Abstract：
:Differences in the pathogenesis of radiation-induced lung injury among murine strains offer a unique opportunity to elucidate the molecular mechanisms driving the divergence in tissue response from repair and recovery to organ failure. Here, we utilized two well-characterized murine models of radiation pneumonitis/fibrosis to compare and contrast differential gene expression in lungs 24 hours after exposure to a single dose of whole thorax lung irradiation sufficient to cause minor to major morbidity/mortality. Expression of 805 genes was altered as a general response to radiation; 42 genes were identified whose expression corresponded to the threshold for lethality. Three genes were discovered whose expression was altered within the lethal, but not the sublethal, dose range. Time-course analysis of the protein product of the most promising gene, resistin-like molecule alpha, demonstrated a significant difference in expression between radiosensitive versus radiotolerant strains, suggesting a unique role for this protein in acute lung injury.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Jackson IL,Zhang Y,Bentzen SM,Hu J,Zhang A,Vujaskovic Zdoi
10.1038/srep36579subject
Has Abstractpub_date
2016-11-15 00:00:00pages
36579issn
2045-2322pii
srep36579journal_volume
6pub_type
杂志文章abstract：:Two-photon polymerization (TPP) is capable of fabricating 3D structures with dimensions from sub-µm to a few hundred µm. As a direct laser writing (DLW) process, fabrication time of 3D TPP structures scale with the third order, limiting its use in large volume fabrication. Here, we report on a scalable fabrication met...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64955-9
更新日期：2020-05-26 00:00:00
abstract：:Our recent studies, using (SWRxNZB)F1 (SNF1) mice, showed a potential contribution of the gut microbiota and pro-inflammatory immune responses of the gut mucosa to systemic autoimmunity in lupus. Here, using this mouse model, we determined the abundance and the nAg reactivity of IgA antibody produced in the intestine ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71272-8
更新日期：2020-08-31 00:00:00
abstract：:Alcoholic liver disease (ALD) causes significant morbidity and mortality, and pharmacological treatment options are limited. In this study, we evaluated the PCSK9 inhibitor alirocumab, a monoclonal antibody that robustly reduces low-density lipoprotein cholesterol (LDL-C), for the treatment of ALD using a rat model of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53603-6
更新日期：2019-11-20 00:00:00
abstract：:Sideroflexin4 (SFXN4) is a member of a family of nuclear-encoded mitochondrial proteins. Rare germline mutations in SFXN4 lead to phenotypic characteristics of mitochondrial disease including impaired mitochondrial respiration and hematopoetic abnormalities. We sought to explore the function of this protein. We show t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55907-z
更新日期：2019-12-23 00:00:00
abstract：:Immunoproteasomes are known for their involvement in antigen presentation. However, their broad tissue presence and other evidence are indicative of nonimmune functions. We examined a role for immunoproteasomes in cellular responses to the endogenous and environmental carcinogen formaldehyde (FA) that binds to cytosol...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00757-w
更新日期：2017-04-05 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-10-20 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56694-3
更新日期：2019-12-27 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep46736
更新日期：2017-04-24 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
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journal_title：Scientific reports
pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2019-12-24 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-06-14 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53291-2
更新日期：2019-11-12 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
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更新日期：2020-05-26 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31884
更新日期：2016-08-22 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07692-w
更新日期：2017-09-05 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27775
更新日期：2016-06-08 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14232-z
更新日期：2017-10-23 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27159
更新日期：2016-06-06 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00309
更新日期：2012-01-01 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2020-09-17 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-04-27 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65849-6
更新日期：2020-06-08 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26191
更新日期：2016-05-18 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30015
更新日期：2016-07-22 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2018-10-15 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-24961-4
更新日期：2018-04-26 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-10-19 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10315
更新日期：2015-05-14 00:00:00
abstract：:Tsunamis can propagate thousands of kilometres across the ocean. Precise calculations of arrival times are essential for reliable early warning systems, determination of source and earth properties using the inverse problem, and time series modulation due to frequency dependency of phase speed. Far field observatories...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52475-0
更新日期：2019-11-14 00:00:00
