Harnessing the microbiomes of Brassica vegetables for health issues.

abstract：:The role of soil organic carbon in global carbon cycles is receiving increasing attention both as a potentially large and uncertain source of CO2 emissions in response to predicted global temperature rises, and as a natural sink for carbon able to reduce atmospheric CO2. There is general agreement that the technical p...

journal_title：Scientific reports

authors： Zomer RJ,Bossio DA,Sommer R,Verchot LV

更新日期：2017-11-14 00:00:00

abstract：:Chemical dissimilarity of tellurium oxide with silica glass increases phase separation and crystallization tendency when mixed and melted for making a glass. We report a novel technique for incorporating an Er(3+)-doped tellurite glass composition into silica substrates through a femtosecond (fs) laser generated plasm...

journal_title：Scientific reports

authors： Chandrappan J,Murray M,Kakkar T,Petrik P,Agocs E,Zolnai Z,Steenson DP,Jha A,Jose G

更新日期：2015-09-15 00:00:00

abstract：:Small oligomers formed early along human islet amyloid polypeptide (hIAPP) aggregation is responsible for the cell death in Type II diabetes. The epigallocatechin gallate (EGCG), a green tea extract, was found to inhibit hIAPP fibrillation. However, the inhibition mechanism and the conformational distribution of the s...

journal_title：Scientific reports

authors： Mo Y,Lei J,Sun Y,Zhang Q,Wei G

更新日期：2016-09-13 00:00:00

abstract：:Humans interact with the oceans in diverse and profound ways. The scope, magnitude, footprint and ultimate cumulative impacts of human activities can threaten ocean ecosystems and have changed over time, resulting in new challenges and threats to marine ecosystems. A fundamental gap in understanding how humanity is af...

journal_title：Scientific reports

authors： Halpern BS,Frazier M,Afflerbach J,Lowndes JS,Micheli F,O'Hara C,Scarborough C,Selkoe KA

更新日期：2019-08-12 00:00:00

abstract：:Studies have proven that IL-2 and IL-15 showed contrasting roles during CIK cells preparation. By employing microarray, we analyzed miRNA expression profiles of PBMC, CIKIL-2 and CIKIL-15. Advanced bioinformatic analyses were performed to explore the key miRNAs which may regulate cell proliferation and anti-tumor acti...

journal_title：Scientific reports

authors： Wang W,Li R,Meng M,Wei C,Xie Y,Zhang Y,Jiang L,Dong R,Wang C,Zhong Y,Yang F,Tang W,Jin X,Liu B,Hou Z

更新日期：2015-03-31 00:00:00

abstract：:Early treatment, soon after infection, reduces HIV transmissions and benefits patients. The Transmission Reduction Intervention Project (TRIP) evaluated a network intervention to detect individuals recently infected (in the past 6 months). TRIP was conducted in Greece (2013-2015) and focused on drug injector networks....

journal_title：Scientific reports

authors： Nikolopoulos GK,Pavlitina E,Muth SQ,Schneider J,Psichogiou M,Williams LD,Paraskevis D,Sypsa V,Magiorkinis G,Smyrnov P,Korobchuk A,Vasylyeva TI,Skaathun B,Malliori M,Kafetzopoulos E,Hatzakis A,Friedman SR

更新日期：2016-12-05 00:00:00

abstract：:At the species level, plants can respond to climate changes by changing their leaf traits; however, there is scant information regarding the responses of morphological, physiological and anatomical traits of plant functional types (PFTs) to aridity. Herein, the leaf traits of five PFTs representing 17 plant species in...

journal_title：Scientific reports

authors： Guo C,Ma L,Yuan S,Wang R

更新日期：2017-01-20 00:00:00

abstract：:The tumor microenvironment (TME) plays critical roles in tumor growth and progression, however key regulators of gene expression in the TME of cutaneous malignant peripheral nerve sheath tumor (C-MPNST) and spindle cell melanoma (SCM) have not been well elucidated. Herein, we investigate the epigenetic regulation of p...

journal_title：Scientific reports

authors： Vougiouklakis T,Aung PP,Vasudevaraja V,Prieto VG,Torres-Cabala CA,Sulman EP,Snuderl M,Jour G

更新日期：2020-08-03 00:00:00

abstract：:Multidomain proteins account for 70% of the eukaryotic proteome. In genetic disease, multidomain proteins are often affected by numerous mutations, but the effects of these mutations on protein stability and their roles in genetic disease are not well understood. Here, we analyzed protein globular domains to understan...

journal_title：Scientific reports

authors： Ortiz FW,Sergeev YV

更新日期：2019-03-06 00:00:00

abstract：:Evidence suggest that overexpression of hypoxia-inducible factor-1α (HIF-1α) is linked to multidrug resistance of epilepsy. Here we explored whether aberrant expression of HIF-1α is regulated by miRNAs. Genome-wide microRNA expression profiling was performed on temporal cortex resected from mesial temporal lobe epilep...

