Selectivity and ligand-based molecular modeling of an odorant-binding protein from the leaf beetle Ambrostoma quadriimpressum (Coleoptera: Chrysomelidae) in relation to habitat-related volatiles.

abstract：:Bacillus thuringiensis insecticidal toxin (Bt) rice will be commercialized as a main food source. Traditional safety assessments on genetically modified products pay little attention on gastrointestinal (GI) health. More data about GI health of Bt rice must be provided to dispel public' doubts about the potential effe...

journal_title：Scientific reports

authors： Yuan Y,Xu W,He X,Liu H,Cao S,Qi X,Huang K,Luo Y

更新日期：2013-01-01 00:00:00

abstract：:Hematopoietic stem cells (HSCs) maintain the entire blood system throughout life and are utilized in therapeutic approaches for blood diseases. Prospective isolation of highly purified HSCs is crucial to understand the molecular mechanisms underlying regulation of HSCs. The zebrafish is an elegant genetic model for th...

journal_title：Scientific reports

authors： Kobayashi I,Kondo M,Yamamori S,Kobayashi-Sun J,Taniguchi M,Kanemaru K,Katakura F,Traver D

更新日期：2019-10-02 00:00:00

abstract：:Observational studies suggest associations of triglyceride levels with longevity and frailty. This study aimed to test whether the associations are causal. We used data from the Rugao Longevity and Ageing Study, a population-based cohort study performed in Rugao, China. A variant in the APOA5 gene region (rs662799) wa...

journal_title：Scientific reports

authors： Liu Z,Burgess S,Wang Z,Deng W,Chu X,Cai J,Zhu Y,Shi J,Xie X,Wang Y,Jin L,Wang X

更新日期：2017-01-30 00:00:00

abstract：:A previous study identified 3 nonsynonymous and 6 synonymous mutations in the entire mosquito sodium channel of Culex quinquefasciatus, the prevalence of which were strongly correlated with levels of resistance and increased dramatically following insecticide selection. However, it is unclear whether this is unique to...

journal_title：Scientific reports

authors： Li T,Zhang L,Reid WR,Xu Q,Dong K,Liu N

更新日期：2012-01-01 00:00:00

abstract：:Meckel syndrome (MKS) is an inherited autosomal recessive hepatorenal fibrocystic syndrome, caused by mutations in TMEM67, characterized by occipital encephalocoele, renal cysts, hepatic fibrosis, and polydactyly. Here we describe an ovine model of MKS, with kidney and liver abnormalities, without polydactyly or occip...

journal_title：Scientific reports

authors： Stayner C,Poole CA,McGlashan SR,Pilanthananond M,Brauning R,Markie D,Lett B,Slobbe L,Chae A,Johnstone AC,Jensen CG,McEwan JC,Dittmer K,Parker K,Wiles A,Blackburne W,Leichter A,Leask M,Pinnapureddy A,Jennings M,Hor

更新日期：2017-05-09 00:00:00

abstract：:Dysregulation of dopaminergic system induced by HIV-1 Tat protein-mediated direct inhibition of the dopamine transporter (DAT) has been implicated as a mediating factor of HIV-1 associated neurocognitive disorders. We have reported that single point mutations on human DAT (hDAT) at tyrosine88 (Y88F), lysine92 (K92M), ...

journal_title：Scientific reports

authors： Sun WL,Quizon PM,Yuan Y,Strauss MJ,McCain R Jr,Zhan CG,Zhu J

更新日期：2019-03-07 00:00:00

abstract：:SIRT1, the NAD+-dependent protein deacetylase, controls cell-cycle progression and apoptosis by suppressing p53 tumour suppressor. Although SIRT1 is known to be phosphorylated by JNK1 upon oxidative stress and subsequently down-regulated, it still remains elusive how SIRT1 stability and activity are controlled. Here, ...

journal_title：Scientific reports

authors： Kim M,Kwon YE,Song JO,Bae SJ,Seol JH

更新日期：2016-11-24 00:00:00

abstract：:Intrahepatic cholestasis represents a frequent manifestation of drug-induced liver injury; however, the mechanisms underlying such injuries are poorly understood. In this study of human HepaRG and primary hepatocytes, we found that bile canaliculi (BC) underwent spontaneous contractions, which are essential for bile a...

journal_title：Scientific reports

authors： Sharanek A,Burban A,Burbank M,Le Guevel R,Li R,Guillouzo A,Guguen-Guillouzo C

更新日期：2016-05-12 00:00:00

abstract：:The phytohormone auxin is a major determinant and regulatory component important for plant development. Auxin transport between cells is mediated by a complex system of transporters such as AUX1/LAX, PIN, and ABCB proteins, and their localization and activity is thought to be influenced by phosphatases and kinases. Fl...

journal_title：Scientific reports

authors： Kuhn BM,Nodzyński T,Errafi S,Bucher R,Gupta S,Aryal B,Dobrev P,Bigler L,Geisler M,Zažímalová E,Friml J,Ringli C

