Retrospective assessment of rat liver microsomal stability at NCATS: data and QSAR models.

abstract：:We propose and experimentally demonstrate real-time locating and speed measurement of fibre fuse by analysing the Doppler shift of reflected light using optical frequency-domain reflectometry (OFDR). Our method can detect the start of a fibre fuse within 200 ms which is equivalent to a propagation distance of about 10...

journal_title：Scientific reports

authors： Jiang S,Ma L,Fan X,Wang B,He Z

更新日期：2016-05-05 00:00:00

abstract：:Cell sorting via flow cytometry is a powerful tool to select subpopulations of cells in many biological fields. Selection of fertilisation-prone sperm is a critical step to ensure a stable and high fertilisation rate in in vitro fertilisation (IVF). However, a combination of conventional cell sorting and IVF system ha...

journal_title：Scientific reports

authors： Nakao S,Takeo T,Watanabe H,Kondoh G,Nakagata N

更新日期：2020-06-01 00:00:00

abstract：:We collected data from Kailuan cohort study from 2006 to 2011 to examine whether short-term effects of ambient temperature on heart rate (HR) and blood pressure (BP) are non-linear or linear, and their potential modifying factors. The HR, BP and individual information, including basic characteristics, life style, soci...

journal_title：Scientific reports

authors： Madaniyazi L,Zhou Y,Li S,Williams G,Jaakkola JJ,Liang X,Liu Y,Wu S,Guo Y

更新日期：2016-02-15 00:00:00

abstract：:Protein kinases are frequently mutated in human cancers, which leads to altered signaling pathways and contributes to tumor growth and progression. ERK3 is an atypical mitogen-activated protein kinase (MAPK) containing an S-E-G activation motif rather than the conserved T-X-Y motif in conventional MAPKs such as ERK1/2...

journal_title：Scientific reports

authors： Alsaran H,Elkhadragy L,Shakya A,Long W

更新日期：2017-11-03 00:00:00

abstract：:Graphene quantum dots (GQDs) have received much attention due to their novel phenomena of charge transport and light absorption/emission. The optical transitions are known to be available up to ~6 eV in GQDs, especially useful for ultraviolet (UV) photodetectors (PDs). Thus, the demonstration of photodetection gain wi...

journal_title：Scientific reports

authors： Kim CO,Hwang SW,Kim S,Shin DH,Kang SS,Kim JM,Jang CW,Kim JH,Lee KW,Choi SH,Hwang E

更新日期：2014-07-07 00:00:00

abstract：:It is well known the thermal properties of three-dimensional (3-D) hybrid graphene (GR)-carbon nanotube (CNT) structures are not superior to that of the individual GR and CNT, however, the 3-D hybrid GR-CNT structures can effectively improve the thermal properties of polymer matrix. Therefore, understanding the therma...

journal_title：Scientific reports

authors： Liu F,Liu X,Hu N,Ning H,Atobe S,Yan C,Mo F,Fu S,Zhang J,Wang Y,Mu X

更新日期：2017-10-31 00:00:00

abstract：:Synchrotron X-ray imaging technique has been used to investigate biofluid flows in a non-destructive manner. This study aims to investigate the feasibility of the X-ray PIV technique with CO2 microbubbles as flow tracer for measurement of pulsatile blood flows under in vivo conditions. The traceability of CO2 microbub...

journal_title：Scientific reports

authors： Park H,Yeom E,Seo SJ,Lim JH,Lee SJ

更新日期：2015-03-06 00:00:00

abstract：:The identification of the modes of action of bioactive compounds is a major challenge in chemical systems biology of diseases. Genome-wide expression profiling of transcriptional responses to compound treatment for human cell lines is a promising unbiased approach for the mode-of-action analysis. Here we developed a n...

journal_title：Scientific reports

authors： Iwata M,Sawada R,Iwata H,Kotera M,Yamanishi Y

更新日期：2017-01-10 00:00:00

abstract：:The AB0 blood group has been linked to ischaemic heart disease, stroke, and periodontal disease, while the Lewis blood group has been linked to ischaemic heart disease and obesity, all of which have been associated with periodontitis. AB0 or Lewis blood group phenotype may therefore constitute common hereditary compon...

journal_title：Scientific reports

authors： Enevold C,Nielsen CH,Molbo D,Lund R,Bendtzen K,Fiehn N-,Holmstrup P

更新日期：2019-04-18 00:00:00

abstract：:We developed a simple, scalable and high-throughput method for fabrication of large-area three-dimensional rose-like microflowers with controlled size, shape and density on graphene films by femtosecond laser micromachining. The novel biomimetic microflower that composed of numerous turnup graphene nanoflakes can be f...

