Effects of SGLT2 inhibitors on UTIs and genital infections in type 2 diabetes mellitus: a systematic review and meta-analysis.

abstract：:In the study, we analyzed role of p53 in predicting outcome in visceral metastasis breast cancer (VMBC) patients. 97 consecutive VMBC patients were studied. P53 positivity rate was 29.9%. In the p53-negative group, median disease free survival (DFS), and time from primary breast cancer diagnosis to death (OS1), time f...

journal_title：Scientific reports

authors： Yang P,Du CW,Kwan M,Liang SX,Zhang GJ

更新日期：2013-01-01 00:00:00

abstract：:Familial hypercholesterolemia (FH) is an inherited disease of lipoprotein metabolism caused by a defect in the LDL receptor (LDLR) leading to severe hypercholesterolemia, and associated with an increased risk of coronary heart disease and myocardial infarction. We have developed a gene therapy protocol for FH using AA...

journal_title：Scientific reports

authors： Hytönen E,Laurema A,Kankkonen H,Miyanohara A,Kärjä V,Hujo M,Laham-Karam N,Ylä-Herttuala S

更新日期：2019-05-06 00:00:00

abstract：:A green, facile and tunable pair electrochemical process was developed for the synthesis of new benzenesulfonamide derivatives by using reductive controlled potential electrolysis of dinitrobenzene (DNB) in the presence of arylsulfinic acids (ASAs). In addition to the usual features associated with paired electrochemi...

journal_title：Scientific reports

authors： Mokhtari B,Nematollahi D,Salehzadeh H

更新日期：2019-03-14 00:00:00

abstract：:Capicua (CIC) has been implicated in pathogenesis of spinocerebellar ataxia type 1 and cancer in mammals; however, the in vivo physiological functions of CIC remain largely unknown. Here we show that Cic hypomorphic (Cic-L(-/-)) mice have impaired bile acid (BA) homeostasis associated with induction of proinflammatory...

journal_title：Scientific reports

authors： Kim E,Park S,Choi N,Lee J,Yoe J,Kim S,Jung HY,Kim KT,Kang H,Fryer JD,Zoghbi HY,Hwang D,Lee Y

更新日期：2015-02-05 00:00:00

abstract：:Topological objects of nontrivial spin or dipolar field textures, such as skyrmions, merons, and vortices, interacting with applied external fields in ferroic materials are of great scientific interest as an intriguing playground of unique physical phenomena and novel technological paradigms. The quest for new topolog...

journal_title：Scientific reports

authors： Shimada T,Lich LV,Nagano K,Wang JS,Wang J,Kitamura T

更新日期：2016-10-07 00:00:00

abstract：:Bagging is an efficient method to improve fruit colour development. This work reported a transcriptome analysis using bagging-treated red Chinese sand pear peels. In total, 8,870 differentially expressed genes were further analysed by a weighted gene co-expression network analysis and early-, middle- and late light-re...

journal_title：Scientific reports

authors： Bai S,Sun Y,Qian M,Yang F,Ni J,Tao R,Li L,Shu Q,Zhang D,Teng Y

更新日期：2017-03-03 00:00:00

abstract：:Baroreflex dysfunction is a diffuse chronic condition that is expected to be followed by a profound loss of organization of BP and HR variability. Nevertheless, long-term effects of baroreflex withdrawal are still debated. Aim of our work was to study BP and HR changes long term after sino-aortic denervation (SAD). In...

journal_title：Scientific reports

authors： Radaelli A,Mancia G,De Carlini C,Soriano F,Castiglioni P

更新日期：2019-02-04 00:00:00

abstract：:Glucagon is a pancreatic hormone and increases the blood glucose levels. It may be incorporated in a dual hormone artificial pancreas, a device to automatically and continuously control blood glucose levels of individuals with diabetes. Artificial pancreas systems have been developed for use in the subcutaneous tissue...

journal_title：Scientific reports

authors： Åm MK,Dirnena-Fusini I,Fougner AL,Carlsen SM,Christiansen SC

更新日期：2020-08-13 00:00:00

abstract：:The hepatitis C virus (HCV) is one of the leading causes of chronic hepatitis, liver cirrhosis and hepatocellular carcinomas and infects approximately 170 million people worldwide. Although several reporter systems have been developed, many shortcomings limit their use in the assessment of HCV infections. Here, we rep...

journal_title：Scientific reports

authors： Ren Q,Li C,Yuan P,Cai C,Zhang L,Luo GG,Wei W

更新日期：2015-03-09 00:00:00

abstract：:Shigella spp., emerging from multiple origins of Escherichia coli, poses a significant health threat as a causative agent of bacillary dysentery. While multiple serotypes of four different species have evolved via independent lineages, Shigella spp. are designated as a single pathotype, primarily because of their comm...

journal_title：Scientific reports

authors： Thomas AK,Preetha S,Omanakuttan A,Vidyullata L,Ashokan A,Rajachandran V,Chattopadhyay S

