Abstract:
:Measuring handgrip strength is the initial step to diagnose sarcopenia. To investigate whether the serum creatinine (Cr)/cystatin C (CysC) ratio could serve as a case-finding tool for low handgrip strength, we conducted a diagnostic accuracy study. Adults (aged ≥ 40 years) with normal renal function were recruited. Trained nurses collected blood samples and conducted the anthropometric measurements and handgrip strength test. The serum concentrations of Cr, CysC, and other biomarkers were measured. We recruited 1098 men and 1241 women. The Cr/CysC ratio was significantly associated with AWGS-defined low handgrip strength among men and women. The areas under the receiver operating characteristic curves were 0.79 among men and 0.78 among women for using the Cr/CysC ratio to identify AWGS-defined low handgrip strength. We set the Cr/CysC ratio cut-off values at < 8.9 among men and < 8.0 among women. The corresponding sensitivity values were 64.9% among men and 63.1% among women, while the specificity values were 83.7% among men and 77.5% among women. In conclusion, the Cr/CysC ratio is positively and linearly associated with handgrip strength and may be helpful for screening low handgrip strength in Chinese middle-aged and older adults dwelling in communities.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Tan L,Li R,Hu X,Zhu Y,Bao T,Zuo Y,Yang Mdoi
10.1038/s41598-020-71028-4subject
Has Abstractpub_date
2020-08-20 00:00:00pages
14028issue
1issn
2045-2322pii
10.1038/s41598-020-71028-4journal_volume
10pub_type
杂志文章abstract::Gut bacteria influence the development of different pathologies caused by bacteria, fungi and parasitoids in insects. Wax moth larvae became more susceptible to fungal infections after envenomation by the ectoparasitoid Habrobracon hebetor. In addition, spontaneous bacterioses occurred more often in envenomated larvae...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40301-6
更新日期:2019-03-08 00:00:00
abstract::Through combined three-dimensional electromagnetic and particle tracking simulations we demonstrate a THz driven electron streak camera featuring a temporal resolution on the order of a femtosecond. The ultrafast streaking field is generated in a resonant THz sub-wavelength antenna which is illuminated by an intense s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05645
更新日期:2014-07-10 00:00:00
abstract::In this study, the effects of different feeding frequencies on the growth and the expression of genes in the GH/IGF axis were assessed in juvenile Chinese sturgeon. The newly hatched Chinese sturgeons were bred for 38 days at three different feeding frequencies groups (feeding frequency of two times a day, TWD; three ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-74120-x
更新日期:2020-10-15 00:00:00
abstract::Faces presented upside-down are harder to recognize than presented right-side up, an effect known as the face inversion effect. With inversion the perceptual processing of the spatial relationship among facial parts is disrupted. Previous literature indicates a face inversion effect in chimpanzees toward familiar and ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02504
更新日期:2013-01-01 00:00:00
abstract::Sodium taurocholate cotransporting polypeptide (NTCP) is a recently discovered hepatitis B virus (HBV) receptor. In the present study, we used TK-NOG mice with a humanized liver to examine the impact of endogenous NTCP expression on HBV infection. Upon inoculation with HBV, these mice exhibited clear viremia in 2 week...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27782
更新日期:2016-06-09 00:00:00
abstract::The spreading of invasive species in new continents can vary from slow and limited diffusion to fast colonisations over vast new areas. We studied the sacred ibis Threskiornis aethiopicus along a 31-year period, from 1989 to 2019, with particular attention to the first area of release in NW Italy. We collected data on...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79137-w
更新日期:2021-01-08 00:00:00
abstract::The charge transport properties of hybrid halide perovskites are investigated with a combination of density functional theory including van der Waals interaction and the Boltzmann theory for diffusive transport in the relaxation time approximation. We find the mobility of electrons to be in the range 5-10 cm(2)V(-1)s(...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12746
更新日期:2015-08-03 00:00:00
abstract::Nanothermometry methods with intracellular sensitivities have the potential to make important contributions to fundamental cell biology and medical fields, as temperature is a relevant physical parameter for molecular reactions to occur inside the cells and changes of local temperature are well identified therapeutic ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44023-7
更新日期:2019-05-17 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-42194-x
更新日期:2019-04-04 00:00:00
abstract::Ginseng rusty root (GRR) symptom is one of the primary diseases of ginseng. There has been a problem of ginseng rusty root, leading to a severe decline in the quality of ginseng. To clarify the relationship between root symptoms of ginseng rust and soil, the physical and chemical properties, enzyme activity, community...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71024-8
更新日期:2020-09-25 00:00:00
abstract::Recent decades have experienced the discovery of numerous complex materials. At the root of the complexity underlying many of these materials lies a large number of contending atomic- and largerscale configurations. In order to obtain a more detailed understanding of such systems, we need tools that enable the detecti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00329
更新日期:2012-01-01 00:00:00
abstract::Private Set Intersection Cardinality (PSI-CA) and Private Set Union Cardinality (PSU-CA) are two cryptographic primitives whereby two or more parties are able to obtain the cardinalities of the intersection and the union of their respective private sets, and the privacy of their sets is preserved. In this paper, we pr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-77579-w
更新日期:2020-12-17 00:00:00
abstract::M. tuberculosis GmhA enzyme catalyzes the isomerization of D-sedoheptulose 7-phosphate into D-glycero-D-α-manno-heptose-7-phosphate in GDP-D-glycero-α-D-manno-heptose biosynthetic pathway. The D-glycero-α-D-manno-heptose is a major constituent of lipopolysaccharide and contributes to virulence and antibiotic resistanc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-77230-8
更新日期:2020-11-30 00:00:00
abstract::The transcriptome of the endometrium early postpartum was profiled to determine if inflammatory gene expression was elevated in cows which subsequently developed uterine disease. Endometrial cytobrush samples were collected at 7 days postpartum (DPP) from 112 Holstein-Friesian dairy cows, from which 27 were retrospect...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75104-7