journal_title：Scientific reports

authors： Shi X,Li X,Jiang L,Qu L,Zhao Y,Ran P,Wang Q,Cao Q,Ma T,Lu Y

更新日期：2015-11-30 00:00:00

abstract：:Gut microbiota acts as a barrier against intestinal pathogens, but species-specific protection of the host from infection remains relatively unexplored. Although lactobacilli and bifidobacteria produce beneficial lactic and short-chain fatty acids in the mammalian gut, the significance of intestinal Escherichia coli p...

journal_title：Scientific reports

authors： Christofi T,Panayidou S,Dieronitou I,Michael C,Apidianakis Y

更新日期：2019-10-08 00:00:00

abstract：:Due to the limitations of current imaging techniques, visualization of lymphatic capillaries within tissue in vivo has been challenging. Here, we present a label-free high resolution optical coherence tomography (OCT) based lymphangiography (OLAG) within human skin in vivo. OLAG enables rapid (~seconds) mapping of lym...

journal_title：Scientific reports

authors： Baran U,Qin W,Qi X,Kalkan G,Wang RK

更新日期：2016-02-19 00:00:00

abstract：:Oviposition site-selection in insects is mediated through innate recognition templates (IRTs) tuned to specific chemical cues. These cues aid gravid insects in choosing suitable oviposition sites and may even enhance the fitness of their offspring by warding off predators and parasitoids. However, studies on the evolu...

journal_title：Scientific reports

authors： Damodaram KJ,Kempraj V,Aurade RM,Rajasekhar SB,Venkataramanappa RK,Nandagopal B,Verghese A

更新日期：2014-12-15 00:00:00

abstract：:Whether the clinical trial treatment effect of urate-lowering therapy (ULT) in patient with chronic kidney disease (CKD) is generalizable to real-word settings is unclear. This study aimed to compare febuxostat with allopurinol for uric acid reduction and renal protection in patients with CKD. Adult CKD patients newly...

journal_title：Scientific reports

authors： Peng YL,Tain YL,Lee CT,Yang YH,Huang YB,Wen YH,Hsu CN

更新日期：2020-07-01 00:00:00

abstract：:The immune responses of males and females to bacterial infections display differences. The mechanisms that underlie this sexual dimorphism are multifactorial. Lipopolysaccharide (LPS) contributes to the pathogenesis of endotoxaemia. We have previously demonstrated that the plasma protein beta-2 glycoprotein-1 (β2GPI) ...

journal_title：Scientific reports

authors： El-Assaad F,Qi M,Gordon AK,Qi J,Dong S,Passam F,Weaver JC,Giannakopoulos B,Krilis SA

更新日期：2017-08-15 00:00:00

abstract：:Acute heart failure (AHF) emerges either de novo or from worsening of chronic heart failure (CHF). The aim of the present study was to evaluate the association between worsening of CHF and mortality in AHF patients. Out of 152 included AHF patients, 47 (30.9%) were de novo AHF patients and 105 (69%) were AHF patients ...

journal_title：Scientific reports

authors： Degoricija V,Trbušić M,Potočnjak I,Radulović B,Terešak SD,Pregartner G,Berghold A,Tiran B,Frank S

更新日期：2018-06-25 00:00:00

abstract：:ABO blood group is associated with cardiovascular disease, with significantly lower risk in blood group O individuals. ABO(H) blood group determinants are expressed on different glycoproteins on platelet surfaces. In addition, ABO(H) structures are also present on VWF glycans. These ABO(H) carbohydrates influence both...

journal_title：Scientific reports

authors： O'Donghaile D,Jenkins PV,McGrath RT,Preston L,Field SP,Ward SE,O'Sullivan JM,O'Donnell JS

更新日期：2020-10-27 00:00:00

abstract：:Extracellular vesicles (EVs) carry information between cells in the form of biomolecules. Such molecules have been found to serve as biomarkers. Glycans attached to surface molecules on EVs are involved in their cellular uptake. In this study, we examined glycan profiles of small EVs which are generally termed exosome...

journal_title：Scientific reports

authors： Shimoda A,Sawada SI,Sasaki Y,Akiyoshi K

更新日期：2019-08-08 00:00:00

abstract：:The biological functions of nitric oxide (NO) depend on its concentration, and excessive levels of NO induce various harmful situations known as nitrosative stress. Therefore, organisms possess many kinds of strategies to regulate the intracellular NO concentration and/or to detoxify excess NO. Here, we used genetic s...

journal_title：Scientific reports

authors： Anam K,Nasuno R,Takagi H

更新日期：2020-04-07 00:00:00

abstract：:The opening of connexin (Cx) hemichannels in the membrane is tightly regulated by calcium (Ca2+) and membrane voltage. Electrophysiological and atomic force microscopy experiments indicate that Ca2+ stabilizes the hemichannel closed state. However, structural data show that Ca2+ binding induces an electrostatic seal p...

