Abstract：
:Exercise physiology is different in males and females. Females are poorly studied due to the complexity of the estrous cycle and this bias has created an exercise sex gap. Here, we evaluated the impact of sexual dimorphism and of the estrous cycle on muscle strength and running power of C57BL/6 mice. Like men, male mice were stronger and more powerful than females. Exercise-induced increase of O2 consumption ([Formula: see text]O2) and CO2 production ([Formula: see text]CO2) were equal between sexes, indicating that running economy was higher in males. Thermoregulation was also more efficient in males. In females, proestrus increased exercise [Formula: see text]O2 and [Formula: see text]CO2 at low running speeds (30-35% female [Formula: see text]O2max) and estrus worsened thermoregulation. These differences translated into different absolute and relative workloads on the treadmill, even at equal submaximal [Formula: see text]O2 and belt speeds. In summary, our results demonstrate the better muscle strength, running power and economy, and exercise-induced thermoregulation of males compared to females. Proestrus and estrus still undermined the running economy and exercise-induced thermoregulation of females, respectively. These results demonstrate an important exercise sex gap in mice.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Aguiar AS Jr,Speck AE,Amaral IM,Canas PM,Cunha RAdoi
10.1038/s41598-018-29050-0subject
Has Abstractpub_date
2018-07-16 00:00:00pages
10742issue
1issn
2045-2322pii
10.1038/s41598-018-29050-0journal_volume
8pub_type
杂志文章abstract：:We identify graphene layer on a disordered substrate as a system where localization of phonons can be observed. Generally, observation of localization for scattering waves is not simple, because the Rayleigh scattering is inversely proportional to a high power of wavelength. The situation is radically different for th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34426-3
更新日期：2018-11-02 00:00:00
abstract：:Transposable elements are emerging as an important source of cis-acting regulatory sequences and epigenetic marks that could influence gene expression. However, few studies have dissected the role of specific transposable element insertions on epigenetic gene regulation. Bari-Jheh is a natural transposon that mediates...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30491-w
更新日期：2018-08-15 00:00:00
abstract：:MCM7, a subunit of mini-chromosome maintenance proteins (MCM) complex, plays an important role in initiating DNA replication during the G1 phase and extending DNA strands during the S phase. Here, we demonstrated that MCM7 is not only sustained but maintains association with chromatin during M phase. Remarkably, MCM7 ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03148-3
更新日期：2017-06-06 00:00:00
abstract：:Antitumor drug development based on the concept of intervening in the antioxidant system of cancer cells has been gaining increased interest. In this study, we propose a promising strategy for cancer treatment using modulation of oxidative stress by suppression of glutathione S-transferases (GSTs), a typical antioxida...
journal_title：Scientific reports
pub_type： 杂志文章,收录出版
doi：10.1038/s41598-019-51462-9
更新日期：2019-10-14 00:00:00
abstract：:Demand for clinical decision support systems in medicine and self-diagnostic symptom checkers has substantially increased in recent years. Existing platforms rely on knowledge bases manually compiled through a labor-intensive process or automatically derived using simple pairwise statistics. This study explored an aut...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05778-z
更新日期：2017-07-20 00:00:00
abstract：:Glassy carbon electrode (GCE) was modified with metal oxides (MO = Fe3O4, ZnO) nanoparticles doped phthalocyanine (Pc) and functionalized MWCNTs, and the electrocatalytic properties were studied. Successful synthesis of the metal oxide nanoparticles and the MO/Pc/MWCNT composite were confirmed using FTIR, Raman and SE...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26938
更新日期：2016-06-01 00:00:00
abstract：:Layered-structure materials are currently relevant given their quasi-2D nature. Knowledge of their physical properties is currently of major interest. Niobium ditelluride possesses a monoclinic layered-structure with a distortion in the tellurium planes. This structural complexity has hindered the determination of its...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35308-4
更新日期：2018-11-19 00:00:00