journal_title：Scientific reports

authors： Li Y,Huang C,Feng P,Jiang Y,Wang W,Zhou D,Chen L

更新日期：2016-08-24 00:00:00

abstract：:We report on high-performance thermochromic ZrO2/V0.982W0.018O2/ZrO2 coatings with a low transition temperature prepared on glass by a low-temperature scalable deposition technique. The V0.982W0.018O2 layers were deposited by a controlled high-power impulse magnetron sputtering of V target, combined with a simultaneou...

journal_title：Scientific reports

authors： Kolenatý D,Vlček J,Bárta T,Rezek J,Houška J,Haviar S

更新日期：2020-07-06 00:00:00

abstract：:Local mRNA translation occurs in growing axons enabling precise control of the proteome in response to signals. To measure quantitatively the spatiotemporal dynamics of protein synthesis in growth cones, we further developed a technique for single molecule translation imaging (SMTI). We report that Netrin-1 triggers a...

journal_title：Scientific reports

authors： Ströhl F,Lin JQ,Laine RF,Wong HH,Urbančič V,Cagnetta R,Holt CE,Kaminski CF

更新日期：2017-04-06 00:00:00

abstract：:Pyroclastic density currents are one of the most devastating volcanic hazards. Understanding their dynamics is a key to develop successful hazard mitigation strategies. The hazard associated with pyroclastic density currents is commonly investigated a posteriori from their deposits or a priori using analogue and numer...

journal_title：Scientific reports

authors： Scharff L,Hort M,Varley NR

更新日期：2019-05-14 00:00:00

abstract：:Genotyping-by-sequencing (GBS) or restriction-site associated DNA marker sequencing (RAD-seq) is a practical and cost-effective method for analysing large genomes from high diversity species. This method of sequencing, coupled with methylation-sensitive enzymes (often referred to as methylation-sensitive restriction e...

journal_title：Scientific reports

authors： Mayne BT,Leemaqz SY,Buckberry S,Rodriguez Lopez CM,Roberts CT,Bianco-Miotto T,Breen J

更新日期：2018-02-01 00:00:00

abstract：:The direct fabrication of microstructures, having a non-symmetrical morphology with controllable inclination, presents nowadays a challenging task. Natural examples of surfaces with inclined topographies have shown to provide anisotropic functionalities, which have attracted the interest of several researchers in the ...

journal_title：Scientific reports

authors： Alamri S,El-Khoury M,Aguilar-Morales AI,Storm S,Kunze T,Lasagni AF

更新日期：2019-04-01 00:00:00

abstract：:Affinity maturation is one of the cardinal strategies for improving antibody function using in vitro evolutionary methods; one such well-established method is phage display. To minimise gene deletion, we previously developed an open sandwich (OS) method wherein selection was performed using only phage-displaying VH fr...

journal_title：Scientific reports

authors： Sanada H,Kobayashi K,Oyama K,Maru T,Nakanishi T,Umetsu M,Asano R,Kumagai I

更新日期：2018-04-03 00:00:00

abstract：:Mathematical models of metabolism from bacterial systems biology have proven their utility across multiple fields, for example metabolic engineering, growth phenotype simulation, and biological discovery. The usefulness of the models stems from their ability to compute a link between genotype and phenotype, but their ...

journal_title：Scientific reports

authors： Aziz RK,Monk JM,Lewis RM,In Loh S,Mishra A,Abhay Nagle A,Satyanarayana C,Dhakshinamoorthy S,Luche M,Kitchen DB,Andrews KA,Fong NL,Li HJ,Palsson BO,Charusanti P

更新日期：2015-11-04 00:00:00

abstract：:Recent advances in next-generation sequencing technologies have paved the path for a considerable amount of sequencing data at a relatively low cost. This has revolutionized the genomics and transcriptomics studies. However, different challenges are now created in handling such data with available bioinformatics platf...

journal_title：Scientific reports

authors： Naranpanawa DNU,Chandrasekara CHWMRB,Bandaranayake PCG,Bandaranayake AU

更新日期：2020-10-26 00:00:00

abstract：:Combining chemotherapy and targeted therapies has resulted in an enhanced survival in metastatic colorectal cancer (mCRC) patients. However, the result of this palliative treatment in patients with metachronous peritoneal carcinomatosis (PC) remains unknown. The current population-based study aims to investigate the u...

journal_title：Scientific reports

authors： van Oudheusden TR,Razenberg LG,van Gestel YR,Creemers GJ,Lemmens VE,de Hingh IH

更新日期：2015-12-21 00:00:00

abstract：:Crotoxin B (CB) is a catalytically active group IIA sPLA2 from Crotalus durissus terrificus snake venom. In contrast to most GIIA sPLA2s, CB exhibits anti-inflammatory effects, including the ability to inhibit leukocyte functions. Lipid droplets (LDs) are lipid-rich organelles associated with inflammation and recogniz...

