Abstract:
:Conflicting results of survival outcomes for primary and secondary muscle-invasive bladder cancer (MIBC) have been reported in previous studies. Primary MIBC is defined as presentation of muscle-invasive disease at initial diagnosis while secondary MIBC presumes that non-muscle invasive disease later progressed to MIBC. Due to the varying reports, we conducted a systematic review and meta-analysis to compare survival outcomes between the two groups. Relevant studies were retrieved from Medline, Embase, the Cochrane Library, and Scopus using a comprehensive search approach. Cancer-specific survival (CSS) was the outcome measure. A total of 14 studies involving 4,075 cases were included. Patients with secondary MIBC were significantly correlated with worse CSS in model I (pooled HR: 1.29, 95% CI: 1.07-1.56, P = 0.008). The results of sensitivity analyses indicated that the omission of any single study each time did not have a significant impact on the combined risk estimates. Egger's test suggested no publication bias among these studies. The European Organization for Research and Treatment of Cancer (EORTC) risk score offers the possibility of stratifying the secondary MIBC patients into different risk groups. In high-risk NMIBC, timely radical cystectomy should be considered. Further study is required to assess the multimodal therapy in both high-risk NMIBC and secondary MIBC patients as well as to evaluate genetic and molecular drivers of tumor induction, promotion, and progression.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ge P,Wang L,Lu M,Mao L,Li W,Wen R,Lin J,Wang J,Chen Jdoi
10.1038/s41598-018-26002-6subject
Has Abstractpub_date
2018-05-15 00:00:00pages
7543issue
1issn
2045-2322pii
10.1038/s41598-018-26002-6journal_volume
8pub_type
杂志文章,meta分析abstract::The rapid rise of bacterial resistance to traditional antibiotics combined with the decline in discovery of novel antibacterial agents has created a global public health crisis. Repurposing existing drugs presents an alternative strategy to potentially expedite the discovery of new antimicrobial drugs. The present stu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16407
更新日期:2015-11-10 00:00:00
abstract::Staphylococcus aureus colonizes the skin of atopic dermatitis (AD) individuals, but the impact of its enterotoxins on the chronic activation of CD4+ T cells demands further analysis. We aimed to analyze the CD4+ T cell anergy profile and their phenotypic and functional features through differential expression of cellu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49421-5
更新日期:2019-09-11 00:00:00
abstract::Plants are key determinants of soil microbial community (SMC). Legumes and grasses are distinct groups in various ecosystems; however, how they differentially shape SMC structure and functioning has yet to be explored. Here, we investigate SMC in soils grown with stylo (legume) or bahiagrass (grass). Soil metagenomic ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10613-6
更新日期:2017-08-31 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-68522-0
更新日期:2020-07-10 00:00:00
abstract::Cytolytic score (CYT), calculated from mRNA expression levels of granzyme and perforin, positively correlates with CD8+ T cell infiltration/activity in a variety of cancers. Unlike other cancers, higher CYT has been associated with worse prognosis in glioblastoma (GBM). To address this discrepancy, we sought to invest...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73793-8
更新日期:2020-10-16 00:00:00
abstract::Due to the increasing environmental impact of food production, carbon footprint as an indicator can guide farmland management. This study established a method and estimated the carbon footprint of grain production in China based on life cycle analysis (LCA). The results showed that grain production has a high carbon f...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04182-x
更新日期:2017-06-29 00:00:00
abstract::Kyoto probe 1 (KP-1) rapidly distinguishes between human ES/iPS (hES/iPS) cells and their differentiated cells. Recently, we generated induced tissue-specific stem cells from pancreas (iTS-P cells) using reprogramming factors and tissue-specific selection. The iTS-P cells have self-renewal potential, and subcutaneousl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75016-6
更新日期:2020-10-22 00:00:00
abstract::Arbuscular mycorrhizal fungi (AMF) can be beneficial for improving restoration of radioactive-cesium (137Cs)-contaminated soils through soil remediation. However, there has been no information on species diversity and the composition of AMF communities in 137Cs-contaminated soil after the Fukushima-Daiichi Nuclear Pow...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44665-7
