Abstract：
:E. coli of the phylogenetic group B2 harbouring Extra intestinal Pathogenic Escherichia coli (ExPEC) genes are frequently seen as colonizers of the intestine in patients with active ulcerative colitis (UC). In this study, we describe the influence of E. coli Nissle (EcN) B2 as add-on treatment to conventional therapies in patients with active UC. For this study one hundred active UC patients were randomized to ciprofloxacin or placebo for 1 week followed by EcN or placebo for 7 weeks. Stool samples were collected at weeks 0, 1, 8, 12, where E. coli were characterized and fecal calprotectin was measured. We showed that in the active UC patient group receiving Placebo/EcN, fewer patients reached remission, in comparison to the patient group receiving Placebo/placebo (p < 0.05). Active UC patients initially colonized with E. coli B2 had increased fecal calprotectin values and Colitis Activity Index scores in comparison to patients colonized with E. coli A and D (p < 0.05*). In conclusion, treatment of UC patients with E. coli Nissle (B2) does not promote clinical remission and active UC patients colonized with E. coli B2 have an increased intestinal inflammation.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Mirsepasi-Lauridsen HC,Halkjaer SI,Mortensen EM,Lydolph MC,Nordgaard-Lassen I,Krogfelt KA,Petersen AMdoi
10.1038/srep31152subject
Has Abstractpub_date
2016-09-30 00:00:00pages
31152issn
2045-2322pii
srep31152journal_volume
6pub_type
杂志文章abstract：:Soil moisture is an important variable for land-climate and hydrological interactions. To investigate emergent large-scale, long-term interactions between soil moisture and other key hydro-climatic variables (precipitation, actual evapotranspiration, runoff, temperature), we analyze monthly values and anomalies of the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61621-y
更新日期：2020-03-16 00:00:00
abstract：:We present a combined experimental and theoretical study of the electronic properties of close-spaced dangling-bond (DB) pairs in a hydrogen-passivated Si(001):H p-doped surface. Two types of DB pairs are considered, called "cross" and "line" structures. Our scanning tunneling spectroscopy (STS) data show that, althou...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14496
更新日期：2015-09-25 00:00:00
abstract：:Organic carbon (OC) stability in tropical soils is strongly interlinked with multivalent cation interaction and mineral association. Low molecular weight organic acids (LMWOAs) represent the readily biodegradable OC. Therefore, investigating retention mechanisms of LMWOAs in mineral-cation-LMWOAs systems is critical t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26127
更新日期：2016-05-23 00:00:00
abstract：:Mycobacterium marinum (M. marinum) is a slowly growing nontuberculous mycobacterium. The incidence of M. marinum infections in Denmark is unknown. We conducted a retrospective nationwide study including all culture confirmed cases of M. marinum from 2004 to 2017 in Denmark. All available medical records were reviewed....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-24702-7
更新日期：2018-04-30 00:00:00
abstract：:The endosymbiotic bacterium Wolbachia spreads rapidly through populations of Aedes aegypti mosquitoes, and strongly inhibits infection with key human pathogens including the dengue and Zika viruses. Mosquito control programs aimed at limiting transmission of these viruses are ongoing in multiple countries, yet there i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16045-6
更新日期：2017-11-16 00:00:00
abstract：:We determined the prevalence of hyposalivation and xerostomia in older Mexicans (≥60 years), and its relationship with diverse factors. A cross-sectional study was realized in elderly subjects from Pachuca, Mexico. Chewing-stimulated saliva was collected under standardized conditions and salivary flow was measured; su...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40686
更新日期：2017-01-17 00:00:00
abstract：:Through a geomorphological study relying on statistically assessed classes of hilltop elevations, we reconstruct a suite of paleo-surfaces along the Tiber River Valley north of Rome that we identify as fluvial terraces formed by interplay between global sea-level fluctuations and regional upift. Using biostratigraphic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02437-1
更新日期：2017-05-31 00:00:00
abstract：:Early diagnosis of hepatocellular carcinoma (HCC) remains challenging to date. Characteristic metabolic deregulations of HCC may enable novel biomarkers discovery for early diagnosis. A capillary electrophoresis-time of flight mass spectrometry (CE-TOF/MS)-based metabolomics approach was performed to discover and vali...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16101
