Calcium binding and voltage gating in Cx46 hemichannels.

abstract：:Classically, neurexins are thought to mediate synaptic connections through trans interactions with a number of different postsynaptic partners. Neurexins are cleaved by metalloproteases in an activity-dependent manner, releasing the soluble extracellular domain. Here, we report that in both immature (before synaptogen...

journal_title：Scientific reports

authors： Wierda KDB,Toft-Bertelsen TL,Gøtzsche CR,Pedersen E,Korshunova I,Nielsen J,Bang ML,Kønig AB,Owczarek S,Gjørlund MD,Schupp M,Bock E,Sørensen JB

更新日期：2020-10-22 00:00:00

abstract：:The current standard treatment for ovarian cancer is aggressive surgery followed by platinum-based combination chemotherapy. Recurrence and chemotherapeutic drug resistance are the two main factors that account for the high mortality of most ovarian cancers. Liposomal doxorubicin is primarily used for the treatment of...

journal_title：Scientific reports

authors： Li S,Cao J,Zhang W,Zhang F,Ni G,Luo Q,Wang M,Tao X,Xia H

更新日期：2016-11-11 00:00:00

abstract：:More and more researchers are interested in and focused on how a limited repertoire of antibodies can bind and correspondingly protect against an almost limitless diversity of invading antigens. In this work, a series of 200-ns molecular dynamics (MD) simulations followed by principal component (PC) analysis and free ...

journal_title：Scientific reports

authors： Chen J,Wang J,Zhu W

更新日期：2016-11-10 00:00:00

abstract：:Alkaline sulfide-rich hot springs provide a unique environment for microbial community and arsenic (As) biogeochemistry. In this study, a representative alkaline sulfide-rich hot spring, Zimeiquan in the Tengchong geothermal area, was chosen to study arsenic geochemistry and microbial community using Illumina MiSeq se...

journal_title：Scientific reports

authors： Jiang Z,Li P,Van Nostrand JD,Zhang P,Zhou J,Wang Y,Dai X,Zhang R,Jiang D,Wang Y

更新日期：2016-04-29 00:00:00

abstract：:This study explores the radiation field temperatures introduced by the laser spot, the re-emitting wall in a hohlraum and the entire hohlraum drive source. This investigation, which is the first of its kind, is based on the radiation fluxes from the laser spot and the re-emitting wall, which have been accurately measu...

journal_title：Scientific reports

authors： Ren K,Liu S,Xie X,Du H,Hou L,Jing L,Yang D,Zhao Y,Yan J,Yang Z,Li Z,Dong J,Yang G,Li S,Cao Z,Lan K,Huo W,Liu J,Ren G,Ding Y,Jiang S

更新日期：2019-03-25 00:00:00

abstract：:A crystalline solid exhibits thermally induced localised non-affine droplets in the absence of external stress. Here we show that upon an imposed shear, the size of these droplets grow until they percolate at a critical strain, well below the value at which the solid begins to yield. This critical point does not manif...

journal_title：Scientific reports

authors： Das T,Ganguly S,Sengupta S,Rao M

更新日期：2015-06-03 00:00:00

abstract：:Propagation of oscillatory spike firing activity at specific frequencies plays an important role in distributed cortical networks. However, there is limited evidence for how such frequency-specific signals are induced or how the signal spectra of the propagating signals are modulated during across-layer (radial) and i...

journal_title：Scientific reports

authors： Toda H,Kawasaki K,Sato S,Horie M,Nakahara K,Bepari AK,Sawahata H,Suzuki T,Okado H,Takebayashi H,Hasegawa I

更新日期：2018-05-16 00:00:00

abstract：:Several studies have shown that the 'poor' sperm DNA quality appears to be an important factor affecting male reproductive ability. In the case of sperm cells from males with the correct somatic karyotype but with deficient spermatogenesis, resulting in a high degree of sperm DNA fragmentation, we observed changes in ...

journal_title：Scientific reports

authors： Wiland E,Fraczek M,Olszewska M,Kurpisz M

更新日期：2016-08-25 00:00:00

abstract：:When lightning strikes soil, it may generate a cylindrical tube of glass known as a fulgurite. The morphology of a fulgurite is ultimately a consequence of the energy of the lightning strike that formed it, and hence fulgurites may be useful in elucidating the energy distribution frequency of cloud-to-ground lightning...

journal_title：Scientific reports

authors： Pasek MA,Hurst M

更新日期：2016-07-28 00:00:00

abstract：:Nitrate treatment has been widely used in various seawater injection projects to treat biologic sulfate reduction or reservoir souring. To design a promising nitrate treatment plan, it is essential to have a comprehensive understanding of reactions that represent the microbial communities of the reservoir and mechanis...

