Abstract：
:This study presents, attenuated total reflection Fourier transforms infrared spectroscopy of dried serum samples in an effort to assess biochemical changes induced by non-Hodgkin's lymphoma and subcutaneous melanoma. An EL4 mouse model of non-Hodgkin lymphoma and a B16 mouse model of subcutaneous melanoma are used to extract a snapshot of tumor-associated alteration in the serum. The study of both cancer-bearing mouse models in wild types and their corresponding control types, emphasizes the diagnostic potential of this approach as a screening technique for non-Hodgkin lymphoma and melanoma skin cancer. Infrared absorbance values of the different spectral bands, hierarchical clustering and integral values of the component bands by curve fitting, show statistically significant differences (student's t-test, two-tailed unequal variance p-value < 0.05) between spectra representing healthy and tumorous mouse. This technique may thus be useful for having individualized route maps for rapid evaluation of lymphoma and melanoma status and associated therapeutic modalities.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ghimire H,Venkataramani M,Bian Z,Liu Y,Perera AGUdoi
10.1038/s41598-017-17027-4subject
Has Abstractpub_date
2017-12-05 00:00:00pages
16993issue
1issn
2045-2322pii
10.1038/s41598-017-17027-4journal_volume
7pub_type
杂志文章abstract：:Mitochondria are key cellular signaling platforms, affecting fundamental processes such as cell proliferation, differentiation and death. However, it remains unclear how mitochondrial signaling affects other organelles, particularly lysosomes. Here, we demonstrate that mitochondrial respiratory chain (RC) impairments ...
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pub_type： 杂志文章
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abstract：:The influenza A virus RNA polymerase cleaves the 5' end of host pre-mRNAs and uses the capped RNA fragments as primers for viral mRNA synthesis. We performed deep sequencing of the 5' ends of viral mRNAs from all genome segments transcribed in both human (A549) and mouse (M-1) cells infected with the influenza A/HongK...
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journal_title：Scientific reports
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pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2020-07-16 00:00:00
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pub_type： 临床试验,杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2014-08-26 00:00:00
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更新日期：2015-12-07 00:00:00
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更新日期：2015-05-08 00:00:00
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journal_title：Scientific reports
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