Phytochemical characterization and comparative studies of four Cecropia species collected in Panama using multivariate data analysis.

abstract：:Investigation of protein-DNA interactions provides crucial information for understanding the mechanisms of gene regulation. Current methods for studying protein-DNA interactions, such as DNaseI footprinting or gel shift assays, involve labeling DNA with radioactive or fluorescent tags, making these methods costly, lab...

journal_title：Scientific reports

authors： Xie Y,Zhang Y,Zhao X,Liu YG,Chen L

更新日期：2016-02-15 00:00:00

abstract：:Myopia is the commonest eye disorder in the world. High myopes are predisposed to ocular pathologies. The vasoactive intestinal peptide receptor 2 (VIPR2) gene was identified as a myopia susceptibility locus by our group and another group. We continued to fine-map this locus. A case-control study was performed in 4 se...

journal_title：Scientific reports

authors： Leung KH,Luo S,Kwarteng R,Chen SG,Yap MKH,Huang CL,Yip SP

更新日期：2019-12-03 00:00:00

abstract：:Hepatic metabolic stability is a key pharmacokinetic parameter in drug discovery. Metabolic stability is usually assessed in microsomal fractions and only the best compounds progress in the drug discovery process. A high-throughput single time point substrate depletion assay in rat liver microsomes (RLM) is employed a...

journal_title：Scientific reports

authors： Siramshetty VB,Shah P,Kerns E,Nguyen K,Yu KR,Kabir M,Williams J,Neyra J,Southall N,Nguyễn ÐT,Xu X

更新日期：2020-11-26 00:00:00

abstract：:This study aimed to determine the clinicopathological features of the subtypes of ampullary carcinoma (AC) to explore the indications for endoscopic papillectomy (EP) in early AC. Fifty-seven patients with AC who underwent curative resection were retrospectively reviewed. The 0/IA stages were significantly more common...

journal_title：Scientific reports

authors： Yamamoto K,Itoi T,Nagata N,Sofuni A,Tsuchiya T,Ishii K,Tanaka R,Tonozuka R,Honjo M,Mukai S,Asai Y,Matsunami Y,Yamaguchi H,Matsubayashi J,Joyama E,Nagakawa Y

更新日期：2021-01-12 00:00:00

abstract：:Cells operate in noisy molecular environments via complex regulatory networks. It is possible to understand how molecular counts are related to noise in specific networks, but it is not generally clear how noise relates to network complexity, because different levels of complexity also imply different overall number o...

journal_title：Scientific reports

authors： Cardelli L,Csikász-Nagy A,Dalchau N,Tribastone M,Tschaikowski M

更新日期：2016-02-08 00:00:00

abstract：:Oligomannose-type glycans on HIV-1 gp120 form a patch that is targeted by several broadly neutralizing antibodies (bnAbs) and that therefore is of interest to vaccine design. However, attempts to elicit similar oligomannose-specific bnAbs by immunizing with oligomannosidic glycoconjugates have only been modestly succe...

journal_title：Scientific reports

authors： Bruxelle JF,Kirilenko T,Qureshi Q,Lu N,Trattnig N,Kosma P,Pantophlet R

更新日期：2020-05-05 00:00:00

abstract：:Ubiquitylation is a protein modification implicated in several cellular processes. This process is reversible by the action of deubiquinating enzymes (DUBs). USP45 is a ubiquitin specific protease about which little is known, aside from roles in DNA damage repair and differentiation of the vertebrate retina. Here, by ...

journal_title：Scientific reports

authors： Conte C,Griffis ER,Hickson I,Perez-Oliva AB

更新日期：2018-09-26 00:00:00

abstract：:Ulcerative colitis (UC) is a chronic relapsing-remitting form of inflammatory bowel disease (IBD) that increases the risk of colorectal cancer, the third most common malignancy in humans. Oxidative stress is a risk factor for the development of UC. The Keap1-Nrf2-ARE pathway is one of the most important defensive mech...

journal_title：Scientific reports

authors： Lu MC,Ji JA,Jiang YL,Chen ZY,Yuan ZW,You QD,Jiang ZY

更新日期：2016-05-24 00:00:00

abstract：:This work presents a method of grouping the electron spinors and the phonon modes of metal oxide crystals such as vanadium dioxide into an SU(2) gauge theory. The gauge "charge" is the electron spin, which is assumed to couple to the transverse acoustic phonons on the basis of spin ordering phenomena in [Formula: see ...

journal_title：Scientific reports

authors： Booth JM,Russo SP

更新日期：2020-07-27 00:00:00

abstract：:Although biophysical yield responses to local warming have been studied, we know little about how crop yield growth-a function of climate and technology-responds to global temperature and socioeconomic changes. Here, we present the yield growth of major crops under warming conditions from preindustrial levels as simul...

journal_title：Scientific reports

authors： Iizumi T,Furuya J,Shen Z,Kim W,Okada M,Fujimori S,Hasegawa T,Nishimori M

