当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Altered Insulin/Insulin-Like Growth Factor Signaling in a Comorbid Rat model of Ischemia and β-Amyloid Toxicity.

Altered Insulin/Insulin-Like Growth Factor Signaling in a Comorbid Rat model of Ischemia and β-Amyloid Toxicity.

Abstract：

:Ischemic stroke and diabetes are vascular risk factors for the development of impaired memory such as dementia and/or Alzheimer's disease. Clinical studies have demonstrated that minor striatal ischemic lesions in combination with β-amyloid (Aβ) load are critical in generating cognitive deficits. These cognitive deficits are likely to be associated with impaired insulin signaling. In this study, we examined the histological presence of insulin-like growth factor-I (IGF-1) and insulin receptor substrate (IRS-1) in anatomically distinct brain circuits compared with morphological brain damage in a co-morbid rat model of striatal ischemia (ET1) and Aβ toxicity. The results demonstrated a rapid increase in the presence of IGF-1 and IRS-1 immunoreactive cells in Aβ + ET1 rats, mainly in the ipsilateral striatum and distant regions with synaptic links to the striatal lesion. These regions included subcortical white matter, motor cortex, thalamus, dentate gyrus, septohippocampal nucleus, periventricular region and horizontal diagonal band of Broca in the basal forebrain. The alteration in IGF-1 and IRS-1 presence induced by ET1 or Aβ rats alone was not severe enough to affect the entire brain circuit. Understanding the causal or etiologic interaction between insulin and IGF signaling and co-morbidity after ischemia and Aβ toxicity will help design more effective therapeutics.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Amtul Z,Hill DJ,Arany EJ,Cechetto DF

doi

10.1038/s41598-018-22985-4

subject

Has Abstract

pub_date

2018-03-23 00:00:00

pages

5136

issue

1

issn

2045-2322

pii

10.1038/s41598-018-22985-4

journal_volume

8

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Acoustic micro-tapping for non-contact 4D imaging of tissue elasticity.

    abstract：:Elastography plays a key role in characterizing soft media such as biological tissue. Although this technology has found widespread use in both clinical diagnostics and basic science research, nearly all methods require direct physical contact with the object of interest and can even be invasive. For a number of appli...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep38967

    authors： Ambroziński Ł,Song S,Yoon SJ,Pelivanov I,Li D,Gao L,Shen TT,Wang RK,O'Donnell M

    更新日期：2016-12-23 00:00:00

  • A novel dry-bonding approach to reduce collagen degradation and optimize resin-dentin interfaces.

    abstract：:In dentistry, the wet-bonding approach relies on water to maintain demineralized collagen expanded for proper resin infiltration; nevertheless, hydrolytic instability of the resin-dentin interface is inevitable with current bonding techniques. Considering dimethyl sulfoxide's (DMSO) ability to "biomodify" collagen and...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-34726-8

    authors： Stape THS,Seseogullari-Dirihan R,Tjäderhane L,Abuna G,Martins LRM,Tezvergil-Mutluay A

    更新日期：2018-11-15 00:00:00

  • Clostridium difficile: New Insights into the Evolution of the Pathogenicity Locus.

    abstract：:The major virulence factors of Clostridium difficile are toxins A and B. These toxins are encoded by tcdA and tcdB genes, which form a pathogenicity locus (PaLoc) together with three additional genes that have been implicated in regulation (tcdR and tcdC) and secretion (tcdE). To date, the PaLoc has always been found ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep15023

    authors： Monot M,Eckert C,Lemire A,Hamiot A,Dubois T,Tessier C,Dumoulard B,Hamel B,Petit A,Lalande V,Ma L,Bouchier C,Barbut F,Dupuy B

    更新日期：2015-10-08 00:00:00

  • Author Correction: Methods for Scarless, Selection-Free Generation of Human Cells and Allele-Specific Functional Analysis of Disease-Associated SNPs and Variants of Uncertain Significance.

    abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-018-24098-4

    authors： Coggins NB,Stultz J,O'Geen H,Carvajal-Carmona LG,Segal DJ

    更新日期：2018-04-12 00:00:00

  • Differential incorporation of one-carbon substrates among microbial populations identified by stable isotope probing from the estuary to South China Sea.

    abstract：:Methanol (MOH) and monomethylamine (MMA) are two typical one-carbon (C1) compounds found in natural environments. They play an important role in marine and atmospheric chemistry, cloud formation, and global climate. The main biological sink of MOH and MMA is rapid consumption by marine microbes. Here, field-based time...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-33497-6

    authors： Deng W,Peng L,Jiao N,Zhang Y

    更新日期：2018-10-18 00:00:00

  • Multiplex quantitative analysis of microRNA expression via exponential isothermal amplification and conformation-sensitive DNA separation.