更新日期：2015-11-03 00:00:00
abstract：:Surface hydrophobicity of silicon with sound durability under mechanical abrasion is highly desirable for practical needs. However, the reported micro-pyramid/nanowires structures suffer from the saturation characteristics of contact angle at around 132 degree, which impede the promotions toward reaching the state of ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37853-4
更新日期：2019-02-07 00:00:00
abstract：:Metal sulfides are of great interest for future electrode materials in supercapacitor and solar cell applications owing to their superior electrochemical activity and excellent electrical conductivity. With this scope, a binary transition metal sulfide (CoS) is prepared via one-step hydrothermal synthesis. Hexagonal p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37463-0
更新日期：2019-02-04 00:00:00
abstract：:The near complete genome sequences of ten field avian orthoreovirus (ARV) strains collected from young chicken between 2002 and 2011 in Hungary have been determined in order to explore the genetic diversity and evolutionary mechanisms affecting ARVs in this region. Sequence analyses and phylogenetic calculations revea...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36960
更新日期：2016-11-10 00:00:00
abstract：:Magnetic resonance imaging (MRI) is a widely used non-invasive methodology for both preclinical and clinical studies. However, MRI lacks molecular specificity. Molecular contrast agents for MRI would be highly beneficial for detecting specific pathological lesions and quantitatively evaluating therapeutic efficacy in ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80181-9
更新日期：2021-01-08 00:00:00
abstract：:A synthetic monoketone analog of curcumin, termed 3, 5-bis (2-flurobenzylidene) piperidin-4-one (EF24), has been reported to inhibit the growth of a variety of cancer cells both in vitro and in vivo. However, whether EF24 has anticancer effects on cholangiocarcinoma (CCA) cells and the mechanisms remain to be investig...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32167
更新日期：2016-08-30 00:00:00
abstract：:Experiments on the Ultimatum Game (UG) repeatedly show that people's behaviour is far from rational. In UG experiments, a subject proposes how to divide a pot and the other can accept or reject the proposal, in which case both lose everything. While rational people would offer and accept the minimum possible amount, i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19503-x
更新日期：2018-01-19 00:00:00
abstract：:Fc domain fusion can improve the therapeutic effects of relatively small biological molecules such as peptides, cytokines, and antibody fragments. Fc fusion proteins can also be used to enhance the cytotoxic effects of small bispecific antibodies (bsAbs). However, fragmentation of Fc fusion proteins, which mainly occu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35489-y
更新日期：2018-11-22 00:00:00
abstract：:The incisive evaluation of psychological stress may be required to determine the exercise performance of stressed hosts. We investigated objective markers of psychological stress that reflect exercise performance, focusing on the neutrophil function. We used murine water-immersion restraint (WIR) stress for our assess...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41077-5
更新日期：2019-03-14 00:00:00
abstract：:Sweet sorghum bagasse (SSB) is a promising raw material for silage fermentation due to its high residual nutritive, but the efficient fermentation strategy of SSB has not been reported yet. This study evaluated the effects of microbial inoculant on the fermentation quality, chemical composition and microbial community...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-57628-0
更新日期：2020-01-21 00:00:00
abstract：:Measuring handgrip strength is the initial step to diagnose sarcopenia. To investigate whether the serum creatinine (Cr)/cystatin C (CysC) ratio could serve as a case-finding tool for low handgrip strength, we conducted a diagnostic accuracy study. Adults (aged ≥ 40 years) with normal renal function were recruited. Tr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71028-4
更新日期：2020-08-20 00:00:00
abstract：:Brazil's large land base is important for global food security but its high dependency on inorganic phosphorus (P) fertilizer for crop production (2.2 Tg rising up to 4.6 Tg in 2050) is not a sustainable use of a critical and price-volatile resource. A new strategic analysis of current and future P demand/supply concl...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20887-z