abstract：:Hirschsprung disease (HSCR) is a common cause of functional colonic obstruction in children. The currently available genetic testing is often inadequate as it mainly focuses on RET and several other genes, accounting for only 15-20% of cases. To identify novel, potentially pathogenic variants, we isolated a panel of g...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-017-14835-6
更新日期：2017-11-01 00:00:00
abstract：:For scanning x-ray microscopy, many attempts have been made to image the phase contrast based on a concept of the beam being deflected by a specimen, the so-called differential phase contrast imaging (DPC). Despite the successful demonstration in a number of representative cases at moderate spatial resolutions, these ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01307
更新日期：2013-01-01 00:00:00
abstract：:The interaction between matter and electromagnetic radiation provides a rich understanding of what the matter is composed of and how it can be quantified using spectrometers. In many cases, however, the calibration of the spectrometer changes as a function of time (such as in electron spectrometers), or the absolute c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-38482-1
更新日期：2019-02-14 00:00:00
abstract：:Intracontinental biotic divisions across the vast Palaearctic region are not well-characterized. Past research has revealed patterns ranging from a lack of population structure to deep divergences along varied lines of separation. Here we compared biogeographic patterns of two Palaearctic shorebirds with different hab...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54715-9
更新日期：2019-12-03 00:00:00
abstract：:We present a new method for the design of devices to manipulate the displacement field in Elastic materials. It consists of solving a nonlinear optimization problem where the objective function defines the error in matching a desired displacement field, and the design variables determine the required material distribu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28069-7
更新日期：2018-06-29 00:00:00
abstract：:Riverine and atmospheric inputs are often considered as the main terrestrial sources of dissolved inorganic nitrogen (DIN), phosphorus (DIP), and silicon (DSi) in the ocean. However, the fluxes of nutrients via submarine groundwater discharge (SGD) often exceed riverine inputs in different local and regional scale set...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20806-2
更新日期：2018-02-05 00:00:00
abstract：:Methods for estimating the spatial distribution of PM2.5 concentrations have been developed but have not yet been able to effectively include spatial correlation. We report on the development of a spatial back-propagation neural network (S-BPNN) model designed specifically to make such correlations implicit by incorpo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50177-1
更新日期：2019-09-24 00:00:00
abstract：:Although habitat transformation is one of the main causes of biodiversity loss, there are many examples of species successfully occupying and even proliferating in highly human-modified habitats such are the cities. Thus, there is an increasing interest in understanding the drivers favoring urban life for some species...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03853-z
更新日期：2017-06-14 00:00:00
abstract：:Fundamental understanding of guest gas replacement in hydrate reservoirs is crucial for the enhanced recovery of natural gas and carbon dioxide (CO2) sequestration. To gain physical insight into this exchange process, this work aims at developing and validating a clathrate hydrate model for gas replacement. Most of th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55476-1
更新日期：2019-12-11 00:00:00
abstract：:Majority of novel X-ray crystal structures of proteins are currently solved using the anomalous diffraction signal provided by selenium after incorporation of selenomethionine instead of natural methionine by genetic engineering methods. However, selenium can be inserted into protein crystals in the form of selenourea...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37123
更新日期：2016-11-14 00:00:00
abstract：:Free-living amoebae are well known for their role in controlling microbial community composition through grazing, but some groups, namely Acanthamoeba species, also frequently serve as hosts for bacterial symbionts. Here we report the first identification of a bacterial symbiont in the testate amoeba Cochliopodium. Th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03642-8
更新日期：2017-06-13 00:00:00
abstract：:Caragana korshinskii Kom. has a significant function in desert-grassland revegetation in arid regions. Plant reproduction in arid regions can be restricted due to inadequate pollen receipt and reduced pollen transfer. An assessment of pollination success as a result of pollen limitation and pollinator visitation in va...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46271-z