journal_title：Scientific reports

authors： Pinto BI,Pupo A,García IE,Mena-Ulecia K,Martínez AD,Latorre R,Gonzalez C

更新日期：2017-11-20 00:00:00

abstract：:Individuals perceive the wor(l)d hierarchically. Firsty, the global visual scene is processed by the right hemisphere, and later, the local features are perceived by the left hemisphere. Based on this hierarchical analysis, humans evolved unique communication ability: reading. However, for about 10% of people reading ...

journal_title：Scientific reports

authors： Franceschini S,Bertoni S,Gianesini T,Gori S,Facoetti A

更新日期：2017-12-12 00:00:00

abstract：:Features from Electrovestibulography (EVestG) recordings have been used to classify and measure the severity of both persistent post-concussion syndrome (PCS) and major depressive disorder. Herein, we examined the effect of comorbid depression on the detection of persistent PCS using EVestG. To validate our previously...

journal_title：Scientific reports

authors： Suleiman A,Lithgow B,Mansouri B,Moussavi Z

更新日期：2018-09-27 00:00:00

abstract：:Double-strand breaks (DSBs) are the most lethal DNA damages induced by ionising radiation (IR) and their efficient repair is crucial to limit genomic instability. The cellular DSB response after low IR doses is of particular interest but its examination requires the analysis of high cell numbers. Here, we present an a...

journal_title：Scientific reports

authors： Lengert N,Mirsch J,Weimer RN,Schumann E,Haub P,Drossel B,Löbrich M

更新日期：2018-11-23 00:00:00

abstract：:We report an integrated system for accelerating assays with concentrators in a standard 12-well plate (ISAAC-12) and demonstrate its versatility for rapid detection of matrix metalloproteinase (MMP)-9 expression in the cell culture supernatant of breast cancer cell line MDA-MB-231 by accelerating the enzymatic reactio...

journal_title：Scientific reports

authors： Wei X,Do VQ,Pham SV,Martins D,Song YA

更新日期：2018-07-17 00:00:00

abstract：:Considering environmental concerns regarding air pollution which is induced by burning fossil fuels to generate electrical power, utilizing solar energy as a green and sustainable energy source is of great interest. This study proposes a novel framework to determine the optimal location for constructing solar photovol...

journal_title：Scientific reports

authors： Mokarram M,Mokarram MJ,Khosravi MR,Saber A,Rahideh A

更新日期：2020-05-18 00:00:00

abstract：:The comet assay is an electrophoretic technique used to assess DNA damage, as a marker of genotoxicity and oxidative stress, in tissues and biological samples including peripheral blood mononuclear cells (PBMCs) and whole blood (WB). Although numerous studies are performed on stored samples, the impact of cryopreserva...

journal_title：Scientific reports

authors： Marino M,Gigliotti L,Møller P,Riso P,Porrini M,Del Bo C

更新日期：2021-01-11 00:00:00

abstract：:Noisy galvanic vestibular stimulation (nGVS) delivered at imperceptible intensities can improve vestibular function in health and disease. Here we evaluated whether nGVS effects on vestibular function are only present during active stimulation or may exhibit relevant post-stimulation after-effects. Initially, nGVS amp...

journal_title：Scientific reports

authors： Keywan A,Badarna H,Jahn K,Wuehr M

更新日期：2020-02-13 00:00:00

abstract：:Priming improves an organism's performance upon a future stress. To test whether cold priming supports protection in spring and how it is affected by cold acclimation, we compared seven Arabidopsis accessions with different cold acclimation potentials in the field and in the greenhouse for growth, photosynthetic perfo...

journal_title：Scientific reports

authors： Cvetkovic J,Müller K,Baier M

更新日期：2017-03-09 00:00:00

abstract：:The protection of tropical forests is one of the most urgent issues in conservation biology because of the rapid deforestation that has occurred over the last 50 years. Even in protected forests, the anthropogenic effects from newly expanding villages such as harvesting of medicinal plants, pasturing cattle and forest...

journal_title：Scientific reports

authors： Popradit A,Srisatit T,Kiratiprayoon S,Yoshimura J,Ishida A,Shiyomi M,Murayama T,Chantaranothai P,Outtaranakorn S,Phromma I

更新日期：2015-10-05 00:00:00

abstract：:The introduction of microCT has made it possible to show that the terminal bronchioles are narrowed and destroyed before the onset of emphysematous destruction in COPD. This report extends those observations to the cellular and molecular level in the centrilobular phenotype of emphysematous destruction in lungs donate...

journal_title：Scientific reports

authors： Suzuki M,Sze MA,Campbell JD,Brothers JF 2nd,Lenburg ME,McDonough JE,Elliott WM,Cooper JD,Spira A,Hogg JC

更新日期：2017-08-25 00:00:00