更新日期:2020-10-26 00:00:00
abstract::Therapies that target the signal transduction and metabolic pathways of cancer stem cells (CSCs) are innovative strategies to effectively reduce the recurrence and significantly improve the outcome of glioblastoma multiforme (GBM). CSCs exhibit an increased rate of glycolysis, thus rendering them intrinsically more se...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15556
更新日期:2015-10-23 00:00:00
abstract::Anthracnose caused by Colletotrichum is one of the most severe diseases of Hevea brasiliensis. However, research on the diversity and geographical distribution of Colletotrichum remains limited in China. In this study, we investigated the phylogenetic diversity of Colletotrichum isolates associated with symptomatic ti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28166-7
更新日期:2018-07-11 00:00:00
abstract::We previously developed red lettuce (Lactuca sativa L.) cultivars with high flavonoid and phenolic acid content and demonstrated their anti-diabetic effect. Here we report on developing three fertile and true-breeding lettuce lines enriched with flavonoids with reported beneficial health effects. These lines were iden...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39287-y
更新日期:2019-03-01 00:00:00
abstract::B cell derived induced pluripotent stem cells (BiPSCs) were recently established from peripheral blood B cells by the simultaneous transfection of Yamanaka factors (Oct3/4, Sox2, Klf4, c-Myc) and C/EBPα using a Sendai virus vector. Here, using a different method, we established BiPSCs with immunoglobulin heavy chain (...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-01627-1
更新日期:2017-05-10 00:00:00
abstract::Contact heat evoked potentials (CHEPs) have become an acknowledged research tool in the assessment of the integrity of the nociceptive system and gained importance in the diagnostic work-up of patients with suspected small fiber neuropathy. For the latter, normative values for CHEP amplitude and latency are indispensa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29145-8
更新日期:2018-07-20 00:00:00
abstract::The complexity of the frictional dynamics at the microscopic scale makes difficult to identify all of its controlling parameters. Indeed, experiments on sheared elastic bodies have shown that the static friction coefficient depends on loading conditions, the real area of contact along the interfaces and the confining ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06772
更新日期:2014-10-27 00:00:00
abstract::The integral membrane-bound Nrf1 transcription factor fulfils important functions in maintaining cellular homeostasis and organ integrity, but how it is controlled vectorially is unknown. Herein, creative use of Gal4-based reporter assays with protease protection assays (GRAPPA), and double fluorescence protease prote...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02006
更新日期:2013-01-01 00:00:00
abstract::Detection of antihypertensive drugs in biological samples is an important tool to assess the adherence of hypertensive patients. Urine and serum/plasma screenings based on qualitative results may lead to misinterpretations regarding drugs with a prolonged detectability. The aim of the present study was to develop a me...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52164-y
更新日期:2019-10-30 00:00:00
abstract::Disordered proteins are highly prevalent in biological systems, they control myriad signaling and regulatory processes, and their levels and/or cellular localization are often altered in human disease. In contrast to folded proteins, disordered proteins, due to conformational heterogeneity and dynamics, are not consid...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15686
更新日期:2015-10-28 00:00:00
abstract::Extracellular vesicles are selectively enriched in RNA that has potential as disease biomarkers. To systemically characterize circulating extracellular RNA (exRNA) profiles, we performed RNA sequencing analysis on plasma extracellular vesicles derived from 50 healthy individuals and 142 cancer patients. Of ~12.6 milli...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19413
更新日期:2016-01-20 00:00:00
abstract::Recent studies have indicated that different post-translational modifications (PTMs) synergistically orchestrate specific biological processes by crosstalks. However, the preference of the crosstalk among different PTMs and the evolutionary constraint on the PTM crosstalk need further dissections. In this study, the i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07331
更新日期:2014-12-05 00:00:00
abstract::Hepatocarcinoma (HCC) is one of the deadliest cancers in the world and represents a significant disease burden. Better biomarkers are needed for early detection of HCC. Metabolomics was applied to urine samples obtained from HCC patients to discover noninvasive and reliable biomarkers for rapid diagnosis of HCC. Metab...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19763
更新日期:2016-01-25 00:00:00
abstract::Notarchirico (Southern Italy) has yielded the earliest evidence of Acheulean settlement in Italy and four older occupation levels have recently been unearthed, including one with bifaces, extending the roots of the Acheulean in Italy even further back in time. New 40Ar/39Ar on tephras and ESR dates on bleached quartz ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68617-8
更新日期:2020-08-14 00:00:00
abstract::Cardiac energy metabolism must cope with early postnatal changes in tissue oxygen tensions, hemodynamics, and cell proliferation to sustain development. Here, we tested the hypothesis that proliferating neonatal cardiomyocytes are dependent on high oxidative energy metabolism. We show that energy-related gene expressi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15656-3
更新日期:2017-11-13 00:00:00
abstract::The aim was to investigate the ability of self-assembling Peptide P11-4 Matrix (SAPM) to remineralize artificial initial caries lesions compared to the use of fluoride varnish. Volunteers were recruited for this randomised, cross-over in situ trial. Bovine specimens, half including orthodontic brackets, were recessed ...
journal_title:Scientific reports
pub_type: 杂志文章,随机对照试验
doi:10.1038/s41598-018-36536-4
更新日期:2019-01-22 00:00:00
abstract::In the modern era, diathermic oils have been gotten the great attention from researchers due to its notable and momentous applications in engineering, mechanics and in the industrial field. The aim of this paper is to model the problem to augment the heat transfer rate of diathermic oils, specifically, Engine-oil (EO)...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33547-z
更新日期:2018-10-16 00:00:00