An inhibitor of the Keap1-Nrf2 protein-protein interaction protects NCM460 colonic cells and alleviates experimental colitis.

abstract：:Breast cancer in young women is typically with higher proportion of adverse pathological features. Breast cancer with BRCA1 mutation is often early-onset, and is usually associated with triple negative phenotpe. In this study, we aim to analyze the clinicopathological characteristics and prognosis in young breast canc...

journal_title：Scientific reports

authors： Wei JT,Huang WH,Du CW,Qiu SQ,Wei XL,Liu J,Zhang GJ

更新日期：2014-06-19 00:00:00

abstract：:Geochemical discrimination has recently been recognised as a potentially useful proxy for identifying tsunami deposits in addition to classical proxies such as sedimentological and micropalaeontological evidence. However, difficulties remain because it is unclear which elements best discriminate between tsunami and no...

journal_title：Scientific reports

authors： Kuwatani T,Nagata K,Okada M,Watanabe T,Ogawa Y,Komai T,Tsuchiya N

更新日期：2014-11-17 00:00:00

abstract：:Although the Guangxi region accounts for 10% of all HIV-1 cases new reported in 2011 in China, the sources of the transmitted HIV-1 strains are virtually unknown. To determine the extent to which recent HIV infections were derived from already circulating local strains as opposed to recently introduced strains, we per...

journal_title：Scientific reports

authors： Li J,Feng Y,Shen Z,Li Y,Tang Z,Xiong R,Zhang H,Wei J,Zhou X,Deng Y,Fang N,Lan G,Liang S,Zhu Q,Xing H,Ruan Y,Shao Y

更新日期：2018-08-27 00:00:00

abstract：:Targeted protein degradation (TPD) through a proteasome-dependent pathway induced by heterofunctional small molecules is initiated by the formation of a ternary complex with recruited E3 ligases. This complex formation affects the degradation ability of TPD molecules, and thus we tested for visualization of the intrac...

journal_title：Scientific reports

authors： Kaji T,Koga H,Kuroha M,Akimoto T,Hayata K

更新日期：2020-02-20 00:00:00

abstract：:Severe sepsis or septic shock is one of the rising causes for mortality worldwide representing nearly 10% of intensive care unit admissions. Susceptibility to sepsis is identified to be mediated by innate pattern recognition receptors and responsive signaling pathways of the host. The c-Jun N-terminal Kinase (JNK)-med...

journal_title：Scientific reports

authors： Prasad KD,Trinath J,Biswas A,Sekar K,Balaji KN,Guru Row TN

更新日期：2014-11-27 00:00:00

abstract：:Recently, long non-coding RNAs (lncRNAs) have emerged as an important class of molecules involved in many cellular processes. One of their primary functions is to shape epigenetic landscape through interactions with chromatin modifying proteins. However, mechanisms contributing to the specificity of such interactions ...

journal_title：Scientific reports

authors： Tu S,Yuan GC,Shao Z

更新日期：2017-01-31 00:00:00

abstract：:Ovarian cancer is one of the leading causes of death in gynecological malignancies, and the resistance to chemotherapeutic agents remains a major challenge to successful ovarian cancer chemotherapy. Dihydromyricetin (DHM), a natural flavonoid derived from Ampeopsis Grossdentata, has been widely applied in food industr...

journal_title：Scientific reports

authors： Xu Y,Wang S,Chan HF,Lu H,Lin Z,He C,Chen M

更新日期：2017-04-24 00:00:00

abstract：:The ability of Treponema pallidum, the syphilis spirochete to colonize various tissues requires the presence of surface-exposed adhesins that have been difficult to identify due to the inability to culture and genetically manipulate T. pallidum. Using a Borrelia burgdorferi-based heterologous system and gain-in-functi...

journal_title：Scientific reports

authors： Chan K,Nasereddin T,Alter L,Centurion-Lara A,Giacani L,Parveen N

更新日期：2016-05-10 00:00:00

abstract：:The accumulation of repetitive DNA sequences on the sex-limited W or Y chromosomes is a well-known process that is likely triggered by the suppression of recombination between the sex chromosomes, which leads to major differences in their sizes and genetic content. Here, we report an analysis conducted on the satellit...

journal_title：Scientific reports

authors： Utsunomia R,Silva DMZA,Ruiz-Ruano FJ,Goes CAG,Melo S,Ramos LP,Oliveira C,Porto-Foresti F,Foresti F,Hashimoto DT

更新日期：2019-04-10 00:00:00

abstract：:Shewanella species are facultative anaerobic bacteria that colonize redox-stratified habitats where O2 and nutrient concentrations fluctuate. The model species Shewanella oneidensis MR-1 possesses genes coding for three terminal oxidases that can perform O2 respiration: a bd-type quinol oxidase and cytochrome c oxidas...