    abstract：:Expression profiling of multiple microRNAs (miRNAs) generally provides valuable information for understanding various biological processes. Thus, it is necessary to develop a sensitive and accurate miRNA assay suitable for multiplexing. Isothermal exponential amplification reaction (EXPAR) has received significant int...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-11895-6

    authors： Na J,Shin GW,Son HG,Lee SV,Jung GY

    更新日期：2017-09-12 00:00:00

  • The selective reversible FAAH inhibitor, SSR411298, restores the development of maladaptive behaviors to acute and chronic stress in rodents.

    abstract：:Enhancing endogenous cannabinoid (eCB) signaling has been considered as a potential strategy for the treatment of stress-related conditions. Fatty acid amide hydrolase (FAAH) represents the primary degradation enzyme of the eCB anandamide (AEA), oleoylethanolamide (OEA) and palmitoylethanolamide (PEA). This study desc...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-20895-z

    authors： Griebel G,Stemmelin J,Lopez-Grancha M,Fauchey V,Slowinski F,Pichat P,Dargazanli G,Abouabdellah A,Cohen C,Bergis OE

    更新日期：2018-02-05 00:00:00

  • Low immunogenic endothelial cells endothelialize the Left Ventricular Assist Device.

    abstract：:Low haemocompatibility of left ventricular assist devices (LVAD) surfaces necessitates anticoagulative therapy. Endothelial cell (EC) seeding can support haemocompatibility, however, the availability of autologous ECs is limited. In contrast, allogeneic ECs are readily available in sufficient quantity, but HLA dispari...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-47780-7

    authors： Figueiredo C,Eicke D,Yuzefovych Y,Avsar M,Hanke JS,Pflaum M,Schmitto JD,Blasczyk R,Haverich A,Wiegmann B

    更新日期：2019-08-05 00:00:00

  • The catalytic activity and secretion of zebrafish RNases are essential for their in vivo function in motor neurons and vasculature.

    abstract：:Angiogenin (hANG), a member of the Ribonuclease A superfamily has angiogenic, neurotrophic and neuroprotective activities. Mutations in hANG have been found in patients with Amyotrophic lateral sclerosis (ALS). The zebrafish (Danio rerio) rnasel-1, 2 and 3 are orthologues of hANG and of these only Rnasel-1 and Rnasel-...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-37140-2

    authors： Ferguson R,Holloway DE,Chandrasekhar A,Acharya KR,Subramanian V

    更新日期：2019-02-01 00:00:00

  • Early weaning increases aggression and stereotypic behaviour in cats.

    abstract：:Behaviour problems are common in companion felines, and problematic behaviour may be a sign of chronic stress. In laboratory animals, early weaning increases the risk for aggression, anxiety, and stereotypic behaviour. However, very few studies have focused on early weaning in one of the world's most popular pets, the...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-11173-5

    authors： Ahola MK,Vapalahti K,Lohi H

    更新日期：2017-09-04 00:00:00

  • Phytochemical characterization and comparative studies of four Cecropia species collected in Panama using multivariate data analysis.

    abstract：:Plant species of the genus Cecropia (Urticaceae) are used as traditional medicine in Latin-America, and are commercially available as food supplements. The aim of this study was to characterize and compare the phytochemical constituents of four Cecropia species collected in Panama. The structures of 11 compounds isola...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-38334-4

    authors： Rivera-Mondragón A,Bijttebier S,Tuenter E,Custers D,Ortíz OO,Pieters L,Caballero-George C,Apers S,Foubert K

    更新日期：2019-02-11 00:00:00

  • A mask R-CNN model for reidentifying extratropical cyclones based on quasi-supervised thought.

    abstract：:The applications of machine learning/deep learning (ML/DL) methods in meteorology have developed considerably in recent years. Massive amounts of meteorological data are conducive to improving the training effect and model performance of ML/DL, but the establishment of training datasets is often time consuming, especi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-71831-z

    authors： Lu C,Kong Y,Guan Z

    更新日期：2020-09-14 00:00:00

  • Two Bombyx mori acetylcholinesterase genes influence motor control and development in different ways.

    abstract：:Among its other biological roles, acetylcholinesterase (AChE, EC 3.1.1.7), encoded by two ace in most insects, catalyses the breakdown of acetylcholine, thereby terminating synaptic transmission. ace1 encodes the synaptic enzyme and ace2 has other essential actions in many insect species, such as Chilo suppressalis an...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-05360-7

    authors： Ye X,Yang L,Stanley D,Li F,Fang Q

    更新日期：2017-07-10 00:00:00

  • Author Correction: Reply to 'Sigmoidal Acquisition Curves are Good Indicators of Conformist Transmission'.

    abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-019-40288-0

    authors： Acerbi A,van Leeuwen EJC,Haun DBM,Tennie C

    更新日期：2019-04-17 00:00:00

  • Anticancer effects of epigallocatechin-3-gallate nanoemulsion on lung cancer cells through the activation of AMP-activated protein kinase signaling pathway.

    abstract：:Epigallocatechin-3-gallate (EGCG), a green tea-derived polyphenol, exhibits antitumor activities. An EGCG nanoemulsion (nano-EGCG) was prepared to improve the stability and reduce the side effects of EGCG for treatment of human lung cancer cells, and the antitumor effects were studied. The possible molecular mechanism...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-62136-2

    authors： Chen BH,Hsieh CH,Tsai SY,Wang CY,Wang CC

    更新日期：2020-03-20 00:00:00

  • Predicting protein thermal stability changes upon point mutations using statistical potentials: Introducing HoTMuSiC.

    abstract：:The accurate prediction of the impact of an amino acid substitution on the thermal stability of a protein is a central issue in protein science, and is of key relevance for the rational optimization of various bioprocesses that use enzymes in unusual conditions. Here we present one of the first computational tools to ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep23257

    authors： Pucci F,Bourgeas R,Rooman M

    更新日期：2016-03-18 00:00:00

  • Heavy metal contamination in the surface sediments of representative limnetic ecosystems in eastern China.

    abstract：:A comprehensive analysis of heavy metal pollution was conducted in the representative limnetic ecosystems of eastern China, which are subject to rapid economic development and population growth. The results demonstrated that the average contents with standard deviations of Cd, Cr, Cu, Ni, Pb and Zn in the surface sedi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep07152

    authors： Tang W,Shan B,Zhang H,Zhang W,Zhao Y,Ding Y,Rong N,Zhu X

    更新日期：2014-11-21 00:00:00

  • Environmental regulations, green innovation and intelligent upgrading of manufacturing enterprises: evidence from China.

    abstract：:Intelligent development is an inevitable choice for the green development of manufacturing enterprises, environmental regulations and green innovation play an important role in the intelligent development of manufacturing enterprises. By analyzing the interrelationships between environmental regulations, green innovat...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-71423-x

    authors： Meng F,Xu Y,Zhao G

    更新日期：2020-09-02 00:00:00

  • Landscape of the spliced leader trans-splicing mechanism in Schistosoma mansoni.

    abstract：:Spliced leader dependent trans-splicing (SLTS) has been described as an important RNA regulatory process that occurs in different organisms, including the trematode Schistosoma mansoni. We identified more than seven thousand putative SLTS sites in the parasite, comprising genes with a wide spectrum of functional class...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-22093-3

    authors： Boroni M,Sammeth M,Gava SG,Jorge NAN,Macedo AM,Machado CR,Mourão MM,Franco GR

    更新日期：2018-03-01 00:00:00

  • A statistical description of scattering at the quantum level.

    abstract：:Quantum physics is undoubtedly the most successful theory of the microscopic world, yet the complexities which arise in applying it even to simple atomic and molecular systems render the description of basic collision probabilities a formidable task. For this reason, approximations are often employed, the validity of ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-33425-8

    authors： Laricchia G,Van Reeth P,Fayer SE,Brawley SJ,Kadokura R,Loreti A,Shipman M

    更新日期：2018-10-10 00:00:00

  • Identifying priority conservation areas in a Saharan environment by highlighting the endangered Cuvier's Gazelle as a flagship species.

    abstract：:Monitoring populations and designing effective conservation actions for endangered species present significant challenges. An accurate understanding of current distribution, ecological traits and habitat requirements is imperative in formulating conservation strategies. Recent surveys on the southernmost Cuvier's Gaze...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-65188-6

    authors： Herrera-Sánchez FJ,Gil-Sánchez JM,Álvarez B,Cancio I,de Lucas J,Arredondo Á,Díaz-Portero MÁ,Rodríguez-Siles J,Sáez JM,Pérez J,McCain E,Qninba A,Abáigar T

    更新日期：2020-05-19 00:00:00

  • p53 functional states are associated with distinct aldehyde dehydrogenase transcriptomic signatures.

    abstract：:p53 and aldehyde dehydrogenase (ALDH) have been implicated in key tumorigenesis processes including cancer initiating cell (CIC) maintenance; however, the relationship between these two mediators remains poorly defined. In this study, ALDH isoform expression diversity was revealed in CICs with disparate p53 functional...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-57758-5

    authors： Gui S,Xie X,O'Neill WQ,Chatfield-Reed K,Yu JG,Teknos TN,Pan Q

    更新日期：2020-01-23 00:00:00

  • Accurate dating of stalagmites from low seasonal contrast tropical Pacific climate using Sr 2D maps, fabrics and annual hydrological cycles.

