Abstract:
:The anuran amphibian Xenopus laevis can regenerate its limbs for a limited time during the larval stage, while limbs are still developing. Using this regeneration model, we evaluated the proximo-distal blastema cell identity when endogenous retinoids were increased by CYP26 inhibition or when RAR-specific agonists altered RA signaling. Simultaneous proximo-distal and antero-posterior limb duplications were generated, and the RAR-specific agonist can modify blastema identity after amputation, because chemical activation of RARβ produced bilateral hindlimb duplications that resulted in a drastic duplication phenotype of regenerating limbs.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Cuervo R,Chimal-Monroy Jdoi
10.1038/srep01886subject
Has Abstractpub_date
2013-01-01 00:00:00pages
1886issn
2045-2322pii
srep01886journal_volume
3pub_type
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