Abstract：
:The microtubule cytoskeleton is composed of α-tubulin and β-tubulin heterodimers, and it serves to regulate the shape, motility, and division of a cell. Post-translational modifications including acetylation are closely associated with the functional aspects of the microtubule, involving in a number of pathological diseases. However, the role of microtubule acetylation in acute kidney injury (AKI) and progression of AKI to chronic kidney disease have yet to be understood. In this study, ischemia/reperfusion (I/R), a major cause of AKI, resulted in deacetylation of the microtubules with a decrease in α-tubulin acetyltransferase 1 (α-TAT1). Paclitaxel (taxol), an agent that stabilizes microtubules by tubulin acetylation, treatment during the recovery phase following I/R injury inhibited tubular cell proliferation, impaired renal functional recovery, and worsened fibrosis. Taxol induced α-tubulin acetylation and post-I/R cell cycle arrest. Taxol aggregated the microtubule in the cytoplasm, resulting in suppression of microtubule dynamics. Our studies have demonstrated for the first time that I/R induced deacetylation of the microtubules, and that inhibition of microtubule dynamics retarded repair of injured tubular epithelial cells leading to an acceleration of fibrosis. This suggests that microtubule dynamics plays an important role in the processes of repair and fibrosis after AKI.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Han SJ,Kim JH,Kim JI,Park KMdoi
10.1038/srep27775subject
Has Abstractpub_date
2016-06-08 00:00:00pages
27775issn
2045-2322pii
srep27775journal_volume
6pub_type
杂志文章abstract：:Silicon is the second most common element on the Earth's crust and its oxide (SiO(2)) the most abundant mineral. Silica and silicates are widely used in medicine and industry as well as in micro- and nano-optics and electronics. However, the fabrication of glass fibres and components requires high temperature and non-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00607
更新日期：2012-01-01 00:00:00
abstract：:Quantum walks often provide telling insights about the structure of the system on which they are performed. In [Formula: see text]-symmetric and lossy dimer lattices, the topological properties of the band structure manifest themselves in the quantization of the mean displacement of such a walker. We investigate the f...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30344-6
更新日期：2018-08-13 00:00:00
abstract：:Charge noise is critical in the performance of gate-controlled quantum dots (QDs). Such information is not yet available for QDs made out of the new material graphene, where both substrate and edge states are known to have important effects. Here we show the 1/f noise for a microscopic graphene QD is substantially lar...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08142
更新日期：2015-01-30 00:00:00
abstract：:Tau is a Microtubule-associated protein that induces and stabilizes the formation of the Microtubule cytoskeleton and plays an important role in neurodegenerative diseases. The Microtubules binding region of Tau has been determined for a long time but where and how Tau binds to its partner still remain a topic of deba...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32096-9
更新日期：2018-09-14 00:00:00
abstract：:The first choice of treatment for patients with plantar fasciitis is non-invasive treatment, rather than corticosteroid injection (CSI). However, no comprehensive study has compared the effectiveness of CSI with non-invasive treatments for plantar fasciitis. We conducted a meta-analysis comparing CSI and non-invasive ...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-018-22402-w
更新日期：2018-03-05 00:00:00
abstract：:A singular adaptive phenotype of a parthenogenetic insect species (Acyrthosiphon pisum) was selected in cold conditions and is characterized by a remarkable apparition of a greenish colour. The aphid pigments involve carotenoid genes well defined in chloroplasts and cyanobacteria and amazingly present in the aphid gen...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00579
更新日期：2012-01-01 00:00:00
abstract：:Anti-mucin1 (MUC1) antibodies have long been used clinically in cancer diagnosis and therapy and specific bindings of some of them are known to be dependent on the differential glycosylation of MUC1. However, a systematic comparison of the binding specificities of anti-MUC1 antibodies was not previously conducted. Her...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53052-1
更新日期：2019-11-12 00:00:00
abstract：:To increase the yield potential while limiting the environmental impact of N management practices is an important issue in rice cultivation. The large-grain rice cultivar Akita 63 showed higher N-use efficiency for grain production. To elucidate this, we analyzed yield characteristics of Akita 63 in comparison with th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69289-0
更新日期：2020-07-22 00:00:00
abstract：:Lithium (Li) is the cornerstone maintenance treatment for bipolar disorders (BD), but response rates are highly variable. To date, no clinical or biological marker is available to reliably define eligibility criteria for a maintenance treatment with Li. We examined whether the prophylactic response to Li (assessed ret...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69073-0
更新日期：2020-07-22 00:00:00
abstract：:The amount of reduction in opioid doses and its effect on postoperative pain outcomes in chronic kidney disease (CKD) patients in the perioperative setting remains unclear. This study aimed to investigate differences in postoperative pain outcomes after major laparoscopic surgery between patients with CKD and those wi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40627-1
更新日期：2019-03-08 00:00:00
abstract：:Sea ice is an important component of the global climate system and a key indicator of climate change. A decreasing trend in Arctic sea-ice concentration is evident in recent years, whereas Antarctic sea-ice concentration exhibits a generally increasing trend. Various studies have investigated the underlying causes of ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45804
更新日期：2017-04-05 00:00:00
abstract：:Gait is an important health indicator and poor gait is strongly associated with disability and risk of falls. Thyroid dysfunction is suggested as a potential determinant of gait deterioration, but this has not been explored in a population-based study. We therefore investigated the association of thyroid function with...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/srep38912
更新日期：2016-12-14 00:00:00
