Comparison of multi echo T2 relaxation and steady state approaches for myelin imaging in the central nervous system.

Abstract:

:The traditional approach for measuring myelin-associated water with quantitative magnetic resonance imaging (MRI) uses multi-echo T2 relaxation data to calculate the myelin water fraction (MWF). A fundamentally different approach, abbreviated "mcDESPOT", uses a more efficient steady-state acquisition to generate an equivalent metric (fM). Although previous studies have demonstrated inherent instability and bias in the complex mcDESPOT analysis procedure, fM has often been used as a surrogate for MWF. We produced and compared multivariate atlases of MWF and fM in healthy human brain and cervical spinal cord (available online) and compared their ability to detect multiple sclerosis pathology. A significant bias was found in all regions (p < 10-5), albeit reversed for spinal cord (fM-MWF =  - 3.4%) compared to brain (+ 6.2%). MWF and fM followed an approximately linear relationship for regions with MWF <  ~ 10%. For MWF >  ~ 10%, the relationship broke down and fM no longer increased in tandem with MWF. For multiple sclerosis patients, MWF and fM Z score maps showed overlapping areas of low Z score and similar trends between patients and brain regions, although those of fM generally had greater spatial extent and magnitude of severity. These results will guide future choice of myelin-sensitive quantitative MRI and improve interpretation of studies using either myelin imaging approach.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Dvorak AV,Ljungberg E,Vavasour IM,Lee LE,Abel S,Li DKB,Traboulsee A,MacKay AL,Kolind SH

doi

10.1038/s41598-020-80585-7

subject

Has Abstract

pub_date

2021-01-14 00:00:00

pages

1369

issue

1

issn

2045-2322

pii

10.1038/s41598-020-80585-7

journal_volume

11

pub_type

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