journal_title：Scientific reports

authors： Jahanbani Veshareh M,Nick HM

更新日期：2019-05-17 00:00:00

abstract：:Cytotoxic T lymphocyte (CTL) responses against the HIV Gag protein are associated with lowering viremia; however, immune control is undermined by viral escape mutations. The rapid viral mutation rate is a key factor, but recombination may also contribute. We hypothesized that CTL responses drive the outgrowth of uniqu...

journal_title：Scientific reports

authors： Chang CH,Kist NC,Stuart Chester TL,Sreenu VB,Herman M,Luo M,Lunn D,Bell J,Plummer FA,Ball TB,Katzourakis A,Iversen AK

更新日期：2015-06-17 00:00:00

abstract：:Chronic atrophic gastritis (CAG) is a common gastrointestinal disease which has been considered as precancerous lesions of gastric carcinoma. Previously, electro-acupuncture stimulation has been shown to be effective in ameliorating symptoms of CAG. However the underlying mechanism of this beneficial treatment is yet ...

journal_title：Scientific reports

authors： Xu J,Zheng X,Cheng KK,Chang X,Shen G,Liu M,Wang Y,Shen J,Zhang Y,He Q,Dong J,Yang Z

更新日期：2017-03-30 00:00:00

abstract：:Autophagy is a protective and life-sustaining process in which cytoplasmic components are packaged into double-membrane vesicles and targeted to lysosomes for degradation. Accumulating evidence supports that autophagy is associated with several pathological conditions. However, research on the functional cross-links b...

journal_title：Scientific reports

authors： Wang JY,Yao WX,Wang Y,Fan YL,Wu JB

更新日期：2017-03-15 00:00:00

abstract：:Bovine lactoferrin is a biglobular multifunctional iron binding glycoprotein that plays an important role in innate immunity against infections. We have previously demonstrated that selected peptides from bovine lactoferrin C-lobe are able to prevent both Influenza virus hemagglutination and cell infection. To deeper ...

journal_title：Scientific reports

authors： Scala MC,Sala M,Pietrantoni A,Spensiero A,Di Micco S,Agamennone M,Bertamino A,Novellino E,Bifulco G,Gomez-Monterrey IM,Superti F,Campiglia P

更新日期：2017-09-06 00:00:00

abstract：:The 'brain regionalization genes' Six3/6, Otx, Pax2/5/8, Gbx, and Hox1 are expressed in a similar fashion in the deuterostome, ecdysozoan, and the cephalopod brain, questioning whether this holds also true for the remaining Mollusca. We investigated developmental Gbx-expression in representatives of both molluscan sis...

journal_title：Scientific reports

authors： Wollesen T,Scherholz M,Rodríguez Monje SV,Redl E,Todt C,Wanninger A

更新日期：2017-07-14 00:00:00

abstract：:This study was carried out to use hyperspectral imaging technique for determining color (L*, a* and b*) and eggshell strength and identifying cracked chicken eggs. Partial least squares (PLS) models based on full and selected wavelengths suggested by regression coefficient (RC) method were established to predict the f...

journal_title：Scientific reports

authors： Xie C,He Y

更新日期：2016-02-17 00:00:00

abstract：:Increasing evidence indicates that static magnetic fields (SMF) reduce cortical activity in both human and animal models. The aim of this work was to investigate the effect of SMF on epileptiform cortical activity, a condition related to an abnormal increase in neuronal excitability. The first experimental block inclu...

journal_title：Scientific reports

authors： Rivadulla C,Aguilar J,Coletti M,Aguila J,Prieto S,Cudeiro J

更新日期：2018-10-30 00:00:00

abstract：:X-linked severe combined immunodeficiency (SCID-X1) caused by mutations in interleukin 2 receptor gamma (IL2RG) gene threatens the survival of affected boys during the first year of life unless hematopoietic stem cell transplantation is provided. Although viral vector-mediated gene therapy has been successfully perfor...

journal_title：Scientific reports

authors： Matsubara Y,Chiba T,Kashimada K,Morio T,Takada S,Mizutani S,Asahara H

更新日期：2014-05-23 00:00:00

abstract：:Given the importance of aerosol particles to radiative transfer via aerosol-radiation interactions, a methodology for tracking and diagnosing causes of temporal changes in regional-scale aerosol populations is illustrated. The aerosol optical properties tracked include estimates of total columnar burden (aerosol optic...

journal_title：Scientific reports

authors： Sullivan RC,Levy RC,da Silva AM,Pryor SC

更新日期：2017-12-22 00:00:00

abstract：:The current flowing through a Mott spin junction depends on the relative spin orientation of the two ferromagnetic layers comprising the "source" and "drain" sides of the junction. The resulting current asymmetry is detected as giant or tunnelling magnetoresistance depending on whether the two ferromagnets are separat...

journal_title：Scientific reports

authors： De Pietro L,Bertolini G,Peter Q,Cabrera H,Vindigni A,Gürlü O,Pescia D,Ramsperger U