更新日期：2018-02-07 00:00:00
abstract：:Understanding how a species utilises its habitat, and the processes that give rise to its movements and patterns of space use, is critical for its conservation. Southern Ground-hornbills Bucorvus leadbeateri are listed as Endangered in South Africa, as a result of habitat loss and persecution. The National Species Rec...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73236-4
更新日期：2020-10-01 00:00:00
abstract：:Although low socioeconomic status (SES) is related to poor glycemic control, the underlying mechanisms remain unclear. We examined potentially modifiable factors involved in the association between low SES and poor glycemic control using data from the baseline survey of a multicenter, prospective cohort study. Five hu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-63253-8
更新日期：2020-04-21 00:00:00
abstract：:In general, the poultry industry uses 0.5-1 ppm chlorine solution in the meat sanitization process. However, chlorine can react with organic material and produce halogenated organic compounds, notably chloroform, which causes bladder and rectal cancer in humans. For this reason, many industries try to avoid chlorine. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58199-w
更新日期：2020-01-31 00:00:00
abstract：:In large random networks, each eigenvector of the Laplacian matrix tends to localize on a subset of network nodes having similar numbers of edges, namely, the components of each Laplacian eigenvector take relatively large values only on a particular subset of nodes whose degrees are close. Although this localization p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01010-0
更新日期：2017-04-25 00:00:00
abstract：:We show that H-bonded host-guest systems associate in ionic liquids (ILs), pure salts with melting point below room temperature, in which dipole-dipole electrostatic interactions should be negligible in comparison with dipole-charge interactions. Binding constants (Ka) obtained from titrations of four H-bonded host-gu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71803-3
更新日期：2020-09-22 00:00:00
abstract：:Studies of personality have suggested that dissimilarities in ability to cope with stressful situations results in differing tendency to develop addictive behaviors. The present study used selectively bred stress-resilient, socially-dominant (Dom) and stress-vulnerable, socially-submissive (Sub) mice to investigate th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19816-x
更新日期：2018-01-29 00:00:00
abstract：:Receding angles have been shown to have great significance when designing a superhydrophobic surface for applications involving self-cleaning. Although apparent receding angles under dynamic conditions have been well studied, the microscopic receding contact line dynamics are not well understood. Therefore, experiment...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08384
更新日期：2015-02-11 00:00:00
abstract：:Transcriptional coactivator PGC-1α and its splice variant NT-PGC-1α play crucial roles in regulating cold-induced thermogenesis in brown adipose tissue (BAT). PGC-1α and NT-PGC-1α are highly induced by cold in BAT and subsequently bind to and coactivate many transcription factors to regulate expression of genes involv...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26244-4
更新日期：2018-05-18 00:00:00
abstract：:As a nutritional factor, folic acid can prevent cardiac and neural defects during embryo development. Our previous study showed that arsenic impairs embryo development by down-regulating Dvr1/GDF1 expression in zebrafish. Here, we investigated whether folic acid could protect against arsenic-mediated embryo toxicity. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16093
更新日期：2015-11-05 00:00:00
abstract：:Invasive fungal infections are a potentially life-threatening complication in immunocompromised patients. The aim of this study was to assess the efficacy and safety of posaconazole as compared with other antifungal agents for preventing invasive fungal infections in immunocompromised patients. Embase, CENTRAL, and ME...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71571-0
更新日期：2020-09-03 00:00:00
abstract：:The accumulation of mannosyl-glycerate (MG), the salinity stress response osmolyte of Thermococcales, was investigated as a function of hydrostatic pressure in Thermococcus barophilus strain MP, a hyperthermophilic, piezophilic archaeon isolated from the Snake Pit site (MAR), which grows optimally at 40 MPa. Strain MP...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29483
更新日期：2016-07-05 00:00:00