更新日期：2017-08-10 00:00:00

abstract：:Trimethylamine-N-Oxide (TMAO) is a microbiome-related metabolite that is cleared by the kidney and linked to renal function. We explored the relationship between TMAO and all-cause mortality, and determined whether this association was modified by renal function. A prospective study was performed among PREVEND partici...

journal_title：Scientific reports

authors： Gruppen EG,Garcia E,Connelly MA,Jeyarajah EJ,Otvos JD,Bakker SJL,Dullaart RPF

更新日期：2017-10-23 00:00:00

abstract：:Bacteriophage T7 is an intracellular parasite that recognizes its host via its tail and tail fiber proteins, known as receptor-binding proteins (RBPs). The RBPs attach to specific lipopolysaccharide (LPS) features on the host. Various studies have shown expansion of the phage's host range via mutations in the genes en...

journal_title：Scientific reports

authors： Holtzman T,Globus R,Molshanski-Mor S,Ben-Shem A,Yosef I,Qimron U

更新日期：2020-01-15 00:00:00

abstract：:Kelp forests are in decline globally and large-scale intervention could be required to halt the loss of these valuable ecosystems. To date kelp forest restoration has had limited success and been expensive and unable to address the increasing scale of ecosystem deterioration. Here we developed and tested a new approac...

journal_title：Scientific reports

authors： Fredriksen S,Filbee-Dexter K,Norderhaug KM,Steen H,Bodvin T,Coleman MA,Moy F,Wernberg T

更新日期：2020-03-04 00:00:00

abstract：:Ultra-fast synchrotron radiation emission can arise from the transverse betatron motion of an electron in a laser plasma wakefield, and the radiation spectral peak is limited to tens of keV. Here, we present a new method for achieving high-energy radiation via accelerated electrons wiggling in an additional laser fiel...

journal_title：Scientific reports

authors： Feng J,Li Y,Wang J,Li D,Li F,Yan W,Wang W,Chen L

更新日期：2019-02-21 00:00:00

abstract：:Chronic inflammation can be a major driver of the failure of a variety of organs, including chronic kidney disease (CKD). The NLR family pyrin domain-containing 3 (NLRP3) inflammasome has been shown to play a pivotal role in inflammation in a mouse kidney disease model. Nuclear factor erythroid 2-related factor 2 (Nrf...

journal_title：Scientific reports

authors： Sogawa Y,Nagasu H,Iwase S,Ihoriya C,Itano S,Uchida A,Kidokoro K,Taniguchi S,Takahashi M,Satoh M,Sasaki T,Suzuki T,Yamamoto M,Horng T,Kashihara N

更新日期：2017-08-18 00:00:00

abstract：:In this study, a noninvasive quantitative measure was used to identify short and long term post-concussion syndrome (PCS) both from each other and from healthy control populations. We used Electrovestibulography (EVestG) for detecting neurophysiological PCS consequent to a mild traumatic brain injury (mTBI) in both sh...

journal_title：Scientific reports

authors： Suleiman A,Lithgow B,Dastgheib Z,Mansouri B,Moussavi Z

更新日期：2017-11-27 00:00:00

abstract：:Metastasis suppressor genes (MS genes) are genes that play important roles in inhibiting the process of cancer metastasis without preventing growth of the primary tumor. Identification of these genes and understanding their functions are critical for investigation of cancer metastasis. Recent studies on cancer metasta...

journal_title：Scientific reports

authors： Zhao M,Li Z,Qu H

更新日期：2015-10-21 00:00:00

abstract：:The anuran amphibian Xenopus laevis can regenerate its limbs for a limited time during the larval stage, while limbs are still developing. Using this regeneration model, we evaluated the proximo-distal blastema cell identity when endogenous retinoids were increased by CYP26 inhibition or when RAR-specific agonists alt...

journal_title：Scientific reports

authors： Cuervo R,Chimal-Monroy J

更新日期：2013-01-01 00:00:00

abstract：:We report the molecular basis of the largest Tunisian cohort with inherited retinal dystrophies (IRD) reported to date, identify disease-causing pathogenic variants and describe genotype-phenotype correlations. A subset of 26 families from a cohort of 73 families with clinical diagnosis of autosomal recessive IRD (AR-...

journal_title：Scientific reports

authors： Habibi I,Falfoul Y,Turki A,Hassairi A,El Matri K,Chebil A,Schorderet DF,El Matri L

更新日期：2020-07-08 00:00:00

abstract：:Alignment-free methods, in which shared properties of sub-sequences (e.g. identity or match length) are extracted and used to compute a distance matrix, have recently been explored for phylogenetic inference. However, the scalability and robustness of these methods to key evolutionary processes remain to be investigat...

journal_title：Scientific reports

authors： Chan CX,Bernard G,Poirion O,Hogan JM,Ragan MA

更新日期：2014-09-30 00:00:00

abstract：:We recently reported a greater sensitivity of female rats to rapid antidepressant-like effects of ketamine compared to male rats, and that ovarian-derived estradiol (E2) and progesterone (P4) are essential for this response. However, to what extent testosterone may also contribute, and whether duration of response to ...