journal_title：Scientific reports

authors： Le Laz S,Kpebe A,Bauzan M,Lignon S,Rousset M,Brugna M

更新日期：2016-01-27 00:00:00

abstract：:Cardiac tissue engineering using biomaterials with or without combination of stem cell therapy offers a new option for repairing infarcted heart. However, the bioactivity of biomaterials remains to be optimized because currently available biomaterials do not mimic the biochemical components as well as the structural p...

journal_title：Scientific reports

authors： Wan L,Chen Y,Wang Z,Wang W,Schmull S,Dong J,Xue S,Imboden H,Li J

更新日期：2017-01-04 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Stringer BW,Day BW,D'Souza RCJ,Jamieson PR,Ensbey KS,Bruce ZC,Lim YC,Goasdoué K,Offenhäuser C,Akgül S,Allan S,Robertson T,Lucas P,Tollesson G,Campbell S,Winter C,Do H,Dobrovic A,Inglis PL,Jeffree RL,Johns TG,Boy

更新日期：2020-01-21 00:00:00

abstract：:Mankind is on the verge of a postantibiotic era. New concepts are needed in our battle to attenuate infectious diseases around the world and broad spectrum plant-inspired synergistic pharmaceutical preparations should find their place in the global fight against pathogenic microorganisms. To progress towards the disco...

journal_title：Scientific reports

authors： Rodrigues AMS,Eparvier V,Odonne G,Amusant N,Stien D,Houël E

更新日期：2019-06-19 00:00:00

abstract：:Liver failure, whether arising directly from acute liver failure or from decompensated chronic liver disease is an increasing problem worldwide and results in many deaths. In the UK only 10% of individuals requiring a liver transplant receive one. Thus the need for alternative treatments is paramount. A BioArtificial ...

journal_title：Scientific reports

authors： Selden C,Bundy J,Erro E,Puschmann E,Miller M,Kahn D,Hodgson H,Fuller B,Gonzalez-Molina J,Le Lay A,Gibbons S,Chalmers S,Modi S,Thomas A,Kilbride P,Isaacs A,Ginsburg R,Ilsley H,Thomson D,Chinnery G,Mankahla N,Loo

更新日期：2017-11-06 00:00:00

abstract：:Horizontal gene transfer (HGT) is a main mechanism of bacterial evolution endowing bacteria with new genetic traits. The transfer of mobile genetic elements such as plasmids (conjugation) requires the close proximity of cells. HGT between genetically distinct bacteria largely depends on cell movement in water films, w...

journal_title：Scientific reports

authors： Berthold T,Centler F,Hübschmann T,Remer R,Thullner M,Harms H,Wick LY

更新日期：2016-11-04 00:00:00

abstract：:Guanine-rich quadruplex (G-QD) are formed by conversion of nucleotides with specific sequences by stabilization of positively charged K+ or Na+. These G-QD structures differentially absorb two-directional (right- and left-handed) circularly polarized light, which can discriminate the parallel or anti-parallel structur...

journal_title：Scientific reports

authors： Kim R,Youn YS,Kang M,Kim E

更新日期：2020-11-24 00:00:00

abstract：:Great interest has been shown in mesenchymal stem cell (MSC) therapy in a wide variety of clinical domains. However, the therapeutic efficiency depends on the proliferation and migration of MSCs. Chemokine receptors are involved in regulating the proliferation and migration to the specific organs of MSCs in different ...

journal_title：Scientific reports

authors： Liu L,Chen JX,Zhang XW,Sun Q,Yang L,Liu A,Hu S,Guo F,Liu S,Huang Y,Yang Y,Qiu HB

更新日期：2018-01-09 00:00:00

abstract：:The definition of the gene expression profile of genes encoding Ion Channels and Transporters (ICT-GEP) represents a novel and attracting aspect in cancer. We determined the ICT-GEP of Follicular Lymphoma (FL), and compared it with that of the more aggressive Diffuse Large B Cell Lymphoma (DLBCL). cDNA microarray data...

journal_title：Scientific reports

authors： Magi A,Masselli M,Sala C,Guerriero A,Laise P,Puccini B,Rigacci L,Breschi C,Crociani O,Pillozzi S,Arcangeli A

更新日期：2019-06-13 00:00:00

abstract：:A three dimensional (3D) numerical solution of unsteady, Ag-MgO hybrid nanoliquid flow with heat and mass transmission caused by upward/downward moving of wavy spinning disk has been scrutinized. The magnetic field has been also considered. The hybrid nanoliquid has been synthesized in the presence of Ag-MgO nanoparti...

journal_title：Scientific reports

authors： Ahmadian A,Bilal M,Khan MA,Asjad MI

更新日期：2020-11-02 00:00:00

abstract：:Studies of past human-landscape interactions rely upon the integration of archaeological, biological and geological information within their geographical context. However, detecting the often ephemeral traces of human activities at a landscape scale remains difficult with conventional archaeological field survey. Geop...