journal_title：Scientific reports

authors： Giannotti KC,Leiguez E,Carvalho AEZ,Nascimento NG,Matsubara MH,Fortes-Dias CL,Moreira V,Teixeira C

更新日期：2017-06-22 00:00:00

abstract：:Sodium butyrate (NaBu), a form of short-chain fatty acid (SCFA), acts classically as a potent anti-angiogenic agent in tumour angiogenesis models, some authors demonstrated that low concentrations of NaBu may contribute to healing of tendon-bone injury in part at least through promotion of tissue remodelling. Here, we...

journal_title：Scientific reports

authors： Liu D,Andrade SP,Castro PR,Treacy J,Ashworth J,Slevin M

更新日期：2016-10-03 00:00:00

abstract：:Optogenetics allows precise, fast and reversible intervention in biological processes. Light-sheet microscopy allows observation of the full course of Drosophila embryonic development from egg to larva. Bringing the two approaches together allows unparalleled precision into the temporal regulation of signaling pathway...

journal_title：Scientific reports

authors： Kaur P,Saunders TE,Tolwinski NS

更新日期：2017-11-30 00:00:00

abstract：:Photomechanical nanocomposites embedded with light-absorbing nanoparticles show promising applications in photoresponsive actuations. Near infrared (nIR)-responsive nanocomposites based photomechanical soft actuators can offer lightweight functional and underexploited entry into soft robotics, active optics, drug deli...

journal_title：Scientific reports

authors： Niu D,Jiang W,Liu H,Zhao T,Lei B,Li Y,Yin L,Shi Y,Chen B,Lu B

更新日期：2016-06-06 00:00:00

abstract：:Papillary thyroid carcinoma (PTC) displays strong but so far largely uncharacterized heritability. Here we studied genetic predisposition in a family with six affected individuals. We genotyped all available family members and conducted whole exome sequencing of blood DNA from two affected individuals. Haplotype analy...

journal_title：Scientific reports

authors： Tomsic J,He H,Akagi K,Liyanarachchi S,Pan Q,Bertani B,Nagy R,Symer DE,Blencowe BJ,de la Chapelle A

更新日期：2015-07-02 00:00:00

abstract：:This study aimed to explore the risk of dementia in a middle- and older-aged population with severe or profound hearing impairments. Data were collected for the Korean National Health Insurance Service-National Sample Cohort from 2002 to 2013. Participants aged 40 or older were selected. The 4,432 severely hearing-imp...

journal_title：Scientific reports

authors： Kim SY,Lim JS,Kong IG,Choi HG

更新日期：2018-10-15 00:00:00

abstract：:Enhancement of endogenous neurogenesis after ischemic stroke may improve functional recovery. We previously demonstrated that medium B, which is a combination with epidermal growth factor (EGF) and fibronectin, can promote neural stem/progenitor cell (NSPC) proliferation and migration. Here, we showed that medium B pr...

journal_title：Scientific reports

authors： Chen YA,Tsai YC,Chen YD,Liu DZ,Young TH,Tsai LK

更新日期：2020-04-20 00:00:00

abstract：:Langerhans cells (LCs) are able to orchestrate adaptive immune responses in the skin by interpreting the microenvironmental context in which they encounter foreign substances, but the regulatory basis for this has not been established. Utilising systems immunology approaches combining in silico modelling of a reconstr...

journal_title：Scientific reports

authors： Polak ME,Ung CY,Masapust J,Freeman TC,Ardern-Jones MR

更新日期：2017-04-06 00:00:00

abstract：:Anti-PD-1 antibodies revolutionized the treatment of advanced melanoma patients. However, one out of three do not respond to this therapy, with an overall poor prognosis. Identification of predictive biomarkers in patients receiving immune-based therapies is necessary for minimizing risk of toxicity and optimizing pat...

journal_title：Scientific reports

authors： Giunta EF,Barra G,De Falco V,Argenziano G,Napolitano S,Vitale P,Zanaletti N,Terminiello M,Martinelli E,Morgillo F,Ciardiello D,De Palma R,Ciardiello F,Troiani T

更新日期：2020-10-19 00:00:00

abstract：:MicroRNAs (miRNAs) are important post-transcriptional regulators involved in animal adipogenesis, however, their roles in bovine fat deposition remain poorly understood. In the present study, we conducted a comparative RNA sequencing to identify the key miRNAs involved in beef lipid accumulation by comparing the backf...

journal_title：Scientific reports

authors： Guo Y,Zhang X,Huang W,Miao X

更新日期：2017-03-08 00:00:00

abstract：:Cell division during the reproductive phase of the Streptomyces life-cycle requires tight coordination between synchronous formation of multiple septa and DNA segregation. One remarkable difference with most other bacterial systems is that cell division in Streptomyces is positively controlled by the recruitment of Ft...

journal_title：Scientific reports

authors： Zhang L,Willemse J,Hoskisson PA,van Wezel GP

更新日期：2018-05-09 00:00:00