更新日期：2017-02-06 00:00:00

abstract：:One of the causal genes for holoprosencephaly (HPE) is ZIC2 (HPE5). It belongs to the zinc finger protein of the cerebellum (Zic) family of genes that share a C2H2-type zinc finger domain, similar to the GLI family of genes. In order to clarify the role of Zic2 in gene regulation, we searched for its direct target gen...

journal_title：Scientific reports

authors： Ishiguro A,Hatayama M,Otsuka MI,Aruga J

更新日期：2018-02-01 00:00:00

abstract：:The dispersion properties of metamaterials and photonic crystals (PhCs) lead to an intensive research in the development of cavity resonators for the confinement of electromagnetic (e-m) radiation. In this work, we investigate the formation of Fabry-Pérot (FP) modes associated with hyperbolic-like dispersion (HLD) reg...

journal_title：Scientific reports

authors： Darthy RR,Venkateswaran C,Subramanian V,Ouyang Z,Yogesh N

更新日期：2020-07-06 00:00:00

abstract：:In dentistry, the wet-bonding approach relies on water to maintain demineralized collagen expanded for proper resin infiltration; nevertheless, hydrolytic instability of the resin-dentin interface is inevitable with current bonding techniques. Considering dimethyl sulfoxide's (DMSO) ability to "biomodify" collagen and...

journal_title：Scientific reports

authors： Stape THS,Seseogullari-Dirihan R,Tjäderhane L,Abuna G,Martins LRM,Tezvergil-Mutluay A

更新日期：2018-11-15 00:00:00

abstract：:Covert facial mimicry involves subtle facial muscle activation in observers when they perceive the facial emotional expressions of others. It remains uncertain whether prototypical facial features in emotional expressions are being covertly mimicked and also whether covert facial mimicry involves distinct facial muscl...

journal_title：Scientific reports

authors： Wingenbach TSH,Brosnan M,Pfaltz MC,Peyk P,Ashwin C

更新日期：2020-03-13 00:00:00

abstract：:Plant health is strongly connected with plants´ microbiome. In case of raw-eaten plants, the microbiome can also affect human health. To study potential impacts on health issues of both hosts, the microbiome composition of seven different Brassica vegetables, originating from different food processing pathways, was an...

journal_title：Scientific reports

authors： Wassermann B,Rybakova D,Müller C,Berg G

更新日期：2017-12-15 00:00:00

abstract：:Hydrophilic polymers have garnered much attention due to their critical roles in various applications such as molecular separation membranes, bio-interfaces, and surface engineering. However, a long-standing problem is that their mechanical properties usually deteriorate at high relative humidity (RH). Through the sim...

journal_title：Scientific reports

authors： Liu T,An QF,Zhao Q,Wu JK,Song YH,Zhu BK,Gao CJ

更新日期：2015-01-14 00:00:00

abstract：:The thermal field theory is applied to fermionic superfluids by doubling the degrees of freedom of the BCS theory. We construct the two-mode states and the corresponding Bogoliubov transformation to obtain the BCS thermal vacuum. The expectation values with respect to the BCS thermal vacuum produce the statistical ave...

journal_title：Scientific reports

authors： Hou XY,Huang Z,Guo H,He Y,Chien CC

更新日期：2018-08-10 00:00:00

abstract：:Immunotherapeutic strategies for glioblastoma, the most frequent malignant primary brain tumor, aim to improve its disastrous consequences. On top of the standard treatment, one strategy uses T cell activation by autologous dendritic cells (DC) ex vivo loaded with tumor lysate to attack remaining cancer cells. Wonderi...

journal_title：Scientific reports

authors： Belmans J,Van Woensel M,Creyns B,Dejaegher J,Bullens DM,Van Gool SW

更新日期：2017-10-24 00:00:00

abstract：:Targeting epigenetic reader proteins by small molecule inhibitors represents a new therapeutic concept in autoimmune diseases such as rheumatoid arthritis (RA). Although inhibitors targeting bromodomain protein 1 (BRD1) are in development, the function of BRD1 has hardly been studied. We investigated the therapeutic p...

journal_title：Scientific reports

authors： Klein K,Kato M,Frank-Bertoncelj M,Kolling C,Ciurea A,Gay S,Ospelt C

更新日期：2018-07-24 00:00:00

abstract：:Neuroimaging studies of the Psychomotor Vigilance Task (PVT) have revealed brain regions involved in attention lapses in sleep-deprived and well-rested adults. Those studies have focused on individual brain regions, rather than integrated brain networks, and have overlooked adolescence, a period of ongoing brain devel...

journal_title：Scientific reports

authors： DiFrancesco MW,Van Dyk T,Altaye M,Drummond SPA,Beebe DW

更新日期：2019-09-26 00:00:00

abstract：:The reflected microwave power from the photo-excited high mobility GaAs/AlGaAs 2D device has been measured over the wide frequency band spanning from 30 to 330 GHz simultaneously along with diagonal magnetoresistance as a function of the magnetic field. Easily distinguishable resonances in the reflected power signal a...

