Chemical activation of RARβ induces post-embryonically bilateral limb duplication during Xenopus limb regeneration.

Abstract:

:The anuran amphibian Xenopus laevis can regenerate its limbs for a limited time during the larval stage, while limbs are still developing. Using this regeneration model, we evaluated the proximo-distal blastema cell identity when endogenous retinoids were increased by CYP26 inhibition or when RAR-specific agonists altered RA signaling. Simultaneous proximo-distal and antero-posterior limb duplications were generated, and the RAR-specific agonist can modify blastema identity after amputation, because chemical activation of RARβ produced bilateral hindlimb duplications that resulted in a drastic duplication phenotype of regenerating limbs.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Cuervo R,Chimal-Monroy J

doi

10.1038/srep01886

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

1886

issn

2045-2322

pii

srep01886

journal_volume

3

pub_type

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