更新日期：2019-03-01 00:00:00

abstract：:Plant health is strongly connected with plants´ microbiome. In case of raw-eaten plants, the microbiome can also affect human health. To study potential impacts on health issues of both hosts, the microbiome composition of seven different Brassica vegetables, originating from different food processing pathways, was an...

journal_title：Scientific reports

authors： Wassermann B,Rybakova D,Müller C,Berg G

更新日期：2017-12-15 00:00:00

abstract：:Visible indication based on the aggregation of colloidal nanoparticles (NPs) is highly advantageous for rapid on-site detection of biological entities, which even untrained persons can perform without specialized instrumentation. However, since the extent of aggregation should exceed a certain minimum threshold to pro...

journal_title：Scientific reports

authors： Lim S,Koo OK,You YS,Lee YE,Kim MS,Chang PS,Kang DH,Yu JH,Choi YJ,Gunasekaran S

更新日期：2012-01-01 00:00:00

abstract：:The 'microgenderome' provides a paradigm shift that highlights the role of sex differences in the host-microbiota interaction relevant for autoimmune and neuro-immune conditions. Analysis of cross-sectional self-report and faecal microbial data from 274 patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome ...

journal_title：Scientific reports

authors： Wallis A,Butt H,Ball M,Lewis DP,Bruck D

更新日期：2016-01-13 00:00:00

abstract：:Medial arterial calcification (MAC) is a common outcome in diabetes and chronic kidney disease (CKD). It occurs as linear mineral deposits along the degraded elastin lamellae and is responsible for increased aortic stiffness and subsequent cardiovascular events. Current treatments for calcification, particularly in CK...

journal_title：Scientific reports

authors： Karamched SR,Nosoudi N,Moreland HE,Chowdhury A,Vyavahare NR

更新日期：2019-02-22 00:00:00

abstract：:Plasma dipeptidyl-peptidase-4 activity (DPP4a) is inversely associated with left ventricular function in patients with heart failure (HF) or diabetes. However, the association between DPP4a and left ventricular function in ST-segment elevation myocardial infarction (STEMI) patients has not been reported. We studied th...

journal_title：Scientific reports

authors： Li JW,Chen YD,Liu YQ,Wang JD,Chen WR,Zhang YQ,Ma Q

更新日期：2017-07-21 00:00:00

abstract：:Macroevolutionary studies of insects at diverse taxonomic scales often reveal dynamic evolutionary patterns, with multiple inferred diversification rate shifts. Responses to major past environmental changes, such as the Cretaceous Terrestrial Revolution, or the development of major key innovations, such as wings or co...

journal_title：Scientific reports

authors： Condamine FL,Clapham ME,Kergoat GJ

更新日期：2016-01-18 00:00:00

abstract：:This study aimed to examine hemodynamic responses and the necessity of breaks under long working hours. Thirty-eight healthy males conducted PC-based work from 9:10 to 22:00. Nine 10-minute short breaks and two long breaks (a 1-hour break and a 50-minute break) were provided, and hemodynamic responses were measured re...

journal_title：Scientific reports

authors： Liu X,Ikeda H,Oyama F,Wakisaka K,Takahashi M

更新日期：2018-09-28 00:00:00

abstract：:Many studies speak in favor of a rhythmic mode of listening, by which the encoding of acoustic information is structured by rhythmic neural processes at the time scale of about 1 to 4 Hz. Indeed, psychophysical data suggest that humans sample acoustic information in extended soundscapes not uniformly, but weigh the ev...

journal_title：Scientific reports

authors： Kubetschek C,Kayser C

更新日期：2021-01-27 00:00:00

abstract：:Understanding the human cytotoxic T lymphocyte (CTL) biology is crucial to develop novel strategies aiming at maximizing their lytic capacity against cancer cells. Here we introduce an agent-based model, calibrated on population-scale experimental data that allows quantifying human CTL per capita killing. Our model hi...

journal_title：Scientific reports

authors： Khazen R,Müller S,Lafouresse F,Valitutti S,Cussat-Blanc S

更新日期：2019-08-23 00:00:00

abstract：:Embryo implantation requires a hospitable uterine environment. A key metabolic change that occurs during the peri-implantation period, and throughout early pregnancy, is the rise in endometrial glycogen content. Glycogen accumulation requires prior cellular uptake of glucose. Here we show that both human and murine en...

journal_title：Scientific reports

authors： Salker MS,Singh Y,Zeng N,Chen H,Zhang S,Umbach AT,Fakhri H,Kohlhofer U,Quintanilla-Martinez L,Durairaj RRP,Barros FSV,Vrljicak P,Ott S,Brucker SY,Wallwiener D,Vrhovac Madunić I,Breljak D,Sabolić I,Koepsell H,Brosens

