been constructed using dominant and co-dominant markers to facilitate mapping of QTL. However, dominant markers are not easily transferable among different laboratories. We constructed a consensus linkag...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08232
更新日期：2015-02-04 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40687
更新日期：2017-01-13 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05808-w
更新日期：2017-07-14 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11288
更新日期：2015-06-19 00:00:00
abstract：:Familial history of hypertension is associated with autonomic dysfunction and increase in blood pressure (BP). However, an active lifestyle has been found to improve a number of health outcomes and reduce all-cause mortality. The aim of the present study was to investigate the effects of an active lifestyle on hemodyn...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69104-w
更新日期：2020-07-24 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05871
更新日期：2014-07-29 00:00:00
abstract：:We design an optical scheme to generate hyperentanglement correlated with degrees of freedom (DOFs) via quantum dots (QDs), weak cross-Kerr nonlinearities (XKNLs), and linearly optical apparatuses (including time-bin encoders). For generating hyperentanglement having its own correlations for two DOFs (polarization and...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19970-2
更新日期：2018-02-07 00:00:00
abstract：:Microstructures in nature are ultrafine and ordered in biological roles, which have attracted material scientists. Spirulina forms three-dimensional helical microstructure, one of remarkable features in nature beyond our current processing technology such as lithography in terms of mass-productivity and structural mul...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04919
更新日期：2014-05-12 00:00:00
abstract：:Mountain ecosystems serve as sentinels of change, and those in the Canadian Rocky Mountains have undergone a pronounced shift over the past century. We present quantitative analyses of 81 high-resolution image pairs of systematic historic surveys and repeat photographs of Canadian Rocky Mountain habitats, measuring tr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66277-2
更新日期：2020-06-16 00:00:00
abstract：:The role of soil organic carbon in global carbon cycles is receiving increasing attention both as a potentially large and uncertain source of CO2 emissions in response to predicted global temperature rises, and as a natural sink for carbon able to reduce atmospheric CO2. There is general agreement that the technical p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15794-8
更新日期：2017-11-14 00:00:00
abstract：:Cold agglutinin disease (CAD) is a rare form of autoimmune haemolytic anaemia, and because of its rareness, there is no standard treatment for CAD patients. We retrospectively analysed the response to rituximab-containing therapy in CAD patients at our hospital. All patients received rituximab-containing therapy for a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69465-2
更新日期：2020-07-29 00:00:00
abstract：:To investigate the influence of chemical weathering on CO2 consumption, an analysis was performed of water chemistry by applying water chemistry equilibria methods in the Bishuiyan subterranean basin, SW China. The average value of total ion concentrations (TZ+) was 1,854.97 μEq/L, which was significantly higher than ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68572-4
更新日期：2020-07-15 00:00:00
abstract：:During development sex differences in aromatase expression in limbic regions of mouse brain depend on sex chromosome factors. Genes on the sex chromosomes may affect the hormonal regulation of aromatase expression and this study was undertaken to explore that possibility. Male E15 anterior amygdala neuronal cultures e...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05658-6
更新日期：2017-07-13 00:00:00
abstract：:Influenza viruses are among the most common pathogens that threaten the health of humans and animals worldwide. Various anti-viral therapeutic agents are currently used for treatment and prophylaxis of influenza virus, but the targets of these drugs are easily mutated and result in resistance. Therefore, medications t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29684
更新日期：2016-07-11 00:00:00
abstract：:Skin malignant melanoma is a highly angiogenic cancer, necessitating early diagnosis for positive prognosis. The current diagnostic standard of biopsy and histological examination inevitably leads to many unnecessary invasive excisions. Here, we propose a non-invasive method of identification of melanoma based on bloo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12825
更新日期：2015-08-11 00:00:00
abstract：:Accurate alignment of an intraocular lens (IOL) is indispensable for achieving accurate postoperative refractive outcomes. Thus, we evaluated decentration and tilt of single- and three-piece IOLs, as well as anterior chamber depth (ACD), at 3 hours, 24 hours, 2 weeks, and 4 weeks after cataract surgery, using swept-so...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-018-28609-1
更新日期：2018-07-06 00:00:00
abstract：:How chromosomes fold into 3D structures and how genome functions are affected or even controlled by their spatial organization remain challenging questions. Hi-C experiment has provided important structural insights for chromosome, and Hi-C data are used here to construct the 3D chromatin structure which are character...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02923-6
更新日期：2017-06-06 00:00:00