journal_title：Scientific reports

authors： Saland SK,Schoepfer KJ,Kabbaj M

更新日期：2016-02-18 00:00:00

abstract：:Both Shewanella oneidensis MR-1 wild type and its mutant ΔomcA/mtrC are capable of transforming Au(III) into Au nanoparticles (AuNPs). Cyclic voltammetry reveals a decrease in redox current after the wild type is exposed to Au(III) but an increase in oxidation current for the mutant. The peak current of the wild type ...

journal_title：Scientific reports

authors： Wu R,Cui L,Chen L,Wang C,Cao C,Sheng G,Yu H,Zhao F

更新日期：2013-11-22 00:00:00

abstract：:Osteoarthritis (OA) is a chronic degenerative joint disease and a major health problem in the elderly population. No disease-modifying osteoarthritis drug (DMOAD) has been made available for clinical use. Here we present a disease-modifying strategy for OA, focusing on messenger RNA (mRNA) delivery of a therapeutic tr...

journal_title：Scientific reports

authors： Aini H,Itaka K,Fujisawa A,Uchida H,Uchida S,Fukushima S,Kataoka K,Saito T,Chung UI,Ohba S

更新日期：2016-01-05 00:00:00

abstract：:Drug addiction remains a prevalent and fatal disease worldwide that carries significant social and economic impacts. Recent reports suggest illicit pregabalin (Lyrica) use may be increasing among youth, however the addictive potential of pregabalin has not been well established. Drug seeking behavior and chronic drug ...

journal_title：Scientific reports

authors： Althobaiti YS,Almalki A,Alsaab H,Alsanie W,Gaber A,Alhadidi Q,Hardy AMG,Nasr A,Alzahrani O,Stary CM,Shah ZA

更新日期：2019-10-22 00:00:00

abstract：:Japan has often been viewed as an Asian country that possesses a genetically homogenous community. The basis for partitioning the country into prefectures has largely been geographical, although cultural and linguistic differences still exist between some of the districts/prefectures, especially between Okinawa and th...

journal_title：Scientific reports

authors： Saw WY,Liu X,Khor CC,Takeuchi F,Katsuya T,Kimura R,Nabika T,Ohkubo T,Tabara Y,Yamamoto K,Yokota M,Japanese Genome Variation Consortium.,Teo YY,Kato N

更新日期：2015-12-09 00:00:00

abstract：:Assessment of colonic motor dysfunction is rarely done because of inadequate methodology and lack of knowledge about normal motor patterns. Here we report on elucidation of intraluminal pressure patterns using High Resolution Colonic Manometry during a baseline period and in response to a meal, in 15 patients with con...

journal_title：Scientific reports

authors： Chen JH,Yu Y,Yang Z,Yu WZ,Chen WL,Yu H,Kim MJ,Huang M,Tan S,Luo H,Chen J,Chen JD,Huizinga JD

更新日期：2017-02-20 00:00:00

abstract：:Age and sleep both affect emotional functioning. Since sleep patterns change over the lifespan, we investigated the effects of short sleep and age on empathic responses. In a randomized cross-over experimental design, healthy young and older volunteers (n = 47 aged 20-30 years and n = 39 aged 65-75 years) underwent fu...

journal_title：Scientific reports

authors： Tamm S,Nilsonne G,Schwarz J,Lamm C,Kecklund G,Petrovic P,Fischer H,Åkerstedt T,Lekander M

更新日期：2017-09-25 00:00:00

abstract：:Proteins involved in genetic stability maintenance and safeguarding DNA replication act not only against cancer initiation but could also play a major role in sustaining cancer progression. Here, we report that the FANC pathway is highly expressed in metastatic melanoma harboring the oncogenic microphthalmia-associate...

journal_title：Scientific reports

authors： Bourseguin J,Bonet C,Renaud E,Pandiani C,Boncompagni M,Giuliano S,Pawlikowska P,Karmous-Benailly H,Ballotti R,Rosselli F,Bertolotto C

更新日期：2016-11-09 00:00:00

abstract：:Adult stem cells divide to renew the stem cell pool and replenish specialized cells that are lost due to death or usage. However, little is known about the mechanisms regulating how stem cells adjust to a demand for specialized cells. A failure of the stem cells to respond to this demand can have serious consequences,...

journal_title：Scientific reports

authors： Malpe MS,McSwain LF,Kudyba K,Ng CL,Nicholson J,Brady M,Qian Y,Choksi V,Hudson AG,Parrott BB,Schulz C

更新日期：2020-03-03 00:00:00

abstract：:Aluminium alloys are re-evaluated as most feasible way to satisfy the industrial needs of light-weight structural materials. However, unlike conventional structural metals such as iron and titanium, aluminium does not have easily accessible secondary phases, which means that aluminium-based alloys cannot be strengthen...

journal_title：Scientific reports

authors： Tsuru T,Shimizu K,Yamaguchi M,Itakura M,Ebihara K,Bendo A,Matsuda K,Toda H

更新日期：2020-04-06 00:00:00