更新日期：2019-07-05 00:00:00
abstract：:Raffinose family oligosaccharides (RFOs) are implicated in plant regulatory mechanisms of abiotic stresses tolerance and, despite their antinutritional proprieties in grain legumes, little information is available about the enzymes involved in RFO metabolism in Fabaceae species. In the present study, the systematic su...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72191-4
更新日期：2020-09-17 00:00:00
abstract：:Copper ferrite, belonging to the wide and technologically relevant class of spinel ferrites, was grown in the form of t-CuFe2O4 nanocrystals within a porous matrix of silica in the form of either an aerogel or a xerogel, and compared to a bulk sample. Extended X-ray absorption fine structure (EXAFS) spectroscopy revea...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-19045-8
更新日期：2018-01-15 00:00:00
abstract：:YidC, a bacterial member of the YidC/Alb3/Oxa1 insertase family, mediates membrane protein assembly and insertion. Cytoplasmic loops are known to have functional significance in membrane proteins such as YidC. Employing microsecond-level molecular dynamics (MD) simulations, we show that the crystallographically unreso...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51052-9
更新日期：2019-10-08 00:00:00
abstract：:Resistance of cancer cells to chemotherapy is a significant problem in oncology, and the development of sensitising agents or small-molecules with new mechanisms of action to kill these cells is needed. Autophagy is a cellular process responsible for the turnover of misfolded proteins or damaged organelles, and it als...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05510
更新日期：2014-07-01 00:00:00
abstract：:E. coli of the phylogenetic group B2 harbouring Extra intestinal Pathogenic Escherichia coli (ExPEC) genes are frequently seen as colonizers of the intestine in patients with active ulcerative colitis (UC). In this study, we describe the influence of E. coli Nissle (EcN) B2 as add-on treatment to conventional therapie...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31152
更新日期：2016-09-30 00:00:00
abstract：:We investigated the association between impulsivity related traits and BMI at the observational and genetic epidemiology level in a cross-sectional population of healthy young American-European adults. We studied 998 students and university staff of European ancestry recruited from Chicago (Illinois) and Athens (Georg...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53922-8
更新日期：2019-11-26 00:00:00
abstract：:The gene separation anxiety (san) encodes Naa50/San, a N-terminal acetyltransferase required for chromosome segregation during mitosis. Although highly conserved among higher eukaryotes, the mitotic function of this enzyme is still poorly understood. Naa50/San was originally proposed to be required for centromeric sis...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39118
更新日期：2016-12-20 00:00:00
abstract：:Past evidence of an early Processing Negativity in auditory Go/NoGo event-related potential (ERP) data suggests that young adults proactively process sensory information in two-choice tasks. This study aimed to clarify the occurrence of Go/NoGo Processing Negativity and investigate the ERP component series related to ...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-020-61060-9
更新日期：2020-03-04 00:00:00
abstract：:Self-aggregated Li4Ti5O12 particles sandwiched between graphene nanosheets (GNSs) and single-walled carbon nanotubes (SWCNTs) network are reported as new hybrid electrodes for high power Li-ion batteries. The multi-layer electrodes are fabricated by sequential process comprising air-spray coating of GNSs layer and the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07334
更新日期：2014-12-05 00:00:00
abstract：:Dramatic functional changes of enzyme usually require scores of alterations in amino acid sequence. However, in the case of guanylate kinase (GK), the functional novelty is induced by a single (S→P) mutation, leading to the functional transition of the enzyme from a phosphoryl transfer kinase into a phosphorprotein in...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08405
更新日期：2015-02-12 00:00:00
abstract：:We investigated the effect of a new Rho kinase inhibitor, SB772077B (SB77) on aqueous outflow facility (OF) in human eyes using human organ-cultured anterior segment (HOCAS). IOP was monitored for 24 h post-treatment with either SB77 (0.1/10/50 µM) or vehicle after a stable baseline pressure. The hydrodynamic pattern ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33932-8
更新日期：2018-10-19 00:00:00