journal_title：Scientific reports

authors： Kriisa A,Samaraweera RL,Heimbeck MS,Everitt HO,Reichl C,Wegscheider W,Mani RG

更新日期：2019-02-20 00:00:00

abstract：:Protein phosphorylation enables a rapid adjustment of cellular activities to diverse intracellular and environmental stimuli. Many phosphoproteins are targeted on more than one site, which allows the integration of multiple signals and the implementation of complex responses. However, the hierarchy and interplay betwe...

journal_title：Scientific reports

authors： Dengler L,Örd M,Schwab LM,Loog M,Ewald JC

更新日期：2021-01-13 00:00:00

abstract：:A novel protein, designated as DOI, isolated from the Chinese yam (Dioscorea opposita Thunb.) could be the first protein drug for the treatment of menopausal syndrome and an alternative to hormone replacement therapy (HRT), which is known to have undesirable side effects. DOI is an acid- and thermo-stable protein with...

journal_title：Scientific reports

authors： Wong KL,Lai YM,Li KW,Lee KF,Ng TB,Cheung HP,Zhang YB,Lao L,Wong RN,Shaw PC,Wong JH,Zhang ZJ,Lam JK,Ye WC,Sze SC

更新日期：2015-07-10 00:00:00

abstract：:The anhydrofructose pathway is an alternate pathway for glycogen degradation by α-1,4-glucan lyase. The sugar 1,5-anhydro-D-fructose (1,5-AF) acts as the central intermediate of this pathway, but its physiological role of in mammals is unclear. Glycation reactions forming advanced glycation end-products (AGEs) are imp...

journal_title：Scientific reports

authors： Sakasai-Sakai A,Takata T,Suzuki H,Maruyama I,Motomiya Y,Takeuchi M

更新日期：2019-07-15 00:00:00

abstract：:The optimized strategy to further increase the success rate of ablation for ventricular arrhythmias (VAs) from the right ventricular outflow tract (RVOT) is challenging. Recent studies have shown that the pulmonary sinus cusp (PSC) region may be the origin of certain RVOT VAs. We evaluated the efficacy of preferential...

journal_title：Scientific reports

authors： Xie Y,Liu A,Jin Q,Zhang N,Jia K,Lin C,Ling T,Chen K,Pan W,Wu L

更新日期：2020-10-20 00:00:00

abstract：:The recent rise of multidrug resistant microbial strains requires development of new and novel therapeutic alternatives. In this study, we present a novel antibacterial system that comprises of modified naturally abundant antimicrobial peptides in conjugation with silver nanoparticles. Further, we propose a simple rou...

journal_title：Scientific reports

authors： Pal I,Bhattacharyya D,Kar RK,Zarena D,Bhunia A,Atreya HS

更新日期：2019-03-14 00:00:00

abstract：:It is a common belief that reptile eggs should not be turned after oviposition once the embryo has attached itself to the inner membrane of the shell as it might kill developing embryos. Here, we used 338 eggs from 32 clutches of the water snake Natrix maura to (1) thoroughly describe natural clutch arrangement, (2) e...

journal_title：Scientific reports

authors： Aubret F,Blanvillain G,Kok PJ

更新日期：2015-08-21 00:00:00

abstract：:Solid state memory and switching devices aimed at replacing the flash memory technology operate by switching from the high to low resistance when conductive filaments are created in response to the electric pulse. The filaments are identified with either structurally different protrusions or purely electronic conducti...

journal_title：Scientific reports

authors： Karpov VG,Niraula D

更新日期：2018-08-15 00:00:00

abstract：:The establishment of clinically relevant models for tumor metastasis and drug testing is a major challenge in cancer research. Here we report a physiologically relevant assay enabling quantitative analysis of metastatic capacity of tumor cells following implantation into the chorioallantoic membrane (CAM). Engraftment...

journal_title：Scientific reports

authors： Pawlikowska P,Tayoun T,Oulhen M,Faugeroux V,Rouffiac V,Aberlenc A,Pommier AL,Honore A,Marty V,Bawa O,Lacroix L,Scoazec JY,Chauchereau A,Laplace-Builhe C,Farace F

更新日期：2020-10-09 00:00:00

abstract：:The transparency of animals is an important biological feature. Ascidian eggs have various degrees of transparency, but this characteristic has not yet been measured quantitatively and comprehensively. In this study, we established a method for evaluating the transparency of eggs to first characterize the transparency...

journal_title：Scientific reports

authors： Shito TT,Hasegawa N,Oka K,Hotta K

更新日期：2020-11-30 00:00:00

abstract：:Clostridium ljungdahlii derives energy by lithotrophic and organotrophic acetogenesis. C. ljungdahlii was grown organotrophically with fructose and also lithotrophically, either with syngas - a gas mixture containing hydrogen (H2), carbon dioxide (CO2), and carbon monoxide (CO), or with H2 and CO2. Gene expression was...

journal_title：Scientific reports

authors： Aklujkar M,Leang C,Shrestha PM,Shrestha M,Lovley DR

更新日期：2017-10-13 00:00:00