abstract：:We tested the hypothesis that modulation of neurocomputational inputs to value-based decision-making affects the rationality of economic choices. The brain's right temporoparietal junction (rTPJ) has been functionally associated with both social behavior and with domain-general information processing and attention. To...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76956-9
更新日期：2020-11-20 00:00:00
abstract：:Models of biological processes are often subject to different sources of noise. Developing an understanding of the combined effects of different types of uncertainty is an open challenge. In this paper, we study a variant of the susceptible-infective-recovered model of epidemic spread, which combines both agent-to-age...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12606-x
更新日期：2017-10-11 00:00:00
abstract：:For a broad class of input-output maps, arguments based on the coding theorem from algorithmic information theory (AIT) predict that simple (low Kolmogorov complexity) outputs are exponentially more likely to occur upon uniform random sampling of inputs than complex outputs are. Here, we derive probability bounds that...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61135-7
更新日期：2020-03-10 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-019-47583-w
更新日期：2019-07-31 00:00:00
abstract：:Phase modulators are one of the key components of many applications in electromagnetic and opto-electric wave propagations. Phase-shifters play an integral role in communications, imaging and in coherent material excitations. In order to realize the terahertz (THz) electromagnetic spectrum as a fully-functional bandwi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38041
更新日期：2016-11-30 00:00:00
abstract：:Nonperturbing and simple transfection methods are important for modern techniques used in biotechnology. Recently, we reported that electrospraying can be applied to DNA transfection in cell lines, bacteria, and chicken embryos. However, the transfection efficiency was only about 2%. To improve the transfection rate, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00289
更新日期：2012-01-01 00:00:00
abstract：:Exercise physiology is different in males and females. Females are poorly studied due to the complexity of the estrous cycle and this bias has created an exercise sex gap. Here, we evaluated the impact of sexual dimorphism and of the estrous cycle on muscle strength and running power of C57BL/6 mice. Like men, male mi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29050-0
更新日期：2018-07-16 00:00:00
abstract：:This was a nine-year retrospective cohort study to investigate obstetric and perinatal outcomes in a cohort of adolescent girls with twin pregnancies from a major Australian tertiary centre in Brisbane, Australia. The adolescent cohort was aged <19 years and the control group was aged 20-24 years. The total study coho...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37364-2
更新日期：2018-12-24 00:00:00
abstract：:Materials' mechanical properties highly depend on their internal structures. Designing novel structure is an effective route to improve materials' performance. One-dimensional disordered (ODD) structure is a kind of particular structure in silicon carbide (SiC), which highly affects its mechanical properties. Herein, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67652-9
更新日期：2020-07-09 00:00:00
abstract：:Conflicting results of survival outcomes for primary and secondary muscle-invasive bladder cancer (MIBC) have been reported in previous studies. Primary MIBC is defined as presentation of muscle-invasive disease at initial diagnosis while secondary MIBC presumes that non-muscle invasive disease later progressed to MIB...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-018-26002-6
更新日期：2018-05-15 00:00:00
abstract：:Rhizomorphic lycopsids are the land plant group that includes the first giant trees to grow on Earth and extant species in the genus Isoetes. Two mutually exclusive hypotheses account for the evolution of terminal rooting axes called rootlets among the rhizomorphic lycopsids. One hypothesis states that rootlets are tr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78171-y
更新日期：2020-12-09 00:00:00
abstract：:High salinity frequently causes inhibition and even failure in anaerobic digestion. To explore the impact of increasing NaCl concentrations on biogas production, and reveal the microbial community variations in response to high salinity stress, the Illumina high-throughput sequencing technology was employed. The resul...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01298-y
更新日期：2017-04-25 00:00:00
abstract：:Colon cancer stem cells have been attributed to poor prognosis, therapeutic resistance and aggressive nature of the malignancy. Recent reports associated CD44v6 expression with relapse, metastasis and reduced 5-year survival of colon cancer patients, thereby making it a potential therapeutic target. Thus, in this stud...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35069-0
更新日期：2018-11-19 00:00:00
abstract：:Single nucleotide polymorphisms (SNPs) and genes associated with susceptibility to hepatitis B virus (HBV) infection that have been identified by genome-wide association studies explain only a limited portion of the known heritability, indicating more genetic variants remain to be discovered. In this study, we adopted...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49777-8
更新日期：2019-09-17 00:00:00
abstract：:Huntington's disease (HD) is a progressive and fatal neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene. Although HD is monogenic, its molecular manifestation appears highly complex and involves multiple cellular processes. The recent application of high throughput platforms such as mic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05224-0
更新日期：2017-07-12 00:00:00
abstract：:Tumor genetic heterogeneity may underlie poor clinical outcomes because diverse subclones could be comprised of metastatic and drug resistant cells. Targeted deep sequencing has been used widely as a diagnostic tool to identify actionable mutations in cancer patients. In this study, we evaluated the clinical utility o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41098-0
更新日期：2019-03-14 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41598-018-20340-1
更新日期：2018-01-23 00:00:00
abstract：:Low miR-96-5p expression is characteristic of many cancers but its role in breast cancer (BCa) remains poorly defined. Here, the role of miR-96-5p in BC development was assessed. We demonstrate that exogenously expressing miR-96-5p inhibits the proliferative, migratory and invasive capacity of BCa cells. Mechanistical...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56571-z
更新日期：2020-01-08 00:00:00