更新日期:2019-06-03 00:00:00
abstract::Bone is the most common site of metastasis in metastatic castration-resistant prostate cancer (mCRPC), which is associated with pain and skeletal events. Radium-223 dichloride (Xofigo) is an alpha-emitting radioactive isotope that can specifically target bone lesions. Herein, we report the results of a retrospective a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63302-2
更新日期:2020-04-21 00:00:00
abstract::Short flashes of blue light (bioluminescence) from dinoflagellates can reduce copepod grazing of light-emitting cells. Other protective strategies against grazing are toxicity, reduced cell chain length and altered swimming patterns in different phytoplankton. Both toxicity and bioluminescence capacity in dinoflagella...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13293-4
更新日期:2017-10-12 00:00:00
abstract::The origin and domestication of cultivated barley have long been under debate. A population-based resequencing and phylogenetic analysis of the single copy of RPB2 gene was used to address barley domestication, to explore genetic differentiation of barley populations on the worldwide scale, and to understand gene-pool...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36122
更新日期:2016-10-27 00:00:00
abstract::House dust mites (HDMs) are one of the major causes of allergies in the world. The group 23 allergen, Der p 23, from Dermatophagoides pteronyssinus, is a major allergen amongst HDM-sensitized individuals. This study aims to determine the specific immunoglobulin E (sIgE) binding frequency and IgE-binding residues of re...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79820-y
更新日期:2021-01-13 00:00:00
abstract::The canine heart is a robust physiological model for the human heart. Recently, birth month associations have been reported and replicated in humans using clinical health records. While animals respond readily to their environment in the wild, a systematic investigation of birth season dependencies among pets and spec...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-25199-w
更新日期:2018-05-17 00:00:00
abstract::Combining the advantages of structured random measurement matrix and chaotic structure, this paper introduces a color image encryption algorithm based on a structural chaotic measurement matrix and random phase mask. The Chebyshev chaotic sequence is used in the algorithm to generate the flip permutation matrix, the s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75562-z
更新日期:2020-10-29 00:00:00
abstract::Due to chromatic aberration, blue images are defocused when the eye is focused to the middle of the visible spectrum, yet we normally are not aware of chromatic blur. The eye suffers from monochromatic aberrations which degrade the optical quality of all images projected on the retina. The combination of monochromatic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79911-w
更新日期:2021-01-11 00:00:00
abstract::Bioactive nanosilicates are emerging prominent next generation biomaterials due to their intrinsic functional properties such as advanced biochemical and biophysical cues. Recent studies show interesting dose-dependent effect of fluoride ions on the stem cells. Despite of interesting properties of fluoride ions as wel...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37327-7
更新日期:2019-01-29 00:00:00
abstract::Primary Sjogren's syndrome (pSS) confers increased risk for non-Hodgkin lymphoma (NHL) development. Two common polymorphisms, the c. 677C > T and c. 1298A > C, of the methylene-tetrahydrofolate reductase (MTHFR) gene, an enzyme essential in DNA synthesis and methylation, have been associated with susceptibility to NHL...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07347-w
更新日期:2017-08-04 00:00:00
abstract::Glutathione-S-transferases mu 2 (GSTM2), a kind of important Phase II antioxidant enzyme of eukaryotes, is degraded by nonsense mediated mRNA decay due to a C27T substitution in the fifth exon of pigs. As a reproductive performance-related gene, GSTM2 is involved in embryo implantation, whereas, functional deficiency ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep38254
更新日期:2016-12-01 00:00:00
abstract::Purpose Global sagittal imbalance with lumbar hypo-lordosis leads to various problems in elderly populations and is often treated with long-segment fusion and osteotomy. These highly invasive procedures result in a wide range of rigid spines with a high rate of complications. Although some reports have mentioned the p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63648-7