journal_title：Scientific reports

authors： De Smedt P,Van Meirvenne M,Herremans D,De Reu J,Saey T,Meerschman E,Crombé P,De Clercq W

更新日期：2013-01-01 00:00:00

abstract：:Wurtzite solid solutions between GaN and ZnO highlight an intriguing paradigm for water splitting into hydrogen and oxygen using solar energy. However, large composition discrepancy often occurs inside the compound owing to the volatile nature of Zn, thereby prescribing rigorous terms on synthetic conditions. Here we ...

journal_title：Scientific reports

authors： Xie Y,Wu F,Sun X,Chen H,Lv M,Ni S,Liu G,Xu X

更新日期：2016-01-12 00:00:00

abstract：:Peripheral nerve injury leads to various injury-induced responses in sensory neurons including physiological pain, neuronal cell death, and nerve regeneration. In this study, we performed single-cell RNA-sequencing (scRNA-seq) analysis of mouse nonpeptidergic nociceptors (NP), peptidergic nociceptors (PEP), and large ...

journal_title：Scientific reports

authors： Hu G,Huang K,Hu Y,Du G,Xue Z,Zhu X,Fan G

更新日期：2016-08-25 00:00:00

abstract：:CRISPR/Cas9 is a valuable tool for both basic and applied research that has been widely applied to different plant species. Nonetheless, a systematical assessment of the efficiency of this method is not available for the allotetraploid Brassica napus-an important oilseed crop. In this study, we examined the mutation e...

journal_title：Scientific reports

authors： Yang H,Wu JJ,Tang T,Liu KD,Dai C

更新日期：2017-08-08 00:00:00

abstract：:The Japanese murrelet (Synthliboramphus wumizusume) is an endangered small seabird species in Japan. Molecular sexing using PCR targeting of the gene encoding chromodomain helicase DNA-binding protein 1(CHD1) has been used for sex identification. Specifically, PCR using any of three commonly used primer sets (CHD1F/1R...

journal_title：Scientific reports

authors： Hatakeyama H,Nakamura Y,Konaka T,Nishida S,Kriangwanich W,Uematsu K,Tsuchida S

更新日期：2020-05-22 00:00:00

abstract：:We report an effective and rare-earth free light conversion material synthesized via a facile fabrication route, in which organic fluorescent dyes, i.e. Rhodamine B (RhB) and fluorescein isothiocyanate (FITC) are embedded into activated boron nitride (αBN) to form a composite phosphor. The composite phosphor shows hig...

journal_title：Scientific reports

authors： Li J,Lin J,Huang Y,Xu X,Liu Z,Xue Y,Ding X,Luo H,Jin P,Zhang J,Zou J,Tang C

更新日期：2015-02-16 00:00:00

abstract：:Many organisms faced with seasonally fluctuating abiotic and biotic conditions respond by altering their phenotype to account for the demands of environmental changes. Here we discovered that newts, which switch seasonally between an aquatic and terrestrial lifestyle, grow a complex adhesive system on their tongue pad...

journal_title：Scientific reports

authors： Heiss E,Handschuh S,Aerts P,Van Wassenbergh S

更新日期：2017-04-21 00:00:00

abstract：:The adipokines chemerin and omentin-1 have been suggested to influence cardiovascular function. The study aimed to investigate the longitudinal association between chemerin, omentin-1 concentrations and risk of incident heart failure (HF), respectively. We conducted a case-cohort study nested within the European Prosp...

journal_title：Scientific reports

authors： Menzel J,di Giuseppe R,Biemann R,Wittenbecher C,Aleksandrova K,Eichelmann F,Fritsche A,Schulze MB,Boeing H,Isermann B,Weikert C

更新日期：2017-10-26 00:00:00

abstract：:In this paper, we investigate the relationship between the quantum speedup, non-Markovianity and formation of a system-environment bound state. Previous results show a monotonic relation between these three such that providing bound states with more negative energy can lead to a higher degree of non-Markovianity, and ...

journal_title：Scientific reports

authors： Ahansaz B,Ektesabi A

更新日期：2019-10-18 00:00:00

abstract：:Amyloid-beta (Aβ)-induced neurotoxicity is a major contributor to the pathologies associated with Alzheimer's disease (AD). The formation of reactive oxygen species (ROS), an early response induced by the peptide and oligomeric derivatives of Aβ, plays a significant role in effecting cellular pathogenesis. Here we emp...

journal_title：Scientific reports

authors： Giordano CR,Terlecky LJ,Bollig-Fischer A,Walton PA,Terlecky SR

更新日期：2014-05-15 00:00:00

abstract：:PICK1 (protein interacting with C-kinase 1) is a peripheral membrane protein that interacts with diverse membrane proteins. PICK1 has been shown to regulate the clustering and membrane localization of synaptic receptors such as AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors, metabotropic glutama...

journal_title：Scientific reports

authors： Xu J,Wang N,Luo JH,Xia J

更新日期：2016-02-12 00:00:00