更新日期：2017-10-03 00:00:00

abstract：:Rapid diagnostic tests (RDTs) have been developed to detect influenza A virus for the swift diagnosis and management of patients. However, despite the simplicity and convenience, the low sensitivity of RDTs remains a limitation for their use in point of care testing (POCT). In this study, we developed a rapid fluoresc...

journal_title：Scientific reports

authors： Yu ST,Thi Bui C,Kim DTH,V T Nguyen A,Thi Trinh TT,Yeo SJ

更新日期：2018-09-07 00:00:00

abstract：:Rice breeding has achieved great productivity improvements by semi-dwarf varieties and hybrid vigour. Due to poor understanding of genetic basis of elite backbone varieties, the continuous increasing in rice yield still faces great challenges. Here, 52 elite rice varieties from three historical representative pedigree...

journal_title：Scientific reports

authors： Zheng X,Li L,Liang F,Tan C,Tang S,Yu S,Diao Y,Li S,Hu Z

更新日期：2017-03-22 00:00:00

abstract：:Enzymatic conversion of chitin, a β-1,4 linked polymer of N-acetylglucosamine, is of major interest in areas varying from the biorefining of chitin-rich waste streams to understanding how medically relevant fungi remodel their chitin-containing cell walls. Although numerous chitinolytic enzymes have been studied in de...

journal_title：Scientific reports

authors： Liu Z,Gay LM,Tuveng TR,Agger JW,Westereng B,Mathiesen G,Horn SJ,Vaaje-Kolstad G,van Aalten DMF,Eijsink VGH

更新日期：2017-05-11 00:00:00

abstract：:The control for the processing of precursor liquids determines whether the properties and functions of the final material product can be engineered. An inherent challenge of processing viscous liquids arises from their large resistance to deform. Here, we report on the discovery of an electric approach that can signif...

journal_title：Scientific reports

authors： Kong T,Li J,Liu Z,Zhou Z,Ng PH,Wang L,Shum HC

更新日期：2016-02-10 00:00:00

abstract：:The ancient harbour of Pisa, Portus Pisanus, was one of Italy's most influential seaports for many centuries. Nonetheless, very little is known about its oldest harbour and the relationships between environmental evolution and the main stages of harbour history. The port complex that ensured Pisa's position as an econ...

journal_title：Scientific reports

authors： Kaniewski D,Marriner N,Morhange C,Vacchi M,Sarti G,Rossi V,Bini M,Pasquinucci M,Allinne C,Otto T,Luce F,Van Campo E

更新日期：2018-08-23 00:00:00

abstract：:Elymus nutans is an herbaceous plant that can be used to restore degraded alpine and subalpine ecosystems. Here, we evaluated how sowing density affects soil reinforcement and slope stabilization properties of vegetation-concrete structures. To investigate the optimal sowing density of E. nutans in vegetation-concrete...

journal_title：Scientific reports

authors： Tan X,Huang Y,Xiong D,Lv K,Chen F

更新日期：2020-11-24 00:00:00

abstract：:Four plant tumorigenic strains 932, 1019, 1078T and 1081 isolated from cane gall tumors on thornless blackberry (Rubus sp.) were characterized. They shared low sequence identity with related Rhizobium spp. based on comparisons of 16S rRNA gene (≤98%) and housekeeping genes atpD, recA and rpoB (<90%). Phylogenetic anal...

journal_title：Scientific reports

authors： Kuzmanović N,Smalla K,Gronow S,Puławska J

更新日期：2018-06-13 00:00:00

abstract：:Our goals was to evaluate how sentinel lymph node biopsy (SLNB) benefit neck management in patients with parotid cancer. Patients diagnosed with cN0 parotid cancer by preoperative fine needle puncture were prospectively enrolled. The neck status was evaluated by SLNB. If node metastasis was proved by SLNB, a neck diss...

journal_title：Scientific reports

authors： Pan W,Ba K,Niu X,Liu F,Fang Q

更新日期：2019-06-06 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are highly plastic cells that are able to transdifferentiate or dedifferentiate under appropriate conditions. In the present study, we reported here that after in vitro induction of osteogenic differentiation, MSCs could be reverted to a primitive stem cell population (dedifferentiated os...

journal_title：Scientific reports

authors： Rui Y,Xu L,Chen R,Zhang T,Lin S,Hou Y,Liu Y,Meng F,Liu Z,Ni M,Tsang KS,Yang F,Wang C,Chan HC,Jiang X,Li G

更新日期：2015-06-08 00:00:00

abstract：:We demonstrate a method for the preparation of negative-index fibre Bragg gratings (FBGs) using 800 nm femtosecond laser overexposure and thermal regeneration. A positive-index type I-IR FBG was first inscribed in H2-free single-mode fibre using a femtosecond laser directed through a phase mask, and then a highly pola...

journal_title：Scientific reports

authors： He J,Wang Y,Liao C,Wang C,Liu S,Yang K,Wang Y,Yuan X,Wang GP,Zhang W

更新日期：2016-03-16 00:00:00