更新日期:2020-04-21 00:00:00
abstract::The general model presented here for the formation of chromatin domains, LADs and TADs, is primarily based on the 3-D structures of the corresponding DNA sequences, the GC-poor and GC-rich isochores. Indeed, the low-heterogeneity GC-poor isochores locally are intrinsically stiff and curved because of the presence of i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35851-0
更新日期:2018-12-13 00:00:00
abstract::Pot experiments were carried out to study the effects of rice straw (RS) and rice straw ash (RSA) on the growth of early rice and α-diversity of bacterial community in soils around rare earth mining areas of Xunwu and Xinfeng counties in South Jiangxi of China. The results showed that the exploitation of rare earth re...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67160-w
更新日期:2020-06-25 00:00:00
abstract::To provide a comprehensive analysis of small molecule genotoxic potential we have developed and validated an automated, high-content, high throughput, image-based in vitro Micronucleus (IVM) assay. This assay simultaneously assesses micronuclei and multiple additional cellular markers associated with genotoxicity. Aco...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-82115-5
更新日期:2021-01-28 00:00:00
abstract::The study aimed to explore the epidemiology and clinical characteristics of chronic osteomyelitis observed in a northern China hospital. Clinical data of 255 patients with chronic osteomyelitis from January 2007 to January 2014 were collected and analyzed, including general information, disease data, treatment and fol...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33106-6
更新日期:2018-10-05 00:00:00
abstract::We present theoretical results on the high-temperature phase stability and phonon spectra of paramagnetic bcc iron which explicitly take into account many-body effects. Several peculiarities, including a pronounced softening of the [110] transverse (T1) mode and a dynamical instability of the bcc lattice in harmonic a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05585
更新日期:2014-07-07 00:00:00
abstract::Allergic contact hypersensitivity (CHS) is an inflammatory skin disease mediated by allergen specific T cells. In this study, we investigated the role of transcription factor NFAT1 in the pathogenesis of contact hypersensitivity. NFAT1 knock out (KO) mice spontaneously developed CHS-like skin inflammation in old age. ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19453
更新日期:2016-01-18 00:00:00
abstract::In this letter, making use of real gait force profiles of healthy and patient groups with Parkinson disease which have different disease severity in terms of Hoehn-Yahr stage, we calculate various heuristic complexity measures of the recurrence quantification analysis (RQA). Using this technique, we are able to evince...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27369-2
更新日期:2018-06-14 00:00:00
abstract::In addition to its role in the treatment of pancreatitis, the serine protease inhibitor nafamostat exhibits a retinal protective effect. However, the exact mechanisms underlying this effect are unknown. In this study, the neuroprotective effects of nafamostat and its orally active derivative sepimostat against excitot...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56905-x
更新日期:2019-12-31 00:00:00
abstract::Various sea foods including fish, shellfish and shrimp were collected from different coastal areas of Fujian in China, and their Pb species characteristics were investigated in detail. The results indicated that there are two different species characteristics of Pb existing in sea food samples. About half of samples w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33294
更新日期:2016-09-14 00:00:00
abstract::Sphingopyxis granuli strain TFA is an α-proteobacterium that belongs to the sphingomonads, a group of bacteria well-known for its degradative capabilities and oligotrophic metabolism. Strain TFA is the only bacterium in which the mineralisation of the aromatic pollutant tetralin has been completely characterized at bi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65258-9
更新日期:2020-05-26 00:00:00
abstract::Cellular clearance mechanisms including the autophagy-lysosome pathway are impaired in amyotrophic lateral sclerosis (ALS). One of the most important proteins involved in the regulation of autophagy is the lysosomal Ca2+ channel Mucolipin TRP channel 1 (TRPML1). Therefore, we investigated the role of TRPML1 in a neuro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46708-5
更新日期:2019-07-24 00:00:00