    abstract：:Tropical Pacific stalagmites are commonly affected by dating uncertainties because of their low U concentration and/or elevated initial 230Th content. This poses problems in establishing reliable trends and periodicities for droughts and pluvial episodes in a region vulnerable to climate change. Here we constrain the ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-021-81941-x

    authors： Faraji M,Borsato A,Frisia S,Hellstrom JC,Lorrey A,Hartland A,Greig A,Mattey DP

    更新日期：2021-01-26 00:00:00

  • Superoxide dismutase down-regulation and the oxidative stress is required to initiate pupation in Bombyx mori.

    abstract：:Perhaps, oxidative stress progresses pupation in some Lepidopteran insects; however, the reasons for this remain obscure. In our previous study, we clarified Bombyx mori SOD1 (BmSOD1) and B. mori SOD2 (BmSOD2) proteins respond in common to ultraviolet irradiation (UV) oxidative stress and metamorphosis. This result st...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-51163-3

    authors： Nojima Y,Bono H,Yokoyama T,Iwabuchi K,Sato R,Arai K,Tabunoki H

    更新日期：2019-10-11 00:00:00

  • CD8+ T cells specific for the islet autoantigen IGRP are restricted in their T cell receptor chain usage.

    abstract：:CD8+ T cells directed against beta cell autoantigens are considered relevant for the pathogenesis of type 1 diabetes. Using single cell T cell receptor sequencing of CD8+ T cells specific for the IGRP265-273 epitope, we examined whether there was expansion of clonotypes and sharing of T cell receptor chains in autorea...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep44661

    authors： Fuchs YF,Eugster A,Dietz S,Sebelefsky C,Kühn D,Wilhelm C,Lindner A,Gavrisan A,Knoop J,Dahl A,Ziegler AG,Bonifacio E

    更新日期：2017-03-16 00:00:00

  • Systemic treatment of patients with metachronous peritoneal carcinomatosis of colorectal origin.

    abstract：:Combining chemotherapy and targeted therapies has resulted in an enhanced survival in metastatic colorectal cancer (mCRC) patients. However, the result of this palliative treatment in patients with metachronous peritoneal carcinomatosis (PC) remains unknown. The current population-based study aims to investigate the u...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep18632

    authors： van Oudheusden TR,Razenberg LG,van Gestel YR,Creemers GJ,Lemmens VE,de Hingh IH

    更新日期：2015-12-21 00:00:00

  • The pervasiveness and policy consequences of medical folk wisdom in the U.S.

    abstract：:Medical folk wisdom (MFW) refers to widely held, but factually inaccurate, beliefs about disease, immunity, pregnancy, and other medically-relevant topics. Examples include the idea that fasting when feverish ("starving a fever") can increase the pace of recovery, or that showering after sex can prevent pregnancy. The...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-67744-6

    authors： Motta M,Callaghan T

    更新日期：2020-07-01 00:00:00

  • N-acetylaspartate reduction in the medial prefrontal cortex following 8 weeks of risperidone treatment in first-episode drug-naïve schizophrenia patients.

    abstract：:It is unclear whether N-acetylaspartate (NAA) depletions documented in schizophrenia patients might be due to the disease progression or medications. Here we investigated longitudinal NAA changes in drug-naïve first-episode patients (FEP) who are relatively free from chronicity. Forty-two drug-naïve FEP and 38 control...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep09109

    authors： Zong X,Hu M,Li Z,Cao H,He Y,Liao Y,Zhou J,Sang D,Zhao H,Tang J,Lv L,Chen X

    更新日期：2015-03-16 00:00:00

  • The Evolution of Covert Signaling.

    abstract：:Human sociality depends upon the benefits of mutual aid and extensive communication. However, diverse norms and preferences complicate mutual aid, and ambiguity in meaning hinders communication. Here we demonstrate that these two problems can work together to enhance cooperation through the strategic use of deliberate...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-22926-1

    authors： Smaldino PE,Flamson TJ,McElreath R

    更新日期：2018-03-20 00:00:00

  • Comparison of multi echo T2 relaxation and steady state approaches for myelin imaging in the central nervous system.

    abstract：:The traditional approach for measuring myelin-associated water with quantitative magnetic resonance imaging (MRI) uses multi-echo T2 relaxation data to calculate the myelin water fraction (MWF). A fundamentally different approach, abbreviated "mcDESPOT", uses a more efficient steady-state acquisition to generate an eq...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-80585-7

    authors： Dvorak AV,Ljungberg E,Vavasour IM,Lee LE,Abel S,Li DKB,Traboulsee A,MacKay AL,Kolind SH

    更新日期：2021-01-14 00:00:00