更新日期：2017-10-16 00:00:00

abstract：:The development of electrochemical biosensors for the simultaneous detection of ascorbic acid (AA), dopamine (DA), uric acid (UA), tryptophan (Trp), and nitrite ([Formula: see text]) in human serum is reported in this work. Free-standing graphene nanosheets were fabricated on Ta wire using the chemical vapor depositio...

journal_title：Scientific reports

authors： Wang X,Gao D,Li M,Li H,Li C,Wu X,Yang B

更新日期：2017-08-01 00:00:00

abstract：:Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a kind of primary cardiomyopathy characterized by the fibro-fatty replacement of right ventricular myocardium. Currently, myocardial microRNAs have been reported to play critical role in the pathophysiology of cardiovascular pathophysiology. So far, the profili...

journal_title：Scientific reports

authors： Zhang H,Liu S,Dong T,Yang J,Xie Y,Wu Y,Kang K,Hu S,Gou D,Wei Y

更新日期：2016-06-16 00:00:00

abstract：:Metamaterial full-sized absorber structures are numerically and experimentally investigated in GHz region and then examined in THz frequency. By manipulating monitoring the number and the position of the defect elements in conventional unit cells, the optimal integrative absorber structures are generated. The proposed...

journal_title：Scientific reports

authors： Tran MC,Le DH,Pham VH,Do HT,Le DT,Dang HL,Vu DL

更新日期：2018-06-22 00:00:00

abstract：:Chronic fatigue syndrome (CFS) is a persistent and unexplained pathological state characterized by exertional and severely debilitating fatigue, with/without infectious or neuropsychiatric symptoms, lasting at least 6 consecutive months. Its pathogenesis remains incompletely understood. Here, we performed comprehensiv...

journal_title：Scientific reports

authors： Yamano E,Sugimoto M,Hirayama A,Kume S,Yamato M,Jin G,Tajima S,Goda N,Iwai K,Fukuda S,Yamaguti K,Kuratsune H,Soga T,Watanabe Y,Kataoka Y

更新日期：2016-10-11 00:00:00

abstract：:Little work has been done on the prediction of malignancy risk in patients with subcentimeter thyroid nodule (TN) categorized as atypia/follicular lesion of undetermined significance (AUS/FLUS). We performed a retrospective analysis on the medical records of subcentimeter TNs whose initial fine-needle aspiration (FNA)...

journal_title：Scientific reports

authors： Ding J,Jiang L,Fang J,Jiang Y,Zhu Y,Hua T,Yuan Y,Wu W

更新日期：2019-10-18 00:00:00

abstract：:Skyrmions in ultrathin ferromagnetic metal (FM)/heavy metal (HM) multilayer systems produced by conventional sputtering methods have recently generated huge interest due to their applications in the field of spintronics. The sandwich structure with two correctly-chosen heavy metal layers provides an additive interfaci...

journal_title：Scientific reports

authors： McVitie S,Hughes S,Fallon K,McFadzean S,McGrouther D,Krajnak M,Legrand W,Maccariello D,Collin S,Garcia K,Reyren N,Cros V,Fert A,Zeissler K,Marrows CH

更新日期：2018-04-09 00:00:00

abstract：:Early diagnosis of hepatocellular carcinoma (HCC) remains challenging to date. Characteristic metabolic deregulations of HCC may enable novel biomarkers discovery for early diagnosis. A capillary electrophoresis-time of flight mass spectrometry (CE-TOF/MS)-based metabolomics approach was performed to discover and vali...

journal_title：Scientific reports

authors： Zeng J,Huang X,Zhou L,Tan Y,Hu C,Wang X,Niu J,Wang H,Lin X,Yin P

更新日期：2015-11-03 00:00:00

abstract：:In the fifty years since the postulation of Moore's Law, the increasing energy consumption in silicon electronics has motivated research into emerging devices. An attractive research direction is processing information via the phase of spin waves within magnonic-logic circuits, which function without charge transport ...

journal_title：Scientific reports

authors： Kanazawa N,Goto T,Sekiguchi K,Granovsky AB,Ross CA,Takagi H,Nakamura Y,Uchida H,Inoue M

更新日期：2017-08-11 00:00:00

abstract：:Methylated non-CpGs (mCpH; H means A, C, and T) have emerged as key epigenetic marks in mammalian embryonic stem cells (ESCs) and neurons, regulating cell type-specific functions. In these two cell types, mCpHs show distinct motifs and correlations to transcription that could be a key in understanding the cell type-sp...

journal_title：Scientific reports

authors： Lee JH,Park SJ,Nakai K

更新日期：2017-09-12 00:00:00

abstract：:In this article, the interaction between bovine serum albumin (BSA) and the cationic 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) at the air-buffer interface was investigated at different subphase's pH values (pH = 3, 5 and 10). Surface pressure measurements (π - A) and penetration kinetics process (π - t) were ca...

journal_title：Scientific reports

authors： Xu G,Hao C,Zhang L,Sun R

更新日期：2018-01-10 00:00:00