Abstract：
:The gene separation anxiety (san) encodes Naa50/San, a N-terminal acetyltransferase required for chromosome segregation during mitosis. Although highly conserved among higher eukaryotes, the mitotic function of this enzyme is still poorly understood. Naa50/San was originally proposed to be required for centromeric sister chromatid cohesion in Drosophila and human cells, yet, more recently, it was also suggested to be a negative regulator of microtubule polymerization through internal acetylation of beta Tubulin. We used genetic and biochemical approaches to clarify the function of Naa50/San during development. Our work suggests that Naa50/San is required during tissue proliferation for the correct interaction between the cohesin subunits Scc1 and Smc3. Our results also suggest a working model where Naa50/San N-terminally acetylates the nascent Scc1 polypeptide, and that this co-translational modification is subsequently required for the establishment and/or maintenance of sister chromatid cohesion.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ribeiro AL,Silva RD,Foyn H,Tiago MN,Rathore OS,Arnesen T,Martinho RGdoi
10.1038/srep39118subject
Has Abstractpub_date
2016-12-20 00:00:00pages
39118issn
2045-2322pii
srep39118journal_volume
6pub_type
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