Abstract：
:The major virulence factors of Clostridium difficile are toxins A and B. These toxins are encoded by tcdA and tcdB genes, which form a pathogenicity locus (PaLoc) together with three additional genes that have been implicated in regulation (tcdR and tcdC) and secretion (tcdE). To date, the PaLoc has always been found in the same location and is replaced in non-toxigenic strains by a highly conserved 75/115 bp non-coding region. Here, we show new types of C. difficile pathogenicity loci through the genome analysis of three atypical clinical strains and describe for the first time a variant strain producing only toxin A (A(+)B(-)). Importantly, we found that the PaLoc integration sites of these three strains are located in the genome far from the usual single known PaLoc integration site. These findings allowed us to propose a new model of PaLoc evolution in which two "Mono-Toxin PaLoc" sites are merged to generate a single "Bi-Toxin PaLoc".
journal_name
Sci Repjournal_title
Scientific reportsauthors
Monot M,Eckert C,Lemire A,Hamiot A,Dubois T,Tessier C,Dumoulard B,Hamel B,Petit A,Lalande V,Ma L,Bouchier C,Barbut F,Dupuy Bdoi
10.1038/srep15023subject
Has Abstractpub_date
2015-10-08 00:00:00pages
15023issn
2045-2322pii
srep15023journal_volume
5pub_type
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